Blog RSS https://www.vumc.org/global-health/ en Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/bridging-childhood-epilepsy-treatment-gap-africa <span class="field--node--title">Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 08/28/2019 - 12:30</span> <a href="/global-health/blog-post-rss/2412" class="feed-icon" title="Subscribe to Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>Principal Investigator: <a href="https://www.vumc.org/global-health/person/edwin-trevathan-md-mph">Edwin Trevathan, MD, MPH</a></strong></p> <p>About half of the world's children with epilepsy do not receive treatment – known as the epilepsy treatment gap – with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs). We will conduct the first cluster-randomized clinical trial (cRCT) to determine the efficacy, implementation, and cost-effectiveness of a novel intervention shifting childhood epilepsy care to epilepsy-trained community health extension workers in an effort to close the epilepsy treatment gap. This research will provide information to help extend epilepsy treatment to children in LMICs and worldwide who suffer from untreated seizures.</p> <p><strong>Abstract: </strong>About half of the world's children with epilepsy are not receiving treatment – known as the epilepsy treatment gap, and largely due to the 67%-90% of children in low- and middle-income countries (LMICs) with epilepsy who do not receive treatment.</p> <p>Task-shifting epilepsy care to community health extension workers (CHEWs) working in primary healthcare centers (PHCs) has been recommended by the World Health Organization, but evidence of efficacy for task-shifted epilepsy care is lacking, and large-scale task-shifted epilepsy care has not been implemented. In preparation for a first cluster-randomized clinical trial (cRCT) of task- shifted childhood epilepsy care, we developed and piloted in northern Nigeria (R21TW010899).</p> <ul> <li>(a) a scalable epilepsy training program for CHEWs,</li> <li>(b) an epilepsy community education program in the local language (Hausa), and</li> <li>(c) an epilepsy data collection and management system. We also</li> <li>(d) validated an epilepsy screening tool in this population and</li> <li>(e) documented the feasibility of enrolling children into a study of task- shifted epilepsy care. We now propose this project, “Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)”, as the first cRCT of task-shifted childhood epilepsy care in Africa.</li> </ul> <p>Sixty PHCs in three northern Nigeria cities (Kano, Zaria, and Kaduna) with an estimated epilepsy treatment gap of 70% will be randomly selected; 30 PHCs will provide task-shifted (to CHEWs) childhood epilepsy care, and 30 PHCs will provide enhanced usual care (EUC) (referral to a physician for epilepsy management plus primary care by an epilepsy- trained CHEW).</p> <p>CHEWs with additional training in epilepsy will screen ~270,000 children ages 1-17, of which we estimate (based on preliminary data) 1700-2552 will have untreated epilepsy, 1530-2297 will enroll in the cRCT, and 1377-2067 will complete the 24-month cRCT. Assuming an equal proportion of children who are seizure-free for at least six months at 24 months follow-up in the two cRCT arms, we will achieve ≥ 80% power to determine an efficacy difference of 10% or greater between the arms.</p> <p>Secondary outcomes of the cRCT will include the percent seizure reduction from enrollment baseline, time to next seizure after a 3-month period of seizure freedom, and accuracy of epilepsy diagnosis and seizure type classification, as determined by blinded physician epilepsy specialists.</p> <p>Socio-behavioral and implementation outcomes will also be determined for the two arms of the cRCT, including acceptability, appropriateness, and feasibility among the healthcare providers and quality of life, epilepsy-associated stigma, and trust in healthcare providers among parents/guardians and enrolled patients (if age 15-17 years).</p> <p>The cost-effectiveness of the task-shifted epilepsy care intervention will be determined in US dollars and Nigerian Naira per additional quality adjusted life year (QALY). This cRCT will inform the implementation of task-shifted care systems to address the childhood epilepsy treatment gap and establish a network of community-based clinical epilepsy research centers in northern Nigeria.</p> <p>More from the NIH Reporter (1R01NS113171-01)</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=715" hreflang="und">Edwin Trevathan</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=716" hreflang="und">Epilepsy</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=111" hreflang="und">Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=784" hreflang="und">Community Health Workers</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=441" hreflang="und">Nigeria</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 28 Aug 2019 17:30:33 +0000 ridingkm 2412 at https://www.vumc.org/global-health The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/partnership-research-emerging-viral-infections-sierra <span class="field--node--title">The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 08/28/2019 - 12:20</span> <a href="/global-health/blog-post-rss/2410" class="feed-icon" title="Subscribe to The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Project Summary/ Abstract: The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have just completed a Planning Grant for Emerging Epidemic Virus Research Training for West African Countries with Widespread Transmission of Ebola- Guinea, Liberia, and Sierra Leone (D71TW010411), that has allowed us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Combining this with our extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades managing institutional research, training, and capacity-building grants; we propose here our comprehensive research training plan in response to PAR-18-840-Global Infectious Disease Research Training. We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone (USL), College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aims are to 1) Enhance research capacity at KGH and COMAHS for the conduct of scientifically valid and ethically acceptable clinical trials, with a focus on Ebola, Lassa, and other VHF; 2) Strengthen and expand the KGH and COMAHS research pool with a focus on Implementation Science research for the clinical management of patients with VHF; and 3) Nurture innovative mentored research by PREVSL trainees/alumni to address the clinical management of VHF. Our comprehensive training program will consist of a combination of (1) long-term Masters training in clinical investigation with a focus on vaccine clinical trial capacity; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research through in-country short courses and Masters training in Public Health; and (4) sustainable capacity building at KGH and COMAHS for the management and administration of future research grant opportunities.