Paul L. Moots, MD

Paul
L.
Moots
MD
Professor
Neurology

Dr. Moots serves as the Adult Co-director of the Vanderbilt Neurofibromatosis Clinic. He is a member of the Vanderbilt-Ingram Cancer Center. Dr. Moots is also Staff Neurologist at the Nashville Veterans Administration Medical Center. 

Dr. Moots’ is board certified in Neurology. His clinical activities focus on the treatment of primary brain tumors including rare forms of CNS malignancy. He also is involved in the care of patients with metastatic cancer involving the nervous system, particularly carcinomatous meningitis, and patients with non-metastatic cancer-related neurological syndromes. 

Dr. Moots earned a B.S. at Duke University, graduating magna cum laude in 1976. He received his medical degree from The Ohio State University in 1980. He completed an internship in Internal Medicine and residency in Neurology at the University of Virginia in 1984 with Dr. T.R. Johns. From 1984 through 1986 he was a fellow in Neuropathology at the University of Virginia under Dr. Rubinstein and Dr. Vandenberg. From 1986 through 1989 he was a fellow in Neuro-oncology at Memorial Sloan Kettering Cancer Center under Dr. Posner and Dr. Shapiro. From 1989 through 1991 he was Assistant Professor of Neurology and Pediatrics at Memorial Sloan Kettering Cancer Center and was the recipient of an American Cancer Society Career Development Award. In 1991 Dr. Moots joined the faculty of the Vanderbilt University School of Medicine as Assistant Professor of Neurology. In 1998 he became Associate Professor of Neurology and Medicine, and in 2015, he became Professor of Neurology. He served on the CNS Tumor Guidelines Committee of the National Comprehensive Cancer Network from 2007 through 2019. He was the section editor for CNS tumors for multiple editions of the Textbook of Uncommon Cancer.

Dr. Moots’ research activities focus on chemotherapy trials for patients with primary CNS neoplasms including gliomas, medulloblastoma, ependymoma, plexiform neurofibronmas, CNS lymphoma and carcinomatous meningitis. He was the study chair for an ECOG adult medulloblastoma trial.     

Karl Misulis, MD, PhD

Karl
Misulis
MD, PhD
Professor
Clinical Neurology

Dr. Karl Misulis is a neurologist at Vanderbilt University Medical Center, specializing in Hospital Neurology. He is currently Professor of Clinical Neurology and Director of the Neurology Hospitalist service. He has a secondary appointment as Professor of Clinical Biomedical Informatics. Dr. Misulis teaches medical students, residents, and fellows in both clinical and non-clinical environments.

Dr. Misulis is board certified in Neurology by the American Board of Psychiatry and Neurology, certified in Clinical Informatics by the American Board of Preventative Medicine, and certified in EEG by the American Board of Clinical Neurophysiology. He is a member of Alpha Omega Alpha and a fellow of the American Academy of Neurology.

Dr. Misulis has published more than 20 books, some translated into multiple languages. He has taught medicine around the world, working directly with physicians on four continents, and lecturing on six.

He received a BSc From Queen's University, Canada, majoring in Life Sciences. He subsequently received a MD from Vanderbilt University School of Medicine and a PhD in Physiology from State University of New York Health Science Center at Syracuse. He was Resident and then Chief Resident in Neurology at Vanderbilt. After a fellowship in neurophysiology, he joined the Vanderbilt faculty practicing general neurology and researching nerve regeneration and brain tumor biology.

Dr. Misulis transitioned to West Tennessee Healthcare where he was a hospital neurologist and Chief Medical Information Officer, while retaining his faculty appointment at Vanderbilt. He has returned to full-time practice at Vanderbilt University Hospital in his current roles. 

Dr. Misulis has published more than 20 medical books, including these, since 2000.

