Holly Hasty, MSN

Holly
Hasty
MSN
Nursing Staff
Neurology

Holly Dunn is an Acute Care Nurse Practitioner in the Department of Neurology at Vanderbilt University Medical Center. Her practice specializes in outpatient Stroke and General Neurology. She is an active member of the American Society of Nurse Practitioners, American Association of Nurse Practitioners, Association for Psychological Science, and the American Association for the Advancement of Science. 

Prior to her current position, Holly worked as a nurse practitioner in outpatient pain management, and has nursing experience in several other clinical areas. She earned her Master of Science in Nursing from Vanderbilt University School of Nursing, completing the Acute Care Nurse Practitioner Accelerated Program, and fulfilling preceptorships in Neurosurgery ICU, Surgical ICU, the Neurosurgery Spinal Team, and the Neurosurgery Brain Tumor Team. She received her BS in Psychology from Virginia Polytechnic Institute and State University (Blacksburg, VA). 

Logan Dumitrescu, PhD

Logan
Caneel
Dumitrescu
PhD
Research Assistant Professor
Neurology

Dr. Logan Dumitrescu is an Assistant Professor of Neurology at Vanderbilt University Medical Center, a faculty member of the Vanderbilt Memory & Alzheimer’s Center and the Vanderbilt Genetics Institute, and the co-leader of the Computational Neurogenomics Team with Dr. Timothy Hohman. As a computational geneticist focused on the characterization of common genetic variants that influence common diseases and phenotypes, Dr. Dumitrescu also serves as a collaborator with the Vanderbilt Memory and Aging Project and an investigator in the Vanderbilt Alzheimer’s Disease Research Center. Dr. Dumitrescu earned a B.S. in Biological Sciences from Vanderbilt University and continued her training at Vanderbilt, where she earned an M.S. in Applied Statistics and a Ph.D. in Human Genetics. Dr. Dumitrescu joined the VUMC faculty in 2018.

Leveraging her training as a computational geneticist with expertise in applied statistics, Dr. Dumitrescu employs advanced statistical approaches to identify genetic drivers of Alzheimer’s disease (AD) and related traits with the goal of uncovering novel treatment targets for AD. She has led numerous multi-institutional, large-scale genetic analyses of AD and cognitive aging leveraging biomarker, cognitive, neuroimaging, and ‘omic data sources to identify molecular drivers of disease. 

Dr. Dumitrescu’s primary area of focus is the sex-specific genetic architecture of AD endophenotypes. Of the more than five million people in the United States afflicted with this disease, two-thirds are women. Women with AD have more neuropathology than men with AD, have more severe cognitive symptoms, and more severe neurodegeneration, suggesting that the disease affects male and female brains in different ways. The Dumitrescu’s central hypothesis is that certain genetic factors act in a sex-specific manner to drive the presentation and progression of AD. Using this framework, her team performs sex-aware analyses to identify the degree to which sex-specific genetic associations contribute to variance in AD endophenotypes, including cerebrospinal fluid biomarkers, neuropathology, and cognitive changes. Elucidation of the sex-specific genetic architecture of AD endophenotypes will help clarify the underlying pathways that contribute to AD risk and could be a critical step toward personalized interventions for AD.

In addition, Dr. Dumitrescu is particularly interested in resilience to AD. Approximately 30% of older adults have all of the neuropathological features of AD (plaques and tangles), but never show clinical symptoms. That is, they are able to endure substantial brain injury without displaying memory or cognitive difficulties. Dr. Dumitrescu has helped developed a phenotype to define and identify these resilient individuals and is applying advanced genomic and proteomic approaches to characterize the molecular drivers of resilience. Dr. Dumitrescu’s overall research goal is to move the field toward precision interventions and provide a sex-aware analytical framework by which the genetic architecture of AD risk and resilience can be comprehensively explored.

Joy Derwenskus, DO

Joy
Derwenskus
DO
Director
Vanderbilt Women’s Neurology Clinic
Associate Professor
Clinical Neurology

Faculty Spotlight

Dr. Joy Derwenskus is an Associate Professor of Neurology at Vanderbilt University Medical Center and head of the General Neurology Division since joining the faculty in 2019. Her primary clinical interests are in general neurology and headache, and she regularly administers botox for the treatment of migraines. She manages patients at both the One Hundred Oaks Clinic and The Vanderbilt Clinic, while also managing patients with Multiple Sclerosis and other related conditions at the Vanderbilt MS Center at Green Hills. Dr. Derwenskus has a strong interest in women’s neurology, especially as it relates to headaches and MS.

