Department of Psychiatry and Behavioral Sciences

Follman EG, Chevée M, Kim CJ, Johnson AR, Tat J, Leonard MZ, Calipari ES. Task parameters influence operant response variability in mice. Psychopharmacology (Berl) [print-electronic]. 2023 Jan; 240(1): 213-25. PMID: 36572717, PMCID: PMC9894580, PII: 10.1007/s00213-022-06298-z, DOI: 10.1007/s00213-022-06298-z, ISSN: 1432-2072.
Jameson AN, Siemann JK, Melchior J, Calipari ES, McMahon DG, Grueter BA. Photoperiod Impacts Nucleus Accumbens Dopamine Dynamics. ENeuro [electronic-print]. 2023 Feb; 10(2): PMID: 36781229, PMCID: PMC9937087, PII: ENEURO.0361-22.2023, DOI: 10.1523/ENEURO.0361-22.2023, ISSN: 2373-2822.
Chevée M, Kim CJ, Crow N, Follman EG, Calipari ES. Sensitivity to outcome devaluation in operant tasks is better predicted by food restriction level than reinforcement training schedule in mice. BioRxiv. 2023 Feb 2/23/2023; PMID: 36865193, PMCID: PMC9980049, PII: 2023.02.23.529699, DOI: 10.1101/2023.02.23.529699.
Christensen BA, Calipari ES. Monitoring Fast Synaptic Transmission of Neuromodulatory Transmitters To Define Drug Effects in the Brain. ACS Chem Neurosci [print-electronic]. 2023 May 5/3/2023; 14(9): 1573-4. PMID: 37043625, DOI: 10.1021/acschemneuro.3c00221, ISSN: 1948-7193.
Emerson SD, Chevée M, Mews P, Calipari ES. The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system. Mol Cell Neurosci [print-electronic]. 2023 Jun; 125: 103823. PMID: 36868542, PMCID: PMC10247534, PII: S1044-7431(23)00017-9, DOI: 10.1016/j.mcn.2023.103823, ISSN: 1095-9327.
Williford KM, Taylor A, Melchior JR, Yoon HJ, Sale E, Negasi MD, Adank DN, Brown JA, Bedenbaugh MN, Luchsinger JR, Centanni SW, Patel S, Calipari ES, Simerly RB, Winder DG. BNST PKCd neurons are activated by specific aversive conditions to promote anxiety-like behavior. Neuropsychopharmacology [print-electronic]. 2023 Jun; 48(7): 1031-41. PMID: 36941364, PMCID: PMC10209190, PII: 10.1038/s41386-023-01569-5, DOI: 10.1038/s41386-023-01569-5, ISSN: 1740-634X.
Manz KM, Brady LJ, Calipari ES, Grueter BA. Accumbal Histamine Signaling Engages Discrete Interneuron Microcircuits. Biol Psychiatry [print-electronic]. 2023 Jun 6/1/2023; 93(11): 1041-52. PMID: 34953589, PMCID: PMC9012818, PII: S0006-3223(21)01668-1, DOI: 10.1016/j.biopsych.2021.10.004, ISSN: 1873-2402.
Brown JA, Petersen N, Centanni SW, Jin AY, Yoon HJ, Cajigas SA, Bedenbaugh MN, Luchsinger JR, Patel S, Calipari ES, Simerly RB, Winder DG. An ensemble recruited by a_2a-adrenergic receptors is engaged in a stressor-specific manner in mice. Neuropsychopharmacology [print-electronic]. 2023 Jul; 48(8): 1133-43. PMID: 36085168, PMCID: PMC10267140, PII: 10.1038/s41386-022-01442-x, DOI: 10.1038/s41386-022-01442-x, ISSN: 1740-634X.
Meckel KR, Simpson SS, Godino A, Peck EG, Sens JP, Leonard MZ, George O, Calipari ES, Hofford RS, Kiraly DD. Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking. Neuropsychopharmacology [print-electronic]. 2023 Aug 8/2/2023; PMID: 37528220, PII: 10.1038/s41386-023-01661-w, DOI: 10.1038/s41386-023-01661-w, ISSN: 1740-634X.

Wilcox JM, Consoli DC, Paffenroth KC, Spitznagel BD, Calipari ES, Bowman AB, Harrison FE. Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype. Pharmacol Biochem Behav [print-electronic]. 2022 Feb; 213: 173337. PMID: 35063467, PMCID: PMC8833139, PII: S0091-3057(22)00016-8, DOI: 10.1016/j.pbb.2022.173337, ISSN: 1873-5177.
Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. Acute restraint stress redirects prefrontal cortex circuit function through mGlu₅ receptor plasticity on somatostatin-expressing interneurons. Neuron [print-electronic]. 2022 Mar 3/16/2022; 110(6): 1068-1083.e5-1083.e5. PMID: 35045338, PMCID: PMC8930582, PII: S0896-6273(21)01044-8, DOI: 10.1016/j.neuron.2021.12.027, ISSN: 1097-4199.
Morel C, Montgomery SE, Li L, Durand-de Cuttoli R, Teichman EM, Juarez B, Tzavaras N, Ku SM, Flanigan ME, Cai M, Walsh JJ, Russo SJ, Nestler EJ, Calipari ES, Friedman AK, Han MH. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors. Nat Commun. 2022 Mar 3/22/2022; 13(1): 1532. PMID: 35318315, PMCID: PMC8940900, PII: 10.1038/s41467-022-29155-1, DOI: 10.1038/s41467-022-29155-1, ISSN: 2041-1723.
Johnson AR, Christensen BA, Kelly SJ, Calipari ES. The influence of reinforcement schedule on experience-dependent changes in motivation. J Exp Anal Behav [print-electronic]. 2022 May; 117(3): 320-30. PMID: 35344601, PMCID: PMC9090977, DOI: 10.1002/jeab.755, ISSN: 1938-3711.
Gipson CD, Soto PL, Calipari ES, Platt DM, Salamone JD, Bevins RA. Using complex behavior to understand brain mechanisms in health and disease. J Exp Anal Behav [print-electronic]. 2022 May; 117(3): 275-8. PMID: 35437760, PMCID: PMC9325376, DOI: 10.1002/jeab.762, ISSN: 1938-3711.
Kutlu MG, Zachry JE, Melugin PR, Tat J, Cajigas S, Isiktas AU, Patel DD, Siciliano CA, Schoenbaum G, Sharpe MJ, Calipari ES. Dopamine signaling in the nucleus accumbens core mediates latent inhibition. Nat Neurosci [print-electronic]. 2022 Aug; 25(8): 1071-81. PMID: 35902648, PMCID: PMC9768922, PII: 10.1038/s41593-022-01126-1, DOI: 10.1038/s41593-022-01126-1, ISSN: 1546-1726.

Gilpin NW, Calipari ES. The critical importance of understanding comorbidities to effectively treat drug addiction [editorial]. Int Rev Neurobiol. 2021; 157: xiii-xv-xv. PMID: 33648677, PII: S0074-7742(21)00021-0, DOI: 10.1016/S0074-7742(21)00021-0, ISSN: 2162-5514.
Lewis AS, Calipari ES, Siciliano CA. Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research. ENeuro [electronic-print]. 2021; 8(2): PMID: 33782101, PMCID: PMC8174055, PII: ENEURO.0498-20.2021, DOI: 10.1523/ENEURO.0498-20.2021, ISSN: 2373-2822.
Zachry JE, Nolan SO, Brady LJ, Kelly SJ, Siciliano CA, Calipari ES. Sex differences in dopamine release regulation in the striatum. Neuropsychopharmacology [print-electronic]. 2021 Feb; 46(3): 491-9. PMID: 33318634, PMCID: PMC8027008, PII: 10.1038/s41386-020-00915-1, DOI: 10.1038/s41386-020-00915-1, ISSN: 1740-634X.
Mews P, Calipari ES, Day J, Lobo MK, Bredy T, Abel T. From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health. J Neurosci [print-electronic]. 2021 Feb 2/3/2021; 41(5): 873-82. PMID: 33446519, PMCID: PMC7880276, PII: JNEUROSCI.1649-20.2020, DOI: 10.1523/JNEUROSCI.1649-20.2020, ISSN: 1529-2401.
Hofford RS, Euston TJ, Wilson RS, Meckel KR, Peck EG, Godino A, Landry JA, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex. J Neurosci [print-electronic]. 2021 Feb 2/17/2021; 41(7): 1553-65. PMID: 33361463, PMCID: PMC7896012, PII: JNEUROSCI.1452-20.2020, DOI: 10.1523/JNEUROSCI.1452-20.2020, ISSN: 1529-2401.
Consoli DC, Brady LJ, Bowman AB, Calipari ES, Harrison FE. Ascorbate deficiency decreases dopamine release in gulo^-/- and APP/PSEN1 mice. J Neurochem [print-electronic]. 2021 May; 157(3): 656-65. PMID: 32797675, PMCID: PMC7882008, DOI: 10.1111/jnc.15151, ISSN: 1471-4159.
