NIH S10 Grant Program | Office of Research

NIH S10 Shared Instrumentation Grants

The next internal proposal cycle will be announced in early 2027.

Program Overview

The NIH S10 Instrumentation program has announced a restructured Shared Instrumentation Grants (SIG) Program that consolidates three existing instrumentation programs (SIG, High-End Instrumentation, and Basic Instrumentation Grant programs). The Notice of Funding Opportunity invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. Types of instruments supported by S10 SIG funding include, but are not limited to supercomputing clusters, radiology imaging systems, such as high field MRI, PET/MRI imagers, electron microscopes, biomedical imagers, light microscopes, RNA imagers, nuclear magnetic resonance spectrometers, mass spectrometers, flow cytometers, cell sorters, DNA and protein sequencers, and X-ray diffractometers.

PAR-27-022
Budget range: $300,000 - $5,000,000

For information about the new S10 Seed Instrumentation Support program (PAR-27-021), contact vumcresearchenterprise@vumc.org

VUMC Internal Applications Process

We are not currently accepting internal applications. The next cycle will open in early 2027 for the July 1 NIH deadline. Watch this page for updates.

Contact:

VUMC investigators: Contact the VUMC Office of Research team at vumcresearchenterprise@vumc.org

VU investigators: Visit the VU S10 site and direct questions to:

selene.colon@vanderbilt.edu (VU Basic Sciences)
janice.m.ascano@vanderbilt.edu (All non-SOM VU departments)

S10 Resources for PIs & Administrators:

Core advisory committee meeting template
Find or register for a Research Resource Identifier (RRID)
"Supporting Shared Instrumentation Grants" - Presentation at ABRF SEASR 2022
Guide to linking publications in myNCBI - contact amy.f.martinez@vumc.org to request
S10 acknowledgement voucher program - see program details below

A micrograph from the Immunophenotyping Shared Resource/Innovative Translational Research Shared Resource from their development of PhenoCycler (CODEX) panels for staining multiple targets on a single section of tissue. In this image DAPI (blue), CD38 (teal), CD45 (red), CD31 (white), CD3 (green), Cytokeratin (fuchsia) are shown on a sample from a head and neck squamous cell carcinoma. The CODEX is supported by S10OD030338.

Core Facilities Vouchers for S10 Award Citations

Internal Funding Opportunity

NIH requires VUMC to submit a report of S10-awarded instrument performance each year. An important part of this report is data related to the publications impact of these awards. The Office of Research encourages all researchers to specifically cite the appropriate S10 grant award(s) when publishing data produced using this NIH-funded equipment. As an incentive, the Office of Research is offering core vouchers to all investigators who submit publication citations for S10 instrument awards within their NIH reporting period.

For each verified citation of an S10 award, an investigator will receive vouchers redeemable for $250 in VUMC core services.

Voucher Program Eligibility

ANY user of an eligible S10-funded instrument may apply!
The user must cite the S10, including the NIH award number (e.g. 1S10OD016245-01), in the manuscript's "Acknowledgements" section, or as specified by the journal.
The list of eligible S10 awards and their recommended acknowledgement text appears in the table below

How to Submit Citations

Submit citations via https://redcap.link/S10vouchers

Questions? Contact Amy Martinez, PhD (amy.f.martinez@vumc.org)

Recommended citations for S10-funded instruments:

Azenta (Brooks) Biostore II Automated Biospecimen Storage, awarded in 2019

Instrument/Project Name: Modular Automated -80C Sample Storage System
Access facilitated through: VANTAGE: Vanderbilt Technologies for Advanced Genomics
Principal Investigator: James Goldenring, MD, PhD, Surgical Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD025092-01A1
for the Biostore II, managed by the Vanderbilt Technologies for Advanced Genomics (VANTAGE) Shared Resource."

Upgrade of a 9.4T MRI Animal Scanner, awarded in 2020

Access facilitated through: Center for Small Animal Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD025085-01A1 for the Upgrade of a 9.4T MRI Animal Scanner for Small Animals, housed in the Vanderbilt University Institute of Imaging Science Center for Small Animal Imaging."

Automated Cassette-Based Radiosynthesis Equipment, awarded in 2021

Access facilitated through: VUIIS Radiochemistry Core
Principal Investigator: Todd Peterson, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD023543-01 for Automated Cassette-Based Radiosynthesis Equipment, housed in the Vanderbilt University Institute of Imaging Science Radiochemistry Core."

CODEX System for Automated and Highly Multiplexed Immunofluorescence, awarded in 2021

Access facilitated through: Ancillary Network for Coordination of Otolaryngology Research
Principal Investigator: Eben Rosenthal, MD, Department of Otolaryngology - Head and Neck Surgery

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD030338-01 for the CODEX System for Automated and Highly Multiplexed Immunofluorescence, housed in the Ancillary Network for Coordination of Otolaryngology Research at Vanderbilt."