Dr. Derwenskus is a member of the American Academy of Neurology. She also works closely with the National MS Society and served as the chairperson of the Healthcare Provider Council for the society’s Mid-South chapter. She regularly engages in clinical trials, both grant- and industry-sponsored. Her publications include peer-reviewed journal articles, book chapters, and invited review articles. Throughout her career, Dr. Derwenskus has presented and lectured on MS regionally and nationally. She engages in teaching activities for medical students, residents, and fellows in both clinical and classroom environments. She is certified in neurology by the American Board of Psychiatry and Neurology.

Prior to her appointment at Vanderbilt, Dr. Derwenskus worked as a private practice neurologist in Tennessee before transitioning back to academic medicine. She was on faculty at Northwestern University for ten years as part of the comprehensive MS program. In that time, she served as the Multiple Sclerosis Fellowship Director and Acting Director of the Women’s Neurology Center.

Dr. Derwenskus received her fellowship training in Multiple Sclerosis at the Mount Sinai School of Medicine, Corinne Goldsmith Dickinson Center for Multiple Sclerosis in New York. In 2005, she earned a Master of Science in clinical research, also from Mount Sinai. Prior to her fellowship, she completed her Neurology residency at Case Western Reserve University following a preliminary internship year at Northwestern University. She earned her DO from the University of Osteopathic Medicine and Health Sciences (Des Moines University). She completed her undergraduate degree at Hope College (Holland, MI), and earned a Master of Arts in physiology from Ball State University (Muncie, IN).

A Midwestern native, Dr. Derwenskus stays busy with her twins and enjoys traveling and experiencing the world.

Thomas L. Davis, MD

Thomas
L.
Davis
MD
Vice Chair
Research
Division Chief
Movement Disorders
Judith Payne Turner Chair, Professor
Parkinson’s Research

Dr. Davis specializes in the treatment of movement disorders and has been a member of the American Board of Psychiatry and Neurology since 1990. In addition to maintaining his clinical research activities and teaching responsibilities, he is currently director of the Division of Movement Disorders, Medical Director of the Vanderbilt Parkinson’s Foundation Center of Excellence, an attending physician at Vanderbilt University Medical Center, and a staff neurologist at the Nashville Veterans Administration Hospital.

He has been the recipient of numerous awards and honors, including Phi Beta Kappa, the Sandoz award, and the Vanderbilt Neurology Resident Teaching Award in 2004 and 2011. He is a frequently invited speaker and has served on numerous review boards and NIH study sections.

Dr. Davis earned a B.A. in Chemistry in 1981 from the College of Wooster. He attended the University of Mississippi School of Medicine in Jackson, Mississippi where he earned a M.D. in 1985. He completed an internship at University of Mississippi followed by residency at Vanderbilt University where he served as chief resident in Neurology in 1981. He then completed a two-year post-doctoral fellowship in Neuropharmacology at the National Institute of Neurological Disease and Stroke in Bethesda, Maryland before returning to Vanderbilt to join the faculty in the Department of Neurology in 1991.

Dr. Davis’ research is patient-oriented and primarily involves various aspects of Parkinson's disease including outcomes research, markers of disease progression, and experimental therapeutics. The Division of Movement Disorders is actively involved with clinical trials in Parkinson's disease, Huntington’s disease, Wilson’s disease, Tourette syndrome, essential tremor, spasticity and dystonia.

Ryan Darby, MD

Richard
Ryan
Darby
MD
Assistant Professor
Neurology

Ryan Darby is an assistant professor of neurology at Vanderbilt University Medical Center. He currently sees patients as the director of the Frontotemporal Dementia Clinic in the Department of Neurology at VUMC.

He received his undergraduate degree from Princeton University in psychology and neuroscience, and his medical degree from Vanderbilt University. He trained in neurology at Massachusetts General Hospital and Brigham and Women's Hospital as part of the Partners Neurology/Harvard Medical School program. He then received the Sidney R. Baer, Jr. Research Fellowship in Clinical Neurosciences at the Beth Israel Deaconess Medical Center. He simultaneously completed a clinical fellowship in behavioral neurology and neuropsychiatry at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and McLean Psychiatric Hospital in Boston. 

Dr. Darby is interested in patients with symptoms at the border zone between neurology and psychiatry. Both neurological and psychiatric patients can share similar symptoms, including delusions, hallucinations, and antisocial and criminal behavior. This suggests that these symptoms may share a common pathway across different diseases. However, these different diseases often have neuroimaging abnormalities in different locations, making it difficult to understand how the same symptom could develop.

