NIH S10 Grant Program | Office of Research

2023 VUMC Submissions to the NIH S10 Programs

VUMC Internal Proposals due April 1
Contact amy.f.martinez@vumc.org with any questions.

Program Overview

The NIH S10 Instrumentation program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instrumentation or an integrated system. Types of instruments supported by S10 funding include, but are not limited to X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.

VUMC investigators who intend to apply to either of the S10 programs below should submit an internal proposal for review. An internal proposal is required for all projects and will be used to arrange matching funds and letters of support. Proposals submitted in collaboration with an SOM core facility or shared resource will be prioritized for matching funds.

Shared Instrumentation Grant (SIG) Program:

https://grants.nih.gov/grants/guide/pa-files/PAR-22-080.html
Budget range: $50,000 - $600,000

High-End Instrumentation (HEI) Grant Program:

https://grants.nih.gov/grants/guide/pa-files/PAR-22-079.html
Budget range: $600,001 - $2,000,000

Note: VUMC will not qualify for the Basic Instrumentation Grant (BIG) program (PAR-22-081)

VUMC Internal Application Process

Submit a VUMC internal proposal by April 1 via https://redcap.link/s10program. Late submissions may be ineligible for matching funds. Investigators are strongly encouraged to read the appropriate RFA(s) and guidance document prior to submission.

Investigators should submit a brief expression of intent to amy.f.martinez@vumc.org prior to starting an internal application. Include PI, partnering core, and brief equipment description (2-3 sentences). Expressions of intent will be used to assess for scientific overlap and ensure that VU and VUMC do not prepare competing proposals.

Contact

VUMC investigators: Contact amy.f.martinez@vumc.org with any questions about the program requirements, eligibility or institutional process.

VU investigators: Find more information about the internal proposal process on the VU S10 site. Please direct any questions to:

chuck.sanders@vanderbilt.edu (VU Basic Sciences)
susannah.a.imhoff@vanderbilt.edu (All non-SOM VU departments)

S10 Resources for PIs & Administrators:

Core advisory committee meeting template
"Supporting Shared Instrumentation Grants" - Presentation at ABRF SEASR 2022
Guide to linking publications in myNCBI - contact amy.f.martinez@vumc.org to request
S10 acknowledgement voucher program - see program details below

A micrograph from the Immunophenotyping Shared Resource/Innovative Translational Research Shared Resource from their development of PhenoCycler (CODEX) panels for staining multiple targets on a single section of tissue. In this image DAPI (blue), CD38 (teal), CD45 (red), CD31 (white), CD3 (green), Cytokeratin (fuchsia) are shown on a sample from a head and neck squamous cell carcinoma. For further information about this shared resource or potential projects please visit https://www.vumc.org/itr-shared-resource/welcome and/or contact Kimberly Brown Dahlman, PhD. The CODEX is supported by S10OD030338.

Core Facilities Vouchers for S10 Award Citations

Internal Funding Opportunity

NIH requires VUMC to submit a report of S10-awarded instrument performance each year. An important part of this report is data related to the publications impact of these awards. The Office of Research encourages all researchers to specifically cite the appropriate S10 grant award(s) when publishing data produced using this NIH-funded equipment. As an incentive, the Office of Research is offering core vouchers to all investigators who submit publication citations for S10 instrument awards within their NIH reporting period.

For each verified citation of an S10 award, an investigator will receive vouchers redeemable for $250 in VUMC core services.

Voucher Program Eligibility

ANY user of an eligible S10-funded instrument may apply!
The user must cite the S10, including the NIH award number (e.g. 1S10OD016245-01), in the manuscript's "Acknowledgements" section, or as specified by the journal.
The list of eligible S10 awards and their recommended acknowledgement text appears in the table below

How to Submit Citations

Submit citations via https://is.gd/S10corevouchers

Questions? Contact Amy Martinez, PhD (amy.f.martinez@vumc.org)

Recommended citations for S10-funded instruments:

PET-CT Scanner, awarded in 2016

Instrument/Project Name: A PET-CT Scanner for Imaging Human Subjects and Large Animals
Access facilitated through: Center for Human Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD012297-01A1 for the PET-CT Scanner, housed in the Vanderbilt Center for Human Imaging."

