Blog RSS https://www.vumc.org/global-health/ en Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II (SPRING) https://www.vumc.org/global-health/current-research-and-training-programs/primary-prevention-stroke-children-scd-sub-saharan-africa-ii <span class="field field--name-title field--type-string field--label-hidden">Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II (SPRING)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 11/19/2021 - 14:56</span> <a href="/global-health/blog-post-rss/2786" class="feed-icon" title="Subscribe to Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II (SPRING)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Strokes in sickle cell anemia (SCA), particularly in children living in Africa, are associated with significant morbidity and an increased risk of premature death. In the US, primary stroke prevention in children with SCA involves screening for elevated transcranial Doppler ultrasound (TCD) velocity coupled with regular blood transfusion therapy for those with elevated velocities. However, regular blood transfusion therapy is not feasible in Africa due to inadequate supply of safe blood and the reluctance of parents to accept regular blood transfusion therapy for their children. Promising preliminary data from our feasibility trial in Kano, Nigeria (1R21NS080639-NCE, NCT01801423; October 2012 - August 2014) support the potential use of moderate dose hydroxyurea (HU) therapy of 20 mg/kg/day for primary prevention of stroke in children with SCA.</p> <p>In the feasibility trial, we screened 331 participants; 92% (25 of 27) of participants with elevated TCD measurements elected to enroll and receive HU therapy. About 75% (210 of 280) of the screened participants with non-elevated TCD measurements agreed to be followed for a minimum of three years to assess the background rate of morbidity and mortality. Among those on HU therapy, 80% (20 of 25) of the participants who reached their third month on HU therapy dropped their elevated TCD value to below 200 cm/sec in both middle cerebral arteries. Based on the results from the recently completed Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea trial (NCT01425307), demonstrating that children with an elevated TCD measurement can be switched to HU therapy after one year of blood transfusion, coupled with our preliminary trial results indicating a decrease in TCD velocities in 2/3rds of the participants over 3 months, we propose a three center randomized partial double-blind Phase III clinical trial (1R01NS094041-01; September 2015 - July 2020) to test the following hypothesis: There will be a 66% relative risk reduction of primary strokes in children with SCA, and elevated TCD measurements (n=220), randomly allocated to moderate dose vs. low dose HU therapy (10 vs. 20 mg/kg/day) for 3 years.</p> <p>The aims of the randomized partial double-blind Phase III clinical trial are to: 1) determine the efficacy of moderate vs. low dose HU therapy for primary stroke prevention; 2) determine the efficacy of moderate dose HU therapy for decreasing the incidence of all cause-hospitalization for any cause (pain, acute chest syndrome, infection, or other) when compared to low dose HU therapy; and 3) assess long-term safety of HU therapy (mean 6.5 years) in participants from the feasibility trial with an elevated TCD measurement (n=25), when compared to children with an initial normal TCD (n= 210, followed for at least 3 years). In preparation for this application, the teams from Nigeria have received 1 month of patient-oriented research training at Vanderbilt University School of Medicine. This trial will help us to determine whether moderate dose HU therapy can prevent thousands of strokes in children at high risk in Africa, while simultaneously helping build research capacity among the next cadre of physician scientists in Nigeria.</p> <p><a href="https://clinicaltrials.gov/ct2/show/NCT02560935?term=NCT02560935&amp;draw=2&amp;rank=1">Visit the Clinical Trials website for more information. </a></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=403" hreflang="und">Michael DeBaun</a>, <a href="/global-health/current-research-and-training-programs?tag=2168" hreflang="und">Hematology/Sickle Cell Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=509" hreflang="und">Sickle Cell Disease</a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-research-and-training-programs?tag=743" hreflang="und">Ghana</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Fri, 19 Nov 2021 20:56:15 +0000 ridingkm 2786 at https://www.vumc.org/global-health Stroke Prevention in Young Adults With Sickle Cell Anemia (SPIYA) https://www.vumc.org/global-health/current-research-and-training-programs/stroke-prevention-young-adults-sickle-cell-anemia-spiya <span class="field field--name-title field--type-string field--label-hidden">Stroke Prevention in Young Adults With Sickle Cell Anemia (SPIYA)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 11/19/2021 - 14:50</span> <a href="/global-health/blog-post-rss/2785" class="feed-icon" title="Subscribe to Stroke Prevention in Young Adults With Sickle Cell Anemia (SPIYA)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Sickle cell disease (SCD) is the most common genetic disease, affecting about 25 million people worldwide. Approximately 150,000 Nigerian children are born each year with sickle cell disease (SCD), making it the country with the largest burden of SCD in the world. Recent advancements in care for children with SCA have translated into improved survival of children in both high and low-resource settings. However, more complications of SCD are seen in those who survive to adulthood. Silent cerebral infarcts (SCI) and strokes are among the most devastating complications of SCD, affecting 40% and 10% of children, respectively.</p> <p>The overall goal of this study is to extend the Investigator's successful capacity-building effort in the assessment of neurological morbidity in children with SCD living in northern Nigeria (Kano) to young adults with SCD living in the same region. About 50% of all adults with SCD live in Nigeria. Despite the high prevalence of SCD in Africa, the neurological morbidity is not well characterized, limiting opportunities for primary and secondary stroke prevention strategies. At least 50% of young adults with sickle cell anemia (SCA), the most severe form of the disease, will have SCIs and an estimated 10% will have strokes, based on studies in high-resource settings. In high-resource settings, screening for abnormal transcranial Doppler (TCD) velocities in children with SCA, coupled with regular blood transfusion has resulted in a 92% reduction of relative risk for strokes. Despite this effective strategy, regular blood transfusion therapy does not seem sustainable in sub-Saharan Africa due to shortages and the risk of transfusion transmissible infections. Additionally, there is a lack of evidence-based stroke prevention strategies in young adults with SCA, either in the high-income or in low-resource settings. Based on the foregoing, the Investigators propose to determine the prevalence of neurological injury (overt stroke, transient ischemic attacks, and silent cerebral infarcts) in young adults at the transition age from 16-25 years. The Investigators will also, for the first time, assess conventional risk factors of stroke in the general population to determine whether a different prevention strategy is required to reduce the incidence of neurological injury in this high-risk population.</p> <p><a href="https://clinicaltrials.gov/ct2/show/NCT04808778?term=NCT04808778&amp;draw=2&amp;rank=1">Visit the Clinical Trials website for more information.