Dr. Newhouse is the Director of the Center for Cognitive Medicine in the Department of Psychiatry and Behavioral Sciences at Vanderbilt University Medical Center. His research has focused on central nicotinic mechanisms in degenerative brain disorders and the role of nicotinic receptor systems in normal and disordered cognitive functioning in humans. Another major focus includes studying the interaction of estrogen and central cholinergic, catecholaminergic, and serotonergic systems in relation to cognitive and emotional aging in the elderly and novel pharmacologic-imaging methodologies. Other interests include treatment of depression and behavioral disturbances in the elderly, and development of effective novel agents for the treatment of neuropsychiatric disorders of the elderly.
He has served on and has chaired numerous NIH grant review committees, and is an editorial board member and frequent reviewer for scientific journals for manuscripts on depression, dementia, and cognitive neuroscience.