Department of Psychiatry and Behavioral Sciences

Andrew Molnar, PhD

Andrew

Molnar, Jr.

PhD [he/him]

Assistant Professor of Psychiatry and Behavioral Sciences

Division of Psychology

Member, Vanderbilt Kennedy Center

Adjunct Assistant Professor in Psychology

Vanderbilt University

Dr. Molnar [he/him] joined the faculty in 2018 after providing clinical services at St. Jude Children's Research Hospital. He is a clinical-child psychologist, with specialization in pediatric neuropsychology. At Vanderbilt University Medical Center, Dr. Molnar manages the Pediatric Neuropsychology Service within the Department, providing cognitive assessment services with his team of licensed psychometrists and trainees to child, adolescent, and young adult patients with neurological and other chronic health conditions. His team evaluates patients with such conditions from early childhood [0-5 years of age], to young adult ages, providing information to help patients and families make decisions about educational and other programming services in their communities. Beyond the clinical endeavors, Dr. Molnar teaches in clinic to psychology trainees and psychiatry residents and fellows, lectures in various didactic series in the Department and across VUMC, and collaborates on several research projects.

Village at Vanderbilt

1500 21st Ave South, Suite 2200

Nashville

Tennessee

37212

Dr. Molnar is particularly interested in early childhood development, executive function, and mental health correlates in youth with neurological and other chronic health conditions. He currently is a collaborator to specialized research projects at VUMC and Vanderbilt University involving young patients with delirium in pediatric intensive care, youth with Tourette syndrome, and preschoolers prenatally exposed to substances.

Representative Publications

Since Joining VUMC in 2018:

Harman, J. L., Molnar, A. E., Cox, L. E., Jurbergs, N., Russell, K. M., Wise, J., & Willard, V. W. (2018). Parent-reported executive functioning in young children treated for cancer. Child Neuropsychology, 26, 1-13. doi: 10.1080/09297049.2018.1503647. PMID 30049262.

Cox, L. E., Kenney, A. E., Harman, J. L., Jurbergs, N., Molnar, A. E., & Willard, V. W. (2019). Psychosocial functioning of young children treated for cancer: Findings from a clinical sample. Journal of Pediatric Oncology Nursing, 36(1), 17-23. doi: 10.1177/1043454218813905. PMID 30798688.

Jurbergs, N., Harman, J. L., Kenney, A. E., Semenkovich, K., Molnar, A. E., & Willard, V. W. (2019). Cognitive and psychosocial development in young children with brain tumors: Observations from a clinical sample. Children, 6(11), 128, published online 19 November 2019. doi: 10.3390/children6110128. PMID 31752377.

Kenney, A. E., Harman, J. L., Molnar, A. E., Jurbergs, N., & Willard, V. W. (2020). Early cognitive
and adaptive functioning of clinically referred infants and toddlers with cancer. Journal of Clinical Psychology in Medical Settings, 27, 41-47. doi: 10.1007/s10880-019-09619-1. PMID 30993575.

Harman, J. L., Molnar, A. E., Jacola, L. M., Corr, A., Scott, A., Potter, B., Schwartzberg, S., Boyer, H., Greear, J., & Willard, V. W. (2021). Establishing a hospital-based early intervention program for young children with cancer: A quality improvement initiative. Clinical Practice in Pediatric Psychology, 9(4), 323-333. doi: http://dx.doi.org/10/1037/cpp0000375.

Boggs, J. E., Pullen, A., Molnar, A. E., Hodges, J., & Reiss, U. M. (2023). Screening for inattention,
hyperactivity, and impulsivity in children with haemophilia: A quality improvement intervention. Haemophilia, 29(1), 210-218. doi: 10.1111/hae.14656. PMID 36112768.

Berl, M.M., Koop, J.I., Ailion, A., Bearden, D.J., …Molnar, A.E. …Perry, M. S. (2023). Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative. Epilepsia. Advance online publication. doi: 10.1111/epi.17579. PMID 36897767.

Cárdenas, E.F., Hill, K.E., Estes, E., Ravi, S., Molnar, A.E., Humphreys, K.L., & Kujawa, A. (2024). Neural and behavioral indicators of cognitive control in preschoolers with and without prenatal opioid exposure. Child Neuropsychology, 30(2), 329-347. doi: 10.1080/09297049.2023.2196397. PMID 37070372.

Schwartzman, J.M., Williams, Z.J., & Molnar, A.E. (2024). Parent and provider differences in ratings of mental health and neurodevelopmental concerns in children with neurologic disorders. Journal of Clinical Psychology in Medical Settings, online ahead of print.
doi: 10.1007/s10880-23-0999-0. PMID 38400951.

Watson, K.H., Eckland, M., Schwartzman, J.M., Molnar, A., Boon, W., Hiller, M., Scholer, S., Mace, R., Rothman, A., Claassen, D.O., Riordan, H.R., Isaacs, D.A. (2024). The association of quality of life with psychosocial factors in adolescents with Tourette syndrome. Child Psychiatry & Human Development, online ahead of print. doi: 10.1007/s10578-023-01656-0. PMID 38311626.

Ravi, S., Molnar, A.E., Cárdenas, E.F., Kujawa, A., & Humphreys, K.L. (2024, accepted and in press). Associations between opioid exposure in gestation, childhood adversity, and preschool age cognitive functioning. International Journal of Behavioral Development.

Molnar, A.E., Walker, J.S., Roback, H.B., & Welch, L. (2024). Psychological Assessment. In M.H. Ebert, P.R. Martin, M.McVoy, R.J. Ronis, & S.H. Weissman (Eds.), Current Diagnosis and Treatment : Psychiatry, Fourth Edition. New York, New York: McGraw Hill LLC.

andrew.e.molnar@vumc.org

Dr. Molnar's pediatric neuropsychology practice serves diverse pediatric patients with neurological and other chronic health conditions throughout VUMC. Within that broad scope, he has specialized interests in youth with brain tumors, cancer, seizure disorders, Tourette syndrome, prenatal exposure to substances, and spina bifida.

Lindsey C. McKernan, PhD, MPH

Lindsey

Colman

McKernan

PhD, MPH

Associate Professor of Psychiatry and Behavioral Sciences

Division of Psychology

Osher Center for Integrative Medicine at Vanderbilt

3401 West End Avenue

Nashville

Tennessee

lindsey.mckernan@vumc.org

Dr. McKernan is an Associate Professor in the Department of Psychiatry and Behavioral Sciences, having joined the faculty in 2014. Clinically, Dr. McKernan specializes in treating the intersection between co-occurring chronic health conditions and mental health. She has particular interests in working with trauma and chronic illness, and has additional expertise in clinical hypnosis.

Currently, Dr. McKernan works as a clinician at the Osher Center for Integrative Medicine (OCIM) and Department of Urologic Surgery. Dr. McKernan also oversees the health psychology postdoctoral fellowship position at OCIM through the Department's APPIC-approved program.

Research Description

Dr. McKernan is currently funded by the National Institute of Health to develop innovative psychosocial treatments for specific pain populations served at VUMC. Recognizing that pain is a highly unique experience to the individual, the lab and its collaborators are working to administer psychosocial interventions for urologic populations, specifically interstitial cystitis/bladder pain syndrome.

The lab's focus is to inform treatment and intervention delivery through applying patient-informed approaches to care, understanding unique patient-level factors that influence pain, expanding treatments to a wider audience, and using data science to inform intervention efforts.

Dr. McKernan has a highly collaborative research lab and you can follow her work by visiting mckernanlab.com or following updates on twitter through @LCMPhD.