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=742" hreflang="und">Sierra Leone</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=156" hreflang="und">Capacity Building Research</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=791" hreflang="und">clinical trial capacity</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=792" hreflang="und">Viral Hemorrhagic Fevers</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=221" hreflang="und">Ebola</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 28 Aug 2019 17:20:55 +0000 ridingkm 2410 at https://www.vumc.org/global-health Mozambique Collaborative Research Ethics Education Program (FoCEP) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/mozambique-collaborative-research-ethics-education <span class="field--node--title">Mozambique Collaborative Research Ethics Education Program (FoCEP)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 08/23/2019 - 12:23</span> <a href="/global-health/blog-post-rss/2411" class="feed-icon" title="Subscribe to Mozambique Collaborative Research Ethics Education Program (FoCEP)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Abstract: The growth in research activity projected for the next decade by the Mozambican government and multiple international agencies highlights the continued need for capacity building in research ethics well into the future. With the groundwork laid for systems of basic, translational, clinical and public health research, parallel capacity development in research ethics will be essential to address critical locally relevant research questions in an ethically-consistent way. The four most evident areas in which attention is needed are: 1) ethics education, review and oversight of graduate and professional student researchers and their thesis research projects; 2) the burgeoning growth of research using biological specimens and clinical and epidemiologic data, including the development of biobanks and a national data warehouse; 3) research on the prevention and treatment of infectious and non-communicable diseases; and 4) international collaborative research that requires dual review and agreement on the authority of the potentially different regulatory requirements of partner countries. A team of experienced research ethics educators from UEM, UTSW, and VIGH, in collaboration with the National Bioethics Committee for Health (CNBS) seeks to renew the Formação Colaborativa em Etíca na Pesquisa, FoCEP (Collaborative Research Ethics Education-Mozambique). We propose a series of interrelated educational aims and activities intended to build capacity for ethical design, review, and conduct of biomedical research in Mozambique. The specific aims of this study are to 1) expand the cadre of Mozambican leaders in biomedical research with in-depth knowledge and practical skills in both research design and the ethical conduct of clinical and epidemiologic research through a tailored MPH program and masters-level curriculum enhancements at UEM; 2) enhance the knowledge and practical skills of Mozambican REC members and research educators in research ethics, RCR, and research integrity; and 3) further create, evaluate, and distribute curricular materials on research ethics and the responsible conduct of research tailored to Portuguese speaking Africa. After 5 years of collaborative engagement in phase one of FoCEP activities, the program implementation team is uniquely familiar with the country's challenges and are well positioned to further develop Mozambique's capacity in research ethics, ethical review of research protocols, and the provision of research ethics and integrity education to the country's next generation of health researchers. The team has comprehensive knowledge of research ethics and the responsible conduct of research; skill in health sciences education; and fluency in Portuguese that, together with its established relationships within the National and Institutional Bioethics Committees, Ministry of Health, and research-oriented universities, make it well suited to carry out this renewal program proposed here.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=231" hreflang="und">Ethics</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=553" hreflang="und">University Eduardo Mondlane (UEM)</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 23 Aug 2019 17:23:47 +0000 ridingkm 2411 at https://www.vumc.org/global-health Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/immunogenetic-predictors-active-and-incipient-tb-hiv <span class="field--node--title">Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 07/11/2019 - 16:47</span> <a href="/global-health/blog-post-rss/2404" class="feed-icon" title="Subscribe to Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>Principal Investigators: </strong></p> <p><a href="https://www.vumc.org/global-health/person/timothy-r-sterling-md">Timothy Sterling, MD</a><br /> Bruno Andrade<br /> Thomas Hawn</p> <p>Critical to preventing tuberculosis (TB) is a better understanding of the protective and predisposing factors for progression from M. tuberculosis infection to TB disease. Our group has reported a peripheral blood correlate of risk (COR) transcriptional signature that identified persons with incipient (asymptomatic) TB who progressed to active (symptomatic)TB within 12 months, and also human genetic polymorphisms in a DNA sensor gene region (PYHIN1-IFI16-AIM2) associated with TB risk. We seek to evaluate the immunogenetic and epidemiologic risk factors for active and incipient TB in a Brazilian cohort of HIV-negative and HIV-positive close TB contacts, to identify host pathways associated with protection against TB (for future vaccines), and to identify persons who would benefit from TB preventive therapy.