Vaillancourt K, Yang J, Chen GG, Yerko V, Théroux JF, Aouabed Z, Lopez A, Thibeault KC, Calipari ES, Labonté B, Mechawar N, Ernst C, Nagy C, Forné T, Nestler EJ, Mash DC, Turecki G. Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster. Mol Psychiatry [print-electronic]. 2021 Jul; 26(7): 3134-51. PMID: 33046833, PMCID: PMC8039060, PII: 10.1038/s41380-020-00909-x, DOI: 10.1038/s41380-020-00909-x, ISSN: 1476-5578.
López AJ, Johnson AR, Euston TJ, Wilson R, Nolan SO, Brady LJ, Thibeault KC, Kelly SJ, Kondev V, Melugin P, Kutlu MG, Chuang E, Lam TT, Kiraly DD, Calipari ES. Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Commun Biol. 2021 Jul 7/16/2021; 4(1): 883. PMID: 34272455, PMCID: PMC8285523, PII: 10.1038/s42003-021-02358-w, DOI: 10.1038/s42003-021-02358-w, ISSN: 2399-3642.
López AJ, Johnson AR, Kunnath AJ, Morris AD, Zachry JE, Thibeault KC, Kutlu MG, Siciliano CA, Calipari ES. An optimized procedure for robust volitional cocaine intake in mice. Exp Clin Psychopharmacol [print-electronic]. 2021 Aug; 29(4): 319-33. PMID: 32658535, PMCID: PMC7890946, PII: 2020-50172-001, DOI: 10.1037/pha0000399, ISSN: 1936-2293.
Vaillancourt K, Chen GG, Fiori L, Maussion G, Yerko V, Théroux JF, Ernst C, Labonté B, Calipari E, Nestler EJ, Nagy C, Mechawar N, Mash DC, Turecki G. Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum. IScience. 2021 Oct 10/22/2021; 24(10): 103169. PMID: 34693223, PMCID: PMC8517202, PII: S2589-0042(21)01137-8, DOI: 10.1016/j.isci.2021.103169, ISSN: 2589-0042.
Kutlu MG, Zachry JE, Melugin PR, Cajigas SA, Chevee MF, Kelly SJ, Kutlu B, Tian L, Siciliano CA, Calipari ES. Dopamine release in the nucleus accumbens core signals perceived saliency. Curr Biol [print-electronic]. 2021 Nov 11/8/2021; 31(21): 4748-4761.e8-4761.e8. PMID: 34529938, PMCID: PMC9084920, PII: S0960-9822(21)01188-X, DOI: 10.1016/j.cub.2021.08.052, ISSN: 1879-0445.
Brady LJ, Erickson KR, Lucerne KE, Osman A, Kiraly DD, Calipari ES. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology (Berl) [print-electronic]. 2021 Dec; 238(12): 3499-509. PMID: 34487190, PMCID: PMC9056006, PII: 10.1007/s00213-021-05967-9, DOI: 10.1007/s00213-021-05967-9, ISSN: 1432-2072.

López AJ, Siciliano CA, Calipari ES. Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder. Handb Exp Pharmacol. 2020; 258: 231-63. PMID: 31628597, DOI: 10.1007/164_2019_257, ISSN: 0171-2004.
Lepack AE, Werner CT, Stewart AF, Fulton SL, Zhong P, Farrelly LA, Smith ACW, Ramakrishnan A, Lyu Y, Bastle RM, Martin JA, Mitra S, O'Connor RM, Wang ZJ, Molina H, Turecki G, Shen L, Yan Z, Calipari ES, Dietz DM, Kenny PJ, Maze I. Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science. 2020 Apr 4/10/2020; 368(6487): 197-201. PMID: 32273471, PMCID: PMC7228137, PII: 368/6487/197, DOI: 10.1126/science.aaw8806, ISSN: 1095-9203.
Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Durand-de Cuttoli R, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Nat Neurosci [print-electronic]. 2020 May; 23(5): 638-50. PMID: 32284606, PMCID: PMC7195257, PII: 10.1038/s41593-020-0617-7, DOI: 10.1038/s41593-020-0617-7, ISSN: 1546-1726.
