Department of Psychiatry and Behavioral Sciences

Malik TN, Cartailler JP, Emeson RB. Quantitative Analysis of Adenosine-to-Inosine RNA Editing. Methods Mol Biol. 2021; 2181: 97-111. PMID: 32729077, PMCID: PMC8208106, DOI: 10.1007/978-1-0716-0787-9_7, ISSN: 1940-6029.
Malik TN, Doherty EE, Gaded VM, Hill TM, Beal PA, Emeson RB. Regulation of RNA editing by intracellular acidification. Nucleic Acids Res. 2021 Apr 4/19/2021; 49(7): 4020-36. PMID: 33721028, PMCID: PMC8053123, PII: 6171293, DOI: 10.1093/nar/gkab157, ISSN: 1362-4962.
Shumate KM, Tas ST, Kavalali ET, Emeson RB. RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. J Neurochem [print-electronic]. 2021 Jul; 158(2): 182-96. PMID: 33894004, PMCID: PMC8282701, DOI: 10.1111/jnc.15372, ISSN: 1471-4159.

Siemann JK, Williams P, Malik TN, Jackson CR, Green NH, Emeson RB, Levitt P, McMahon DG. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Sci Rep. 2020 Sep 9/22/2020; 10(1): 15437. PMID: 32963273, PMCID: PMC7508939, PII: 10.1038/s41598-020-72263-5, DOI: 10.1038/s41598-020-72263-5, ISSN: 2045-2322.

Bartelt A, Jeschke A, Müller B, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel RF, Emeson RB, Amling M, Niemeier A, Heeren J, Schinke T, Keller J. Differential effects of Calca-derived peptides in male mice with diet-induced obesity. PLoS ONE. 2017; 12(6): e0180547. PMID: 28666011, PMCID: PMC5493411, PII: PONE-D-17-05775, DOI: 10.1371/journal.pone.0180547, ISSN: 1932-6203.
Ferrick-Kiddie EA, Rosenthal JJ, Ayers GD, Emeson RB. Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing. Sci Rep. 2017 Feb 2/20/2017; 7: 41095. PMID: 28216637, PMCID: PMC5316942, PII: srep41095, DOI: 10.1038/srep41095, ISSN: 2045-2322.
O'Neil RT, Wang X, Morabito MV, Emeson RB. Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing. Mol Brain. 2017 Apr 4/6/2017; 10(1): 11. PMID: 28385157, PMCID: PMC5382662, PII: 10.1186/s13041-017-0291-1, DOI: 10.1186/s13041-017-0291-1, ISSN: 1756-6606.
Stamm S, Gruber SB, Rabchevsky AG, Emeson RB. The activity of the serotonin receptor 2C is regulated by alternative splicing. Hum. Genet [print-electronic]. 2017 Jun 6/29/2017; PMID: 28664341, PII: 10.1007/s00439-017-1826-3, DOI: 10.1007/s00439-017-1826-3, ISSN: 1432-1203.

Zhang Z, Shen M, Gresch PJ, Ghamari-Langroudi M, Rabchevsky AG, Emeson RB, Stamm S. Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake. EMBO Mol Med. 2016; 8(8): 878-94. PMID: 27406820, PII: emmm.201506030, DOI: 10.15252/emmm.201506030, ISSN: 1757-4684.

Zhou C, Ding L, Deel ME, Ferrick EA, Emeson RB, Gallagher MJ. Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome. Neurobiol. Dis [print-electronic]. 2015 Jan; 73: 407-17. PMID: 25447232, PMCID: PMC4418938, PII: S0969-9961(14)00334-9, DOI: 10.1016/j.nbd.2014.10.021, ISSN: 1095-953X.

Anastasio NC, Stutz SJ, Fox RG, Sears RM, Emeson RB, DiLeone RJ, O'Neil RT, Fink LH, Li D, Green TA, Moeller FG, Cunningham KA. Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. Neuropsychopharmacology [print-electronic]. 2014 Jan; 39(2): 370-82. PMID: 23939424, PMCID: PMC3970795, PII: npp2013199, DOI: 10.1038/npp.2013.199, ISSN: 1740-634X.
Hood JL, Morabito MV, Martinez CR, Gilbert JA, Ferrick EA, Ayers GD, Chappell JD, Dermody TS, Emeson RB. Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions. Mol. Cell. Neurosci [print-electronic]. 2014 Jul; 61: 97-109. PMID: 24906008, PMCID: PMC4134954, PII: S1044-7431(14)00062-1, DOI: 10.1016/j.mcn.2014.06.001, ISSN: 1095-9327.
Ulbricht RJ, Emeson RB. One hundred million adenosine-to-inosine RNA editing sites: hearing through the noise. Bioessays [print-electronic]. 2014 Aug; 36(8): 730-5. PMID: 24889193, PMCID: PMC4359916, DOI: 10.1002/bies.201400055, ISSN: 1521-1878.

