Vanderbilt-Nigeria Biostatistics Training Program (VN-BioStat)
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Fellowship applications are open for this NIH collaborative research training grant focused on creating a cohort of highly skilled Nigerian biostatisticians with the capacity to lead and supervise high-level biostatistics activities for HIV research studies in West Africa.
Focus includes hands-on biostatistics training. Trainees will take biostatistics courses, become members of a team of biostatisticians doing HIV research at Vanderbilt, and will be assigned to HIV research projects using data from Aminu Kano Teaching Hospital (AKTH).
Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II (SPRING)
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Strokes in sickle cell anemia (SCA), particularly in children living in Africa, are associated with significant morbidity and an increased risk of premature death. In the US, primary stroke prevention in children with SCA involves screening for elevated transcranial Doppler ultrasound (TCD) velocity coupled with regular blood transfusion therapy for those with elevated velocities. However, regular blood transfusion therapy is not feasible in Africa due to inadequate supply of safe blood and the reluctance of parents to accept regular blood transfusion therapy for their children.
Stroke Prevention in Young Adults With Sickle Cell Anemia (SPIYA)
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Sickle cell disease (SCD) is the most common genetic disease, affecting about 25 million people worldwide. Approximately 150,000 Nigerian children are born each year with sickle cell disease (SCD), making it the country with the largest burden of SCD in the world. Recent advancements in care for children with SCA have translated into improved survival of children in both high and low-resource settings. However, more complications of SCD are seen in those who survive to adulthood.
Applying Research for a Healthy Liberia
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The University of Liberia College of Health Sciences is the leading educational institution for developing Liberia’s clinicians, researchers, health policymakers and innovators.
Mobile Health and Treat (mHAT) for Malaria Elimination
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Principal Investigator(s):
Martin Were, M.D., M.S.
David Wright, Ph.D.
The Risk Of HIV Acquisition Among Traditional Healers In South Africa: Implementing Novel Strategies To Improve Protective Behavior
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Traditional healers, community-based partners with the national health system of South Africa, are exposed to patient blood an average of 1,500 times during their careers due to the practice of delivering herbal remedies via herbs rubbed into dozens of sub-cutaneous cuts. The purpose of this proposal is to compare two implementation strategies to increase consistent use of PPE: (1) a health care worker provided training program followed by 3 educational outreach and coaching visits at the healer's place of practice vs.
Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis "RePORT-Brazil"
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Principal Investigator(s):
Timothy R. Sterling, M.D.
Valeria Cavalcanti Rolla, M.D., Ph.D.
HIV Mobility and Engagement in Care in TN
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The project connects Vanderbilt researchers across disciplines in order to understand how often people living with HIV move within or outside of the state, and if this mobility is associated with HIV outcomes.
An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria
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Young people living with HIV (Y-PLWH) have poor adherence to antiretroviral therapy and engagement in HIV care, making HIV the leading cause of death for African adolescents. Depression and psychological distress are much more common among Y-PLWH than in the general population, and are associated with significantly worse adherence to care and treatment when compared to Y-PLWH without these co-morbid conditions. Thus, untreated depression and severe psychological distress are important contributors to poor HIV outcomes in this population.
CareConekta: study protocol for a randomized controlled trial of a mobile health intervention to improve engagement in postpartum HIV care in South Africa
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South Africa has more HIV/AIDS patients than any other country and is home to the world’s largest antiretroviral program. According to the World Bank, as of 2018 the prevalence of HIV among South Africans ages 15 to 49 was 20.4%. Nearly one in three pregnant women attending antenatal care in South Africa is living with HIV.
As South Africans with HIV move around the country, there is a risk they will disengage from the health care system or otherwise become lost to follow-up care.
Partnerships for Enhanced Engagement in Research Liberia (PEER/Liberia) Consortium
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Principal Investigator(s):
Bonnie Miller, M.D.
Troy Moon, M.D. M.P.H.