</p> <p>Drs. Timothy Sterling, Bruno Andrade (Instituto Brasileiro para Investigação da Tuberculose (IBIT), Salvador, Brazil), and Thomas Hawn (University of Washington) received a 5 year R01 grant from the National Institutes of Health entitled, “Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts” (R01AI147765). This was in response to PAR-16-254, "Mechanisms of Mycobacterial-Induced Immunity in HIV-Infected and Uninfected Individuals to Inform Innovative Tuberculosis Vaccine Design (R01)." Total funding awarded for the 5-year project is $3.6 million, with subcontracts to the Fundação para o Desenvolvimento Científico e Tecnológico em Saúde (FIOTEC; Brazil), the University of Washington, and the University of Cape Town (South Africa). Collaborators include Spyros Kalams, Simon Mallal, Mark Pilkinton, and Peter Rebeiro at Vanderbilt; Valeria Rolla, Afranio Kritski, Marcelo Cordeiro Santos, Solange Cavalcante, Cristina Lourenco, and Ricardo Khouri in Brazil; Javeed Shah at the University of Washington; and Mark Hatherill, Thomas Scriba, and Stanley Kimbung at the University of Cape Town.</p> <p>This grant project seeks to understand the protective and predisposing factors for progression from M. tuberculosis infection to TB disease. The group has previously reported a peripheral blood correlate of risk (COR) transcriptional signature that identifies persons with incipient (asymptomatic) TB who subsequently progress to active (symptomatic) TB within 12 months, and also human genetic polymorphisms in a DNA sensor gene region (PYHIN1-IFI16-AIM2) associated with TB risk. In this project, the group will evaluate innate immune responses in macrophages and their correlates with human genetic polymorphisms, acquired immunity to M. tuberculosis, and epidemiologic factors associated with the risk of incipient and active TB. These studies will be performed in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort, which includes culture-confirmed TB cases and their close contacts in racially and ethnically diverse Brazil. This work may identify host pathways associated with protection against TB (for future host-directed therapies and vaccines), and to identify persons infected with M. tuberculosis who would benefit most from TB preventive therapy.</p> <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9848749&amp;icde=45469321">MORE from the NIH Reporter website</a></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=537" hreflang="und">Timothy Sterling</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=782" hreflang="und">Tuberculosis</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=306" hreflang="und">HIV</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Thu, 11 Jul 2019 21:47:05 +0000 ridingkm 2404 at https://www.vumc.org/global-health Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/community-i-star-mozambique-community-implementation <span class="field--node--title">Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/index.php/users/leadee1-0" typeof="schema:Person" property="schema:name" datatype="">leadee1</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 05/06/2019 - 13:46</span> <a href="/global-health/index.php/blog-post-rss/2363" class="feed-icon" title="Subscribe to Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>PI: <a href="https://www.vumc.org/global-health/index.php/person/carolyn-audet-phd">Carolyn Audet, Ph.D.</a></p> <p><strong>Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique</strong><br /> Hazardous drinking is a major public health burden worldwide with significant morbidity and mortality. Community I-STAR Mozambique will examine the implementation and effectiveness of two different strategies to train and supervise community health workers in Mozambique to sustainably provide community-based services to reduce hazardous drinking. The first strategy is Screening, Brief Intervention, Referral to Treatment (SBIRT), which utilizes mobile health technology. The second strategy will involve traditional training and supervision. Working with the Research Foundation for Mental Hygeine, Dr. Audet is responsible for providing assistance in study design, implementation, and training for fellows. This study will leverage existing platforms and participation of policy makers ready to apply and sustain evidence-informed policies over time, and it will inform policy decision-making and clinical practice not only in Mozambique but also in many other low- and middle-income countries.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 06 May 2019 18:46:20 +0000 leadee1 2363 at https://www.vumc.org/global-health Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/higher-education-partnership-innovation-and <span class="field--node--title">Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/index.php/users/leadee1-0" typeof="schema:Person" property="schema:name" datatype="">leadee1</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 04/19/2019 - 12:00</span> <a href="/global-health/index.php/blog-post-rss/2351" class="feed-icon" title="Subscribe to Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>PI: <a href="https://www.vumc.org/global-health/index.php/person/martin-c-were-md-ms">Martin C. Were, M.D., M.S. </a></p> <p>VIGH core faculty member <a href="https://www.vumc.org/global-health/index.php/person/martin-c-were-md-ms" rel="noreferrer" target="_blank">Martin Were</a>, M.D., M.S., associate professor of Biomedical Informatics and Medicine, was recently awarded a cooperative agreement from the United States Agency for International Development (USAID) to establish the Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya).  </p> <p>PISBIC Kenya focuses on building workforce capacity; building evidence about the impact, costs, and benefits of health informatics systems; and producing locally responsive digital health solutions.</p> <p>The program is a partnership between Moi University's Institute of Biomedical Informatics and Aga Khan University in Kenya and Vanderbilt University Medical Center and Purdue University in the United States. Dr. Were and his team will pursue the project goals to further the use of digital health technologies in order to improve health care quality, patient and population health outcomes, and data-driven decision-making to improve healthcare delivery systems.</p> <p>This program is one of four projects under the <a href="https://www.vumc.org/global-health/index.php/sites/vumc.org.global-health/files/documents/ALP%20one%20pager%202.25.19.pdf">Accelerating Local Potential Program</a> umbrella to help propel "higher education institutions in low- and middle-income countries to become global leaders in scientific education and research, and to increase their presence as a source of knowledge and innovation for local government officials, policy makers, and other development actors."