To address this problem, Dr. Darby helped to develop a new neuroimaging approach to localize complex behaviors to brain networks, rather than specific brain locations. He first studied this in patients with focal brain lesions, showing that brain lesions in different locations causing the same syndrome were all functionally connected to the same brain network. Dr. Darby’s current work is focused on applying this method to neurodegenerative disorders in order to understand why brain atrophy in different locations can cause the same clinical syndrome. He is using this method in combination with behavioral testing to study criminal behavior in frontotemporal dementia patients and delusions/hallucinations in patients with Alzheimer’s Disease, Parkinson’s Disease, and Lewy Body Dementia. Dr. Darby has received numerous awards for his research, including the Stanley Cobb Award from the Boston Society for Neurology and Psychiatry, the Young Investigator Award from the American Neuropsychiatric Association, the S. Weir Mitchell Award for Outstanding Early Career Investigator from the American Academy of Neurology, and the Norman Geschwind Prize in Behavioral Neurology. His work is generously funded by the Sidney R. Baer, Jr Foundation, the Alzheimer's Association, the BrightFocus Foundation, and the Department of Defense.

For more information on Dr. Darby’s research, please visit his lab website.

Angela N. Crudele, MD

Angela
N.
Crudele
MD
Assistant Professor
Neurology
Associate Program Director
Epilepsy Fellowship

Dr. Crudele joined the faculty of Vanderbilt University Medical Center in 2019 as Assistant Professor of Neurology, specializing in epilepsy. In addition to her inpatient and outpatient care of patients with epilepsy, Dr. Crudele is active in the area of fellow education and participates in frequent teaching conferences and bedside teaching with trainees. She is the Associate Program Director for the Epilepsy Fellowship. She has multiple teaching roles throughout the Vanderbilt Medical School.

Dr. Crudele earned a BA in History in 2008 from Williams College in Williamstown, MA. She attended Jefferson Medical College of Thomas Jefferson University Hospitals in Philadelphia, PA where she earned MD in 2013. She remained in Philadelphia where she completed an internship followed by Neurology residency at Thomas Jefferson University Hospital. She served as chief resident in her final year of residency. She then completed two years of dedicated epilepsy fellowship training at the Cleveland Clinic Foundation in Cleveland, OH. Her second year of training was focused on the surgical care of medically intractable epilepsy during which time she also served as chief fellow. 

Michael K. Cooper, MD

Michael
K.
Cooper
MD
Associate Professor
Neurology
Chief
VA Neurology

Dr. Cooper is the Chief of Neurology at the Veteran’s Affairs Medical Center. He is an Associate Professor of Neurology in the Neuro-Oncology Division. Dr. Cooper earned his medical degree from the University of Alabama School of Medicine. During medical training, he received a Howard Hughes Medical Student Research Training Fellowship to study molecular genetics in the laboratory of Dr. Jeffrey C. Hall at Brandeis University. Dr. Cooper completed residency and fellowship training at the Johns Hopkins Hospital. Dr. Cooper received a Howard Hughes Postdoctoral Research Fellowship for Physicians to study Hedgehog signaling in the laboratory of Dr. Philip A. Beachy in the Department of Molecular Biology and Genetics at the Johns Hopkins School of Medicine.

The Cooper laboratory studies brain tumor cellular heterogeneity with respect to molecular pathways that drive glioma cell growth and adaptive responses to therapeutic modalities. Towards these goals, the laboratory utilizes a patient tissue repository to identify the specific glioma subtypes in which the Hedgehog signaling pathway is operational and activated. Dr. Cooper’s research team has established a preclinical model for growing human malignant gliomas in mice to demonstrate that Hedgehog signaling regulates glioma growth and that pathway inhibition enhances survival. The Hh pathway appears to be activated in a subset of glioma cells (CD133+ cells), and determining how Hh signaling impacts this cellular compartment in gliomas is a primary focus of research. Longer term goals of these preclinical studies are to design clinical trials of Hedgehog inhibitors based upon selecting patients with malignant glioma who might best respond to Hedgehog inhibitors, defining the mechanism of action of Hedgehog pathway inhibition on glioma cancer stem cells and avoiding potential mechanisms of drug resistance.

There is a tremendous need to model glioma cellular compartments and their dynamic responses to therapeutic interventions. To address this need, Dr. Cooper’s laboratory is involved in several collaborative efforts. One of these is to generate monoclonal antibodies against heterogeneous malignant glioma cell types. A central goal of these studies is to determine if these antibodies can be used to define subclasses of glioma tumor initiating cells and their lineages.

Ciaran Michael Considine, PhD, ABPP-CN

Ciaran
Michael
Considine
PhD, ABPP-CN
Associate Professor
Clinical Neurology

Dr. Ciaran Michael Considine, PhD, ABPP-CN is an Assistant Professor of Neurology at Vanderbilt University School of Medicine and a board certified clinical neuropsychologist within the associated Vanderbilt University Medical Center. He earned his undergraduate degree at the University of Michigan and graduate degree from the University of Windsor. Subsequently, he completed internship residency at the Detroit VA Medical Center, and then concurrently finished his training as a postdoctoral resident fellow at the Milwaukee VA Medical center and postdoctoral visiting fellow at the Medical College of Wisconsin.