Follow @LCMPhD

Sonia Matwin, PhD

Sonia

Matwin

PhD

Assistant Professor

Psychiatry and Behavioral Sciences

Vanderbilt Psychiatric Hospital

1601 23rd Avenue South, Suite 3060

Suite 3050

Nashville

Tennessee

37212

Matwin S, Chang G. Readiness to change and risk drinking women. J Subst Abuse Treat [print-electronic]. 2011 Apr; 40(3): 230-40. PMID: 21193283, PMCID: PMC3072060, PII: S0740-5472(10)00237-0, DOI: 10.1016/j.jsat.2010.11.004, ISSN: 1873-6483.
Ellington L, Sheldon LK, Matwin S, Smith JA, Poynton MM, Crouch BI, Caravati EM. An examination of adherence strategies and challenges in poison control communication. J Emerg Nurs [print-electronic]. 2009 Jun; 35(3): 186-90; quiz 274. PMID: 19446121, PMCID: PMC3167489, PII: S0099-1767(08)00055-X, DOI: 10.1016/j.jen.2008.02.015, ISSN: 1527-2966.
Ellington L, Matwin S, Jasti S, Williamson J, Crouch B, Caravati M, Dudley W. Poison control center communication and impact on patient adherence. Clin Toxicol (Phila). 2008 Feb; 46(2): 105-9. PMID: 18259957, PMCID: PMC3167482, PII: 789498762, DOI: 10.1080/15563650701338914, ISSN: 1556-3650.
Wainryb C, Brehl BA, Matwin S. Being hurt and hurting others: children's narrative accounts and moral judgments of their own interpersonal conflicts. Monogr Soc Res Child Dev. 2005; 70(3): 1-114. PMID: 16359348, PII: MONO350, DOI: 10.1111/j.1540-5834.2005.00350.x, ISSN: 0037-976X.

sonia.matwin@vumc.org

Sonia Matwin completed her Ph.D. in Social Psychology, at the University of Utah in 2007, after which she worked as a Research Associate in the Department of Psychiatry at Harvard Medical School. In 2013, Dr. Matwin completed a clinical respecialization program at Suffolk University, and began working as an Associate Psychologist in the Department of Psychiatry at Brigham and Women's Hospital, integrating her research on patient provider communication with her clinical practice. During this time, Dr. Matwin became increasingly involved in teaching evidence-based psychotherapy, which is currently her primary focus as an Assistant Professor and the Director of Psychotherapy Education in the Department of Psychiatry and Behavioral Sciences at Vanderbilt University Medical Center.

Dr. Matwin's primary clinical, teaching, and research interests focus on the provision and teaching of CBT and mindfulness-based therapies, as well as the use and integration of technology for both teaching and treatment.

Clinical Description

Dr. Matwin's areas of clinical expertise include: Cognitive-behavioral therapy, acceptance and mindfulness-based psychotherapy, health behavior change and related decision-making, psychological distress related to chronic disease management, health behavior change, anxiety, and depression.

Research Description

Dr. Matwin engages in research that examines the theory and practice of effective health communications, particularly in relation to health promotion and related decision-making. Dr. Matwin is also active in the development, testing, and teaching of novel mindfulness-based interventions for the treatment of anxiety and depression; as well as the use and integration of technology for teaching and treatment.

Tarah Kuhn, PhD

Tarah

Kuhn

PhD

Associate Professor of Clinical Psychiatry and Behavioral Sciences

Division of Psychology

Clinical Director, Vanderbilt Center of Excellence for Children in State Custody

Dr. Tarah Kuhn is a licensed clinical psychologist and has been a member of the faculty since 2005. Areas of expertise include juvenile justice, trauma and system level interventions. Dr. Kuhn is the Clinical Director of the Vanderbilt Center of Excellence for Children in State Custody (COE) providing ongoing consultation, training, dissemination of best practices and statewide quality improvement projects. The COE is part of a statewide network funded under an agreement with the State of Tennessee to improve the public health by enhancing the quality of services provided to children in or at-risk of entering the Tennessee child welfare or juvenile justice systems.

In the Department of Psychiatry and Behavioral Sciences, Dr. Kuhn provides teaching and supervision for the Child and Adolescent Psychiatry Fellowship program, Psychiatry residents, as well as Psychology practicum students, Predoctoral Interns and Postdoctoral Fellows.

Dr. Kuhn's research interests include trauma informed care, child welfare, juvenile justice and systems of care.

Representative Publications

Thome, J., Gracey, K., Epstein, R., Cull, M., Kuhn, T., Raman, R. (2024). Reporting of Child Maltreatment during the COVID-19 Pandemic in a Southern State in the United States. Public Health Reports. 2024;0(0). doi:10.1177/00333549241245846.

Joseph, J., DesAutels, S., Gracey, K., Kronenberg, M., Kuhn, T, Raman, R. (2023). Child and family outcomes of the Safe Babies Court Team – A scoping review. Children and Youth Services Review, Volume 149, 106956, ISSN 0190-7409, https://doi.org/10.1016/j.childyouth.2023.106956.

Siciliano, R. E., Anderson, A. S., Vreeland, A. J., Gruhn, M. A., Henry, L. M., Watson, K. H., Liu, Q., Cole, D. A., Ebert, J., Kuhn, T., & Compas, B. E. (2023). Physiology and emotions: Within individual associations during caregiver–adolescent conflict. Psychophysiology, 60, e14397. https://doi.org/10.1111/psyp.14397

Henry, L., Watson, K., Cole, D. A., Torres, S., Vreeland, A., Siciliano, R., Anderson, A. S., Gruhn, M., Ciriegio, A., Broll, B., Ebert, J., Kuhn, T., & Compas, B. E. (2023). Mean-level correspondence and moment-to-moment synchrony in adolescent and parent affect: Exploring associations with adolescent age and internalizing and externalizing symptoms. Development and Psychopathology, 35(2), 809-822. doi:10.1017/S0954579422000062

Anderson, A.S., Siciliano, R., Henry, L., Watson, K., Gruhn, M., Kuhn, T., Ebert, J., Vreeland, A., Ciriegio, A., Guthrie, C., Compas, B.E. (2022) Adverse Childhood Experiences, Parenting, and Socioeconomic Status: Associations with Internalizing and Externalizing Symptoms in Adolescence. Child Abuse & Neglect. doi.org/10.1016/j.chiabu.2022.105493.

Henry, L., Gracey, K., Shaffer, A., Ebert, J., Kuhn, T., Watson, K., Gruhn, M., Vreeland, A., Siciliano, R., Dickey, L., Lawson, V., Broll, C., Cole, D., Compas, B. (2021). Comparison of Three Models of Adverse Childhood Experiences: Associations with Child and Adolescent Internalizing and Externalizing Symptoms. Journal of Abnormal Psychology, 130(1), 9-25. doi: 10.1037/abn0000644

Vreeland, A., Ebert, J., Kuhn, T., Gracey, K., Shaffer, A., Watson, K., Gruhn, M., Henry, L., Dickey, L., Siciliano, R., Anderson, A., Compas, B. (2020). Predictors of Placement Disruptions in Foster Care. Child Abuse & Neglect, 99. 104283. doi:10.1016/j.chiabu.2019.104283

Kuhn, T., Cyperski, M., Shaffer, A., Gracey, K., Adams, M., Billings, G., Ebert, J. (2019) Installing Trauma Informed Care Through the Tennessee Child Protective Services Academy. Psychological Services (Vol. 16, 143-152). doi.org/10.1037/ser0000320

Kuhn, T., Ebert, J., Gracey, K., Chapman, G. & Epstein, R. (2015) Evidence-Based Interventions for Adolescents with Disruptive Behaviors in School-Based Settings. Child and Adolescent Psychiatry Clinics of North America, 24 (2), 305-317

Bank, B., Kuhn, T. & Blackford, J. (2015) Modifying Dialectical Behavior Therapy for Incarcerated Female Youth: A Pilot Study. Journal of Juvenile Justice, 4 (1), 1-17

tarah.kuhn@vumc.org

Dr. Kuhn’s background includes clinical work with children and families with histories of complex trauma and juvenile justice involvement. An additional focus has been on multi-systemic collaboration to improve services and advocate for the clinical needs of children and families. Areas of training and technical support include Motivational Interviewing (MI) and Trauma and Resiliency Informed Care within child serving systems.

Joseph LaBarbera, PhD

Joseph

LaBarbera

PhD

Associate Professor of Clinical Psychiatry and Behavioral Sciences

Division of Psychology

Village at Vanderbilt

1500 21st Ave South, Suite 2200

Nashville

Tennessee

37212

Joseph.LaBarbera@vumc.org

Dr. Joseph LaBarbera, who has been a member of the faculty since 1978, is a clinical psychologist specializing in work with children, adolescents, and young adults. His primary professional activities include psychotherapy and evaluation of psychological and educational problems. Frequently, evaluations are sought for young people by their parents; other times professionals such as psychiatrists, primary care physicians, therapists, and teachers may want direction or assistance. Dr. LaBarbera has an active forensic practice and works with attorneys and courts.

