Warren D. Taylor, M.D., MHSc, James G Blakemore Professor of Psychiatry, served as lead author of a new publication proposing how dysfunction in the dopamine system may influence depression in older adults. This may influence risk for depression but also serve as a new target for treatment. The manuscripts provides the rationale for a current multi-site study being conducted at Vanderbilt examining the effect of levodopa (Sinemet) on late-life depression. The paper appears in the journal Molecular Psychiatry.
A Vanderbilt University Medical Center pilot study of treating late-life depression in nonsmokers with transdermal nicotine (nicotine patch) has yielded some promising results, but the study’s author cautions that more study is needed. Late-life depression — depression that occurs in adults 60 years or older — is characterized by poor response to antidepressant medications and often memory issues. About half of those treated for late-life depression fail to respond to initial treatments.
Yi Deng, M.D., resident in Psychiatry & Behavioral Sciences, and Warren Taylor, M.D., professor of Psychiatry & Behavioral Sciences, have worked together to publish a paper titled "Predictors of recurrence in remitted late-life depression" in the journal Depression and Anxiety. The paper examines factors in older adults that may predict the return of depression after successful antidepressant treatment. Click here to view the abstract.
Meghan Riddle, M.D., Assistant Professor of Psychiatry & Behavioral Sciences, and Warren Taylor, M.D., Professor of Psychiatry & Behavioral Sciences, were among the authors of an article titled "Longitudinal cognitive outcomes of clinical phenotypes of late-life depression," published recently in the March issue of The American Journal of Geriatric Psychiatry.
Warren D. Taylor, M.D., Associate Professor of Psychiatry & Behavioral Sciences, served as co-author on a new paper titled "Frontocingulate cerebral blood flow and cerebrovascular reactivity as predictors of antidepressant response in late-life depression." The paper appears in the Journal of Affective Disorders. The study was directed by Dr. Margarita Abi Zeid Daou, a PGY4 resident in the Department of Psychiatry & Behavioral Sciences, mentored by Dr. Taylor.
Warren D Taylor, M.D., MHSc., Associate Professor of Psychiatry and Director of the Mood Disorders Program Center for Cognitive Medicine, was recently awarded NIMH funding toward his K24 Midcareer Investigator Award in Patient-Oriented Research. This proposal will support Dr. Taylor in his efforts to mentor young scientists and researchers, from medical students to medical residents to junior faculty.
Warren D. Taylor, M.D., MHSc, Associate Professor of Psychiatry and Investigator in the Vanderbilt Center for Cognitive Medicine, was one of several authors of the recently published article "Effects of early life stress on depression, cognitive performance, and brain morphology." The article appears in the journal Psychological Medicine. Click here to view the abstract.
Lawrence S. Gaines, Ph.D., Associate Professor of Psychiatry and Medicine, will soon be published in the American Journal of Gastroenterology. His paper is titled "Association between affective-cognitive symptoms of depression and exacerbation of Crohn's Disease." Affective-cognitive symptoms of depression predicted subsequent Crohn's disease activity and hospitalization rate, suggesting a temporal relationship.