Marie Martin, M.Ed., Ph.D.
UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER)
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Building on over a decade of partnership, the Faculty of Medicine at University Eduardo Mondlane (UEM) and the Vanderbilt Institute for Global Health (VIGH) are seeking to expand upon the groundwork laid by the longstanding PRISM (Partnership for Research in Implementation Science – Mozambique
Cure Sickle Cell Initiative Data Coordinating Center
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Project Details: NIH Reporter
VU-Mozambique Collaborative Research Ethics Education (FoCEP) Program
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Principal Investigator(s):
Elizabeth Heitman, Ph.D.
Troy Moon, M.D., M.P.H.
Liberia IRB Practicum and Workshop Series: Ethics Supplement
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Building on the partnership with University of Liberia, College of Health Sciences (ULCHS), the Vanderbilt Institute for Global Health (VIGH) will develop a develop a one-year research ethics education program for members of four institutional review boards (IRBs) in Monrovia, Liberia. Research education and training activities will adapt to the Liberian context from the well-established Collaborative Research Ethics Education (Formação Colaborativa em Etica na Pesquisa, FoCEP) Program for Mozambique.
The South African National HIV Pregnancy Cohort: evaluating continuity of care among women living with HIV
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Project Details: NIH Reporter
Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care
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Principal Investigator(s):
Carolyn Audet, Ph.D.
Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa
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In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to the health facility. South Africa has made progress towards their 90-90-90 goals, yet a substantial proportion of the population do not test regularly; only 33.9% of adults in rural Mpumalanga (our study site) underwent HIV testing in the past year.
Implementation of Rapid HIV Testing and Linkage to HIV Treatment or Prevention Among Vulnerable Populations in Tennessee
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Human Immunodeficiency Virus (HIV) infection remains a significant public health problem in the United States (US). It is estimated that almost 15% of the 1.17 million people living with HIV (PLWH) in the US are unaware of their HIV status. And despite the existence of highly effective HIV treatment (antiretroviral therapy, ART), only 65% of people living with diagnosed HIV have achieved viral suppression. Similarly, among HIV-negative people eligible for PrEP, only 18% have used PrEP.
Partnership for Research in Implementation Science – Mozambique (PRISM)
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The Republic of Mozambique, a Portuguese-speaking country of 28 million people on the southeast coast of Africa, has experienced significant economic growth and distinct progress in improving health indicators over the past two decades. Since the end of a devastating civil war in 1992, health has been a government priority, particularly in response to the crushing burden of HIV/AIDS.
Examining antibody response to SARS-CoV-2 in Sierra Leone
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Excerpt from the article Fogarty awards $3.3M in COVID-19 supplements to support research, training published in Global Health Matters by the Fogarty International Center:
Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)
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Principal Investigator(s):
Muktar Aliyu, M.D., M.P.H., Dr.P.H.
Edwin Trevathan, M.D., M.P.H.
Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)
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Status epilepticus (SE) is the most common serious neurological emergency among children worldwide. In the low- and middle-income countries (LMICs) of sub-Saharan Africa, the burden of childhood SE-associated mortality and morbidity appears to be especially high. However, the phenotypes of childhood SE, clinical predictors of SE-associated mortality and of SE-associated neurodevelopmental morbidity, and genomic predictors of SE, SE-associated mortality and neurodevelopmental morbidity have not been well-characterized in this region.
Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria
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Principal Investigator(s):
Muktar Aliyu, M.D., M.P.H., Dr.P.H.
William Wester, M.D., M.P.H.
Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP)
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About V-RAMP
Expanding on the decade-long Vanderbilt-AKTH partnership, Aminu Kano Teaching Hospital (AKTH), Bayero University Kano (BUK) in Kano, Nigeria, and the Vanderbilt Institute for Global Health (VIGH) are partnering on a new infrastructure development training program supported by the Fogarty International Center of the National Institutes of Health (NIH). The project will strengthen infrastructure capacity in research administration and research ethics in Nigeria.