Hood JL, Emeson RB. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr. Top. Microbiol. Immunol. 2012; 353: 61-90. PMID: 21796513, PMCID: PMC4109139, DOI: 10.1007/82_2011_157, ISSN: 0070-217X.
O'Neil RT, Emeson RB. Quantitative analysis of 5HT(2C) receptor RNA editing patterns in psychiatric disorders. Neurobiol. Dis [print-electronic]. 2012 Jan; 45(1): 8-13. PMID: 21914481, PMCID: PMC3225646, PII: S0969-9961(11)00292-0, DOI: 10.1016/j.nbd.2011.08.026, ISSN: 1095-953X.

Olaghere da Silva UB, Morabito MV, Canal CE, Airey DC, Emeson RB, Sanders-Bush E. Impact of RNA editing on functions of the serotonin 2C receptor in vivo. Front Neurosci. 2010; 4: 26. PMID: 20582266, PMCID: PMC2858556, DOI: 10.3389/neuro.23.001.2010, ISSN: 1662-453X.
Morabito MV, Ulbricht RJ, O'Neil RT, Airey DC, Lu P, Zhang B, Wang L, Emeson RB. High-throughput multiplexed transcript analysis yields enhanced resolution of 5-hydroxytryptamine 2C receptor mRNA editing profiles. Mol. Pharmacol [print-electronic]. 2010 Jun; 77(6): 895-902. PMID: 20181818, PMCID: PMC2879922, PII: mol.109.061903, DOI: 10.1124/mol.109.061903, ISSN: 1521-0111.
Morabito MV, Abbas AI, Hood JL, Kesterson RA, Jacobs MM, Kump DS, Hachey DL, Roth BL, Emeson RB. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiol. Dis [print-electronic]. 2010 Aug; 39(2): 169-80. PMID: 20394819, PMCID: PMC2906772, PII: S0969-9961(10)00101-4, DOI: 10.1016/j.nbd.2010.04.004, ISSN: 1095-953X.
Stefl R, Oberstrass FC, Hood JL, Jourdan M, Zimmermann M, Skrisovska L, Maris C, Peng L, Hofr C, Emeson RB, Allain FH. The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell. 2010 Oct 10/15/2010; 143(2): 225-37. PMID: 20946981, PMCID: PMC2956598, PII: S0092-8674(10)01074-3, DOI: 10.1016/j.cell.2010.09.026, ISSN: 1097-4172.

Jacobs MM, Fogg RL, Emeson RB, Stanwood GD. ADAR1 and ADAR2 expression and editing activity during forebrain development. Dev. Neurosci [print-electronic]. 2009; 31(3): 223-37. PMID: 19325227, PMCID: PMC2692045, PII: 000210185, DOI: 10.1159/000210185, ISSN: 1421-9859.
Morabito MV, Emeson RB. RNA editing as a therapeutic target for CNS disorders. Neuropsychopharmacology. 2009 Jan; 34(1): 246. PMID: 19079070, PII: npp2008159, DOI: 10.1038/npp.2008.159, ISSN: 1740-634X.
Lanfranco MF, Seitz PK, Morabito MV, Emeson RB, Sanders-Bush E, Cunningham KA. An innovative real-time PCR method to measure changes in RNA editing of the serotonin 2C receptor (5-HT(2C)R) in brain. J. Neurosci. Methods [print-electronic]. 2009 May 5/15/2009; 179(2): 247-57. PMID: 19428534, PMCID: PMC3794365, PII: S0165-0270(09)00081-8, DOI: 10.1016/j.jneumeth.2009.01.027, ISSN: 1872-678X.