</a></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=403" hreflang="und">Michael DeBaun</a>, <a href="/global-health/current-research-and-training-programs?tag=509" hreflang="und">Sickle Cell Disease</a>, <a href="/global-health/current-research-and-training-programs?tag=2168" hreflang="und">Hematology/Sickle Cell Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Fri, 19 Nov 2021 20:50:15 +0000 ridingkm 2785 at https://www.vumc.org/global-health TN Together: Opioid Abuse and Response https://www.vumc.org/global-health/current-research-and-training-programs/tn-together-opioid-abuse-and-response <span class="field field--name-title field--type-string field--label-hidden">TN Together: Opioid Abuse and Response</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/17/2021 - 09:43</span> <a href="/global-health/blog-post-rss/2783" class="feed-icon" title="Subscribe to TN Together: Opioid Abuse and Response"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Tennessee anti-drug coalitions are working to reduce dependence on harmful and potentially lethal substances such as prescription drugs, alcohol, and tobacco. In partnership with the Hamilton County Coalition, researchers from Vanderbilt University Medical Center (VUMC) collect and analyze program demographics and outcomes. The Nu-Start program provides access to treatment and recovery services for individuals and families overcoming opioid dependency.</p> <p><strong>Carolyn Audet, PhD, MSci</strong>, associate director of the Center for Clinical Quality and Implementation Research and associate professor of Epidemiology and Health Policy leads the VUMC research team.</p> <p>The project is supported by the Tennessee Department of Mental Health and Substance Abuse Services.</p> <p>In partnership with the Hamilton County Coalition, researchers from Vanderbilt University Medical Center collect and analyze  provided this analysis of the Nu-Start program that provides access to treatment and recovery services for individuals and families overcoming opioid dependency.</p> <p>The project is supported by the Tennessee Department of Mental Health and Substance Abuse Services.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-research-and-training-programs?tag=2172" hreflang="und">Mariah Pettipiece-Phillips</a>, <a href="/global-health/current-research-and-training-programs?tag=2164" hreflang="und">Local is Global</a>, <a href="/global-health/current-research-and-training-programs?tag=2177" hreflang="und">Substance Abuse</a>, <a href="/global-health/current-research-and-training-programs?tag=2169" hreflang="und">Mental Health</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 17 Nov 2021 15:43:32 +0000 ridingkm 2783 at https://www.vumc.org/global-health Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) https://www.vumc.org/global-health/current-research-and-training-programs/artificial-intelligencemachine-learning-consortium-advance <span class="field field--name-title field--type-string field--label-hidden"> Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Tue, 11/16/2021 - 16:53</span> <a href="/global-health/blog-post-rss/2782" class="feed-icon" title="Subscribe to Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This summer the National Institutes of Health (NIH) announced a new flagship initiative, the Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity, or AIM-AHEAD.</p> <p>The initiative seeks to quell common biases that beset biomedicine and aims specifically to redress two glaring deficits identified by the NIH: a lack of diversity among artificial intelligence researchers and a lack of representation from various segments of society in the data available to support machine learning and the implementation of artificial intelligence in the health domain.</p> <p>The Coordinating Center includes 14 investigators from around the country, among them Vanderbilt University Medical Center’s Toufeeq Ahmed, PhD, MS, assistant professor of Biomedical Informatics, who’s one of nine investigators for the center’s Leadership Core, and Bradley Malin, PhD, Accenture Professor of Biomedical Informatics, Biostatistics and Computer Science, who’s one of three investigators for the center’s Infrastructure Core. </p> <p>Under the leadership of Drs. Toufeeq and Malin, <strong>VIGH member Martin Were, MD, associate professor of Biomedical Informatics and Medicine</strong> will focus on software infrastructure to facilitate artificial intelligence and health disparities research.</p> <p><a href="https://news.vumc.org/2021/10/21/initiative-seeks-to-improve-diversity-of-ai-research/">Full VUMC Reporter Article</a></p> <p><a href="https://aim-ahead.net/home">AIM-AHEAD Website</a></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=713" hreflang="und">Martin Were</a>, <a href="/global-health/current-research-and-training-programs?tag=2165" hreflang="und">mHealth Biomedical Informatics</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Tue, 16 Nov 2021 22:53:51 +0000 ridingkm 2782 at https://www.vumc.org/global-health Applying Research for a Healthy Liberia https://www.vumc.org/global-health/current-research-and-training-programs/applying-research-healthy-liberia <span class="field field--name-title field--type-string field--label-hidden">Applying Research for a Healthy Liberia</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a>, <a href="/global-health/current-research-and-training-programs?cat=79" hreflang="und">Education and Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 23:31</span> <a href="/global-health/blog-post-rss/2726" class="feed-icon" title="Subscribe to Applying Research for a Healthy Liberia"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The University of Liberia College of Health Sciences is the leading educational institution for developing Liberia’s clinicians, researchers, health policymakers and innovators. As one of only two public universities in the country, it is poised to become a globally recognized leader in research utilization, meaningfully connecting academics with policymaking, innovation, and clinical practice. Devastated by civil war, the Ebola epidemic, and now COVID-19, Liberia’s health system has dealt with severe resource constraints, shortages in healthcare workers, and other systemic challenges including gaps in evidence-based medical training and practices. </p> <p>The Vanderbilt Institute of Global Health (VIGH) partnered with Yale University and the University of Liberia College of Health Sciences (ULCHS) to establish a public-private-academic hub for research utilization in the Liberian health sector and an academic network to strengthen Liberia’s education and health sectors.</p> <p>Funding for the Applying Research for a Healthy Liberia project comes from the United States Agency for International Development (USAID), Bringing Research to Impact for Development, Global Engagement, and Utilization (BRIDGE-U) program. It will allow the three institutions to build on a longstanding partnership to create the Center for Teaching, Learning, and Innovation (CTLI) in Liberia.</p> <p>This program builds off the successful implementation of capacity-building activities by the three institutions, including the <a href="https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/residency-integrated-medical-education-and">Partnerships for Enhanced Engagement in Research (PEER Liberia) </a>USAID grant designed to strengthen medical training, build subspecialty medical capacity, and enhance research training in Liberia.</p> <p>The BRIDGE-U program will enhance ULCHS’s role as a national hub for research and interprofessional training by getting a Center for Teaching, Learning, and Innovation fully operational and connecting ULCHS faculty and students directly with policymakers, clinicians, and private-sector innovators to translate research outputs.</p> <p>As an academic hub, CTLI will comprise an experiential learning and assessment lab, a health start-up incubator as well as initiatives to translate and implement existing research findings, and programming to impart research utilization competencies.</p> <p>The BRIDGE-U program is part of <a href="https://www.usaid.gov/hesn/hesn-2-0">USAID’s Higher Education Solutions Network</a>. This network provides a platform for USAID to partner with higher education institutions from around the world to address critical development challenges, build local capacity and cultivate innovation.</p> <p><strong>Program objectives include:</strong></p> <ul> <li>Advancing research utilization in health and health sciences education for improved health outcomes and equitable economic growth in Liberia.</li> <li>Building research utilization skills among Liberia’s current and future health sciences students, faculty, clinicians, policymakers, and entrepreneurs.</li> <li>Generating new knowledge about how to translate and utilize research findings more effectively to achieve development goals.</li> </ul> <p>Funding for the project comes from award number 7200AA21CA00010.