  • Zimmerman E, Samuels MA, Kirshner HS, Misulis KE: Neurologic Localization and Diagnosis: How Neurologists Think. Elsevier, Philadelphia. In prep for Q1 2021. 
  • Abou-Khalil BA, Sonmezturk H, Ess K, Misulis KE, Atlas of EEG, Seizure Semiology, and Management. Oxford University Press In prep Q4 2020.
  • Frisse ME, Misulis KE, Essentials of Clinical Informatics. Oxford University Press, 2019.
  • Misulis KE, Murray EL, Essentials of Hospital Neurology. Oxford University Press 2017.
  • Misulis KE, Head TC; Netter’s Concise Neurology. Updated edition. Elsevier, Philadelphia 2017.
  • Misulis KE; Atlas of EEG, Seizure Semiology, and Management. 2nd edition. Oxford University Press 2013. With Bassel Abou-Khalil
  • Misulis KE, Head TC; Netter’s Guide to Clinical Neurology. Elsevier, Philadelphia 2007.
  • Abou-Khalil B, Misulis KE, Atlas of EEG & Seizure Semiology, Elsevier, Philadelphia, 2005
  • Misulis KE; Review Manual for Neurology in Clinical Practice 4th edition. Elsevier, Philadelphia 2004
  • Misulis KE, Head TC: Essentials of Clinical Neurophysiology. 3rd ed. Butterworth-Heinemann, Boston 2002
  • Shevlin B, Misulis KE, Samuels M: Shared Care in Neurology. Martin- Dunitz, London 2001

Michael J. McLean, MD, PhD

Michael
J.
McLean
MD, PhD
Associate Professor
Neurology

Dr. Michael McLean has been Associate Professor of Neurology, specializing in epilepsy, at Vanderbilt University Medical Center since 1993. His current efforts include use of acupuncture to treat neurological conditions and pain.

From 1989 – 1993 and from 2016 to the present, Dr. McLean also has worked in the Department of Neurology at the Veterans Affairs Medical Center in Nashville. Since 2016, he has established clinics specializing in the care of veterans with traumatic brain injuries and in acupuncture. He maintains an epilepsy clinic and is developing a neuro-acupuncture clinic in collaboration with Anesthesiology/Pain at Vanderbilt under the guidance of Dr. Dane Chetkovich and Dr. David Edwards.

Dr. McLean earned a BA in Biology from University of Chicago in 1970, and received his PhD in Physiology in 1976 and his MD in 1978 from University of Virginia and University of Virginia School of Medicine. Dr. McLean then pursued postdoctoral studies with Dr. Nick Sperelakis in the Department of Physiology at University of Virginia, and served an internship and his first year of residency in Internal Medicine at Vanderbilt University from 1978 – 1980. In 1983 he completed his residency in Neurology at University of Michigan Hospitals. Dr. McLean was instructor of Neurology, then assistant professor of Neurology at University of Michigan Medical Center from 1983 – 1985. During those years he also studied antiepileptic drug mechanisms of action under the mentorship of Dr. Robert Macdonald. He then joined the faculty at Vanderbilt University Medical Center where he continued laboratory and clinical investigations of antiepileptic drugs and studied potential therapeutic effects of magnetic fields on neurons in cell culture and animal seizure models until 2010. Since then he has concentrated on clinical efforts.

Katherine E. McDonell, MD

Katherine
E.
McDonell
MD
Assistant Professor
Neurology

Dr. Katherine McDonell is an Assistant Professor of Neurology and a board-certified neurologist specializing in neurodegenerative disorders. Clinically, Dr. McDonell sees patients with cognitive and movement disorders including Alzheimer’s disease and other dementias, Parkinson disease, and Huntington disease. She is a core faculty member of the Vanderbilt Level 1 Center of Excellence for Huntington disease and directs the predictive genetic testing program for Huntington Disease at Vanderbilt.

She received her undergraduate degree from Washington University in St. Louis, graduating with honors in biology and philosophy-neuroscience-psychology. She earned her medical degree at Northwestern University and completed her residency training in neurology at Beth Israel Deaconess Medical Center in Boston, MA. She subsequently completed a fellowship in cognitive neurology and a Master of Science in Clinical Investigation at Vanderbilt. 

Dr. McDonell is interested in how neurodegenerative disorders affect cognition and behavior. Her current research focuses on characterizing early cognitive and behavioral changes in patients with Huntington disease using cognitive neuroscience tasks and electrophysiology. She is the recipient of an NINDS K23 award investigating inhibitory control and externalizing behaviors as potential early markers of disease in youth at risk for Huntington disease. Dr. McDonell is also involved in several clinical trials investigating new treatments for Huntington disease.