</p> <p>PISBIC Kenya is supported by the U.S. Agency for International Development (USAID), the world's premier international development agency and a catalytic actor driving development results. USAID's work advances U.S. national security and economic prosperity, demonstrates American generosity, and promotes a path to recipient self-reliance and resilience. For more info, visit <a href="https://www.usaid.gov/">www.usaid.gov</a>.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=713" hreflang="und">Martin Were</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=360" hreflang="und">Kenya</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 19 Apr 2019 17:00:12 +0000 leadee1 2351 at https://www.vumc.org/global-health Population-based survey for Lwala Community Alliance https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/population-based-survey-lwala-community-alliance <span class="field--node--title">Population-based survey for Lwala Community Alliance </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 12/07/2018 - 16:12</span> <a href="/global-health/blog-post-rss/2325" class="feed-icon" title="Subscribe to Population-based survey for Lwala Community Alliance "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>PI: <strong><a href="https://www.vumc.org/global-health/person/troy-moon-md-mph">Troy Moon, M.D., M.P.H.</a></strong></p>&#13; &#13; <p>In collaboration with Lwala Community Alliance, VIGH is developing and implementing a population-based survey for the North, East, South &amp; Central Kamagambo wards of Rongo sub-county, Kenya. The implementation plan includes data and statistical analysis, and technical support. In addition, to providing a sampling frame, other support includes oversight of  Vanderbilt MPH student thesis and manuscript generation.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=374" hreflang="und">Lwala Community Alliance</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=809" hreflang="und">Monitoring and Evaluation</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 07 Dec 2018 22:12:45 +0000 Visitor 2325 at https://www.vumc.org/global-health Population mobility and retention in HIV care among postpartum women in South Africa https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/population-mobility-and-retention-hiv-care-among <span class="field--node--title">Population mobility and retention in HIV care among postpartum women in South Africa</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 10/01/2018 - 00:00</span> <a href="/global-health/blog-post-rss/2323" class="feed-icon" title="Subscribe to Population mobility and retention in HIV care among postpartum women in South Africa"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/kate-clouse-phd-mph">Kate Clouse, Ph.D., M.P.H.</a></p> <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=8919531&amp;icde=39447271&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=4&amp;csb=default&amp;cs=ASC&amp;pball="><strong>Population mobility and retention in HIV care among postpartum women in South Africa (K01MH107256)</strong></a><br /> HIV-positive women in South Africa are at high risk of dropping out of HIV care soon after delivery, endangering the life of the mother and infant. The impact of population mobility around the time of delivery on retention in HIV care is unknown. This mentored K01 award will support training and research to explore the impact of population mobility on retention in postpartum HIV care and gather critical information for the development of future interventions to improve retention in HIV care.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=355" hreflang="und">Kate Clouse</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=387" hreflang="und">Maternal and Child Health</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 01 Oct 2018 05:00:00 +0000 Visitor 2323 at https://www.vumc.org/global-health UNZA Mentoring Programme https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/unza-mentoring-programme <span class="field--node--title">UNZA Mentoring Programme </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Sun, 07/01/2018 - 00:00</span> <a href="/global-health/blog-post-rss/2324" class="feed-icon" title="Subscribe to UNZA Mentoring Programme "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>PI: <a href="https://www.vumc.org/global-health/person/douglas-c-heimburger-md-ms">Douglas Heimburger, M.D.</a> and <a href="https://www.vumc.org/global-health/person/marie-h-martin-phd-med">Marie Martin, Ph.D., M.Ed.</a></strong></p> <p>The Clayton-Dedonder Global Health Mentorship Fellows Program (CD) is a mentorship and training program awarded to the University of Zambia (UNZA) and its institutional partners. This fellowship will utilize and build upon the existing UNZA-Vanderbilt Partnership for HIV Nutrition-Metabolic Research Training (UVP) program by designing and implementing a Ph.D. mentoring program. The CD Fellowship will support intensive mentorship training to strengthen the UNZA Ph.D. Program under the UNZA College of Medicine to enhance its capacity to train future researchers. </p> <p>The intensive mentorship and leadership training program will both train junior faculty members and engage senior faculty members to hone their mentorship skills. Both senior and junior groups will comprise all Ph.D.-training disciplines at UNZA. Two core principles will guide this capacity building approach. First, senior UNZA faculty will lead the curriculum development process to facilitate context-appropriateness, ensure sustainability, enhance their knowledge, and hone their mentorship skills. Second, the IHI Collaborative Model will serve as a framework for curriculum development, implementation, and evaluation.</p> <p>Overall, this program will support UNZA to establish and grow its Ph.D. mentor training program for the College of Medicine's four schools (Medicine, Public Health, Health Sciences, and Nursing), train 10 Clayton-Dedonder fellows in mentorship of UNZA Ph.D. students and use an iterative evaluation model to optimize the training program and integrate it as a required component of the UNZA Ph.D. Program.