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=2151" hreflang="und">Applying Research for a Healthy Liberia - AR4HL</a>, <a href="/global-health/current-research-and-training-programs?tag=382" hreflang="und">Marie Martin</a>, <a href="/global-health/current-research-and-training-programs?tag=121" hreflang="und">Ann Green</a>, <a href="/global-health/current-research-and-training-programs?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-research-and-training-programs?tag=2148" hreflang="und">Harriett Myers</a>, <a href="/global-health/current-research-and-training-programs?tag=741" hreflang="und">Liberia</a>, <a href="/global-health/current-research-and-training-programs?tag=156" hreflang="und">Capacity Building Research</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Thu, 11 Nov 2021 05:31:33 +0000 ridingkm 2726 at https://www.vumc.org/global-health VU-Mozambique Collaborative Research Ethics Education (FoCEP) Program https://www.vumc.org/global-health/current-research-and-training-programs/vu-mozambique-collaborative-research-ethics-education-focep <span class="field field--name-title field--type-string field--label-hidden">VU-Mozambique Collaborative Research Ethics Education (FoCEP) Program</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2135" class="feed-icon" title="Subscribe to VU-Mozambique Collaborative Research Ethics Education (FoCEP) Program"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> Elizabeth Heitman, Ph.D.<br /> <a href="https://www.vumc.org/global-health/person/troy-moon-md-mph">Troy Moon, M.D., M.P.H.</a></p> <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9253856&amp;icde=39448420&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball="><strong>VU-Mozambique Collaborative Research Ethics Education Program (R25TW09722-04)</strong></a><br /> The VU-Collaborative Research Ethics Education (Formacao Colaborativa na Etica em Pesquisa, FoCEP) program will nurture a new generation of global health researchers from Mozambique in the ethical review of human participant research and the responsible conduct of research (RCR). This program will also strengthen the development and institutionalization of a system for ethical review of human research protocols in Mozambique's biomedical research institutions and newly developed Research Ethics Committees (REC). The present proposal has been developed in response to focused and carefully considered requests from the leadership of UEM and the Mozambican National Bioethics Committee for VUMC's assistance in developing national capacity for ethical review of human studies protocols and teaching research ethics to biomedical and public health investigators.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-research-and-training-programs?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-research-and-training-programs?tag=231" hreflang="und">Ethics</a>, <a href="/global-health/current-research-and-training-programs?tag=795" hreflang="und">International Training Grant/Program</a>, <a href="/global-health/current-research-and-training-programs?tag=800" hreflang="und">Capacity Building</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 Visitor 2135 at https://www.vumc.org/global-health UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER) https://www.vumc.org/global-health/current-research-and-training-programs/uem-vanderbilt-academic-partnership-enhancements-research <span class="field field--name-title field--type-string field--label-hidden">UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2667" class="feed-icon" title="Subscribe to UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p style="margin-bottom:11px">Building on over a decade of partnership, the Faculty of Medicine at University Eduardo Mondlane (UEM) and the Vanderbilt Institute for Global Health (VIGH) are seeking to expand upon the groundwork laid by the longstanding <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="67616c68-1b20-4d64-b0af-a7800ed9efdd" href="https://www.vumc.org/global-health/current-research-and-training-programs/partnership-research-implementation-science-mozambique-prism">PRISM (Partnership for Research in Implementation Science – Mozambique </a>collaboration for HIV implementation science research capacity at UEM.</p> <p>Through a series of evaluations from PRISM, UEM identified two priority areas for further institutional strengthening. As such, the Academic Partnership for Enhancements in Research (APER), a three-year project funded by the Fogarty International Center of the NIH, focuses on grants management through activities designed to reinforce a newly created Office of Project Support at UEM, as well as reinforcing the discipline of biostatistics within the Faculty of Medicine.</p> <p><strong><a name="_Hlk71898155" id="_Hlk71898155">Key components of the program include:</a></strong></p> <p>1) Promotion of sustainability and increased faculty competitiveness in grants management through capacitation of the newly created UEM Office of Project Support in coordination with the Faculty of Medicine Administration/Finance Office.</p> <p>2) Development of a Biostatistics “Core” within UEM´s Implementation Science Unit to provide biostatistics support to faculty and students in the conduct of their research.</p> <p>The Fogarty International Center supports this project under agreement <a href="https://reporter.nih.gov/search/CNrx5ChKmEKSwh4Z2tZDDQ/project-details/10259747">G11TW011529.</a></p> <div> </div> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-research-and-training-programs?tag=156" hreflang="und">Capacity Building Research</a>, <a href="/global-health/current-research-and-training-programs?tag=790" hreflang="und">Implementation Science</a>, <a href="/global-health/current-research-and-training-programs?tag=553" hreflang="und">University Eduardo Mondlane (UEM)</a>, <a href="/global-health/current-research-and-training-programs?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-research-and-training-programs?tag=635" hreflang="und">VU Biostatistics</a>, <a href="/global-health/current-research-and-training-programs?tag=2149" hreflang="und">Grants Management</a>, <a href="/global-health/current-research-and-training-programs?tag=121" hreflang="und">Ann Green</a>, <a href="/global-health/current-research-and-training-programs?tag=2148" hreflang="und">Harriett Myers</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2667 at https://www.vumc.org/global-health Cure Sickle Cell Initiative Data Coordinating Center https://www.vumc.org/global-health/current-research-and-training-programs/cure-sickle-cell-initiative-data-coordinating-center <span class="field field--name-title field--type-string field--label-hidden">Cure Sickle Cell Initiative Data Coordinating Center</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2745" class="feed-icon" title="Subscribe to Cure Sickle Cell Initiative Data Coordinating Center"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Project Details: <a href="https://reporter.nih.gov/search/36glQgxD8kWcd5yVIEF98w/project-details/9788996">NIH Reporter</a></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=403" hreflang="und">Michael DeBaun</a>, <a href="/global-health/current-research-and-training-programs?tag=448" hreflang="und">Non-Communicable Diseases</a>, <a href="/global-health/current-research-and-training-programs?tag=2168" hreflang="und">Hematology/Sickle Cell Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=2165" hreflang="und">mHealth Biomedical Informatics</a>, <a href="/global-health/current-research-and-training-programs?tag=425" hreflang="und">Nashville</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2745 at https://www.vumc.org/global-health Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECD) https://www.vumc.org/global-health/current-research-and-training-programs/vanderbilt-emory-cornell-duke-consortium-global-health <span class="field field--name-title field--type-string field--label-hidden">Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECD)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2137" class="feed-icon" title="Subscribe to Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECD)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Vanderbilt-Emory-Cornell-Duke (VECD) is one of six consortia that comprise the <strong><a href="https://www.fic.nih.gov/News/Pages/2017-fogarty-global-health-training-program.aspx">Fogarty Global Health Program for Fellows and Scholars</a></strong>, which replaced the Fogarty International Clinical Research Scholars &amp; Fellows (FICRS-F) Program in 2012. The purpose of this program is to provide mentored global health research training opportunities in low- and middle-income countries (LMICs) for pre- and post-doctoral candidates from the U.S. and LMICs. The program is sponsored by the <strong><a href="https://www.fic.nih.gov/Pages/Default.aspx">Fogarty International Center (FIC)</a></strong> and several collaborating Institutes and Centers at the National Institutes of Health (NIH). Multiple training sites are available through the <strong><a href="https://www.vumc.org/vecd/node/104">Vanderbilt-Emory-Cornell-Duke (VECD) Consortium</a></strong>.