To learn more about her research, please visit the Cognition and Movement lab page.

Beth Ann Malow, MD

Beth Ann
Malow
MD
Professor
Neurology

Dr. Malow is Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, holds the Burry Endowed Chair in Cognitive Childhood Development, and serves as director of the Vanderbilt Kennedy Center Clinical Translational Core. Dr. Malow is board certified in neurology and Sleep Medicine. She previously served as Vice-Chair for Research and also Academic Affairs within Neurology, and Vice Chair of the governor-appointed Tennessee Autism Council. She also served as PI for the Vanderbilt site of the NeuroNEXT Network (NINDS Network of Excellence in Neuroscience Clinical Trials) and principal investigator for Vanderbilt’s Autism Treatment Network, one of several regional autism centers across North America developing standards of medical care for children with autism.

Prior to joining the faculty at Vanderbilt, Malow was a tenured associate professor of Neurology at the University of Michigan and director of the Sleep Medicine Fellowship Program and the General Clinical Research Center Sleep Program. She received her B.S. degree from Northwestern University in Evanston, IL in 1984 and her M.D. from Northwestern University Medical School in Chicago. She then did her internship in Medicine at Beth Israel Medical Center, New York, NY from 1987-88. Her residency in the Harvard-Longwood Neurological Training Program in Boston, MA from 1988-91 was followed by a fellowship in epilepsy, EEG, and sleep at the National Institutes of Health in Bethesda, MD from 1991-94.

Dr. Malow’s research has emphasized the interface of sleep and epilepsy, autism, and related disorders of neurodevelopment. Through collaborations and mentorship, she is also involved in the study of sleep as it relates to medical disorders as well as aspects of sleep medicine related to genetics and circadian biology. She has expertise in carrying out interventional research in autism across the lifespan, on-line and via telehealth, and in projects involving data derived from the electronic health record.

Christopher Lee, MD, MPH

Christopher
Lee
MD, MPH
Vice Chair
Education
Associate Professor
Neurology

Dr. Lee is Associate Professor of Neurology in the Neuromuscular Division at Vanderbilt University Medical Center. His clinic work includes serving patients with ALS, myasthenia gravis, muscular dystrophy, polyneuropathy, and he also is part of the inpatient teleneurology consult team.

Dr. Lee has a strong interest in medical student and resident education, serving in roles of Associate Program Director, Master Clinical Teacher for clerkship students, and as a Portfolio Coach, working with a section of the class of 2020 longitudinally through their four-year student careers. In 2018, he was appointed Program Director for the Neurology Residency. He has taken leadership roles in the transition of electronic medical records systems at Vanderbilt, the creation of a practice feedback self-assessment project for all of the neurology residents, and in the development of neurohospitalist roles within Vanderbilt University Hospital.

He is the co-chair of the ventilation committee of the Northeast ALS Consortium (ALS) and has publications in muscle ultrasound in ALS, epidemiology of Guillain-Barre syndrome and other disorders, among other publications.

He is a diplomate of the American Board of Psychiatry and Neurology and the American Board of Electrodiagnostic Medicine. Dr. Lee is a Fellow of the American Neurological Association.

Dr. Lee graduated magna cum laude from Davidson College in 2000 with a degree in Mathematics. He earned his M.D. at Wake Forest University School of Medicine in 2004. His internship and residency in Neurology were at Vanderbilt University, where he served as Neurology Chief Resident from 2007-2008. He completed a Clinical Neurophysiology fellowship with an emphasis in neuromuscular disorders at Vanderbilt in June 2009, and was subsequently appointed as Associate Professor of Neurology. In 2011, he received a Master’s of Public Health (MPH) degree from Vanderbilt. 