Thompson BJ, Washington MK, Kurre U, Singh M, Rula EY, Emeson RB. Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Dig. Dis. Sci [print-electronic]. 2008 Jan; 53(1): 229-41. PMID: 17530400, DOI: 10.1007/s10620-007-9848-7, ISSN: 0163-2116.
Huebner AK, Keller J, Catala-Lehnen P, Perkovic S, Streichert T, Emeson RB, Amling M, Schinke T. The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation. Arch. Biochem. Biophys [print-electronic]. 2008 May 5/15/2008; 473(2): 210-7. PMID: 18307972, PII: S0003-9861(08)00075-1, DOI: 10.1016/j.abb.2008.02.013, ISSN: 1096-0384.
Rula EY, Lagrange AH, Jacobs MM, Hu N, Macdonald RL, Emeson RB. Developmental modulation of GABA(A) receptor function by RNA editing. J. Neurosci. 2008 Jun 6/11/2008; 28(24): 6196-201. PMID: 18550761, PMCID: PMC2746000, PII: 28/24/6196, DOI: 10.1523/JNEUROSCI.0443-08.2008, ISSN: 1529-2401.

Rula EY, Emeson RB. Mouse models to elucidate the functional roles of adenosine-to-inosine editing. Meth. Enzymol. 2007; 424: 333-67. PMID: 17662849, PII: S0076-6879(07)24016-9, DOI: 10.1016/S0076-6879(07)24016-9, ISSN: 0076-6879.
Singh M, Kesterson RA, Jacobs MM, Joers JM, Gore JC, Emeson RB. Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2. J. Biol. Chem [print-electronic]. 2007 Aug 8/3/2007; 282(31): 22448-59. PMID: 17567573, PII: M700265200, DOI: 10.1074/jbc.M700265200, ISSN: 0021-9258.

Feng Y, Sansam CL, Singh M, Emeson RB. Altered RNA editing in mice lacking ADAR2 autoregulation. Mol. Cell. Biol. 2006 Jan; 26(2): 480-8. PMID: 16382140, PMCID: PMC1346902, PII: 26/2/480, DOI: 10.1128/MCB.26.2.480-488.2006, ISSN: 0270-7306.
Stefl R, Xu M, Skrisovska L, Emeson RB, Allain FH. Structure and specific RNA binding of ADAR2 double-stranded RNA binding motifs. Structure. 2006 Feb; 14(2): 345-55. PMID: 16472753, PII: S0969-2126(06)00044-X, DOI: 10.1016/j.str.2005.11.013, ISSN: 0969-2126.
Xu M, Wells KS, Emeson RB. Substrate-dependent contribution of double-stranded RNA-binding motifs to ADAR2 function. Mol. Biol. Cell [print-electronic]. 2006 Jul; 17(7): 3211-20. PMID: 16672376, PMCID: PMC1552048, PII: E06-02-0162, DOI: 10.1091/mbc.E06-02-0162, ISSN: 1059-1524.
Huebner AK, Schinke T, Priemel M, Schilling S, Schilling AF, Emeson RB, Rueger JM, Amling M. Calcitonin deficiency in mice progressively results in high bone turnover. J. Bone Miner. Res. 2006 Dec; 21(12): 1924-34. PMID: 17002587, DOI: 10.1359/jbmr.060820, ISSN: 0884-0431.

Sansam, CL and RB Emeson. MRNA Editing. In: Encyclopedia of Life Sciences. 2005; John Wiley & Sons, Ltd: Chichester: [doi:10.1038/npg.els.0005041].
Stefl R, Skrisovska L, Xu M, Emeson RB, Allain FH. Resonance assignments of the double-stranded RNA-binding domains of adenosine deaminase acting on RNA 2 (ADAR2) [letter]. J. Biomol. NMR. 2005 Jan; 31(1): 71-2. PMID: 15692744, DOI: 10.1007/s10858-004-6058-x, ISSN: 0925-2738.
Emeson RB, Morabito MV. Food fight: the NPY-serotonin link between aggression and feeding behavior. Sci. STKE. 2005 Mar 3/29/2005; 2005(277): pe12. PMID: 15798100, PII: stke.2772005pe12, DOI: 10.1126/stke.2772005pe12, ISSN: 1525-8882.