</p> <p>The VECD Consortium comprises four outstanding institutions—Vanderbilt (V), Emory (E), Cornell (C), and Duke (D)—with decades-long global partnerships with premier LMIC research institutions in Africa, Asia, Latin America, and the Caribbean. Collectively, VECD’s well-funded research portfolio encompasses diverse and complementary topics in all relevant communicable and non-communicable diseases. VECD institutions and faculty have a long history of global engagement, investigative accomplishment and mentoring excellence, as demonstrated by high-impact global health discoveries by VECD trainees.</p> <p>The VECD international partners are themselves outstanding research institutions based in low- and middle-income countries (including Botswana, Ethiopia, Georgia, Ghana, Guatemala, Haiti, India, Kenya, Mozambique, Nepal, Nicaragua, Nigeria, Rwanda, Sierra Leone, South Africa, Sri Lanka, Tanzania, Vietnam, and Zambia). All sites conduct NIH-supported research and training and have published extensively in major journals. The VECD Global Health Fellows Consortium represents more than 100 faculty members from our U.S. and international collaborating institutions who serve as potential mentors for fellows.</p> <p data-entity-type="" data-entity-uuid="" style="text-align: center;"><span><img alt="vecd" data-entity-type="" data-entity-uuid="" height="130" src="https://www.vumc.org/vecd/sites/vumc.org.vecd/files/public_files/images/vecd_logo_composite_footer.png" width="650" /></span></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=212" hreflang="und">Doug Heimburger</a>, <a href="/global-health/current-research-and-training-programs?tag=420" hreflang="und">Muktar Aliyu</a>, <a href="/global-health/current-research-and-training-programs?tag=2117" hreflang="und">Donna Ingles</a>, <a href="/global-health/current-research-and-training-programs?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-research-and-training-programs?tag=743" hreflang="und">Ghana</a>, <a href="/global-health/current-research-and-training-programs?tag=610" hreflang="und">Vietnam</a>, <a href="/global-health/current-research-and-training-programs?tag=678" hreflang="und">Zambia</a>, <a href="/global-health/current-research-and-training-programs?tag=2163" hreflang="und">Infectious Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=448" hreflang="und">Non-Communicable Diseases</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 Visitor 2137 at https://www.vumc.org/global-health Liberia IRB Practicum and Workshop Series: Ethics Supplement https://www.vumc.org/global-health/current-research-and-training-programs/liberia-irb-practicum-and-workshop-series-ethics-supplement <span class="field field--name-title field--type-string field--label-hidden">Liberia IRB Practicum and Workshop Series: Ethics Supplement</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2668" class="feed-icon" title="Subscribe to Liberia IRB Practicum and Workshop Series: Ethics Supplement"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="MsoNormal">Building on the partnership with University of Liberia, College of Health Sciences (ULCHS), the Vanderbilt Institute for Global Health (VIGH) will develop a develop a one-year research ethics education program for members of four institutional review boards (IRBs) in Monrovia, Liberia. Research education and training activities will adapt to the Liberian context from the well-established Collaborative Research Ethics Education (Formação Colaborativa em Etica na Pesquisa, FoCEP) Program for Mozambique.<p></p></p> <ul> <li>Two-Part Research Ethics Practicum Targeting Liberian IRB Directors/Administrators</li> <li>Two Part IRB Committee Member Workshop Series on Research Ethics, Research Integrity, and RCR<span style="font-size:11.0pt;font-family:&quot;Arial&quot;,sans-serif;mso-fareast-font-family:&#10;Calibri;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA;mso-bidi-font-style:italic"> </span></li> </ul> <p>This project is a Supplement for VU-Mozambique Collaborative Research Ethics Education Program: <p></p>Formação Colaborativa em Ética na Pesquisa (FoCEP). <p></p></p> <p>This program builds upon successes of its first five-year period and will continue to nurture a new generation of global health researchers from Mozambique in the ethical review of human participant research and the responsible conduct of research (RCR). This program will continue to strengthen the development and institutionalization of a system for ethical review of human research protocols in Mozambique's biomedical research institutions and newly developed Research Ethics Committees (REC). The present proposal has been developed in response to focused and carefully considered requests from the leadership of UEM and the Mozambican National Bioethics Committee for Health (Comité Nacional de Bioética para Saúde, CNBS) for VUMC's assistance in developing national capacity for ethical review of human studies protocols and teaching research ethics to biomedical and public health investigators.</p> <p><a href="https://projectreporter.nih.gov/project_info_details.cfm?aid=9927718&amp;icde=52694503">NIH Reporter Details</a></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-research-and-training-programs?tag=2105" hreflang="und">Ethics Research Training</a>, <a href="/global-health/current-research-and-training-programs?tag=2106" hreflang="und">Elizabeth Heitman</a>, <a href="/global-health/current-research-and-training-programs?tag=741" hreflang="und">Liberia</a>, <a href="/global-health/current-research-and-training-programs?tag=382" hreflang="und">Marie Martin</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2668 at https://www.vumc.org/global-health The South African National HIV Pregnancy Cohort: evaluating continuity of care among women living with HIV https://www.vumc.org/global-health/current-research-and-training-programs/south-african-national-hiv-pregnancy-cohort-evaluating <span class="field field--name-title field--type-string field--label-hidden">The South African National HIV Pregnancy Cohort: evaluating continuity of care among women living with HIV</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/index.php/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/index.php/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/index.php/blog-post-rss/2746" class="feed-icon" title="Subscribe to The South African National HIV Pregnancy Cohort: evaluating continuity of care among women living with HIV"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Project Details: <a href="https://reporter.nih.gov/search/zuVusUWc1EeIqJYRwA-ldg/project-details/10137991">NIH Reporter</a></p> <p>ABSTRACT For the first time on a national level, we propose to utilize routinely-collected laboratory data to develop a cohort of pregnant women living with HIV in South Africa in a way that is uniquely robust to transfer across facilities. South Africa is home to more people living with HIV than any other country, and nearly one in three pregnant women attending antenatal care is living with HIV. Access to antiretroviral therapy (ART) has increased substantially since the start of the national ART program in 2004, with &gt;95% ART coverage during pregnancy and delivery, and mother-to-child transmission of HIV greatly reduced. However, our work has demonstrated that women who initiate ART during pregnancy are at heightened risk of dropping out of care, particularly after delivery, leading to the potential for viral transmission, morbidity and mortality. It is difficult to evaluate