Presentations at Scientific Meetings: 

  • Brown DM, Clary RS, Lee CD, Monroe WG, Vaughn DA, Ragheb RT, Erter JW, Schiraldi DA. A green, one-pot, preparative route to the biphenyldicarboxylic acids and mechanical properties of polyesters based on these monomers. Poster presented by Dr. Schiraldi at the 219th National Meeting of the American Chemical Society, San Francisco, CA, March, 2000. Polym Preprints 2000, 41: 123–124 
  • Lee CD, Song Y, Peltier AC, Donofrio, PD. Muscle ultrasound quantifies the rate of reduction of muscle thickness in ALS patients. Poster presentation at the 62nd Annual Meeting of the American Academy of Neurology, Toronto, Canada. April 13, 2010. 
  • Lee CD, Jones TF. Hospital discharge database optimization in Guillain-Barré Syndrome surveillance. Poster presentation at the American Neurological Association 136th Annual Meeting. San Diego, CA. September 26, 2011. [peer-reviewed]
  • Lee CD, Butka B, Donofrio P. Frequency of accelerated loss of ventilatory function in ALS. Poster presentation at the 11th Annual Northeast ALS Consortium (NEALS) Annual Meeting. Clearwater, FL. October 25, 2012. [peer-reviewed]
  • Lee CD, Butka B, Donofrio P. Weekly Home-based Monitoring Alerts Clinicians of Loss of Ventilatory Function in ALS. Platform presentation at the 13th Annual Northeast ALS Consortium (NEALS) Annual Meeting. Clearwater, FL. October 23, 2014. [peer-reviewed and selected for platform session]
  • Lee CD, Brooks B. Symposium on respiratory assist devices and pulmonary support for patients with ALS. October 2, 2018. Clearwater, FL.

Andre H. Lagrange, MD, PhD

Andre
H.
Lagrange
MD, PhD
Associate Professor
Neurology

Dr. Lagrange is Associate Professor of Neurology at Vanderbilt University Medical Center, specializing in epilepsy. In addition to his laboratory and clinical research activities, Dr. Lagrange is involved in the teaching and mentoring of residents, fellows, graduate and undergraduate students, and also serves as ad hoc reviewer for Epilepsia, Epilepsy & Behavior, Epilepsy Research, Journal of Physiology, Neurology and Neuropharmacology

Dr. Lagrange’s honors include being the past recipient of a William Penry Epilepsy Minifellowship (2000) and the American Academy of Neurology Residents Scholarship (2001). He is also a fellow of the American Epilepsy Society and American Neurological Association.

Dr. Lagrange earned BS degrees is both Chemistry and Biology (with Honors) at the University of Washington in 1987. He earned a PhD in Physiology and Pharmacology in 1996 and a MD in 1997, both at the Oregon Health Sciences University, while supported by a NIMH pre-doctoral NRSA fellowship. The next year he did an internal medicine internship at Saint Joseph Mercy Hospital in Ann Arbor, MI, followed by Neurology residency (1998-2001) and Clinical Neurophysiology Fellowship (2001-02) at the University of Michigan, Ann Arbor. He joined the faculty at Vanderbilt as Assistant Professor in 2002, and was later promoted to Associate Professor.

Dr. Lagrange’s lab uses electrophysiological techniques with brain slices and immortalized cultured cells to study the tuning of inhibitory neurotransmission during normal brain function and in disease states, including epilepsy. GABA is the primary inhibitory neurotransmitter in the adult brain and is critical for normal brain function. However, in the developing brain, GABA acts as an excitatory signal that directs normal neuronal migration and synaptogenesis. Dr. Lagrange’s lab has found that a predominant GABA receptor expressed primarily during early life is subject to RNA editing in a developmentally regulated fashion. By introducing a single amino acid change in a key portion of these GABA receptors, RNA editing leads to significant changes in receptor function, thereby producing a brief window in late embryogenesis/early postnatal life in which GABA causes the prolonged/slow depolarizations that are important for the subsequent formation of both excitatory and inhibitory connections later in life.

Dr. Lagrange's clinical interest is in the treatment of women with epilepsy. It has been known for a few years that some of the medications used to treat epilepsy may increase the risk of having a child with congenital malformations. Unfortunately, these teratogenic drugs are also widely used for a number of other neurological and psychiatric disorders, such as migraines and bipolar disorder. Alarmingly, recent work has suggested that children exposed to a subset of these drugs in utero have reduced IQ later in life, and an increased incidence of neurodevelopmental disorders such as autism. Further animal work has suggested that these poor cognitive outcomes may involve subtle cortical malformation/laminar disruption, which are thought to be mediated by the GABA modulatory nature of these drugs. Dr. Lagrange's lab is working to understand the role of specific GABA receptors in brain development and how these processes are regulated during normal development, as well as how they may be disrupted by disease states and medications.

