Hollender Lecture in Geriatric Psychiatry 11/04 | Eric Lenze, MD

Hollender Lecture AY23

"Turning the tide on depression in older adults: new evidence for optimal management of treatment-resistant depression"


This presentation is designed to help the learner:
1.    Describe pharmacological treatment strategies in treatment resistant depression in older adults
2.    Identify the appropriateness of use of ketamine for depression in older adults
3.    Develop treatment algorithm for treatment resistant depression in older adults

About the Speaker:

Eric J. Lenze, MD   
Wallace and Lucille K. Renard Professor and Chair of Psychiatry
Professor of Anesthesiology, Investigator Track
Washington University School of Medicine

CME/CE credit for Psychiatry Grand Rounds is only available during the live feed time and for a brief time immediately following. The code for this week's session is displayed at the opening and closing of the meeting and also in the Chair's Office Zoom Account Name during the meeting.


For CME/CE information about this session, please visit:





Grand Rounds Enrichment Discussion 

Wednesday November 2, 2023
12pm Orr Conference Room VPH 1205

The articles up for discussion are:

Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial

  • Eric J Lenze, Benoit H Mulsant, Daniel M Blumberger, Jordan F Karp, John W Newcomer, Stewart J Anderson, Mary Amanda Dew, Meryl A Butters, Jacqueline A Stack, Amy E Begley, Charles F Reynolds III

Optimizing Outcomes of Treatment- Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized

  • Pilar Cristancho, M.D., Emily Lenard, M.S.W., Eric J. Lenze, M.D., J. Philip Miller, A.B., Patrick J. Brown, Ph.D., Steven P. Roose, M.D., Carolina Montes-Garcia, B.A., Daniel M. Blumberger, M.D., M.Sc., F.R.C.P.C., Benoit H. Mulsant, M.D., M.S., Helen Lavretsky, M.D., Bruce L. Rollman, M.D., M.P.H., Charles F. Reynolds III, M.D., Jordan F. Karp, M.D.

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

  • Eric J. Lenze, MD; Caline Mattar, MD; Charles F. Zorumski, MD; Angela Stevens, BA; Julie Schweiger; Ginger E. Nicol, MD; J. Philip Miller, AB; Lei Yang, MPH, MSIS; Michael Yingling, MS; Michael S. Avidan, MBBCh; Angela M. Reiersen, MD, MPE

This talk is sponsored by the
Hollender Lecture Fund
Department of Psychiatry and Behavioral Sciences 
This educational activity received no commercial support.