Kimberly Kayser, PhD

Kimberly

Kayser

PhD

Assistant Professor of Psychiatry and Behavioral Sciences

Division of Psychology

kimberly.kayser@vumc.org

Dr. Kayser is a pediatric neuropsychologist and Assistant Professor of Psychiatry and Behavioral Sciences. She received her Doctor of Philosophy from the University of Texas at Austin. She completed her internship at Texas Children's Hospital/Baylor College of Medicine and 2-year post-doctoral fellowship at Advanced Neurobehavioral Health of Southern California in pediatric neuropsychology.

Dr. Kayser was previously on faculty at Children's Hospital Los Angeles (CHLA) Children's Center for Cancer and Blood Diseases (CCCBD) as an Assistant Professor of Clinical Pediatrics through the University of Southern California Keck School of Medicine. During her time at the CCCBD, she developed and launched an integrated multi-line pediatric neuropsychology service, allowing for the incorporation of neuropsychological services into standard healthcare practices. In her role, Dr. Kayser directed and oversaw the planning, development, and implementation of clinical service operations, training, and research. She has consulted and lectured nationally and internationally on topics related to the establishment and implementation of tiered systems of neuropsychological surveillance and care. Dr. Kayser joined Vanderbilt University Medical Center in 2019.

Clinical Description

Dr. Kayser's clinical work focuses on neuropsychological monitoring and evaluation of infants, children, and adolescents with neurological, developmental, genetic, and systemic medical conditions. She additionally provides evidence-based treatments for diverse pediatric populations, with a strong interest in early childhood and infant mental health.

Research Description

Dr. Kayser's research has focused on investigating the impact of cancer and associated treatments on the developing brain and how those disruptions impact general functioning and quality of life. Most recently, her research has been dedicated to establishing practical and effective methods for detecting and screening neurobehavioral functioning.

Monica Jacobs, PsyD, ABPP

Monica

Jacobs

PsyD, ABPP

Assistant Professor of Clinical Psychiatry and Behavioral Sciences

Division of Psychology

Vanderbilt Psychiatric Hospital

monica.l.jacobs@vumc.org

Monica Jacobs, PsyD, ABPP is board certified in neuropsychology by the American Board of Professional Psychology. She joined the Department of Psychiatry at Vanderbilt University Medical Center in 2010 as a Neuropsychologist. She provides neuropsychological evaluations for adults for a broad range of referral questions including dementia, Mild Cognitive Impairment, epilepsy and traumatic brain injury. She also provides consults in the Vanderbilt Comprehensive Assessment Program. These evaluations include cognitive assessment and return to work decisions of professionals referred for comprehensive mental health evaluations by various licensing boards and hospitals.

Lawrence Gaines, PhD

Lawrence

Gaines

PhD

Associate Professor of Psychiatry and Behavioral Sciences

Division of Psychology

Village at Vanderbilt

1500 21st Ave South, Suite 2200

Nashville

Tennessee

37212

lawrence.gaines@vumc.org

Dr. Larry Gaines has been a member of the faculty since 1987. He initiated behavioral medicine-clinical psychology services for VUMC programs in surgical weight loss and inflammatory bowel disease. He is interested in symptom dimensions of depression and chronic disease, particularly inflammatory bowel disease.

Jon Ebert, PsyD

Jon

Ebert

PsyD

Associate Professor of Clinical Psychiatry and Behavioral Sciences

Division of Psychology

Dr. Ebert is a licensed clinical psychologist and Associate Professor in Clinical Psychiatry and Behavioral Health & Associate Professor in Vanderbilt Department of Human & Organizational Development. He has over 25 years experience and expertise in clinical, consultation and training in the assessment and delivery of services to children and families who have experienced traumatic stress and mental health challenges. Dr. Ebert is the Director of the Vanderbilt Center of Excellence for Children in State Custody (COE) which is part of a statewide network funded under an agreement with the State of Tennessee to improve the public health by enhancing the quality of services provided to children in or at-risk of entering the Tennessee child welfare or juvenile justice systems

Education and Leadership

Dr. Ebert is the Director of the APA approved Vanderbilt University Medical Center Internship in Professional Psychology (VUMC-IPP), co-director of the Child & Adolescent Psychology predoctoral internship track and Director of the Division of Psychology postdoctoral fellowship training program. He is Chairman of the Treatment Subcommittee for the Tennessee Joint Task Force on Children's Justice and Child Sexual Abuse which is charged with identifying existing problems and recommending solutions to the Tennessee child welfare system (DCS) regarding the investigation and prosecution of child abuse and neglect. He is 1 of 4 national Technical Advisors for the Complex Trauma Training Consortium (CTTC) which aims to provide national trainer-training and workforce development in complex trauma understanding, assessment, and treatment. He also serves as a senior leader and advisor for the Tennessee Best Practice Initiative which is responsible for the statewide implementation of evidence based treatments. Under his leadership, models such as: Trauma Focused Cognitive Behavioral Therapy (TF-CBT), Attachment Regulation & Competence (ARC), Teen Outreach Program (TOP), Child Parent Psychotherapy (CPP) and Parent Child Interaction Therapy (PCIT) continue to be trained & supported in TN.

In the Department of Psychiatry, Dr. Ebert provides didactic training and supervision to psychiatry child & adolescent fellows, psychiatry residents, psychology practicum students, predoctoral interns and postdoctoral fellows.

Green Hills Office Building

3841 Green Hills Village Dr

Nashville

37215

Dr. Ebert's research interests include dissemination & implementation science, treatments for childhood traumatic stress, developmental trauma and trauma & resiliency informed care in organizations.

Research Publications:

Siciliano, R.E., Anderson, A.S., Vreeland, A.J., Gruhn, M.A., Henry, L.M., Watson, K.H., Ebert, J., Kuhn, T., Liu, Q., Cole, D.A., & Compas, B.E. (2023, in press). Physiology and emotions: Within individual associations during caregiver-adolescent conflict. Psychophysiology.

Henry, L., Gracy, K., Shaffer, A., Ebert, J., Kuhn, T., Watson, K., Gruhn, M., Vreeland, A., Siciliano, R., Dickey, L., Lawson, V., Broll, C., Cole, D., Compas, B. (2021). Comparison of Three Models of Adverse Childhood Experiences: Associations with Child and Adolescent Internalizing and Externalizing Symptoms. Journal of Abnormal Psychology. PMID: 33271039 DOI: 10.1037/abn0000644
Walsh, C., Unertl, K, Ebert, J. (2020) Rapid Supportive Response to a Traumatic “Zoombombing” During the COVID-19 Pandemic, Academic Medicine: Volume Publish Ahead of Print - PMID: 32897926 DOI: 10.1097/ACM.0000000000003739
Vreeland, A., Ebert, J., Kuhn, T., Gracey, K., Shaffer, A., Watson, K., Gruhn, M., Henry, L., Dickey, L., Siciliano, R., Anderson, A., Compas, B. (2020). Predictors of Placement Disruptions in Foster Care. Child Abuse & Neglect, 99. 104283. doi: PMID: 31765852 PMCID: PMC7984659 DOI: 10.1016/j.chiabu.2019.104283
Kuhn, T., Cyperski, M., Shaffer, A., Gracey, K., Adams, M., Billings, G., Ebert, J. (2018). Installing Trauma Informed Care Through the Tennessee Child Protective Services Academy. Psychological Services. PMID: 30570285 DOI: 10.1037/ser0000320
Kuhn, T., Ebert, J., Gracey, K., Chapman, G. & Epstein, R. (2015) Evidence-Based Interventions for Adolescents with Disruptive Behaviors in School-Based Settings. Child and Adolescent Psychiatry Clinics of North America, 24 (2), 305-317. PMID: 25773326 DOI: 10.1016/j.chc.2014.11.005

jon.s.ebert@vumc.org

Dr. Ebert is a certified trainer in Treating Traumatic Stress in Children & Youth; Attachment, Regulation & Competence (ARC). As a certified trainer, he has trained ARC nationally and internationally. He has national recognition for his training & technical support in Motivational Interviewing (MI), Trauma & Resiliency Informed Care, Working With Problematic Sexual Behaviors in Children & Youth, and Maintaining Wellness While Working in Trauma.

