Dual Use Research of Concern (DURC)
DURC is  defined as life sciences research that, based on current understanding, can be reasonably anticipated to provide knowledge, information, products, or technologies that could be directly misapplied to pose a significant threat with broad potential consequences to public health and safety, agricultural crops and other plants, animals, the environment, materiel, or national security.  VUMC has established an institutional policy for review and management of proposed life sciences research that may fall under the definition of DURC consistent with the United States Government Policy for Institutional Oversight of Life Sciences Dual Use Research of Concern. The VUMC policy outlines responsibilities for compliance with the Federal policy related to DURC for principal investigators (PIs), the institution, and the Institutional Review Entity (IRE).

LINK TO VUMC POLICY for Dual Use Research of Concern (DURC)

LINK TO VUMC SOP for the Institutional Review Entity (IRE)

United States Government Policy for Institutional Oversight of Life Sciences DURC

Principal Investigator (PI) report for VUMC INITIAL DURC ASSESSMENT (IDA) (VUnet ID required)



Who is responsible for compliance with Federal requirements related to DURC?
Vanderbilt University Medical Center (VUMC) is responsible for establishing polices and procedures to support compliance with US Federal Government requirements related to DURC.  Each principal investigator (PI) is responsible for awareness of the federal and institutional policies related to Dual Use Research of Concern (DURC), and for reporting potential DURC to the Institutional Review Entity (IRE) in compliance with these policies.


I am a PI for a project, and I need to report my research for potential DURC.  How to I do that?
Please submit the VUMC INITIAL DURC ASSESSMENT (IDA) (VUnet ID required)


What is the VUMC Institutional Review Entity (IRE)?
The IRE is a committee of faculty, subject matter experts and designated administrators appointed and empowered by the institution to execute the requirements of the federal Policy on DURC.​


Who is the Institutional Contact for Dual Use Research (ICDUR)? 
The ICDUR is designated by the institution to serve as an institutional point of contact for questions regarding compliance with and implementation of the requirements for the oversight of DURC. The ICDUR is the liaison (as necessary) between the institution and the relevant federal funding agency. At VUMC, the Director for Research Resources & Strategy, Susan Meyn, serves as the ICDUR.


What agents and toxins are subject to review for potential DURC?

  1) Avian influenza virus (highly pathogenic)
  2) Bacillus anthracis​
  3) Botulinum neurotoxin (any quantity, including Botox)
  4) Burkholderia mallei
  5) Burkholderia pseudomallei​
  6) Ebola virus
  7) Foot-and-mouth disease virus
  8) Francisella tularensis​
  9) Marburg virus
10) Reconstructed 1918 Influenza virus
11) Rinderpest virus
12) Toxin-producing strains of Clostridium botulinum
13) Variola major virus
14) Variola minor virus
15) Yersinia pestis​

Who do I contact if I have any questions about DURC?


Where can I learn more about DURC?