Population mobility and retention in HIV care among postpartum women in South Africa
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Principal Investigator(s):
Kate Clouse, Ph.D., M.P.H.
UNZA-Vanderbilt Partnership for HIV-NCD Research (UVP-2)
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The UNZA-Vanderbilt Training Partnership for HIV-Nutrition-Metabolic Research (UVP-1) and the UNZA-Vanderbilt Partnership for HIV-NCD Research (UVP-2) continue a longstanding training collaboration between the University of Zambia School of Medicine/University Teaching Hospital (UNZA/UTH), Vanderbilt University (VU) and the Vanderbilt Institute for Global Health (VIGH).
Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya)
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PI: Martin C. Were, M.D., M.S.
Vanderbilt Institute for Research Development and Ethics (VIRDE)
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VIRDE is an annual intensive research training program designed to facilitate trainee research productivity in low- and middle-income countries (LMICs). This month-long program is intended to bolster and further develop the skill sets necessary for conducting responsible human subjects’ research and developing a grant proposal for submission. Attendees participate in a series of grant writing, research ethics/scientific integrity, and career development seminars and workshops.
Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts
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Principal Investigators:
Timothy Sterling, MD
Bruno Andrade
Thomas Hawn
Improving Perioperative Anesthesia Care and Training in Africa (ImPACT Africa)
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The Improving Perioperative Anesthesia Care and Training in Africa (ImPACT Africa) program addresses the critical need for safe surgery by training local anesthesia providers and building educational capacity of local institutions. Vanderbilt Institute for Global Health (VIGH) faculty members, Marie Martin and Elizabeth Rose, along with other VIGH staff and student collaborators, have partnered with ImPACT Africa leaders to provide education consulting and develop new courses.
The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL)
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The West African Ebola outbreak of 2014-2015 exposed the fragility of Sierra Leone’s health system and highlighted the need for further investments to ensure its future capability of responding to a disease outbreak of this magnitude.
Collaborative Research Ethics Education-Mozambique (Formaçao Colaborativa em Etica na Pesquisa, FoCEP)
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The growth in research activity projected for the next decade by the Mozambican government and international agencies highlights the continued need for capacity building in research ethics well into the future. With the groundwork laid for systems of basic, translational, clinical and public health research, capacity development in research ethics has been essential to address critical research questions in an ethically consistent way. The four most evident areas in which attention is still needed are:
Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)
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Principal Investigator: Edwin Trevathan, MD, MPH
Etiology of Persistent Microalbuminuria in Nigeria
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The Vanderbilt Institute for Global Health (VIGH) and Aminu Kano Teaching Hospital (AKTH) in Kano, Nigeria have received a federal grant to study the factors associated with microalbuminuria among participants in an ongoing clinical trial of genetically at-risk HIV-positive adult Nigerians.
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant will provide $2.2 million over the next four years.
Management of severe acute malnutrition in children with sickle cell disease greater than 5 years of age living in northern Nigeria
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Project Details: NIH Reporter
Abstract Text
PeerNaija: A Mobile Health Platform
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The scale-up of global antiretroviral therapy (ART) represents an unparalleled global health success story, leading to impressive overall reductions in HIV-related morbidity and mortality. However, adolescents and young adults (AYA), especially those in Sub-Saharan Africa, have largely been left out of this story. While AIDS-related deaths declined by 30% for adults from 2005-2012, they increased by 50% among AYA over the same period, making AIDS the leading cause of death among African youth. AYA living with HIV perform poorly across the entire care continuum.
Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (V-BRCH)
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https://vumc.org/v-brch
The Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (V-BRCH) Program builds capacity of Nigerian investigators to successfully initiate and implement high-quality clinical trials in HIV-associated non-communicable diseases.
Avante: Towards Epidemic Control
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https://www.vumc.org/friends-in-global-health/avante
Principal Investigator(s):
William Wester, M.D., M.P.H.