MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells. Evavold B & Jenkins M et al. in Nature Biotechnology, May 23, 2021 Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Mwakingwe-Omari A, Et al.

Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Fukumura K et al. in Cancer Immunology Research, April 10, 2021 A microRNA expression and regulatory element activity atlas of the mouse immune system. Brown B et al.

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SorTn-seq: a high-throughput functional genomics approach to discovering regulators of bacterial gene expression. Fineran P et al. in Nature Protocols, August 4, 2021 Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Duffy P et al.

The adenovirus-based vaccine is a type of vaccine that uses a surrogate virus instead of the actual coronavirus to deliver the components needed to induce an immune response. When the adenovirus infects your cells, it will release DNA coding that your cells can use to produce the spike protein. The spike protein – a harmless piece of the coronavirus – will train your immune response to protect you from getting infected/sick if you later encounter the actual virus. In addition to adding the coronavirus DNA, scientists also remove portions of the adenovirus essential for replication; thus, each virus can only infect one cell and cannot make copies of itself. Engineering the adenovirus further enhances the safety of the vaccine.... Click the infographic to learn more!

Dr. Dash is a faculty member in the Meharry Medical College Center for AIDS Health Disparities Research (CAHDR) and the Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience. His research focuses on understanding the mechanisms of HIV-1 infection and probing the effects of drugs of abuse on HIV pathogenesis.

Ireti Eni-aganga received her Bachelor of Science in Biochemistry from Arizona State University in 2014. She's currently a PhD candidate at Meharry Medical College in the laboratory of Dr. Jui Pandhare. Her work is part of the Center for AIDS Health Disparities Research (CAHDR)... Click the image on the left to continue reading.

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Baruch E, et al. in Science, February 5, 2021 Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Heming M, et al.

Dr. Alexander earned his undergraduate degree from Duke University and his M.D./Ph.D. from the University of Virginia School of Medicine. He's an Assistant Professor of Medicine and Molecular Physiology & Biophysics at Vanderbilt researching the role of adaptive immunity in the pathogenesis of hypertension and associated cardiovascular disease... Click Dr. Alexander's photo to continue reading.