Issler O, van der Zee YY, Ramakrishnan A, Wang J, Tan C, Loh YE, Purushothaman I, Walker DM, Lorsch ZS, Hamilton PJ, Peña CJ, Flaherty E, Hartley BJ, Torres-Berrío A, Parise EM, Kronman H, Duffy JE, Estill MS, Calipari ES, Labonté B, Neve RL, Tamminga CA, Brennand KJ, Dong Y, Shen L, Nestler EJ. Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression. Neuron [print-electronic]. 2020 Jun 6/17/2020; 106(6): 912-926.e5-926.e5. PMID: 32304628, PMCID: PMC7305959, PII: S0896-6273(20)30230-0, DOI: 10.1016/j.neuron.2020.03.023, ISSN: 1097-4199.
Dash S, Balasubramaniam M, Martínez-Rivera FJ, Godino A, Peck EG, Patnaik S, Suar M, Calipari ES, Nestler EJ, Villalta F, Dash C, Pandhare J. Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells. Sci Rep. 2020 Jul 7/8/2020; 10(1): 11197. PMID: 32641757, PMCID: PMC7343862, PII: 10.1038/s41598-020-68144-6, DOI: 10.1038/s41598-020-68144-6, ISSN: 2045-2322.
Kutlu MG, Zachry JE, Brady LJ, Melugin PR, Kelly SJ, Sanders C, Tat J, Johnson AR, Thibeault K, Lopez AJ, Siciliano CA, Calipari ES. A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies. Neuropsychopharmacology [print-electronic]. 2020 Aug; 45(9): 1463-72. PMID: 32375157, PMCID: PMC7360782, PII: 10.1038/s41386-020-0692-1, DOI: 10.1038/s41386-020-0692-1, ISSN: 1740-634X.
Liu Y, Montgomery SE, Juarez B, Morel C, Zhang S, Kong Y, Calipari ES, Nestler EJ, Zhang L, Han MH. Different adaptations of dopamine release in Nucleus Accumbens shell and core of individual alcohol drinking groups of mice. Neuropharmacology [print-electronic]. 2020 Sep 9/15/2020; 175: 108176. PMID: 32497591, PMCID: PMC7492398, PII: S0028-3908(20)30244-6, DOI: 10.1016/j.neuropharm.2020.108176, ISSN: 1873-7064.
Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature [print-electronic]. 2020 Oct; 586(7829): 417-23. PMID: 32999463, PMCID: PMC7577179, PII: 10.1038/s41586-020-2777-8, DOI: 10.1038/s41586-020-2777-8, ISSN: 1476-4687.
Nolan SO, Zachry JE, Johnson AR, Brady LJ, Siciliano CA, Calipari ES. Direct dopamine terminal regulation by local striatal microcircuitry. J Neurochem [print-electronic]. 2020 Dec; 155(5): 475-93. PMID: 32356315, PMCID: PMC7606645, DOI: 10.1111/jnc.15034, ISSN: 1471-4159.
Calipari ES. Dopamine Release in the Midbrain Promotes Anxiety. Biol Psychiatry. 2020 Dec 12/1/2020; 88(11): 815-7. PMID: 33153526, PMCID: PMC7687288, PII: S0006-3223(20)31875-8, DOI: 10.1016/j.biopsych.2020.08.016, ISSN: 1873-2402.

Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH. A₁- and ß₃-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice. Biol Psychiatry [print-electronic]. 2019 Feb 2/1/2019; 85(3): 226-36. PMID: 30336931, PMCID: PMC6800029, PII: S0006-3223(18)31818-3, DOI: 10.1016/j.biopsych.2018.08.020, ISSN: 1873-2402.
Yohn SE, Galbraith J, Calipari ES, Conn PJ. Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway. ACS Chem Neurosci [print-electronic]. 2019 May 5/15/2019; 10(5): 2125-43. PMID: 30933466, PMCID: PMC7898461, DOI: 10.1021/acschemneuro.8b00601, ISSN: 1948-7193.
Johnson AR, Thibeault KC, Lopez AJ, Peck EG, Sands LP, Sanders CM, Kutlu MG, Calipari ES. Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement. Neuropsychopharmacology [print-electronic]. 2019 Jun; 44(7): 1189-97. PMID: 30728447, PMCID: PMC6785030, PII: 10.1038/s41386-019-0320-0, DOI: 10.1038/s41386-019-0320-0, ISSN: 1740-634X.
Thibeault KC, Kutlu MG, Sanders C, Calipari ES. Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction. Brain Res [print-electronic]. 2019 Jun 6/15/2019; 1713: 1-15. PMID: 30580012, PMCID: PMC6506354, PII: S0006-8993(18)30642-5, DOI: 10.1016/j.brainres.2018.12.024, ISSN: 1872-6240.