3T MRI, awarded in 2016

Instrument/Project Name: Replacement and Upgrade of a 3T MR Scanner for Research
Access facilitated through: Center for Human Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD021771-01 for the 3T MRI, housed in the Vanderbilt Center for Human Imaging."

Radiochemistry Equipment for Molecular Imaging Tracer Production, awarded in 2017

Instrument/Project Name: Radiochemistry Equipment for Molecular Imaging Tracer Production
Access facilitated through: Center for Molecular Probes - Radiochemistry Core
Principal Investigator: Todd Peterson, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD023543-01 for the Radiochemistry Equipment for Molecular Imaging Tracer Production, housed in the Vanderbilt Center for Molecular Probes - Radiochemistry Core."

Leica Bond RX Automated Immunohistochemistry and in situ stainer, awarded in 2018

Instrument/Project Name: The Leica Bond RX
Access facilitated through: Translational Pathology Shared Resource
Principal Investigator: Katherine Gibson-Corley, DVM, PhD, Pathology, Microbiology, & Immunology

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD023475-01A1 for the Leica Bond RX, housed in the Vanderbilt Translational Pathology Shared Resource."

Azenta (Brooks) Biostore II Automated Biospecimen Storage, awarded in 2019

Instrument/Project Name: Modular Automated -80C Sample Storage System
Access facilitated through: VANTAGE: Vanderbilt Technologies for Advanced Genomics
Principal Investigator: James Goldenring, MD, PhD, Surgical Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD025092-01A1
for the Biostore II , managed by the Vanderbilt Technologies for Advanced Genomics (VANTAGE) Shared Resource."

9.4T MRI Animal Scanner, awarded in 2020

Instrument/Project Name: Upgrade of a 9.4T MRI Animal Scanner
Access facilitated through: Center for Small Animal Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD025085-01A1 for the Upgrade of a 9.4T MRI Animal Scanner for Small Animals, housed in the Vanderbilt Center for Small Animal Imaging."

Automated Radiosynthesis Equipment, awarded in 2021

Instrument/Project Name: Automated Cassette-Based Radiosynthesis Equipment
Access facilitated through: Center for Molecular Probes - Radiochemistry Core
Principal Investigator: Todd Peterson, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD023543-01 for Automated Cassette-Based Radiosynthesis Equipment, housed in the Vanderbilt Center for Molecular Probes - Radiochemistry Core."

CODEX Immunofluorescence System, awarded in 2021

Instrument/Project Name: CODEX System for Automated and Highly Multiplexed Immunofluorescence
Access facilitated through: Immunophenotyping Shared Resource/Innovative Translational Research Shared Resource
Principal Investigator: Kimberly Dahlman, PhD, Department of Medicine

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD030338-01 for the CODEX System for Automated and Highly Multiplexed Immunofluorescence, housed in the Vanderbilt Immunophenotyping Shared Resource/Innovative Translational Research Shared Resource."

7T MRI Scanner, awarded in 2021

Instrument/Project Name: Upgrade and Refurbishment of a 7T MRI Scanner for Research
Access facilitated through: Center for Human Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD030389-01 for the 7T MRI, housed in the Vanderbilt Center for Human Imaging."

cGMP Compliant HPLC for Radiopharmaceutical Quality Control, awarded in 2022

Instrument/Project Name: cGMP Compliant HPLC for Radiopharmaceutical Quality Control
Access facilitated through: Center for Molecular Probes - Radiochemistry Core
Principal Investigator: Todd Peterson, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD032383-01
for cGMP Compliant HPLC for Radiopharmaceutical Quality Control, housed in the Vanderbilt Center for Molecular Probes - Radiochemistry Core."