Other areas of clinical interest and teaching include autoimmune epilepsy, advanced functional imaging for epilepsy and post-traumatic epilepsy. 

Heather Koons, MD

Heather
Koons
MD
Assistant Professor
Neurology

Dr. Koons is an Assistant Professor in the Movement Disorders Division at the Vanderbilt University Medical Center Neurology Department. She currently follows movement disorders patients at VUMC, as well as the Nashville Veteran’s Affairs Medical Center. 

In addition to patient care, Dr. Koons is actively involved in education. She served as the Neurology Department’s Residency Program Director and continues to serve as the Associate Program Director. She is the VA neurology rotation site director for Vanderbilt neurology residents, Meharry Medical College psychiatry residents, and Meharry Medical College internal medicine residents, along with coordinating Vanderbilt psychiatry outpatient neurology rotations. She is also the site director for the Meharry Medical College occupational health residents. She directs the Deep Brain Stimulation elective for Vanderbilt medical students. 

Dr. Koons has remained active in global health, having previously spent time working in Lusaka, Zambia, Gaborone, Botswana, and Georgetown, Guyana. She participates in Vanderbilt's Institute for Global Health, "Global Health Education Subcommittee for GME."

Dr. Koons received her B.A. degree (with distinction) in Neuroscience and Religious Studies from the University of Virginia in 2002. She received her medical degree from the Yale School of Medicine in 2006. She completed her internship in internal medicine at Vanderbilt University Medical Center where she also completed her neurology residency. She served as chief resident for the neurology residency in her final year. After completing her training, she continued her time at Vanderbilt as an Affiliate Assistant Professor of Neurology while spending a year as the Consultant Neurologist at Bokamoso Private Hospital in Gaborone, Botswana. She returned to Nashville and Vanderbilt as a lecturer in the General Neurology Division and Fellow in the Movement Disorders Division, and was subsequently appointed to faculty.

Kirk J. Kleinfeld, MD

Kirk
J.
Kleinfeld
MD
Assistant Professor
Clinical Neurology

Dr. Kirk Kleinfeld is an Assistant Professor of Clinical Neurology at Vanderbilt University Medical Center. As a general neurologist, he evaluates and treats a wide array of neurological conditions primarily in the outpatient clinical setting in Franklin, TN. Dr. Kleinfeld is certified in both Neurology and Clinical Neurophysiology by the American Board of Psychiatry and Neurology, and is a member of the American Academy of Neurology.

Dr. Kleinfeld completed his internship and Neurology residency at VUMC, followed by a fellowship in Clinical Neurophysiology with a focus on EEG/evoked potentials and EMG/nerve conduction, also at Vanderbilt. Prior to his current position, he served as an attending physician at the Brain and Spine Center at St. Luke’s Hospital in Missouri. He completed his undergraduate coursework at the University of Evansville, and subsequently earned his Doctor of Medicine degree from the University of Tennessee Health Science Center.

Deborah L. G. Kerrigan, MD, MA

Deborah
L. G.
Kerrigan
MD
Assistant Professor
Neurology

Dr. Kerrigan practices both general and vascular neurology and is licensed to practice medicine in Tennessee and Kentucky. She has been a member of the American Board of Psychiatry and Neurology since 2018. In addition to her clinical practice at both the Vanderbilt University Medical Center and the Nashville VA Medical Center, Dr. Kerrigan is active with telemedicine. As an Assistant Professor of Medicine, Dr. Kerrigan is involved with medical student, resident, and fellow education.

Dr. Kerrigan earned a BS in both Elementary Education and Psychology concentrating in Neuroscience in 2006 from Vanderbilt University. She then performed medical research and completed a post-baccalaureate, pre-medical program, earning a MA in Biology from Washington University in St. Louis in 2010. She earned her MD from Saint Louis University School of Medicine in 2014 and then completed her Neurology residency and a Vascular Neurology fellowship at the Cleveland Clinic. She joined the faculty of Vanderbilt in August 2019.