Ariel Deutch, PhD

Ariel

Deutch

Professor

Psychiatry and Behavioral Sciences

Verbeeck N, Spraggins JM, Wang H-D, Murphy MJM, Deutch AY, Caprioli RM, Van de Plas R. Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis. Biochim Biophys Acta. 2017; 1865: 967-77.
White MG, Cody PA, Bubser M, Wang HD, Deutch AY, Mathur BN. Cortical hierarchy governs rat claustrocortical circuit organization. J. Comp. Neurol [print-electronic]. 2016 Jan 1/23/2016; PMID: 26801010, PMCID: PMC4958609, DOI: 10.1002/cne.23970, ISSN: 1096-9861.

Deutch AY. Extending Corticostriatal Systems. JAMA Psychiatry [print-electronic]. 2016 Jun 6/29/2016; PMID: 27367649, PII: 2529150, DOI: 10.1001/jamapsychiatry.2016.0242, ISSN: 2168-6238.
Deutch AY, Mathur BN. Editorial: The Claustrum: charting a way forward for the brain's most mysterious nucleus. Front Syst Neurosci. 2015; 9: 103. PMID: 26236204, PMCID: PMC4502348, DOI: 10.3389/fnsys.2015.00103, ISSN: 1662-5137.

Mingote S, Chuhma N, Kusnoor SV, Field B, Deutch AY, Rayport S. Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions. J. Neurosci. 2015 Dec 12/9/2015; 35(49): 16259-71. PMID: 26658874, PMCID: PMC4682788, PII: 35/49/16259, DOI: 10.1523/JNEUROSCI.1674-15.2015, ISSN: 1529-2401.
Deutch AY. The thorny problem of dyskinesias: dendritic spines, synaptic plasticity, and striatal dysfunction. Biol. Psychiatry. 2014 May 5/1/2014; 75(9): 676-7. PMID: 24731696, PMCID: PMC4120525, PII: S0006-3223(14)00135-8, DOI: 10.1016/j.biopsych.2014.02.019, ISSN: 1873-2402.

Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, Wess J, Wood MR, Lindsley CW, Gore JC, Conn PJ, Jones CK. Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Neuropsychopharmacology [print-electronic]. 2014 Jun; 39(7): 1578-93. PMID: 24442096, PMCID: PMC4023154, PII: npp20142, DOI: 10.1038/npp.2014.2, ISSN: 1740-634X.

Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. J. Neurochem [print-electronic]. 2014 Jul; 130(1): 109-14. PMID: 24611756, PMCID: PMC4065617, DOI: 10.1111/jnc.12697, ISSN: 1471-4159.

Kraemer BR, Snow JP, Vollbrecht P, Pathak A, Valentine WM, Deutch AY, Carter BD. A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. J. Biol. Chem [print-electronic]. 2014 Aug 8/1/2014; 289(31): 21205-16. PMID: 24939843, PMCID: PMC4118083, PII: M114.563403, DOI: 10.1074/jbc.M114.563403, ISSN: 1083-351X.
Deutch, AY, Hedera P, Colbran RJ. REEPing the benefits of an animal model of hereditary spastic paraplegia. Journal of Clinical Investigation. 2013; 123(10): 4134-6.

Deutch AY. Parkinson's disease redefined. Lancet Neurol [print-electronic]. 2013 May; 12(5): 422-3. PMID: 23582176, PII: S1474-4422(13)70052-8, DOI: 10.1016/S1474-4422(13)70052-8, ISSN: 1474-4465.
Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS ONE [print-electronic]. 2012; 7(9): e45323. PMID: 23028932, PMCID: PMC3448631, PII: PONE-D-12-17469, DOI: 10.1371/journal.pone.0045323, ISSN: 1932-6203.

Rong Y, Wei P, Parris J, Guo H, Pattarini R, Correia K, Li L, Kusnoor SV, Deutch AY, Morgan JI. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. J Neurochem. 2012; 120: 528-40.

Wei P, Pattarini R, Rong Y, Guo H, Bansal PK, Kusnoor SV, Deutch AY, Parris J, Morgan JI. The Cbln family of proteins interact with multiple signaling pathways. J Neurochem. 2012; 121: 717-29.

Rong Y, Wei P, Parris J, Guo H, Pattarini R, Correia K, Li L, Kusnoor SV, Deutch AY, Morgan JI. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. J. Neurochem. 2012 Feb; 120(4): 528-40. PMID: 22117778, PMCID: PMC3259274, DOI: 10.1111/j.1471-4159.2011.07604.x, ISSN: 1471-4159.

Kusnoor SV, Bubser M, Deutch AY. The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Brain Res [print-electronic]. 2012 Mar 3/29/2012; 1446: 46-55. PMID: 22353754, PMCID: PMC3772731, PII: S0006-8993(12)00101-1, DOI: 10.1016/j.brainres.2012.01.040, ISSN: 1872-6240.
Ansah TA, Ferguson MC, Nayyar T, Bubser M, Garcia BG, Deutch AY. Age- and duration-dependent effects of MPTP on cortical serotonin systems. Neurosci Lett. 2011; 504: 160-4.

Ansah TA, Ferguson MC, Nayyar T, Deutch AY. Age- and duration-dependent effects of MPTP on cortical serotonin systems. Neurosci. Lett [print-electronic]. 2011 Oct 10/24/2011; 504(2): 160-4. PMID: 21964387, PMCID: PMC3210582, PII: S0304-3940(11)01301-2, DOI: 10.1016/j.neulet.2011.09.026, ISSN: 1872-7972.
Ferguson MC, Nayyar T, Deutch AY, Ansah TA. 5-HT2A receptor antagonists improve motor impairments in the MPTP mouse model of Parkinson's disease. Neuropharmacology [print-electronic]. 2010 Jul; 59(1-2): 31-6. PMID: 20361986, PMCID: PMC2878885, PII: S0028-3908(10)00089-4, DOI: 10.1016/j.neuropharm.2010.03.013, ISSN: 1873-7064.

Kusnoor SV, Parris J, Muly EC, Morgan JI, Deutch AY. Extracerebellar role for Cerebellin1: modulation of dendritic spine density and synapses in striatal medium spiny neurons. J. Comp. Neurol. 2010 Jul 7/1/2010; 518(13): 2525-37. PMID: 20503425, PMCID: PMC2919330, DOI: 10.1002/cne.22350, ISSN: 1096-9861.

Gustin RM, Bichell TJ, Bubser M, Daily J, Filonova I, Mrelashvili D, Deutch AY, Colbran RJ, Weeber EJ, Haas KF. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Neurobiol. Dis [print-electronic]. 2010 Sep; 39(3): 283-91. PMID: 20423730, PMCID: PMC2922926, PII: S0969-9961(10)00128-2, DOI: 10.1016/j.nbd.2010.04.012, ISSN: 1095-953X.

Garcia BG, Neely MD, Deutch AY. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cereb. Cortex [print-electronic]. 2010 Oct; 20(10): 2423-32. PMID: 20118184, PMCID: PMC2936803, PII: bhp317, DOI: 10.1093/cercor/bhp317, ISSN: 1460-2199.
Kusnoor SV, Muly EC, Morgan JI, Deutch AY. Is the loss of thalamostriatal neurons protective in parkinsonism?. Parkinsonism and Related Disorders. 2009; 15 (S3): 162-6.

Neely MD, Robert EM, Baucum AJ, Colbran RJ, Muly EC, Deutch AY. Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Brain Res [print-electronic]. 2009 Jun 6/5/2009; 1274: 55-65. PMID: 19362076, PMCID: PMC2723059, PII: S0006-8993(09)00693-3, DOI: 10.1016/j.brainres.2009.03.067, ISSN: 1872-6240.

Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA. Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. Eur. J. Neurosci. 2009 Jul; 30(2): 207-16. PMID: 19659923, PMCID: PMC2765981, PII: EJN6806, DOI: 10.1111/j.1460-9568.2009.06806.x, ISSN: 1460-9568.

