Brain imaging studies have shown structural and functional abnormalities in people with psychosis in the connections between the cortex and the thalamus, the major waystation for incoming sensory information and a critical regulator of cortical activity. A new study shows that those differences are not present during development, but that the integrity of the connections is compromised in youth with psychosis spectrum symptoms.
Several Psychiatry & Behavioral Sciences faculty recently contributed to a new published article in the American Journal of Psychiatry. The article, "Thalamic Nuclei Volumes in Psychotic Disorders and in Youths with Psychosis Spectrum Disorders," was produced by Anna S. Huang, Ph.D., Baxter P. Rogers, Ph.D., Julia M. Sheffield, Ph.D., Maria E. Jalbrzikowski, Ph.D., Alan Anticevic, Ph.D., Jennifer Urbano Blackford, Ph.D., Stephan Heckers, M.D., and Neil D. Woodward, Ph.D.
Maureen McHugo, Ph.D., Research Assistant Professor of Psychiatry & Behavioral Sciences, was lead author on a new article published in the journal Translational Psychiatry. "Hippocampal volume in early psychosis: a 2-year longitudinal study" was created by Hugo as well as fellow Psychiatry & Behavioral Sciences faculty and staff members Kristan Armstrong, LMSW; Maxwell J. Roeske; Neil D. Woodward, Ph.D.; Jennifer Blackford, Ph.D.; and Stephan Heckers, M.D., MSc.
Patients with psychosis have accelerated aging of two brain networks important for general cognition -- the frontoparietal network (FPN) and cingulo-opercular network (CON) -- according to a new study in Biological Psychiatry. Efficiency of the FPN network was normal in early psychosis but reduced in chronic patients, indicating that the decline happens after illness onset.
Neil Woodward, Ph.D., associate professor of Psychiatry & Behavioral Sciences, was recently awarded NIMH funding to study the development of brain circuits underlying cognitive function in healthy individuals and youth at risk for developing psychosis. Serving as oo-principal investigator alongside Dr. Woodward is Alan Anticevic, Ph.D., at Yale University.