the success of policies of expanded access to ART care, and assess continuity of care, due to the lack of a national longitudinal HIV care database. In addition, patient movement between unlinked facilities means that self-transfer often is misclassified as loss to care. To address this major shortcoming, our team at the Health Economics and Epidemiology Office (HE2RO) partnered with the South African National Health Laboratory Services in 2015 to use existing HIV-related laboratory data to create the South African National HIV Cohort. Now, through this five-year award, we propose to expand this successful project to use routinely- collected laboratory data to develop a cohort of pregnant women living with HIV in South Africa. We propose three specific aims. First, we will develop and validate a novel national cohort of pregnant women accessing HIV care. Using laboratory test data matched to facility type, we will identify entry to antenatal care to build the cohort, then describe key treatment milestones, including 1) engagement in antenatal care, 2) initiation of ART, 3) HIV viremia, and 4) continuity of HIV care in the postpartum period. Second, we will measure the effect of system-wide factors impacting continuity of care among pregnant women. We will assess policies of expanded treatment access on continuity of care using regression-discontinuity analyses. We then will assess mobility and its effect on continuity of care during and after pregnancy. Third, we will identify individual-level risk factors for loss from HIV care in order to develop targeted interventions to improve engagement in HIV care.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/index.php/current-research-and-training-programs?tag=355" hreflang="und">Kate Clouse</a>, <a href="/global-health/index.php/current-research-and-training-programs?tag=306" hreflang="und">HIV</a>, <a href="/global-health/index.php/current-research-and-training-programs?tag=387" hreflang="und">Maternal and Child Health</a>, <a href="/global-health/index.php/current-research-and-training-programs?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/index.php/current-research-and-training-programs?tag=2163" hreflang="und">Infectious Disease </a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2746 at https://www.vumc.org/global-health Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care https://www.vumc.org/global-health/current-research-and-training-programs/partners-based-hiv-treatment-sero-concordant-couples <span class="field field--name-title field--type-string field--label-hidden">Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2138" class="feed-icon" title="Subscribe to Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/carolyn-audet-phd">Carolyn Audet, Ph.D.</a></p> <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9346956&amp;icde=39449080&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care (R01 MH113478-01)</a></strong><br /> The purpose of this R01 proposal is to evaluate the clinical impact, hypothesized mechanisms of behavior change, and cost-effectiveness of a partners-focused integrated elimination of mother-to-child transmission of HIV (PMTCT) package comprised of: 1) antenatal care-based couples HIV testing, ART enrollment, and care for sero-concordant HIV+ expectant couples; (2) Couples-based treatment in the post-partum period; (3) Couple-based education and skills building; and (4) Treatment continuity with the support of expert-patient (peer) supporters from couples who have successfully navigated PMTCT. This innovative approach to scaling up PMTCT services, if proven feasible and effective, will be adopted in PEPFAR programs to accelerate progress toward PMTCT and helping families with HIV infection live long, healthy lives.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-research-and-training-programs?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-research-and-training-programs?tag=387" hreflang="und">Maternal and Child Health</a>, <a href="/global-health/current-research-and-training-programs?tag=790" hreflang="und">Implementation Science</a>, <a href="/global-health/current-research-and-training-programs?tag=2172" hreflang="und">Mariah Pettipiece-Phillips</a>, <a href="/global-health/current-research-and-training-programs?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-research-and-training-programs?tag=2163" hreflang="und">Infectious Disease </a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 Visitor 2138 at https://www.vumc.org/global-health Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa https://www.vumc.org/global-health/current-research-and-training-programs/traditional-healer-initiated-hiv-counseling-and-testing <span class="field field--name-title field--type-string field--label-hidden">Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2681" class="feed-icon" title="Subscribe to Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to the health facility. South Africa has made progress towards their 90-90-90 goals, yet a substantial proportion of the population do not test regularly; only 33.9% of adults in rural Mpumalanga (our study site) underwent HIV testing in the past year. In South Africa, people of low socioeconomic status (SES), men, immigrants, and those who distrust the health system have higher rates of HIV stigma, are more likely to seek care from traditional healers, and are less likely to receive an HIV test.</p> <p>The demographic and sociological characteristics of healers closely mirror this population, making them an ideal group to bridge the health care utilization divide. Development of a Healer-Clinician HIV Prevention Collaborative will facilitate testing and preventive service linkage among those who have traditionally avoided/refused testing via three synergistic strategies: (1) Healer-Initiated Counseling and Testing (HICT) to reinforce the value of HIV testing and teach HIV stigma reduction and coping strategies; (2) Establishing a path for patients to navigate between traditional and allopathic systems to encourage repeat HIV testing (or treatment, if HIV-positive); and (3) Improving the environment at the health facility via a stigma reduction training and “open house” sessions where healers and providers work together to provide patients an opportunity to better understand health services (and increase the likelihood that patients return).</p> <p>We propose to pilot this novel intervention with patients seeking treatment from a select group of trained traditional healers. We hypothesize that patient's seeking traditional treatment will find the offer of testing acceptable, will uptake HIV testing despite high levels of stigma and mistrust of the health system, and will engage in treatment at the health facility after linkage by their traditional healer.</p> <p>The Specific Aims of this study are to: (1) Conduct qualitative interviews with “non-testers” from varied SES and demographic groups to understand the interface of HIV stigma, mistrust in the health system, and HIV testing to create the most acceptable model of healer-based testing; (2) Adapt a successful South African community-based HIV prevention project to create a Healer-Clinician HIV Testing and Prevention Collaborative; and (3) Pilot our Healer-Clinician Collaborative and assess uptake of HIV testing as well as linkage to treatment and prevention services among participants offered healer-initiated counseling and testing. Our team has a proven record of engaging traditional healers to improve patient outcomes, conducting research to evaluate and address mistrust in the health system, HIV stigma, and developing interventions to increase HIV testing uptake.</p> <p>Project Details: <a href="https://reporter.nih.gov/search/24X-n988L0mA1F6vCdgNxA/project-details/10159679">NIH Reporter</a></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-research-and-training-programs?tag=783" hreflang="und">Traditional Healers</a>, <a href="/global-health/current-research-and-training-programs?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-research-and-training-programs?