Mathur BN, Caprioli RM, Deutch AY. Proteomic analysis illuminates a novel structural definition of the claustrum and insula. Cereb. Cortex [print-electronic]. 2009 Oct; 19(10): 2372-9. PMID: 19168664, PMCID: PMC2742595, PII: bhn253, DOI: 10.1093/cercor/bhn253, ISSN: 1460-2199.

Neely MD, Stanwood GD, Deutch AY. Combination of diOlistic labeling with retrograde tract tracing and immunohistochemistry. J. Neurosci. Methods [print-electronic]. 2009 Nov 11/15/2009; 184(2): 332-6. PMID: 19712695, PMCID: PMC2796483, PII: S0165-0270(09)00449-X, DOI: 10.1016/j.jneumeth.2009.08.016, ISSN: 1872-678X.

Kusnoor SV, Muly EC, Morgan JI, Deutch AY. Is the loss of thalamostriatal neurons protective in parkinsonism?. Parkinsonism Relat. Disord. 2009 Dec; 15 Suppl 3: S162-6. PMID: 20082981, PMCID: PMC2900831, PII: S1353-8020(09)70806-5, DOI: 10.1016/S1353-8020(09)70806-5, ISSN: 1873-5126.

Wang HD, Stanwood GD, Grandy DK, Deutch AY. Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice. Brain Res [print-electronic]. 2009 Dec 12/1/2009; 1300: 58-64. PMID: 19747903, PMCID: PMC2783753, PII: S0006-8993(09)01882-4, DOI: 10.1016/j.brainres.2009.09.008, ISSN: 1872-6240.
Andersson M, Groseclose MR, Deutch AY, Caprioli RM. Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction. Nat. Methods. 2008 Jan; 5(1): 101-8. PMID: 18165806, PII: nmeth1145, DOI: 10.1038/nmeth1145, ISSN: 1548-7105.

Mathur BN, Deutch AY. Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3. Neurosci. Lett [print-electronic]. 2008 Apr 4/18/2008; 435(2): 90-4. PMID: 18358609, PMCID: PMC3679921, PII: S0304-3940(08)00122-5, DOI: 10.1016/j.neulet.2008.01.082, ISSN: 0304-3940.

Wang HD, Deutch AY. Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment. Neuropsychopharmacology [print-electronic]. 2008 May; 33(6): 1276-86. PMID: 17687264, PII: 1301521, DOI: 10.1038/sj.npp.1301521, ISSN: 0893-133X.

Clark JA, Flick RB, Pai LY, Szalayova I, Key S, Conley RK, Deutch AY, Hutson PH, Mezey E. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Mol. Psychiatry [print-electronic]. 2008 May; 13(5): 498-506. PMID: 17622221, PMCID: PMC3392182, PII: 4002041, DOI: 10.1038/sj.mp.4002041, ISSN: 1476-5578.

Lieberman JA, Bymaster FP, Meltzer HY, Deutch AY, Duncan GE, Marx CE, Aprille JR, Dwyer DS, Li XM, Mahadik SP, Duman RS, Porter JH, Modica-Napolitano JS, Newton SS, Csernansky JG. Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacol. Rev. 2008 Sep; 60(3): 358-403. PMID: 18922967, PII: 60/3/358, DOI: 10.1124/pr.107.00107, ISSN: 1521-0081.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J. Neurosci. 2008 Oct 10/8/2008; 28(41): 10422-33. PMID: 18842902, PMCID: PMC2577155, PII: 28/41/10422, DOI: 10.1523/JNEUROSCI.1850-08.2008, ISSN: 1529-2401.
Deutch AY, Colbran RJ, Winder DJ. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism Relat. Disord. 2007; 13 Suppl 3: S251-8. PMID: 18267246, PII: S1353-8020(08)70012-9, DOI: 10.1016/S1353-8020(08)70012-9, ISSN: 1353-8020.

Hackler EA, Turner GH, Gresch PJ, Sengupta S, Deutch AY, Avison MJ, Gore JC, Sanders-Bush E. 5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation. J. Pharmacol. Exp. Ther [print-electronic]. 2007 Mar; 320(3): 1023-9. PMID: 17138863, PII: jpet.106.113357, DOI: 10.1124/jpet.106.113357, ISSN: 0022-3565.

Mathur BN, Neely MD, Dyllick-Brenzinger M, Tandon A, Deutch AY. Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Brain Res [print-electronic]. 2007 Sep 9/7/2007; 1168: 83-9. PMID: 17706185, PMCID: PMC2040265, PII: S0006-8993(07)01645-9, DOI: 10.1016/j.brainres.2007.06.076, ISSN: 0006-8993.

Neely MD, Schmidt DE, Deutch AY. Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neuroscience [print-electronic]. 2007 Oct 10/26/2007; 149(2): 457-64. PMID: 17888581, PMCID: PMC2094700, PII: S0306-4522(07)00807-X, DOI: 10.1016/j.neuroscience.2007.06.044, ISSN: 0306-4522.

Deutch AY, Bubser M. The orexins/hypocretins and schizophrenia. Schizophr Bull [print-electronic]. 2007 Nov; 33(6): 1277-83. PMID: 17728265, PMCID: PMC2779882, PII: sbm096, DOI: 10.1093/schbul/sbm096, ISSN: 0586-7614.
Deutch AY. Striatal plasticity in parkinsonism: dystrophic changes in medium spiny neurons and progression in Parkinson's disease. J. Neural Transm. Suppl. 2006; (70): 67-70. PMID: 17017511, ISSN: 0303-6995.

Deutch AY, Winder DG. A channel to neurodegeneration. Nature medicine. 2006 Jan; 12(1) Sect. 17,8.

Day M, Wang Z, Ding J, An X, Ingham CA, Shering AF, Wokosin D, Ilijic E, Sun Z, Sampson AR, Mugnaini E, Deutch AY, Sesack SR, Arbuthnott GW, Surmeier DJ. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat. Neurosci [print-electronic]. 2006 Feb; 9(2): 251-9. PMID: 16415865, PII: nn1632, DOI: 10.1038/nn1632, ISSN: 1097-6256.

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL. P90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Mar 3/21/2006; 103(12): 4717-22. PMID: 16537434, PMCID: PMC1450237, PII: 0600585103, DOI: 10.1073/pnas.0600585103, ISSN: 0027-8424.

Fadel J, Dobner PR, Deutch AY. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice. Neurosci. Lett [print-electronic]. 2006 Jul 7/10/2006; 402(1-2): 97-101. PMID: 16632196, PII: S0304-3940(06)00316-8, DOI: 10.1016/j.neulet.2006.03.043, ISSN: 0304-3940.
Zaja-Milatovic S, Milatovic D, Schantz AM, Zhang J, Montine KS, Samii A, Deutch AY, Montine TJ. Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease. Neurology. 2005 Feb 2/8/2005; 64(3): 545-7. PMID: 15699393, PII: 64/3/545, DOI: 10.1212/01.WNL.0000150591.33787.A4, ISSN: 1526-632X.

Petrie KA, Schmidt D, Bubser M, Fadel J, Carraway RE, Deutch AY. Neurotensin activates GABAergic interneurons in the prefrontal cortex. J. Neurosci. 2005 Feb 2/16/2005; 25(7): 1629-36. PMID: 15716398, PII: 25/7/1629, DOI: 10.1523/JNEUROSCI.3579-04.2005, ISSN: 1529-2401.

Bubser M, Fadel JR, Jackson LL, Meador-Woodruff JH, Jing D, Deutch AY. Dopaminergic regulation of orexin neurons. Eur. J. Neurosci. 2005 Jun; 21(11): 2993-3001. PMID: 15978010, PII: EJN4121, DOI: 10.1111/j.1460-9568.2005.04121.x, ISSN: 0953-816X.

Brown AM, Deutch AY, Colbran RJ. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Eur. J. Neurosci. 2005 Jul; 22(1): 247-56. PMID: 16029214, PII: EJN4190, DOI: 10.1111/j.1460-9568.2005.04190.x, ISSN: 0953-816X.
Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology. 2004 Feb; 29(2): 362-72. PMID: 14627996, PII: 1300336, DOI: 10.1038/sj.npp.1300336, ISSN: 0893-133X.

Wang HD, Dunnavant FD, Jarman T, Deutch AY. Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat. Neuropsychopharmacology. 2004 Jul; 29(7): 1230-8. PMID: 15085089, PII: 1300449, DOI: 10.1038/sj.npp.1300449, ISSN: 0893-133X.