Dr. Considine’s present research interests focus on the intersection between sleep pathology and neurological disease. His primary focus at present is as a coordinating member of the Glymphatics & Cognition Lab. Specifically, his research interests focus on the role of sleep-wake functioning on the brain’s glymphatic system, an important system that is thought to clear brain waste products associated with neurodegenerative dementias. His specific overarching goal is to investigate whether sleep offers a mechanism to optimized glymphatic functioning, potentially reducing or slowing the aggregation of pathology related to dementias.

He also is pursuing other projects related to sleep and cognition, focused on 1) determining whether changes to sleep represent a biomarker (warning) of underlying neuropathology not yet obvious to clinical examination, and 2) whether treating comorbid sleep dysfunction in neurological patients improves their overall neurobehavioral status.

Please call 615-875-1257 for more information about ongoing studies and opportunities to participate.

Dr. Considine is primarily interested in neurodiagnostic consultation within adult neurological populations. His clinical practice neurodegenerative conditions, cerebrovascular disease, acquired brain injury, neuro-oncological disease, sleep disorders, and other medical/neuropsychiatric referrals. He is Director of the Aeromedical Neuropsychology Clinic, where he offers FAA-compliant evaluations for airpersons with possible aeromedically disqualifying neurological or psychiatric conditions. Additionally, he offers neuropsychological fitness-for-duty evaluations for Vanderbilt’s Faculty & Physician Wellness Program. He is Co-director of VUMC’s Brain Health Clinic service model, with services in Neurology and Concierge Medicine, which offers neuropsychological screening for patients seeking to identify medical and lifestyle factors potentially contributing to their cognitive symptoms. As a consulting member of the Vanderbilt Undiagnosed Diseases Program, he contributes to comprehensive workup for patients with difficult to diagnose and rare diseases.

Patricia A. Commiskey, DrPH

Patricia
A.
Commiskey
DrPH
Research Associate Professor
Neurology

Dr. Patricia Commiskey is a faculty member in the Department of Neurology at Vanderbilt University. Prior to coming to Vanderbilt in 2016, she served as adjunct faculty at Tulane University School of Public Health and Tropical Medicine. She attended Tulane University School of Public Health and Tropical Medicine in New Orleans, Louisiana and earned a DrPH in Community Health Sciences in 2011. She earned a MA in Legal and Ethical Studies from the University of Baltimore in Baltimore, Maryland in 1996, and a BA in Communications from the University of South Alabama in Mobile, Alabama in 1991.

With a background in public health, Dr. Commiskey has focused her research on improving stroke care across the continuum through innovative, technology-based, integrated systems of care, particularly during post-discharge recovery for patients, caregivers, and their families. She also focuses on identifying and reducing differences in health outcomes for stroke and neurological care, as well as patient, caregiver and family engagement. She served as Program Manager and Research Scientist for a CMS Health Care Innovation Award (HCIA #1C1CMS330143; PI: KGaines; 2012-2015). Dr. Commiskey is currently Co-Investigator and Chief Research Scientist for C3FIT (Coordinated, Collaborative, Comprehensive, Family-based, Integrated, and Technology-enabled Care; #PCS-2017C3-9081; PI: KGaines; 2019-2024), a $16.2 million, PCORI-funded, pragmatic randomized stroke trial comparing two models of stroke care at 18 national sites. She is also Principal Investigator (PI) for a USDA Distance Learning and Telemedicine Grant to explore the feasibility of implementing an ambulance-based telemedicine network between EMS and advanced stroke-trained personnel in the field, as well as an internally funded health communication grant to explore attitudes and perceived impact of telemedicine.

Charles D. Clarke, MD

Charles
D.
Clarke
MD
Assistant Professor
Clinical Neurology

Dr. Charles Clarke is an Assistant Professor of Clinical Neurology at Vanderbilt University Medical Center, a position he has held since 2013. As a general neurologist, he evaluates and treats a wide array of neurological conditions primarily in the outpatient clinical setting in Franklin, TN. Dr. Clarke has presented a number of lectures at local and national conferences, primarily focused on concussions and headaches. He is a member of the American Academy of Neurology, Tennessee Medical Association, Nashville Academy of Medicine, and the Tennessee Academy of Neurology, the latter of which he served as president from 2012-2018.

Dr. Clarke completed his Neurology residency and subsequent Neuromuscular Medicine Fellowship at Vanderbilt. He earned his MD from The Ohio State University College of Medicine and Public Health, and his BS (summa cum laude) from West Virginia University.