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-research-and-training-programs?tag=2163" hreflang="und">Infectious Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=2172" hreflang="und">Mariah Pettipiece-Phillips</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2681 at https://www.vumc.org/global-health Implementation of Rapid HIV Testing and Linkage to HIV Treatment or Prevention Among Vulnerable Populations in Tennessee https://www.vumc.org/global-health/current-research-and-training-programs/implementation-rapid-hiv-testing-and-linkage-hiv-treatment <span class="field field--name-title field--type-string field--label-hidden">Implementation of Rapid HIV Testing and Linkage to HIV Treatment or Prevention Among Vulnerable Populations in Tennessee</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2747" class="feed-icon" title="Subscribe to Implementation of Rapid HIV Testing and Linkage to HIV Treatment or Prevention Among Vulnerable Populations in Tennessee"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Human Immunodeficiency Virus (HIV) infection remains a significant public health problem in the United States (US). It is estimated that almost 15% of the 1.17 million people living with HIV (PLWH) in the US are unaware of their HIV status. And despite the existence of highly effective HIV treatment (antiretroviral therapy, ART), only 65% of people living with diagnosed HIV have achieved viral suppression. Similarly, among HIV-negative people eligible for PrEP, only 18% have used PrEP. These gaps between evidence and practice are deepened in the US South, where the opioid crisis has further increased the risk for acquiring HIV in this region. In order to achieve US Ending the HIV Epidemic (EHE) goals, implementation research, particularly in the US South, is needed to close the gap between evidence-based interventions and practice in the HIV neutral continuum of care.</p> <p>Thus, our overarching goal is to support and evaluate the implementation of a sustainable HIV health service model for rapid HIV testing and linkage to HIV treatment (ART) or prevention (PrEP) in Tennessee (TN), a state located in the US South. Our Core Project will focus on implementation and evaluation of rapid HIV testing and linkage to ART from the Shelby County Health Department, the highest volume HIV testing facility in Memphis, TN (a southern US city which ranks 4th among all US Metropolitan Statistical Areas for HIV incidence) to several nearby Ryan White-funded HIV care clinics. Our Collaborative Project will focus on implementation and evaluation of rapid HIV testing and linkage to local PrEP providers from: 1) Street Works, a Community Based Organization (CBO) providing a Syringe Service Program (SSP) to the Nashville community and 2) A Betor Way, a CBO providing a SSP to the Memphis community. We are uniquely positioned to perform the work we propose for three important reasons.</p> <p>First, we plan to leverage an established collaboration with implementation and community partners in Memphis and Nashville including colleagues from St. Jude Children’s Research Hospital, University of Memphis, Shelby County Health Department, Street Works, and A Betor Way. Second, we will leverage resources available at the TN Center for AIDS Research, Vanderbilt Center for Health Services Research, and the Meharry-Vanderbilt Alliance/Community Engaged Research Core. Thirdly, the investigators involved in this proposal possess the expertise in HIV clinical care and prevention, implementation science, and public health practice necessary to complete the proposed work. The proposed study will support the implementation of a contextually appropriate rapid HIV testing and linkage to HIV treatment (ART) or prevention (PrEP) in Memphis and Nashville, TN.</p> <p>The results will inform future scaling of these models to additional HIV testing, care, prevention sites across TN, a geographic area at the epicenter of important US HIV disparities. Importantly, our work will support the Memphis and Nashville communities in reaching their local EHE goals through leveraging of our unique academic, public health, and community-based partnerships.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-research-and-training-programs?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-research-and-training-programs?tag=2163" hreflang="und">Infectious Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=2164" hreflang="und">Local is Global</a>, <a href="/global-health/current-research-and-training-programs?tag=2173" hreflang="und">Project Details: NIH Reporter</a>, <a href="/global-health/current-research-and-training-programs?tag=2172" hreflang="und">Mariah Pettipiece-Phillips</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2747 at https://www.vumc.org/global-health Partnership for Research in Implementation Science – Mozambique (PRISM) https://www.vumc.org/global-health/current-research-and-training-programs/partnership-research-implementation-science-mozambique-prism <span class="field field--name-title field--type-string field--label-hidden">Partnership for Research in Implementation Science – Mozambique (PRISM)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2140" class="feed-icon" title="Subscribe to Partnership for Research in Implementation Science – Mozambique (PRISM)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The Republic of Mozambique, a Portuguese-speaking country of 28 million people on the southeast coast of Africa, has experienced significant economic growth and distinct progress in improving health indicators over the past two decades. Since the end of a devastating civil war in 1992, health has been a government priority, particularly in response to the crushing burden of HIV/AIDS. While national efforts to expand HIV health care service delivery have focused on strengthening community-based and regional clinics, there has simultaneously been significant targeted investment to build infrastructure and human capacity in HIV research, innovation, and health education. Medical research, including epidemiologic and health services research, has grown dramatically. This growth has stemmed from international collaborative projects such as the Partnership for Research in Implementation Science- Mozambique (PRISM) funded by the Fogarty International Center of the NIH, a partnership between the Faculty of Medicine at University Eduardo Mondale (UEM) and the Vanderbilt Institute for Global Health (VIGH). </p> <p>Since the launch of the project in 2015, PRISM has focused on supporting the education and research of both master’s and doctoral students at UEM with a focus on HIV implementation Science, modernizing and strengthening UEM’s MPH instruction, and establishing an Implementation Science Unit at UEM. </p> <p>Renewed for a second five-year period, our Specific Aims currently are to:</p> <ol> <li>Train PhD scientists from UEM in HIV implementation science research and strengthen the UEM PhD program</li> <li>Solidify the UEM Faculty of Medicine Implementation Science Unit as a Center of Excellence in Implementation Science training and research</li> <li>Expand opportunities for the conduct of HIV implementation science research by capacitating two Mozambican HIV research institutions/field sites (Aurum-Mozambique and the Center for Health Research-Manhiça [CISM])</li> </ol> <p>The Fogarty International Center supports this project under agreement <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9310386&amp;icde=39449257&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">TW009745</a>.</p> <p><em><a href="https://news.vumc.org/2020/06/09/vigh-awarded-3-million-for-building-research-capacity-in-nigeria-and-mozambique/">More from the VUMC Reporter</a></em></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-research-and-training-programs?tag=790" hreflang="und">Implementation Science</a>, <a href="/global-health/current-research-and-training-programs?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-research-and-training-programs?