Petrie KA, Bubser M, Casey CD, Davis MD, Roth BL, Deutch AY. The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology. 2004 Oct; 29(10): 1878-88. PMID: 15150532, PII: 1300494, DOI: 10.1038/sj.npp.1300494, ISSN: 0893-133X.
Deutch AY, Roth RH. Neurotransmitters. Fundamental Neuroscience (Squire LR, Bloom FE, McConnell SK, Roberts JL, Spitzer NC, Zigmond MJ Eds), Academic Press, New York, pp 163-196 (Second edition). 2003; (()).

Dobner PR, Deutch AY, Fadel J. Neurotensin: dual roles in psychostimulant and antipsychotic drug responses. Life Sci. 2003 Jun 6/27/2003; 73(6): 801-11. PMID: 12801600, PII: S0024320503004119, ISSN: 0024-3205.

Scruggs JL, Schmidt D, Deutch AY. The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats. Neurosci. Lett. 2003 Aug 8/7/2003; 346(3): 137-40. PMID: 12853103, PII: S0304394003005470, ISSN: 0304-3940.

Gu G, Deutch AY, Franklin J, Levy S, Wallace DC, Zhang J. Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochem. Biophys. Res. Commun. 2003 Aug 8/15/2003; 308(1): 197-205. PMID: 12890501, PII: S0006291X03012336, ISSN: 0006-291X.
Woo NS, Lu J, England R, McClellan R, Dufour S, Mount DB, Deutch AY, Lovinger DM, Delpire E. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus. 2002; 12(2): 258-68. PMID: 12000122, DOI: 10.1002/hipo.10014, ISSN: 1050-9631.

Fadel J, Deutch AY. Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience. 2002; 111(2): 379-87. PMID: 11983323, PII: S0306452202000179, ISSN: 0306-4522.

Bubser M, Deutch AY. Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum. Eur. J. Neurosci. 2002 Feb; 15(4): 713-20. PMID: 11886451, ISSN: 0953-816X.

Fadel J, Bubser M, Deutch AY. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J. Neurosci. 2002 Aug 8/1/2002; 22(15): 6742-6. PMID: 12151553, PII: 22/15/6742, DOI: 20026632, ISSN: 1529-2401.
Bubser M, Backstrom JR, Sanders-Bush E, Roth BL, Deutch AY. Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Synapse. 2001 Mar 3/15/2001; 39(4): 297-304. PMID: 11169779, PII: 10.1002/1098-2396(20010315)39:4<297::AID-SYN1012>3.0.CO;2-Q, DOI: 10.1002/1098-2396(20010315)39:4<297::AID-SYN1012>3.0.CO;2-Q, ISSN: 0887-4476.

Fadel J, Dobner PR, Deutch AY. The neurotensin antagonist SR 48692 attenuates haloperidol-induced striatal Fos expression in the rat. Neurosci. Lett. 2001 Apr 4/27/2001; 303(1): 17-20. PMID: 11297813, PII: S0304394001017086, ISSN: 0304-3940.

Deutch AY. Introduction. Parkinsonism Relat. Disord. 2001 Jul; 7(3): 163. PMID: 11331181, PII: S1353-8020(00)00052-3, ISSN: 1873-5126.

Dobner PR, Fadel J, Deitemeyer N, Carraway RE, Deutch AY. Neurotensin-deficient mice show altered responses to antipsychotic drugs. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Jul 7/3/2001; 98(14): 8048-53. PMID: 11427716, PMCID: PMC35465, PII: 141042198, DOI: 10.1073/pnas.141042198, ISSN: 0027-8424.
Bubser M, Scruggs JL, Young CD, Deutch AY. The distribution and origin of the calretinin-containing innervation of the nucleus accumbens of the rat. Eur. J. Neurosci. 2000 May; 12(5): 1591-8. PMID: 10792437, PII: ejn052, ISSN: 0953-816X.

Salvatore MF, Garcia-Espana A, Goldstein M, Deutch AY, Haycock JW. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. J. Neurochem. 2000 Jul; 75(1): 225-32. PMID: 10854265, ISSN: 0022-3042.

Scruggs JL, Patel S, Bubser M, Deutch AY. DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons. J. Neurosci. 2000 Dec 12/1/2000; 20(23): 8846-52. PMID: 11102493, PII: 20/23/8846, ISSN: 1529-2401.
Abi-Saab WM, Bubser M, Roth RH, Deutch AY. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology. 1999 Jan; 20(1): 92-6. PMID: 9885788, PII: S0893-133X(98)00046-3, DOI: 10.1016/S0893-133X(98)00046-3, ISSN: 0893-133X.

Bubser M, Deutch AY. Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. Synapse. 1999 Apr; 32(1): 13-22. PMID: 10188633, PII: 10.1002/(SICI)1098-2396(199904)32:1<13::AID-SYN2>3.0.CO;2-R, DOI: 10.1002/(SICI)1098-2396(199904)32:1<13::AID-SYN2>3.0.CO;2-R, ISSN: 0887-4476.

Young CD, Bubser M, Meltzer HY, Deutch AY. Clozapine pretreatment modifies haloperidol-elicited forebrain Fos induction: a regionally-specific double dissociation. Psychopharmacology (Berl.). 1999 Jun; 144(3): 255-63. PMID: 10435392, ISSN: 0033-3158.
Bubser M, Deutch AY. Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Brain Res. 1998 Mar 3/23/1998; 787(2): 304-10. PMID: 9518661, PII: S0006-8993(97)01373-5, ISSN: 0006-8993.

Grobin AC, Deutch AY. Dopaminergic regulation of extracellular gamma-aminobutyric acid levels in the prefrontal cortex of the rat. J. Pharmacol. Exp. Ther. 1998 Apr; 285(1): 350-7. PMID: 9536031, ISSN: 0022-3565.

Young CD, Deutch AY. The effects of thalamic paraventricular nucleus lesions on cocaine-induced locomotor activity and sensitization. Pharmacol. Biochem. Behav. 1998 Jul; 60(3): 753-8. PMID: 9678661, PII: S0091-3057(98)00051-3, ISSN: 0091-3057.

Young CD, Meltzer HY, Deutch AY. Effects of desmethylclozapine on Fos protein expression in the forebrain: in vivo biological activity of the clozapine metabolite. Neuropsychopharmacology. 1998 Jul; 19(1): 99-103. PMID: 9608582, PII: S0893133X97002030, DOI: 10.1016/S0893-133X(97)00203-0, ISSN: 0893-133X.

Deutch AY, Bubser M, Young CD. Psychostimulant-induced Fos protein expression in the thalamic paraventricular nucleus. J. Neurosci. 1998 Dec 12/15/1998; 18(24): 10680-7. PMID: 9852603, ISSN: 0270-6474.
Willins DL, Deutch AY, Roth BL. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse. 1997 Sep; 27(1): 79-82. PMID: 9268067, PII: 10.1002/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A, DOI: 10.1002/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A, ISSN: 0887-4476.
Deutch AY, Duman RS. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization. Neuroscience. 1996 Jan; 70(2): 377-89. PMID: 8848147, PII: 0306-4522(95)00357-6, ISSN: 0306-4522.

Deutch AY, Lewis DA, Whitehead RE, Elsworth JD, Iadarola MJ, Redmond DE, Roth RH. Effects of D2 dopamine receptor antagonists on Fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse. 1996 Jul; 23(3): 182-91. PMID: 8807746, PII: 10.1002/(SICI)1098-2396(199607)23:3<182::AID-SYN7>3.0.CO;2-4, DOI: 10.1002/(SICI)1098-2396(199607)23:3<182::AID-SYN7>3.0.CO;2-4, ISSN: 0887-4476.
Fitzgerald LW, Deutch AY, Gasic G, Heinemann SF, Nestler EJ. Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J. Neurosci. 1995 Mar; 15(3 Pt 2): 2453-61. PMID: 7891180, ISSN: 0270-6474.

Deutch AY, Ongür D, Duman RS. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action. Neuroscience. 1995 May; 66(2): 337-46. PMID: 7477876, PII: 0306-4522(94)00571-L, ISSN: 0306-4522.