Upgrade and Refurbishment of a 7T MRI Scanner for Research, awarded in 2021

Access facilitated through: Center for Human Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD030389-01 for the 7T MRI, housed in the Vanderbilt University Institute of Imaging Science Center for Human Imaging."

cGMP Compliant HPLC for Radiopharmaceutical Quality Control, awarded in 2022

Access facilitated through: VUIIS Radiochemistry Core
Principal Investigator: Todd Peterson, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD032383-01
for cGMP Compliant HPLC for Radiopharmaceutical Quality Control, housed in the Vanderbilt University Institute of Imaging Science Radiochemistry Core."

Ultra-High Performance Gradients for a 3T MRI Research Scanner, awarded in 2023

Access facilitated through: Center for Human Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10MH133645-01 for Ultra-High Performance Gradients for a 3T MRI Research Scanner, housed in the Vanderbilt University Institute of Imaging Science Center for Human Imaging."

Nikon Multiphoton (MP) Imaging System, awarded in 2023

Access facilitated through: Cell Imaging Shared Resource
Principal Investigator: James Cassat, MD, PhD, Department of Pediatrics

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD032216-01A1
for a Nikon Multiphoton (MP) Imaging System, housed in the Vanderbilt University Cell Imaging Shared Resource."

High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Scanner, awarded in 2023

Access facilitated through: Center for Human Imaging
Principal Investigator: Jeffry Nyman, PhD, Department of Orthopaedic Surgery

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD034316-01 for a High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Scanner, housed in the Vanderbilt University Institute of Imaging Science Center for Human Imaging."

Cytek Aurora CS Cell Sorter, awarded in 2023

Access facilitated through: Flow Cytometry Shared Resource
Principal Investigator: Eric Skaar, PhD, Department of Pathology, Microbiology & Immunology

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD034336-01
for a Cytek Aurora CS Cell Sorter, housed in the Vanderbilt Flow Cytometry Shared Resource."

Conventional 200 keV Transmission Electron Microscope, awarded in 2023

Access facilitated through: Cell Imaging Shared Resource
Principal Investigator: Walter G. (Jay) Jerome, PhD, Department of Pathology, Microbiology & Immunology

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD034315-01 for a Conventional 200 keV Transmission Electron Microscope, housed in the Vanderbilt University Cell Imaging Shared Resource."

Automation of Liquid Nitrogen Freezer for Cryopreservation of Unique Human Biospecimens, awarded in 2023

Access facilitated through: VANTAGE: Vanderbilt Technologies for Advanced Genomics
Principal Investigator: Alex Bick, MD, PhD, Department of Medicine

Recommended acknowledgement text for citations: "This work was supported by grant 1R24OD035459-01 for an Automated Liquid Nitrogen Freezer for Cryopreservation of Unique Human Biospecimens, housed in the Vanderbilt University Medical Center Biospecimen Storage Facility."

Triple Quadrupole Mass Spectrometer System with QTRAP Functionality, awarded in 2024

Access facilitated through: Eicosanoid Core Laboratory
Principal Investigator: Ginger Milne, PhD, Department of Medicine

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD036357-01 for a triple quadrupole mass spectrometer system with QTRAP functionality, housed in the Eicosanoid Core Laboratory."

Automated Multi-run Carbon-11 Radiosynthesis System, awarded in 2024

Access facilitated through: VUIIS Radiochemistry Core
Principal Investigator: Todd Peterson, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD036385-01 for an automated multi-run carbon-11 radiosynthesis system, housed in the Vanderbilt University Institute of Imaging Science Radiochemistry Core."

Integrated MRI-PET Scanner for Small Animals, awarded in 2025

Access facilitated through: VUIIS Center for Small Animal Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD036274-01A1 for an integrated MRI-PET scanner for small animals, housed in the Vanderbilt University Institute of Imaging Science Center for Small Animal Imaging."

Real-time Blood Parameter Monitoring System, awarded in 2025

Access facilitated through: S. R. Light Laboratory Surgical Facility
Principal Investigator: Rei Ukita, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD038300-01 for a real-time blood parameter monitoring system, housed in the S.R. Light Laboratory Surgical Facility."

Whole-Body 3T MRI Scanner, awarded in 2025

Access facilitated through: Center for Human Imaging
Principal Investigator: John Gore, PhD, Department of Radiology & Radiological Sciences

Recommended acknowledgement text for citations: "This work was supported by grant 1S10OD038266-01 for a Whole-Body 3T MRI Scanner, housed in the Vanderbilt University Institute of Imaging Science Center for Human Imaging."