</p> <p>The<a href="https://www.fic.nih.gov/News/Pages/2018-hiv-aids-mentoring-supplements-fellows-scholars.aspx"> Clayton-Dedonder Global Health Mentorship Fellows Program is funded by Fogarty</a> as part of its effort to strengthen HIV/AIDS research training in low- and middle-income countries. UNZA is one of six organizations to receive this funding.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=795" hreflang="und">International Training Grant/Program</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=789" hreflang="und">University of Zambia (UNZA)</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=212" hreflang="und">Doug Heimburger</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=382" hreflang="und">Marie Martin</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Sun, 01 Jul 2018 05:00:00 +0000 Visitor 2324 at https://www.vumc.org/global-health UNICEF Nutrition Evaluation & Capacity Building: Zambézia & Nampula Provinces, Mozambique https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/unicef-nutrition-evaluation-capacity-building-zambezia <span class="field--node--title">UNICEF Nutrition Evaluation &amp; Capacity Building: Zambézia &amp; Nampula Provinces, Mozambique</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 01/01/2018 - 00:00</span> <a href="/global-health/blog-post-rss/2134" class="feed-icon" title="Subscribe to UNICEF Nutrition Evaluation &amp; Capacity Building: Zambézia &amp; Nampula Provinces, Mozambique"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s):<br /><a href="https://www.vumc.org/global-health/person/troy-moon-md-mph">Troy Moon, M.D., M.P.H.</a></p>&#13; &#13; <p>This Nutrition baseline assessment (cross-sectional survey) will generate baseline information on nutritional status of under-five children in targeted districts and within the wider provinces of Nampula and Zambezia in year one of the implementation of a multi-years EU programme. The surveys will also include indicators related to knowledge, attitudes, behaviors and practices and will generate findings on breastfeeding and complementary feeding practices, improved water access, hand-washing, hygiene, particularly related to the first 1,000 days, and sanitation practices. Additional areas of interest are knowledge, attitudes and practices related to a range of maternal and child health interventions and behaviors. These will inform progress towards UNICEF's country programme 2017-2021 plan. Results will serve as baseline information against which progress will be measured after 3 and 5 years. In addition survey results will be disseminated through workshop to the districts and provinces targeted. Results will also be used to develop policy briefs and district and provincial nutrition profiles which will be used for advocacy purposes with the aim of increasing awareness and leadership among provincial and districts level stakeholders in all relevant sectors. </p>&#13; &#13; <p>The nutrition program of UNICEF Mozambique will focus in Zambezia and Nampula, the two provinces with the highest burden of malnutrition and will specifically aim to contribute to the government five-year plan to reduce stunting among children under-five· to 35% by 2020 and achieve the six maternal, infant and young child nutrition targets of the World Health Assembly.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=800" hreflang="und">Capacity Building</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=738" hreflang="und">Nutrition</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=547" hreflang="und">UNICEF</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=231" hreflang="und">Ethics</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=709" hreflang="und">Friends in Global Health, FGH</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=754" hreflang="und">Non-Communicable Diseases (NCDs)</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 01 Jan 2018 06:00:00 +0000 Visitor 2134 at https://www.vumc.org/global-health Partnership for Residency, Integrated Medical Education, and Research (PRIMER-Liberia) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/partnership-residency-integrated-medical-education-and <span class="field--node--title"> Partnership for Residency, Integrated Medical Education, and Research (PRIMER-Liberia)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 11/01/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2133" class="feed-icon" title="Subscribe to Partnership for Residency, Integrated Medical Education, and Research (PRIMER-Liberia)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/bonnie-miller-md">Bonnie Miller, M.D.</a><br /> <a href="https://www.vumc.org/global-health/person/troy-moon-md-mph">Troy Moon, M.D. M.P.H.</a><br /> <a href="https://www.vumc.org/global-health/person/marie-h-martin-phd-med">Marie Martin, M.Ed., Ph.D.</a></p> <p><a href="http://sites.nationalacademies.org/PGA/PEERLiberia/index.htm"><strong>Partnership for Residency, Integrated Medical Education, and Research (PRIMER-Liberia)</strong></a><br /> Partnerships for Enhanced Engagement in Research Liberia (PEER/Liberia) is a sub-program under PEER sponsored by the United States Agency for International Development (USAID) and implemented by the U.S. National Academies of Sciences, Engineering, and Medicine.</p> <p>In the aftermath of the Western Africa Ebola outbreak of 2014-2015, hundreds of Ebola survivors have developed a range of ocular conditions from persistent Ebola virus in the eye’s aqueous humor — fluid that fills space between the lens and cornea — for months following the initial hemorrhagic infection. Care and treatment of these individuals requires specialized medical expertise, and more research is need to understand ocular diseases among survivors.</p> <p>PRIMER-Liberia will focus on developing institutional capacity for a new, fully accredited Ophthalmology residency training program through the Liberian College of Physicians and Surgeons (LCPS) in Monrovia, Liberia; as well as providing technical assistance towards medical curriculum reform and overall research capacity of the AM Dogliotti College of Medicine (AMD). This initiative will also compliment Liberia’s preclinical sustainability plan, and help to strengthen the health system more broadly. Training and education activities include, curriculum development, in-county workshops, distance learning, training for community-based and ancillary health care providers, mentoring of faculty and residents, apprenticeships and clinical rotations.