Zachry JE, Johnson AR, Calipari ES. Sex Differences in Value-Based Decision Making Underlie Substance Use Disorders in Females. Alcohol Alcohol. 2019 Jul 7/1/2019; 54(4): 339-41. PMID: 31220203, PMCID: PMC6671483, PII: 5521159, DOI: 10.1093/alcalc/agz052, ISSN: 1464-3502.
Calipari ES, Godino A, Salery M, Damez-Werno DM, Cahill ME, Werner CT, Gancarz AM, Peck EG, Jlayer Z, Rabkin J, Landry JA, Smith ACW, Defilippi P, Kenny PJ, Hurd YL, Neve RL, Dietz DM, Nestler EJ. Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration. J Neurosci [print-electronic]. 2019 Jul 7/17/2019; 39(29): 5634-46. PMID: 31092585, PMCID: PMC6636087, PII: JNEUROSCI.0024-19.2019, DOI: 10.1523/JNEUROSCI.0024-19.2019, ISSN: 1529-2401.
Fakira AK, Peck EG, Liu Y, Lueptow LM, Trimbake NA, Han MH, Calipari ES, Devi LA. The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences. Neuropharmacology [print-electronic]. 2019 Oct; 157: 107666. PMID: 31199956, PMCID: PMC6677605, PII: S0028-3908(19)30220-5, DOI: 10.1016/j.neuropharm.2019.107666, ISSN: 1873-7064.
Brady LJ, Hofford RS, Tat J, Calipari ES, Kiraly DD. Granulocyte-Colony Stimulating Factor Alters the Pharmacodynamic Properties of Cocaine in Female Mice. ACS Chem Neurosci [print-electronic]. 2019 Oct 10/16/2019; 10(10): 4213-20. PMID: 31479229, PMCID: PMC7328281, DOI: 10.1021/acschemneuro.9b00309, ISSN: 1948-7193.

Calipari ES, Godino A, Peck EG, Salery M, Mervosh NL, Landry JA, Russo SJ, Hurd YL, Nestler EJ, Kiraly DD. Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine. Nat Commun. 2018 Jan 1/16/2018; 9(1): 9. PMID: 29339724, PMCID: PMC5770429, PII: 10.1038/s41467-017-01881-x, DOI: 10.1038/s41467-017-01881-x, ISSN: 2041-1723.
Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK, Han MH. Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice. Nat Commun. 2018 Feb 2/8/2018; 9(1): 653. PMID: 29422549, PMCID: PMC5805722, PII: 10.1038/s41467-018-02921-w, DOI: 10.1038/s41467-018-02921-w, ISSN: 2041-1723.
Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ. Corrigendum: Sex-specific transcriptional signatures in human depression. Nat Med. 2018 Apr 4/10/2018; 24(4): 525. PMID: 29634684, PII: nm0418-525d, DOI: 10.1038/nm0418-525d, ISSN: 1546-170X.
Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, Kronman H, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat A, Pirpinias S, Mouzon E, Han MH, Neve RL, Bagot RC, Kasarskis A, Koo JW, Nestler EJ. Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine. Nat Commun. 2018 Aug 8/8/2018; 9(1): 3149. PMID: 30089879, PMCID: PMC6082848, PII: 10.1038/s41467-018-05657-9, DOI: 10.1038/s41467-018-05657-9, ISSN: 2041-1723.
Mervosh NL, Wilson R, Rauniyar N, Hofford RS, Kutlu MG, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area. Proteomes. 2018 Sep 9/23/2018; 6(4): PMID: 30249060, PMCID: PMC6313867, PII: proteomes6040035, DOI: 10.3390/proteomes6040035, ISSN: 2227-7382.
Kutlu MG, Brady LJ, Peck EG, Hofford RS, Yorgason JT, Siciliano CA, Kiraly DD, Calipari ES. Granulocyte Colony Stimulating Factor Enhances Reward Learning through Potentiation of Mesolimbic Dopamine System Function. J Neurosci [print-electronic]. 2018 Oct 10/10/2018; 38(41): 8845-59. PMID: 30150359, PMCID: PMC6181308, PII: JNEUROSCI.1116-18.2018, DOI: 10.1523/JNEUROSCI.1116-18.2018, ISSN: 1529-2401.
Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ. Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry. Biol Psychiatry [print-electronic]. 2018 Dec 12/15/2018; 84(12): 867-80. PMID: 29861096, PMCID: PMC6202276, PII: S0006-3223(18)31447-1, DOI: 10.1016/j.biopsych.2018.04.009, ISSN: 1873-2402.