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-research-and-training-programs?tag=800" hreflang="und">Capacity Building</a>, <a href="/global-health/current-research-and-training-programs?tag=2147" hreflang="und">Moshin Sidat</a>, <a href="/global-health/current-research-and-training-programs?tag=121" hreflang="und">Ann Green</a>, <a href="/global-health/current-research-and-training-programs?tag=2148" hreflang="und">Harriett Myers</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 Visitor 2140 at https://www.vumc.org/global-health Examining antibody response to SARS-CoV-2 in Sierra Leone https://www.vumc.org/global-health/current-research-and-training-programs/examining-antibody-response-sars-cov-2-sierra-leone <span class="field field--name-title field--type-string field--label-hidden">Examining antibody response to SARS-CoV-2 in Sierra Leone</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2780" class="feed-icon" title="Subscribe to Examining antibody response to SARS-CoV-2 in Sierra Leone"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-author field--type-string field--label-hidden field__item">Fogarty International Center</div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Excerpt from the article <a href="https://www.fic.nih.gov/News/GlobalHealthMatters/Pages/Fogarty-awards-3.3M-in-COVID-19-supplements-to-support-research.aspx"><em>Fogarty awards $3.3M in COVID-19 supplements to support research, training</em> published in Global Health Matters </a>by the Fogarty International Center: </p> <p>Sierra Leone has experienced much lower COVID-19 caseloads and much less disease severity than countries in other parts of Africa. Preliminary testing done on blood samples collected prior to the pandemic showed Sierra Leoneans had a higher antibody response to SARS-CoV-2, SARS-CoV, MERS and and other human coronavirus strains than their U.S. counterparts. </p> <p>“One theory is that there may be other circulating coronaviruses in that part of the world that don’t necessarily cause disease—or severe disease—yet may be providing some level of protection,” said Vanderbilt University’s Dr. Troy Moon.</p> <p>Vanderbilt and its partners at Tulane have been using a Fogarty grant to help build research capacity in Sierra Leone in the wake of the 2014-16 Ebola outbreak. With supplemental funding, Moon and his colleagues will expand on this preliminary data to determine the percentage of participants who are seropositive to different human coronaviruses, including SARS-CoV-2, both before and during the pandemic, but prior to vaccination. In addition the team will determine the proportion of positive-testing patients whose serum has neutralizing antibodies against SARS-CoV-2. Finally, the team will determine if this pre-existing immunity has any impact on the immune response in their cohort of participants following COVID-19 vaccination.</p> <p>The onsite work will be led by Sierra Leonean investigator Dr. Robert Samuels, who recently trained at Vanderbilt as a scholar with support from the original Fogarty grant. Samuels will apply his newly acquired knowledge of research methods and management to lead and oversee the day-to-day implementation of the study, while gaining hands-on experience.</p> <p>Moon believes this research could provide essential clues to further understand how coronaviruses operate. “I think it opens up many questions as we try to better understand our immune response and coexistence with different respiratory pathogens and how that affects us at different time points when we see different illnesses,” he noted. “This is now the third pathologic coronavirus epidemic we've seen and one that probably will be with us for a long time. This is not going to be the last time we hear from coronaviruses.”</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-research-and-training-programs?tag=2163" hreflang="und">Infectious Disease </a>, <a href="/global-health/current-research-and-training-programs?tag=121" hreflang="und">Ann Green</a>, <a href="/global-health/current-research-and-training-programs?tag=762" hreflang="und">Fogarty International Center (FIC)</a>, <a href="/global-health/current-research-and-training-programs?tag=742" hreflang="und">Sierra Leone</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2780 at https://www.vumc.org/global-health Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE) https://www.vumc.org/global-health/current-research-and-training-programs/bridging-childhood-epilepsy-treatment-gap-northern-nigeria <span class="field field--name-title field--type-string field--label-hidden">Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2141" class="feed-icon" title="Subscribe to Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/muktar-aliyu-md-mph-drph">Muktar Aliyu, M.D., M.P.H., Dr.P.H.</a><br /> <a href="https://www.vumc.org/global-health/person/edwin-trevathan-md-mph">Edwin Trevathan, M.D., M.P.H.</a></p> <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9406559&amp;icde=39449438&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball="><strong>Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE) (R21TW010899-01)</strong></a><br /> Epilepsy is the most common serious neurological disorder among children worldwide, about 80% of whom live in low- and middle income countries (LMICs) where the advances in epilepsy care over the past 40 years have not translated to improved outcomes. Approximately 67%-90% of children with epilepsy in the LMICs of sub- Saharan Africa do not receive consistent appropriate treatment – a phenomena known as the epilepsy treatment gap, with associated increased risk of co-morbid conditions and premature death. This BRIDGE project lays a foundation for future clinical trials designed to bridge the childhood epilepsy treatment gap in SSA by (a) mapping the childhood epilepsy treatment gap in Kano, Nigeria, (b) developing and piloting task- shifted epilepsy care teams to target areas of the most severe treatment gap, and (c) developing and piloting epilepsy diagnostic paradigms for use in resource-limited environments like Kano with limited access to EEG. BRIDGE, and the clinical trials to follow, has the potential to reduce the childhood epilepsy treatment gap in Nigeria and throughout sub-Saharan Africa.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=715" hreflang="und">Edwin Trevathan</a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-research-and-training-programs?tag=716" hreflang="und">Epilepsy</a>, <a href="/global-health/current-research-and-training-programs?tag=420" hreflang="und">Muktar Aliyu</a>, <a href="/global-health/current-research-and-training-programs?tag=2117" hreflang="und">Donna Ingles</a>, <a href="/global-health/current-research-and-training-programs?tag=2155" hreflang="und">Neurology/Epilepsy/Stroke</a>, <a href="/global-health/current-research-and-training-programs?tag=448" hreflang="und">Non-Communicable Diseases</a>, <a href="/global-health/current-research-and-training-programs?tag=2174" hreflang="und">Angela Paolucci</a>, <a href="/global-health/current-research-and-training-programs?tag=2175" hreflang="und">Lizet Tirres</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 Visitor 2141 at https://www.vumc.org/global-health Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED) https://www.vumc.org/global-health/current-research-and-training-programs/childhood-status-epilepticus-and-epilepsy-determinants <span class="field field--name-title field--type-string field--label-hidden">Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2696" class="feed-icon" title="Subscribe to Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Status epilepticus (SE) is the most common serious neurological emergency among children worldwide. In the low- and middle-income countries (LMICs) of sub-Saharan Africa, the burden of childhood SE-associated mortality and morbidity appears to be especially high. However, the phenotypes of childhood SE, clinical predictors of SE-associated mortality and of SE-associated neurodevelopmental morbidity, and genomic predictors of SE, SE-associated mortality and neurodevelopmental morbidity have not been well-characterized in this region.<br /> <br /> The clinical and genomic predictors of benzodiazepine-resistant SE, which is common and may contribute to SE-associated mortality, have also not been well-characterized, especially among African children. A large percentage of children (~80%) with SE in northern Nigeria experience SE as their first seizure, and the estimated incidence of childhood SE in Kano is relatively high. Little is known of the clinical and genomic risk factors for the development of epilepsy among African children who experience SE as their first seizure.