Dawson TR, Sansam CL, Emeson RB. Structure and sequence determinants required for the RNA editing of ADAR2 substrates. J. Biol. Chem [print-electronic]. 2004 Feb 2/6/2004; 279(6): 4941-51. PMID: 14660658, PII: M310068200, DOI: 10.1074/jbc.M310068200, ISSN: 0021-9258.
Schinke T, Liese S, Priemel M, Haberland M, Schilling AF, Catala-Lehnen P, Blicharski D, Rueger JM, Gagel RF, Emeson RB, Amling M. Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. J. Bone Miner. Res [print-electronic]. 2004 Dec; 19(12): 2049-56. PMID: 15537449, DOI: 10.1359/JBMR.040915, ISSN: 0884-0431.

Maison SF, Emeson RB, Adams JC, Luebke AE, Liberman MC. Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve. J. Neurophysiol [print-electronic]. 2003 Nov; 90(5): 2941-9. PMID: 12904337, PII: 00596.2003, DOI: 10.1152/jn.00596.2003, ISSN: 0022-3077.
Sansam CL, Wells KS, Emeson RB. Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Nov 11/25/2003; 100(24): 14018-23. PMID: 14612560, PMCID: PMC283538, PII: 2336131100, DOI: 10.1073/pnas.2336131100, ISSN: 0027-8424.

El Meskini R, Jin L, Marx R, Bruzzaniti A, Lee J, Emeson R, Mains R. A signal sequence is sufficient for green fluorescent protein to be routed to regulated secretory granules. Endocrinology. 2001 Feb; 142(2): 864-73. PMID: 11159860, DOI: 10.1210/endo.142.2.7929, ISSN: 0013-7227.
Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, Emeson RB, Sanders-Bush E. RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology. 2001 May; 24(5): 478-91. PMID: 11282248, PII: S0893-133X(00)00223-2, DOI: 10.1016/S0893-133X(00)00223-2, ISSN: 0893-133X.
Berg KA, Cropper JD, Niswender CM, Sanders-Bush E, Emeson RB, Clarke WP. RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity. Br. J. Pharmacol. 2001 Sep; 134(2): 386-92. PMID: 11564657, PMCID: PMC1572953, DOI: 10.1038/sj.bjp.0704255, ISSN: 0007-1188.

Singh M and Emeson RB. Adenosine to Inosine RNA Editing: Substrates and Consequences. RNA Editing: Frontiers in Molecular Biology. (BL Bass, ed.) Oxford University Press:London. 2000; 109-38.
Gott JM, Emeson RB. Functions and mechanisms of RNA editing. Annu. Rev. Genet. 2000; 34: 499-531. PMID: 11092837, PII: 34/1/499, DOI: 10.1146/annurev.genet.34.1.499, ISSN: 0066-4197.

Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, Sanders-Bush E. RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J. Biol. Chem. 1999 Apr 4/2/1999; 274(14): 9472-8. PMID: 10092629, ISSN: 0021-9258.
Rueter SM, Dawson TR, Emeson RB. Regulation of alternative splicing by RNA editing. Nature. 1999 May 5/6/1999; 399(6731): 75-80. PMID: 10331393, DOI: 10.1038/19992, ISSN: 0028-0836.
Liu Y, Emeson RB, Samuel CE. Serotonin-2C receptor pre-mRNA editing in rat brain and in vitro by splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase ADAR1. J. Biol. Chem. 1999 Jun 6/25/1999; 274(26): 18351-8. PMID: 10373439, ISSN: 0021-9258.
Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, Emeson RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol. Cell. Neurosci. 1999 Aug; 14(2): 99-120. PMID: 10532808, PII: S1044-7431(99)90767-4, DOI: 10.1006/mcne.1999.0767, ISSN: 1044-7431.

Rueter S and RB Emeson. Adenosine to Inosine Conversion in mRNA. Modification and editing of RNA: the alteration of RNA structure and function. (H. Grosjean and R. Benne, eds.) ASM Press:East Norwalk, CT. 1998; 343-61.
Sanes, J.R., E.D. Apel, R.W. Burgess, R.B. Emeson, G. Feng, M. Gautam, D. Glass, R.M. Grady, E. Krejci, J.W. Lichtman, J.T. Lu, J. Massoulie, J.H. Miner, L.M. Moscoso, Q. Nguyen, M. Nichol, P.G. Noakes, B.L. Patton, Y.J. Son, G.D. Yancopoulos and H. Zhou. Development of the neuromuscular junction: genetic analysis in mice. J Physiol Paris. 1998; 92: 167 172.
Niswender CM, Sanders-Bush E, Emeson RB. Identification and characterization of RNA editing events within the 5-HT2C receptor. Ann. N. Y. Acad. Sci. 1998 Dec 12/15/1998; 861: 38-48. PMID: 9928237, ISSN: 0077-8923.