Goldstein M, Lee KY, Lew JY, Harada K, Wu J, Haycock JW, Hokfelt T, Deutch AY. Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40. J. Neurochem. 1995 May; 64(5): 2281-7. PMID: 7722513, ISSN: 0022-3042.
Bourdelais AJ, Deutch AY. The effects of haloperidol and clozapine on extracellular GABA levels in the prefrontal cortex of the rat: an in vivo microdialysis study. Cereb. Cortex. 1994 Jan; 4(1): 69-77. PMID: 8180492, ISSN: 1047-3211.

Deutch AY. Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression. J Clin Psychiatry. 1994 Sep; 55 Suppl B: 37-42. PMID: 7961570, ISSN: 0160-6689.

Rasmusson AM, Goldstein LE, Deutch AY, Bunney BS, Roth RH. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse. 1994 Nov; 18(3): 218-24. PMID: 7855734, DOI: 10.1002/syn.890180307, ISSN: 0887-4476.
Deutch AY. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. J. Neural Transm. Gen. Sect. 1993; 91(2-3): 197-221. PMID: 8099797.

Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic mechanisms of posttraumatic stress disorder. Arch. Gen. Psychiatry. 1993 Apr; 50(4): 295-305. PMID: 8466391, ISSN: 0003-990X.

Brog JS, Salyapongse A, Deutch AY, Zahm DS. The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J. Comp. Neurol. 1993 Dec 12/8/1993; 338(2): 255-78. PMID: 8308171, DOI: 10.1002/cne.903380209, ISSN: 0021-9967.
Deutch AY. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J. Neural Transm. Suppl. 1992; 36: 61-89. PMID: 1527521, ISSN: 0303-6995.

Deutch AY, Cameron DS. Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Neuroscience. 1992; 46(1): 49-56. PMID: 1350665, ISSN: 0306-4522.

Deutch AY, Zahm DS. The current status of neurotensin-dopamine interactions. Issues and speculations. Ann. N. Y. Acad. Sci. 1992; 668: 232-52. PMID: 1361115, ISSN: 0077-8923.

During MJ, Freese A, Deutch AY, Kibat PG, Sabel BA, Langer R, Roth RH. Biochemical and behavioral recovery in a rodent model of Parkinson's disease following stereotactic implantation of dopamine-containing liposomes. Exp. Neurol. 1992 Feb; 115(2): 193-9. PMID: 1735466, PII: 0014-4886(92)90053-S, ISSN: 0014-4886.

Goldstein M, Deutch AY. Dopaminergic mechanisms in the pathogenesis of schizophrenia. FASEB J. 1992 Apr; 6(7): 2413-21. PMID: 1348713, ISSN: 0892-6638.

Grobin AC, Roth RH, Deutch AY. Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3a,21-dihydroxy-5a-pregnane-20-one. Brain Res. 1992 Apr 4/24/1992; 578(1-2): 351-6. PMID: 1511287, PII: 0006-8993(92)90270-J, ISSN: 0006-8993.

Rosin DL, Clark WA, Goldstein M, Roth RH, Deutch AY. Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. Neuroscience. 1992 Jun; 48(4): 831-9. PMID: 1352864, PII: 0306-4522(92)90271-3, ISSN: 0306-4522.

Clark JA, Deutch AY, Gallipoli PZ, Amara SG. Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter. Neuron. 1992 Aug; 9(2): 337-48. PMID: 1497897, PII: 0896-6273(92)90172-A, ISSN: 0896-6273.

Deutch AY, Lee MC, Iadarola MJ. Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action. Mol. Cell. Neurosci. 1992 Aug; 3(4): 332-41. PMID: 19912876, PII: 1044-7431(92)90030-6, ISSN: 1044-7431.

Klitenick MA, Deutch AY, Churchill L, Kalivas PW. Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum. Neuroscience. 1992 Sep; 50(2): 371-86. PMID: 1279461, PII: 0306-4522(92)90430-A, ISSN: 0306-4522.

Duman RS, Craig JS, Winston SM, Deutch AY, Hernandez TD. Amygdala kindling potentiates seizure-stimulated immediate-early gene expression in rat cerebral cortex. J. Neurochem. 1992 Nov; 59(5): 1753-60. PMID: 1402920, ISSN: 0022-3042.
Janson AM, Fuxe K, Goldstein M, Deutch AY. Hypertrophy of dopamine neurons in the primate following ventromedial mesencephalic tegmentum lesion. Exp Brain Res. 1991; 87(1): 232-8. PMID: 1756831, ISSN: 0014-4819.

Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophr. Res. 1991 Mar; 4(2): 121-56. PMID: 1674882, PII: 0920-9964(91)90030-U, ISSN: 0920-9964.

Deutch AY, Lee MC, Gillham MH, Cameron DA, Goldstein M, Iadarola MJ. Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex. Cereb. Cortex. 1991 Jul; 1(4): 273-92. PMID: 1668366, ISSN: 1047-3211.
Deutch AY, Roth RH. The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog. Brain Res. 1990; 85: 367-402; discussion 402. PMID: 2094906, ISSN: 0079-6123.

Robbins RJ, Torres-Aleman I, Lebranth C, Bradberry CW, Deutch AY, Welsh S, Roth RH, Spencer D, Redmond DE, Naftolin F. Cryopreservation of human brain tissue. Exp. Neurol. 1990 Mar; 107(3): 208-13. PMID: 1968397, ISSN: 0014-4886.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain Res. 1990 Apr 4/16/1990; 513(2): 320-4. PMID: 2350702, PII: 0006-8993(90)90474-P, ISSN: 0006-8993.

Gruen RJ, Deutch AY, Roth RH. Perinatal diazepam exposure: alterations in exploratory behavior and mesolimbic dopamine turnover. Pharmacol. Biochem. Behav. 1990 May; 36(1): 169-75. PMID: 2349259, PII: 0091-3057(90)90144-7, ISSN: 0091-3057.

Deutch AY, Clark WA, Roth RH. Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Brain Res. 1990 Jun 6/25/1990; 521(1-2): 311-5. PMID: 2119850, PII: 0006-8993(90)91557-W, ISSN: 0006-8993.

Deutch AY, During MJ. A cautionary note on the potential benefits of striatal dopamine implants [letter]. Ann. Neurol. 1990 Jul; 28(1): 111. PMID: 2375628, DOI: 10.1002/ana.410280127, ISSN: 0364-5134.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neurosci. Lett. 1990 Jul 7/13/1990; 114(3): 316-22. PMID: 2402341, ISSN: 0304-3940.

Deutch AY, Elsworth JD, Roth RH, Goldstein M. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Brain Res. 1990 Sep 9/10/1990; 527(1): 96-102. PMID: 2126479, ISSN: 0006-8993.
Elsworth JD, Deutch AY, Redmond DE, Taylor JR, Sladek JR, Roth RH. Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates: biochemical changes in striatal regions. Neuroscience. 1989; 33(2): 323-31. PMID: 2622529, ISSN: 0306-4522.

Bradberry CW, Karasic DH, Deutch AY, Roth RH. Regionally-specific alterations in mesotelencephalic dopamine synthesis in diabetic rats: association with precursor tyrosine. J. Neural Transm. Gen. Sect. 1989; 78(3): 221-9. PMID: 2529883.

Deutch AY, Gruen RJ, Roth RH. The effects of perinatal diazepam exposure on stress-induced activation of the mesotelencephalic dopamine system. Neuropsychopharmacology. 1989 Jun; 2(2): 105-14. PMID: 2742725, PII: 0893-133X(89)90013-4, ISSN: 0893-133X.

Deutch AY, Rosin DL, Goldstein M, Roth RH. 3-Acetylpyridine-induced degeneration of the nigrostriatal dopamine system: an animal model of olivopontocerebellar atrophy-associated parkinsonism. Exp. Neurol. 1989 Jul; 105(1): 1-9. PMID: 2568269, ISSN: 0014-4886.

Knorr AM, Deutch AY, Roth RH. The anxiogenic beta-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 1989 Aug 8/28/1989; 495(2): 355-61. PMID: 2765936, PII: 0006-8993(89)90228-X, ISSN: 0006-8993.

