Electron Microscopy

Electron microscopy (EM) is valuable in addressing a wide variety of anatomic pathology problems. These include:   

1.  Neoplasms: mesothelioma vs. carcinoma

  • small round blue cell tumors
  • spindle cell tumors
  • Melanoma
  • neuroendocrine tumors
  • undifferentiated tumors

2.  Storage diseases

3.  Cilia disorders (immotile cilia diseases)

4.  Infectious diseases: viral diseases

5.  *Whipple's disease and microsporidia

6.  Miscellaneous: congenital bullous skin diseases  
In addition to tissue samples, representative H & E-stained slides as well as a completed EM requisition should be sent. Please also provide the results of any other studies (i.e. immunohistochemistry) to aid in our diagnostic evaluation. Tissue processing for EM requires 2-3 days. Results are reported by telephone, fax, and a final printed report.
Samples can be shipped at ambient temperature. We can provide glutaraldehyde fixative, EM requisitions, and pre-printed airbills upon request. Samples are accepted Monday through Friday.
Samples in 2% glutaraldehyde may be multiple, but should not exceed 1mm in dimension because of the penetrating abilities of this fixative. If glutaraldehyde is unavailable please contact us by phone 615-322-3070 or by e-mail, and we will provide you with specimen containers containing this fixative. Formalin, or other fixed tissue is also usually adequate if no glutaraldehyde is available. Sometimes a paraffin embedded specimen can be used, but with some sacrifice of quality.