Breyer RM, Emeson RB, Davis LS, Breyer MD. Structure and localization of the rabbit prostaglandin EP3 receptor. Adv. Exp. Med. Biol. 1997; 400A: 261-8. PMID: 9547567, ISSN: 0065-2598.
Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature. 1997 May 5/15/1997; 387(6630): 303-8. PMID: 9153397, DOI: 10.1038/387303a0, ISSN: 0028-0836.
Bass BL, Nishikura K, Keller W, Seeburg PH, Emeson RB, O'Connell MA, Samuel CE, Herbert A. A standardized nomenclature for adenosine deaminases that act on RNA [letter]. RNA. 1997 Sep; 3(9): 947-9. PMID: 9292492, PMCID: PMC1369539, ISSN: 1355-8382.

Simpson L, Emeson RB. RNA editing. Annu. Rev. Neurosci. 1996; 19: 27-52. PMID: 8833435, DOI: 10.1146/annurev.ne.19.030196.000331, ISSN: 0147-006X.
Emeson, R.B. Post-transcriptional regulation of calcitonin gene-related peptide (CGRP) mRNA production. Neurogenic Inflammation. (P. Geppetti and P. Holzer, eds.), CRC Press, Boca Raton, FL. 1996; 15-30.
Canton H, Emeson RB, Barker EL, Backstrom JR, Lu JT, Chang MS, Sanders-Bush E. Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. Mol. Pharmacol. 1996 Oct; 50(4): 799-807. PMID: 8863824, ISSN: 0026-895X.

Rueter SM, Burns CM, Coode SA, Mookherjee P, Emeson RB. Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine. Science. 1995 Mar 3/10/1995; 267(5203): 1491-4. PMID: 7878468, ISSN: 0036-8075.

Breyer RM, Emeson RB, Tarng JL, Breyer MD, Davis LS, Abromson RM, Ferrenbach SM. Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor. J. Biol. Chem. 1994 Feb 2/25/1994; 269(8): 6163-9. PMID: 8119961, ISSN: 0021-9258.

Yeakley JM, Hedjran F, Morfin JP, Merillat N, Rosenfeld MG, Emeson RB. Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol. Cell. Biol. 1993 Oct; 13(10): 5999-6011. PMID: 8413203, PMCID: PMC364659, ISSN: 0270-7306.

Emeson RB, Yeakley JM, Hedjran F, Merillat N, Lenz HJ, Rosenfeld MG. Posttranscriptional regulation of calcitonin/CGRP gene expression. Ann. N. Y. Acad. Sci. 1992 Jun 6/30/1992; 657: 18-35. PMID: 1386208, ISSN: 0077-8923.
Rosenfeld MG, Emeson RB, Yeakley JM, Merillat N, Hedjran F, Lenz J, Delsert C. Calcitonin gene-related peptide: a neuropeptide generated as a consequence of tissue-specific, developmentally regulated alternative RNA processing events. Ann. N. Y. Acad. Sci. 1992 Jun 6/30/1992; 657: 1-17. PMID: 1637077, ISSN: 0077-8923.

Emeson RB, Hedjran F, Yeakley JM, Guise JW, Rosenfeld MG. Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor. Nature. 1989 Sep 9/7/1989; 341(6237): 76-80. PMID: 2788825, DOI: 10.1038/341076a0, ISSN: 0028-0836.

Rosenfeld M, Crenshaw EB, Emeson R, Leff S, Guise J, Lira S, Nelson C, Nelson C, Russo A. Transcriptional and post-transcriptional strategies in neuroendocrine gene expression. Dev. Biol. (NY). 1988; 5: 317-34. PMID: 3077978.

Emeson RB, Eipper BA. Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. J. Neurosci. 1986 Mar; 6(3): 837-49. PMID: 3007691, ISSN: 0270-6474.

Emeson RB. Hypothalamic peptidyl-glycine alpha-amidating monooxygenase: preliminary characterization. J. Neurosci. 1984 Oct; 4(10): 2604-13. PMID: 6491725, ISSN: 0270-6474.

Ronald Emeson, Ph.D.

Selected Publications