<br /> <br /> The H3Africa consortium is yielding insights into the genomic factors of common human diseases across the African continent and and will provide controls for genome-wide association studies (GWAS) of SE. This project, Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED), will establish a large cohort of children with SE in Kano, northern Nigeria who present to pediatric emergency rooms in Kano. Innovative capacity building will include the incorporation of point-of-care EEG and EEG-video in large pediatric emergency rooms in Kano, performed by specially trained community health extension workers (CHEWs) who will be trained in both basic epilepsy care and EEG technology.<br /> <br /> A team of specialists working together at Aminu Kano Teaching Hospital (AKTH) and at Vanderbilt University Medical Center (VUMC) will utilize video exams, EEG-video, detailed histories, and brain MRI to perform deep phenotyping on this large cohort of children with SE. Clinical risk factors for in-hospital SE-associated mortality, short-term SE- associated mortality, long-term SE-associated mortality, and SE-associated neurodevelopmental morbidity will be determined.<br /> <br /> GWAS will be performed on the entire cohort, with gender matched controls from H3Africa, through collaborations between AKTH, Bayero University Kano, the Sydney Brenner Institute for Molecular Bioscience in South Africa, and VUMC. Genomic risk factors for childhood SE-associated mortality and morbidity will be determined, as well as clinical and genomic risk factors for development of epilepsy among children who experience SE as their first seizure and clinical and genomic risk factors for benzodiazepine- resistant SE. SEED will provide valuable insights into childhood SE in sub-Saharan Africa.</p> <p><strong><a href="https://reporter.nih.gov/search/m_2mDM0dI0yfqAecOVdqcA/project-details/10051221#details">Link to NIH Reporter site for more details. </a></strong></p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=2155" hreflang="und">Neurology/Epilepsy/Stroke</a>, <a href="/global-health/current-research-and-training-programs?tag=448" hreflang="und">Non-Communicable Diseases</a>, <a href="/global-health/current-research-and-training-programs?tag=715" hreflang="und">Edwin Trevathan</a>, <a href="/global-health/current-research-and-training-programs?tag=2127" hreflang="und">Aminu Kano Teaching Hospital AKTH and Bayero University Kano</a>, <a href="/global-health/current-research-and-training-programs?tag=2128" hreflang="und">Sydney Brenner Institute for Molecular Bioscience and H3Africa</a>, <a href="/global-health/current-research-and-training-programs?tag=2104" hreflang="und">University of the Witwatersrand</a>, <a href="/global-health/current-research-and-training-programs?tag=387" hreflang="und">Maternal and Child Health</a>, <a href="/global-health/current-research-and-training-programs?tag=2117" hreflang="und">Donna Ingles</a>, <a href="/global-health/current-research-and-training-programs?tag=2176" hreflang="und">Jessica Barbee</a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2696 at https://www.vumc.org/global-health Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria https://www.vumc.org/global-health/current-research-and-training-programs/optimal-management-hiv-infected-adults-risk-kidney-disease <span class="field field--name-title field--type-string field--label-hidden">Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria </span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2142" class="feed-icon" title="Subscribe to Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/muktar-aliyu-md-mph-drph">Muktar Aliyu, M.D., M.P.H., Dr.P.H.</a><br /> <a href="https://www.vumc.org/global-health/person/c-william-bill-wester-md-mph">William Wester, M.D., M.P.H.</a></p> <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9241189&amp;icde=39449508&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria (U01DK112271-01)</a></strong><br /> In this study, we plan to determine the optimal means to manage and thereby reduce the risk of kidney and potentially other end organ complications among genetically at-risk northern Nigerian HIV-infected adults. Based on data from the diabetic literature using medications that block the renin angiotensin aldosterone system (RAAS), we plan to evaluate whether or not RAAS inhibition (using one or two different medications that block RAAS) in HIV-infected adults produces similarly promising results.</p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=669" hreflang="und">William Wester</a>, <a href="/global-health/current-research-and-training-programs?tag=306" hreflang="und">HIV</a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-research-and-training-programs?tag=801" hreflang="und">Kidney Disease</a>, <a href="/global-health/current-research-and-training-programs?tag=420" hreflang="und">Muktar Aliyu</a>, <a href="/global-health/current-research-and-training-programs?tag=2117" hreflang="und">Donna Ingles</a>, <a href="/global-health/current-research-and-training-programs?tag=448" hreflang="und">Non-Communicable Diseases</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 Visitor 2142 at https://www.vumc.org/global-health Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP) https://www.vumc.org/global-health/v-ramp <span class="field field--name-title field--type-string field--label-hidden">Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-research-and-training-programs?cat=2170" hreflang="und">Research-Training</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/10/2021 - 11:31</span> <a href="/global-health/blog-post-rss/2701" class="feed-icon" title="Subscribe to Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><h2><strong>Upcoming Webinar</strong></h2> <h2><a href="https://redcap.vanderbilt.edu/surveys/?s=AJAHKAEWPLCNJFLN">REGISTER HERE</a></h2> <p><img alt="v-ramp webinar" data-entity-type="" data-entity-uuid="" height="455" src="https://www.vumc.org/global-health/sites/default/files/images/V-RAMP%20webinar.png" width="909" class="align-center" /></p> <h2>About V-RAMP</h2> <p>Expanding on the decade-long Vanderbilt-AKTH partnership, Aminu Kano Teaching Hospital (AKTH), Bayero University Kano (BUK) in Kano, Nigeria, and the Vanderbilt Institute for Global Health (VIGH) are partnering on a new infrastructure development training program supported by the Fogarty International Center of the National Institutes of Health (NIH). The project will strengthen infrastructure capacity in research administration and research ethics in Nigeria. The Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP) will leverage senior research management’s extensive expertise at Vanderbilt.</p> <p>Africa’s most populous country, Nigeria, has seen significant expansion in biomedical research. The increasing volume and complexity of Nigeria’s research activities necessitate measures to improve infrastructure in grants administration (project management, financial accountability, reporting and compliance oversight) and to strengthen ethical frameworks to protect the rights and welfare of research participants. V-RAMP will establish a high-quality research administration environment that is knowledgeable and compliant with the fiscal, management, and ethical standards of sponsored research through fellowships at Vanderbilt, skills-building courses in Nigeria, and administrative process improvements, such as the creation of a Community Advisory Board (CAB).</p> <p>This work is supported by the Fogarty International Center of the National Institutes of Health under Award Number G11TW011819</p> <p> </p> </div> <div> <strong>Tags</strong> <div> <div><a href="/global-health/current-research-and-training-programs?tag=420" hreflang="und">Muktar Aliyu</a>, <a href="/global-health/current-research-and-training-programs?tag=669" hreflang="und">William Wester</a>, <a href="/global-health/current-research-and-training-programs?tag=2111" hreflang="und">Holly Cassell</a>, <a href="/global-health/current-research-and-training-programs?tag=2117" hreflang="und">Donna Ingles</a>, <a href="/global-health/current-research-and-training-programs?tag=2127" hreflang="und">Aminu Kano Teaching Hospital AKTH and Bayero University Kano</a>, <a href="/global-health/current-research-and-training-programs?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-research-and-training-programs?tag=156" hreflang="und">Capacity Building Research</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Wed, 10 Nov 2021 17:31:33 +0000 ridingkm 2701 at https://www.vumc.org/global-health