</p> <p>While the primary outcome is to enhance medical school training that will develop a pipeline of faculty in Ophthalmology with the requisite skills to ensure Ophthalmology Residency Programs meet accreditation standards of the West African College of Physicians, this initiative will also compliment Liberia’s preclinical sustainability plan, and help to strengthen the health system more broadly. Training and education activities include, curriculum development, in-county workshops, distance learning, training for community-based and ancillary health care providers, mentoring faculty and residents, apprenticeships and clinical rotations.</p> <p><strong><a href="https://news.vanderbilt.edu/2018/02/08/partnership-enhances-eye-care-for-ebola-survivors-in-liberia/">Learn more &gt;&gt;</a></strong></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=795" hreflang="und">International Training Grant/Program</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=741" hreflang="und">Liberia</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=778" hreflang="und">Ophthalmology</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=221" hreflang="und">Ebola</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=382" hreflang="und">Marie Martin</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=800" hreflang="und">Capacity Building</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=754" hreflang="und">Non-Communicable Diseases (NCDs)</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 01 Nov 2017 05:00:00 +0000 Visitor 2133 at https://www.vumc.org/global-health Laboratory test-comparable mobile assessments of hemoglobin for anemia detection https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/laboratory-test-comparable-mobile-assessments <span class="field--node--title">Laboratory test-comparable mobile assessments of hemoglobin for anemia detection</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 09/18/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2122" class="feed-icon" title="Subscribe to Laboratory test-comparable mobile assessments of hemoglobin for anemia detection"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> Young Kim, Ph.D., M.S. and <a href="https://www.vumc.org/global-health/person/martin-c-were-md-ms">Martin Were, M.D., M.S.</a></p> <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9341800&amp;icde=39510229">Laboratory test-comparable mobile assessments of hemoglobin for anemia detection (R21TW010620-01)</a></strong><br /> Anemia, which is defined as a decrease in the amount of hemoglobin in the blood, is a major public health problem in low- and middle-income countries. However, portable/point-of-care hemoglobin measurement modalities often remain inaccessible/unaffordable and current noninvasive mobile-based technologies still lack sensitivity/specificity for different levels of anemia. In this respect, we will develop mobile smartphone-based noninvasive hemoglobin analyzer (mHema), implement a user-friendly application in conventional mobile smartphones, and evaluate the accuracy and precision of mHema in low-resource settings.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=781" hreflang="und">Global Health Informatics</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=713" hreflang="und">Martin Were</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=787" hreflang="und">Anemia</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=754" hreflang="und">Non-Communicable Diseases (NCDs)</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=360" hreflang="und">Kenya</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 18 Sep 2017 05:00:00 +0000 Visitor 2122 at https://www.vumc.org/global-health Mobile Health and Treat (mHAT) for Malaria Elimination https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/mobile-health-and-treat-mhat-malaria-elimination <span class="field--node--title">Mobile Health and Treat (mHAT) for Malaria Elimination</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 09/18/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2123" class="feed-icon" title="Subscribe to Mobile Health and Treat (mHAT) for Malaria Elimination"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /><a href="https://www.vumc.org/global-health/person/martin-c-were-md-ms">Martin Were, M.D., M.S.</a><br />&#13; David Wright, Ph.D. </p>&#13; &#13; <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9341772&amp;icde=39450462&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Mobile Health and Treat (mHAT) for Malaria Elimination</a></strong><br />&#13; While malaria control efforts have shown success in limiting the spread of the disease, elimination campaigns will require improved surveillance capabilities and faster information workflow after the identification of an index case. This proposal, a collaborative effort between Vanderbilt University and the Macha Research Trust in Zambia, describes the development and testing of a “mobile health and treat” malaria elimination strategy that is sustainable and scalable.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=781" hreflang="und">Global Health Informatics</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=376" hreflang="und">Malaria</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=713" hreflang="und">Martin Were</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=678" hreflang="und">Zambia</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 18 Sep 2017 05:00:00 +0000 Visitor 2123 at https://www.vumc.org/global-health Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/optimal-management-hiv-infected-adults-risk-kidney <span class="field--node--title">Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria </span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 09/15/2017 - 00:00</span> <a href="/global-health/index.php/blog-post-rss/2142" class="feed-icon" title="Subscribe to Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /><a href="https://www.vumc.org/global-health/index.php/person/muktar-aliyu-md-mph-drph">Muktar Aliyu, M.D., M.P.H., Dr.P.H.</a><br /><a href="https://www.vumc.org/global-health/index.php/person/c-william-bill-wester-md-mph">William Wester, M.D., M.P.H.</a></p>&#13; &#13; <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9241189&amp;icde=39449508&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Optimal Management of HIV Infected Adults at Risk for Kidney Disease in Nigeria (U01DK112271-01)</a></strong><br />&#13; In this study, we plan to determine the optimal means to manage and thereby reduce the risk of kidney and potentially other end organ complications among genetically at-risk northern Nigerian HIV-infected adults. Based on data from the diabetic literature using medications that block the renin angiotensin aldosterone system (RAAS), we plan to evaluate whether or not RAAS inhibition (using one or two different medications that block RAAS) in HIV-infected adults produces similarly promising results.