Mews P, Calipari ES. Cross-talk between the epigenome and neural circuits in drug addiction. Prog. Brain Res [print-electronic]. 2017; 235: 19-63. PMID: 29054289, PII: S0079-6123(17)30113-9, DOI: 10.1016/bs.pbr.2017.08.012, ISSN: 1875-7855.
Mews P, Calipari ES. Cross-talk between the epigenome and neural circuits in drug addiction. Prog. Brain Res [print-electronic]. 2017; 235: 19-63. PMID: 29054289, PII: S0079-6123(17)30113-9, DOI: 10.1016/bs.pbr.2017.08.012, ISSN: 1875-7855.
Calipari ES, Juarez B, Morel C, Walker DM, Cahill ME, Ribeiro E, Roman-Ortiz C, Ramakrishnan C, Deisseroth K, Han MH, Nestler EJ. Dopaminergic dynamics underlying sex-specific cocaine reward. Nat Commun. 2017 Jan 1/10/2017; 8: 13877. PMID: 28072417, PMCID: PMC5234081, PII: ncomms13877, DOI: 10.1038/ncomms13877, ISSN: 2041-1723.
Muir J, Lorsch ZS, Ramakrishnan C, Deisseroth K, Nestler EJ, Calipari ES, Bagot RC. In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens. Neuropsychopharmacology [print-electronic]. 2017 Jun 6/7/2017; PMID: 28589967, PII: npp2017122, DOI: 10.1038/npp.2017.122, ISSN: 1740-634X.
Dash S, Balasubramaniam M, Rana T, Godino A, Peck EG, Goodwin JS, Villalta F, Calipari ES, Nestler EJ, Dash C, Pandhare J. Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. ENeuro. 2017 Jul; 4(4): PMID: 28828398, PMCID: PMC5562297, PII: eN-NWR-0089-17, DOI: 10.1523/ENEURO.0089-17.2017, ISSN: 2373-2822.
Dash S, Balasubramaniam M, Rana T, Godino A, Peck EG, Goodwin JS, Villalta F, Calipari ES, Nestler EJ, Dash C, Pandhare J. Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. ENeuro. 2017 Jul; 4(4): PMID: 28828398, PMCID: PMC5562297, PII: eN-NWR-0089-17, DOI: 10.1523/ENEURO.0089-17.2017, ISSN: 2373-2822.
Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ. Sex-specific transcriptional signatures in human depression. Nat. Med [print-electronic]. 2017 Sep; 23(9): 1102-11. PMID: 28825715, PII: nm.4386, DOI: 10.1038/nm.4386, ISSN: 1546-170X.
Barker DJ, Miranda-Barrientos J, Zhang S, Root DH, Wang HL, Liu B, Calipari ES, Morales M. Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission. Cell Rep. 2017 Nov 11/14/2017; 21(7): 1757-69. PMID: 29141211, PMCID: PMC5699228, PII: S2211-1247(17)31529-2, DOI: 10.1016/j.celrep.2017.10.066, ISSN: 2211-1247.
Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. Amphetamine reverses escalated cocaine intake via restoration of dopamine transporter conformation. J. Neurosci [print-electronic]. 2017 Nov 11/24/2017; PMID: 29175958, PII: JNEUROSCI.2604-17.2017, DOI: 10.1523/JNEUROSCI.2604-17.2017, ISSN: 1529-2401.
Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ. Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol. Psychiatry [print-electronic]. 2017 Dec 12/1/2017; 82(11): 794-805. PMID: 28577753, PMCID: PMC5671915, PII: S0006-3223(17)31517-2, DOI: 10.1016/j.biopsych.2017.04.013, ISSN: 1873-2402.
Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK, Han MH. Midbrain circuit regulation of individual alcohol drinking behaviors in mice. Nat Commun. 2017 Dec 12/20/2017; 8(1): 2220. PMID: 29263389, PMCID: PMC5738419, PII: 10.1038/s41467-017-02365-8, DOI: 10.1038/s41467-017-02365-8, ISSN: 2041-1723.

Siciliano CA, Calipari ES, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR. Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend [print-electronic]. 2016 Jan 1/1/2016; 158: 159-63. PMID: 26627912, PMCID: PMC4698076, PII: S0376-8716(15)01728-7, DOI: 10.1016/j.drugalcdep.2015.10.031, ISSN: 1879-0046.
Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology [print-electronic]. 2016 Feb; 101: 471-9. PMID: 26525189, PMCID: PMC4681685, PII: S0028-3908(15)30148-9, DOI: 10.1016/j.neuropharm.2015.10.025, ISSN: 1873-7064.
Calipari ES, Bagot RC, Purushothaman I, Davidson TJ, Yorgason JT, Peña CJ, Walker DM, Pirpinias ST, Guise KG, Ramakrishnan C, Deisseroth K, Nestler EJ. In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2016 Mar 3/8/2016; 113(10): 2726-31. PMID: 26831103, PMCID: PMC4791010, PII: 1521238113, DOI: 10.1073/pnas.1521238113, ISSN: 1091-6490.
Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jimenez VA, Helms CM, Grant KA, Jones SR. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Psychopharmacology (Berl.) [print-electronic]. 2016 Apr; 233(8): 1435-43. PMID: 26892380, PMCID: PMC4814331, PII: 10.1007/s00213-016-4239-4, DOI: 10.1007/s00213-016-4239-4, ISSN: 1432-2072.
Salvatore MF, Calipari ES, Jones SR. Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. ACS Chem Neurosci [print-electronic]. 2016 Jul 7/20/2016; 7(7): 941-51. PMID: 27124386, PMCID: PMC4956566, DOI: 10.1021/acschemneuro.6b00064, ISSN: 1948-7193.
Damez-Werno DM, Sun H, Scobie KN, Shao N, Rabkin J, Dias C, Calipari ES, Maze I, Pena CJ, Walker DM, Cahill ME, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Neve RL, Hurd YL, Shen L, Nestler EJ. Histone arginine methylation in cocaine action in the nucleus accumbens. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2016 Aug 8/23/2016; 113(34): 9623-8. PMID: 27506785, PMCID: PMC5003250, PII: 1605045113, DOI: 10.1073/pnas.1605045113, ISSN: 1091-6490.
Wook Koo J, Labonté B, Engmann O, Calipari ES, Juarez B, Lorsch Z, Walsh JJ, Friedman AK, Yorgason JT, Han MH, Nestler EJ. Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors. Biol. Psychiatry [print-electronic]. 2016 Sep 9/15/2016; 80(6): 469-78. PMID: 26858215, PMCID: PMC4909591, PII: S0006-3223(15)01045-8, DOI: 10.1016/j.biopsych.2015.12.009, ISSN: 1873-2402.
Kiraly DD, Walker DM, Calipari ES, Labonte B, Issler O, Pena CJ, Ribeiro EA, Russo SJ, Nestler EJ. Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine. Sci Rep. 2016 Oct 10/18/2016; 6: 35455. PMID: 27752130, PMCID: PMC5067576, PII: srep35455, DOI: 10.1038/srep35455, ISSN: 2045-2322.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci [print-electronic]. 2015 Jan 1/21/2015; 6(1): 27-36. PMID: 25491345, PMCID: PMC4304501, DOI: 10.1021/cn5002705, ISSN: 1948-7193.
Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci [print-electronic]. 2015 Jan 1/21/2015; 6(1): 155-62. PMID: 25474655, PMCID: PMC4304485, DOI: 10.1021/cn500262x, ISSN: 1948-7193.
Calipari ES, Siciliano CA, Zimmer BA, Jones SR. Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Neuropsychopharmacology [print-electronic]. 2015 Feb; 40(3): 728-35. PMID: 25212486, PMCID: PMC4289961, PII: npp2014238, DOI: 10.1038/npp.2014.238, ISSN: 1740-634X.
Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR. Voluntary ethanol intake predicts ¿-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. J. Neurosci. 2015 Apr 4/15/2015; 35(15): 5959-68. PMID: 25878269, PMCID: PMC4397597, PII: 35/15/5959, DOI: 10.1523/JNEUROSCI.4820-14.2015, ISSN: 1529-2401.
Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology [print-electronic]. 2015 Jul; 40(8): 1826-36. PMID: 25689882, PMCID: PMC4839519, PII: npp201545, DOI: 10.1038/npp.2015.45, ISSN: 1740-634X.
Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience [print-electronic]. 2015 Oct 10/29/2015; 307: 253-61. PMID: 26321241, PMCID: PMC4591251, PII: S0306-4522(15)00785-X, DOI: 10.1016/j.neuroscience.2015.08.053, ISSN: 1873-7544.

Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J. Neurochem [print-electronic]. 2014 Jan; 128(2): 224-32. PMID: 24102293, PMCID: PMC3947316, DOI: 10.1111/jnc.12452, ISSN: 1471-4159.
Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol [print-electronic]. 2014 Mar; 19(2): 145-55. PMID: 22458761, PMCID: PMC3390453, DOI: 10.1111/j.1369-1600.2012.00456.x, ISSN: 1369-1600.
Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J. Neurosci. 2014 Apr 4/16/2014; 34(16): 5575-82. PMID: 24741047, PMCID: PMC3988413, PII: 34/16/5575, DOI: 10.1523/JNEUROSCI.4050-13.2014, ISSN: 1529-2401.
Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J. Pharmacol. Exp. Ther [print-electronic]. 2014 May; 349(2): 192-8. PMID: 24566123, PMCID: PMC3989803, PII: jpet.114.212993, DOI: 10.1124/jpet.114.212993, ISSN: 1521-0103.
Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology [print-electronic]. 2014 Jul; 39(8): 1833-42. PMID: 24513972, PMCID: PMC4059891, PII: npp201430, DOI: 10.1038/npp.2014.30, ISSN: 1740-634X.
Calipari ES, Jones SR. Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration. Neuropharmacology [print-electronic]. 2014 Jul; 82: 1-10. PMID: 24632529, PMCID: PMC4028393, PII: S0028-3908(14)00086-0, DOI: 10.1016/j.neuropharm.2014.02.021, ISSN: 1873-7064.
Siciliano CA, Calipari ES, Jones SR. Amphetamine potency varies with dopamine uptake rate across striatal subregions. J. Neurochem [print-electronic]. 2014 Nov; 131(3): 348-55. PMID: 24988947, PMCID: PMC4205180, DOI: 10.1111/jnc.12808, ISSN: 1471-4159.
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ. ß-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature [print-electronic]. 2014 Dec 12/4/2014; 516(7529): 51-5. PMID: 25383518, PMCID: PMC4257892, PII: nature13976, DOI: 10.1038/nature13976, ISSN: 1476-4687.

Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013; 4: 2720. PMID: 24193139, PMCID: PMC4017736, PII: ncomms3720, DOI: 10.1038/ncomms3720, ISSN: 2041-1723.
Rose JH, Calipari ES, Mathews TA, Jones SR. Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics. PLoS One. 2013; 8(12): e83852. PMID: 24349553, PMCID: PMC3861521, PII: PONE-D-13-30624, DOI: 10.1371/journal.pone.0083852, ISSN: 1932-6203.
Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci [print-electronic]. 2013 May 5/15/2013; 4(5): 693-703. PMID: 23581570, PMCID: PMC3656744, DOI: 10.1021/cn400026v, ISSN: 1948-7193.
Calipari ES, Ferris MJ. Amphetamine mechanisms and actions at the dopamine terminal revisited. J Neurosci. 2013 May 5/22/2013; 33(21): 8923-5. PMID: 23699503, PMCID: PMC3753078, PII: 33/21/8923, DOI: 10.1523/JNEUROSCI.1033-13.2013, ISSN: 1529-2401.
Ferris MJ, Calipari ES, Melchior JR, Roberts DC, España RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur. J. Neurosci [print-electronic]. 2013 Aug; 38(4): 2628-36. PMID: 23725404, PMCID: PMC3748159, DOI: 10.1111/ejn.12266, ISSN: 1460-9568.
Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology [print-electronic]. 2013 Nov; 38(12): 2385-92. PMID: 23719505, PMCID: PMC3799057, PII: npp2013136, DOI: 10.1038/npp.2013.136, ISSN: 1740-634X.
Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci [print-electronic]. 2013 Dec; 38(12): 3749-57. PMID: 24118121, PMCID: PMC3865236, DOI: 10.1111/ejn.12381, ISSN: 1460-9568.

Calipari ES, España RA. Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms. Front Behav Neurosci. 2012; 6: 54. PMID: 22933994, PMCID: PMC3423791, DOI: 10.3389/fnbeh.2012.00054, ISSN: 1662-5153.
Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DC, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology [print-electronic]. 2012 Jun; 37(7): 1708-16. PMID: 22395730, PMCID: PMC3358740, PII: npp201217, DOI: 10.1038/npp.2012.17, ISSN: 1740-634X.
Calipari ES, Huggins KN, Mathews TA, Jones SR. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochem Int [print-electronic]. 2012 Dec; 61(7): 986-91. PMID: 22819794, PMCID: PMC3593229, PII: S0197-0186(12)00228-8, DOI: 10.1016/j.neuint.2012.07.008, ISSN: 1872-9754.

Erin Calipari, Ph.D.

Selected Publications