Schizophrenia and bipolar disorder share common genetic underpinnings, Vanderbilt University investigators have discovered. The researchers combined high-resolution gene expression studies that show which genes are turned “on” or “off” with gene association data to reveal signaling pathways linked to schizophrenia and bipolar disorder.
The findings, published in Molecular Psychiatry, implicate pathways involving lysosomes, which influence many cellular processes, and actin cytoskeleton remodeling in these psychiatric disorders.