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=669" hreflang="und">William Wester</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=801" hreflang="und">Kidney Disease</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=420" hreflang="und">Muktar Aliyu</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 15 Sep 2017 05:00:00 +0000 Visitor 2142 at https://www.vumc.org/global-health Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/bridging-childhood-epilepsy-treatment-gap-northern <span class="field--node--title">Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 09/11/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2141" class="feed-icon" title="Subscribe to Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /><a href="https://www.vumc.org/global-health/person/muktar-aliyu-md-mph-drph">Muktar Aliyu, M.D., M.P.H., Dr.P.H.</a><br /><a href="https://www.vumc.org/global-health/person/edwin-trevathan-md-mph">Edwin Trevathan, M.D., M.P.H.</a></p>&#13; &#13; <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9406559&amp;icde=39449438&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball="><strong>Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE) (R21TW010899-01)</strong></a><br />&#13; Epilepsy is the most common serious neurological disorder among children worldwide, about 80% of whom live in low- and middle income countries (LMICs) where the advances in epilepsy care over the past 40 years have not translated to improved outcomes. Approximately 67%-90% of children with epilepsy in the LMICs of sub- Saharan Africa do not receive consistent appropriate treatment – a phenomena known as the epilepsy treatment gap, with associated increased risk of co-morbid conditions and premature death. This BRIDGE project lays a foundation for future clinical trials designed to bridge the childhood epilepsy treatment gap in SSA by (a) mapping the childhood epilepsy treatment gap in Kano, Nigeria, (b) developing and piloting task- shifted epilepsy care teams to target areas of the most severe treatment gap, and (c) developing and piloting epilepsy diagnostic paradigms for use in resource-limited environments like Kano with limited access to EEG. BRIDGE, and the clinical trials to follow, has the potential to reduce the childhood epilepsy treatment gap in Nigeria and throughout sub-Saharan Africa.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=715" hreflang="und">Edwin Trevathan</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=716" hreflang="und">Epilepsy</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=420" hreflang="und">Muktar Aliyu</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 11 Sep 2017 05:00:00 +0000 Visitor 2141 at https://www.vumc.org/global-health Supporting Sustainable Implementation of HIV and TB Services for Epidemic Control in the Republic of Mozambique "Avante 2" https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/supporting-sustainable-implementation-hiv-and-tb <span class="field--node--title">Supporting Sustainable Implementation of HIV and TB Services for Epidemic Control in the Republic of Mozambique &quot;Avante 2&quot;</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 09/01/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2132" class="feed-icon" title="Subscribe to Supporting Sustainable Implementation of HIV and TB Services for Epidemic Control in the Republic of Mozambique &quot;Avante 2&quot;"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s):<br /> <a href="https://www.vumc.org/global-health/person/c-william-bill-wester-md-mph">William Wester, M.D., M.P.H.</a></p> <p><strong>Supporting Sustainable Implementation of HIV and TB Services<br /> for Epidemic Control in the Republic of Mozambique "Avante 2" (1NU2GGH001943-02)</strong></p> <p>HIV Services in Mozambique supported by CDC/PEPFAR</p> <p>Vanderbilt University Medical Center (VUMC) facilitates the expansion and coordination of global health training, service, and research initiatives with a commitment to improve health services and outcomes in resource limited settings. Vanderbilt established Friends in Global Health (FGH), a non-profit organization, to serve as the implementing organization in Mozambique. Since 2007, FGH has been registered with the Mozambican government for the implementation of CDC/PEPFAR-funded HIV care and treatment programs. The FGH team works closely with Ministry of Health officials at national, provincial, and district levels to provide technical assistance for the implementation of sustainable models of community and facility-based services that cover the full spectrum of the HIV response.</p> <p> </p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=669" hreflang="und">William Wester</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=799" hreflang="und">Technical Assistance</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=781" hreflang="und">Global Health Informatics</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=709" hreflang="und">Friends in Global Health, FGH</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=782" hreflang="und">Tuberculosis</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 01 Sep 2017 05:00:00 +0000 Visitor 2132 at https://www.vumc.org/global-health Predictors of Resistance Emergence Evaluation in MDR-TB Patients on Treatment (PREEMPT) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/predictors-resistance-emergence-evaluation-mdr-tb <span class="field--node--title">Predictors of Resistance Emergence Evaluation in MDR-TB Patients on Treatment (PREEMPT)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Tue, 08/15/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2124" class="feed-icon" title="Subscribe to Predictors of Resistance Emergence Evaluation in MDR-TB Patients on Treatment (PREEMPT)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br />&#13; Charles R. Horsburgh, Jr., M.D.<br /><a href="https://www.vumc.org/global-health/person/timothy-r-sterling-md">Timothy R. Sterling, M.D.