Yurek DM, Deutch AY, Roth RH, Sladek JR. Morphological, neurochemical, and behavioral characterizations associated with the combined treatment of diethyldithiocarbamate and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res. 1989 Sep 9/18/1989; 497(2): 250-9. PMID: 2573405, PII: 0006-8993(89)90270-9, ISSN: 0006-8993.

Lee KY, Lew JY, Tang D, Schlesinger DH, Deutch AY, Goldstein M. Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase. J. Neurochem. 1989 Oct; 53(4): 1238-44. PMID: 2570128, ISSN: 0022-3042.

Bean AJ, During MJ, Deutch AY, Roth RH. Effects of dopamine depletion on striatal neurotensin: biochemical and immunohistochemical studies. J. Neurosci. 1989 Dec; 9(12): 4430-8. PMID: 2593006, ISSN: 0270-6474.

Sesack SR, Deutch AY, Roth RH, Bunney BS. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 1989 Dec 12/8/1989; 290(2): 213-42. PMID: 2592611, DOI: 10.1002/cne.902900205, ISSN: 0021-9967.
Roth RH, Tam SY, Ida Y, Yang JX, Deutch AY. Stress and the mesocorticolimbic dopamine systems. Ann. N. Y. Acad. Sci. 1988; 537: 138-47. PMID: 3059920, ISSN: 0077-8923.

Deutch AY, Goldstein M, Baldino F, Roth RH. Telencephalic projections of the A8 dopamine cell group. Ann. N. Y. Acad. Sci. 1988; 537: 27-50. PMID: 2462395, ISSN: 0077-8923.

Deutch AY, Bean AJ, Roth RH. Regulation of A8 dopamine neurons by somatostatin. Eur. J. Pharmacol. 1988 Mar 3/1/1988; 147(2): 317-20. PMID: 2896598, ISSN: 0014-2999.

Goldstein M, Lieberman AN, Helmer E, Koslow M, Ransohoff J, Elsworth JD, Roth RH, Deutch AY. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Ann. Neurol. 1988 Nov; 24(5): 685-8. PMID: 2904793, DOI: 10.1002/ana.410240517, ISSN: 0364-5134.
Sladek JR, Collier TJ, Haber SN, Deutch AY, Elsworth JD, Roth RH, Redmond DE. Reversal of parkinsonism by fetal nerve cell transplants in primate brain. Ann. N. Y. Acad. Sci. 1987; 495: 641-57. PMID: 2886092, ISSN: 0077-8923.

Sladek JR, Redmond DE, Collier TJ, Haber SN, Elsworth JD, Deutch AY, Roth RH. Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Prog. Brain Res. 1987; 71: 309-23. PMID: 3495818, ISSN: 0079-6123.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sci. 1987 Jan 1/12/1987; 40(2): 193-202. PMID: 3491946, ISSN: 0024-3205.

Deutch AY, Roth RH. Calcitonin gene-related peptide in the ventral tegmental area: selective modulation of prefrontal cortical dopamine metabolism. Neurosci. Lett. 1987 Feb 2/24/1987; 74(2): 169-74. PMID: 3554009, ISSN: 0304-3940.

Deutch AY, Tam SY, Freeman AS, Bowers MB, Roth RH. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Eur. J. Pharmacol. 1987 Feb 2/24/1987; 134(3): 257-64. PMID: 3569414, ISSN: 0014-2999.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Res. 1987 Jul 7/14/1987; 415(2): 293-9. PMID: 3496938, PII: 0006-8993(87)90211-3, ISSN: 0006-8993.

Deutch AY, Bean AJ, Bissette G, Nemeroff CB, Robbins RJ, Roth RH. Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions. Brain Res. 1987 Aug 8/11/1987; 417(2): 350-4. PMID: 2888514, PII: 0006-8993(87)90462-8, ISSN: 0006-8993.

Deutch AY, Holliday J, Roth RH, Chun LL, Hawrot E. Immunohistochemical localization of a neuronal nicotinic acetylcholine receptor in mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 1987 Dec; 84(23): 8697-701. PMID: 3317419, PMCID: PMC299613, ISSN: 0027-8424.
Deutch AY, Goldstein M, Roth RH. Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area. Brain Res. 1986 Jan 1/22/1986; 363(2): 307-14. PMID: 3942901, PII: 0006-8993(86)91016-4, ISSN: 0006-8993.

Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S. Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet. 1986 May 5/17/1986; 1(8490): 1125-7. PMID: 2871381, PII: S0140-6736(86)91839-8, ISSN: 0140-6736.

Deutch AY, Elsworth JD, Goldstein M, Fuxe K, Redmond DE, Sladek JR, Roth RH. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurosci. Lett. 1986 Jul 7/11/1986; 68(1): 51-6. PMID: 3487756, ISSN: 0304-3940.

Bannon MJ, Deutch AY, Tam SY, Zamir N, Eskay RL, Lee JM, Maggio JE, Roth RH. Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin. Brain Res. 1986 Sep 9/3/1986; 381(2): 393-6. PMID: 2428438, PII: 0006-8993(86)90097-1, ISSN: 0006-8993.

Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S. Transplants of primate neurons [letter]. Lancet. 1986 Nov 11/1/1986; 2(8514): 1046. PMID: 2877218, PII: S0140-6736(86)92664-4, ISSN: 0140-6736.

Deutch AY, Goldstein M, Roth RH. The ascending projections of the dopaminergic neurons of the substantia nigra, zona reticulata: a combined retrograde tracer-immunohistochemical study. Neurosci. Lett. 1986 Nov 11/21/1986; 71(3): 257-63. PMID: 2879262, ISSN: 0304-3940.
Deutch AY, Maggio JE, Bannon MJ, Kalivas PW, Tam SY, Goldstein M, Roth RH. Substance K and substance P differentially modulate mesolimbic and mesocortical systems. Peptides. 1985; 6 Suppl 2: 113-22. PMID: 2417207, ISSN: 0196-9781.

Deutch AY, Tam SY, Roth RH. Footshock and conditioned stress increase 3,4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra. Brain Res. 1985 Apr 4/29/1985; 333(1): 143-6. PMID: 3995282, PII: 0006-8993(85)90134-9, ISSN: 0006-8993.

Kalivas PW, Deutch AY, Maggio JE, Mantyh PW, Roth RH. Substance K and substance P in the ventral tegmental area. Neurosci. Lett. 1985 Jun 6/24/1985; 57(3): 241-6. PMID: 2412193, ISSN: 0304-3940.
Deutch AY, Clark LS, Peacock LJ. Kainic acid stimulation of the lateral septum elicits tachycardia. Brain Res. Bull. 1984 Mar; 12(3): 209-14. PMID: 6144375, ISSN: 0361-9230.
Deutch AY, Martin RJ. Mesencephalic dopamine modulation of pituitary and central beta-endorphin: relation to food intake regulation. Life Sci. 1983 Jul 7/18/1983; 33(3): 281-7. PMID: 6865661, ISSN: 0024-3205.

ariel.deutch@vumc.org

Central dopamine (DA) systems are critically involved in a number of neuropsychiatric disorders, including schizophrenia and Parkinson's disease. Our lab focuses on the studies of the DA innervations of prefrontal cortex and striatal complex, using a number of anatomical, biochemical and molecular approaches.

Studies on the prefrontal cortical DA innervation seek to delineate the anatomical organization of the projections and to define the mechanisms through which alterations in cortical DA systems transsynaptically regulate subcortical systems. The latter studies involve two broad experimental strategies: biochemical studies aimed at characterizing the regulation of GABAergic interneurons in the cortex by DA, and examination of the regulatory changes induced in subcortical DA systems by selective destruction of the cortical DA innervations. A major effort is devoted to understanding how antipsychotic drugs, particularly atypical antipsychotic drugs, elicit their therapeutic and side effects.

Studies of the DA innervation of the striatum aim to understand the progressive nature of Parkinson's disease, particularly changes in dendritic spines of neurons that receive convergent dopaminergic and glutamatergic inputs. To this end we use both structural and biochemical measures to study the plasticity of dendritic spines following striatal dopamine depletion.

A third set of studies explores the mechanisms of action of hallucinogens and their ability to alter thalamocortical and corticothalamic signaling. We are particularly interested in dissociating event initiating at the thalamus or cortex determining if ability of hallucinogens to activate the cortex.

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