</a></p>&#13; &#13; <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9410579&amp;icde=39447043&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Predictors of Resistance Emergence Evaluation in MDR-TB Patients on Treatment (PREEMPT) (R01AI134430-01)</a></strong><br />&#13; Multi-drug-resistant tuberculosis (MDR-TB) affects over 500,000 persons each year around the world and many patients die from it. During treatment, some patients discover that the germs with which they are infected have developed resistance to some of the antibiotics they are taking. The purpose of this study is to determine why this happens and to identify ways that this could be prevented.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=782" hreflang="und">Tuberculosis</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=537" hreflang="und">Timothy Sterling</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=732" hreflang="und">Brazil</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Tue, 15 Aug 2017 05:00:00 +0000 Visitor 2124 at https://www.vumc.org/global-health Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/partners-based-hiv-treatment-sero-concordant-couples <span class="field--node--title">Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 05/12/2017 - 00:00</span> <a href="/global-health/blog-post-rss/2138" class="feed-icon" title="Subscribe to Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /><a href="https://www.vumc.org/global-health/person/carolyn-audet-phd">Carolyn Audet, Ph.D.</a></p>&#13; &#13; <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9346956&amp;icde=39449080&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care (R01 MH113478-01)</a></strong><br />&#13; The purpose of this R01 proposal is to evaluate the clinical impact, hypothesized mechanisms of behavior change, and cost-effectiveness of a partners-focused integrated elimination of mother-to-child transmission of HIV (PMTCT) package comprised of: 1) antenatal care-based couples HIV testing, ART enrollment, and care for sero-concordant HIV+ expectant couples; (2) Couples-based treatment in the post-partum period; (3) Couple-based education and skills building; and (4) Treatment continuity with the support of expert-patient (peer) supporters from couples who have successfully navigated PMTCT. This innovative approach to scaling up PMTCT services, if proven feasible and effective, will be adopted in PEPFAR programs to accelerate progress toward PMTCT and helping families with HIV infection live long, healthy lives.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=387" hreflang="und">Maternal and Child Health</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=790" hreflang="und">Implementation Science</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=471" hreflang="und">PMTCT</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=709" hreflang="und">Friends in Global Health, FGH</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 12 May 2017 05:00:00 +0000 Visitor 2138 at https://www.vumc.org/global-health Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis "RePORT-Brazil" https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/predictors-treatment-toxicity-failure-and-relapse-hiv <span class="field--node--title">Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis &quot;RePORT-Brazil&quot; </span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 08/12/2016 - 00:00</span> <a href="/global-health/blog-post-rss/2127" class="feed-icon" title="Subscribe to Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis &quot;RePORT-Brazil&quot; "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s):<br /><a href="https://www.vumc.org/global-health/person/timothy-r-sterling-md">Timothy R. Sterling, M.D.</a><br />&#13; Valeria Cavalcanti Rolla, M.D., Ph.D.</p>&#13; &#13; <p><strong><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9199006&amp;icde=39447759&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=1&amp;csb=default&amp;cs=ASC&amp;pball=">Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis "RePORT-Brazil" (R01 AI120790-01A1)</a></strong><br />&#13; The over-arching goal of this project is to optimize the treatment of HIV-related tuberculosis in a large, genetically diverse cohort in Brazil. We will characterize the relationship between human genetic single nucleotide polymorphisms (SNPs), tuberculosis and HIV drug levels, and three key tuberculosis treatment outcomes: drug toxicity, 2-month sputum culture-positivity, and tuberculosis treatment failure/reIapse. These results will lay the groundwork for drug dosing and regimens that improve outcomes and treatment effectiveness of HIV-related tuberculosis.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=782" hreflang="und">Tuberculosis</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=732" hreflang="und">Brazil</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=537" hreflang="und">Timothy Sterling</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 12 Aug 2016 05:00:00 +0000 Visitor 2127 at https://www.vumc.org/global-health Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy "RePORT SA" https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/identifying-innovative-bacterial-and-host-mediated <span class="field--node--title">Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy &quot;RePORT SA&quot; </span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 01/01/2016 - 00:00</span> <a href="/global-health/blog-post-rss/2144" class="feed-icon" title="Subscribe to Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy &quot;RePORT SA&quot; "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> </p> <p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/timothy-r-sterling-md">Timothy Sterling, M.D.</a></p> <p>Identifying Innovative Bacterial and Host-Mediated Biomarkers of Treatment Response to Tuberculosis Chemotherapy (RePORT SA) (CRDF # OISE-9531011) RePORT SA initiated in 2016</p> <p>Funding provided through the South African Medical Research Council (SAMRC), with funds from the South African Department of Health (NDoH), and National Institute of Allergy and Infection Diseases (NIAID) and National Institute of Health (NIH) &amp; PEPFAR </p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=537" hreflang="und">Timothy Sterling</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=782" hreflang="und">Tuberculosis</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=516" hreflang="und">South Africa</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 01 Jan 2016 06:00:00 +0000 Visitor 2144 at https://www.vumc.org/global-health