Blog RSS https://www.vumc.org/global-health/ en Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/vanderbilt-nigeria-research-administration-and <span class="field--node--title">Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 05/12/2021 - 09:34</span> <a href="/global-health/blog-post-rss/2701" class="feed-icon" title="Subscribe to Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The increasing volume and complexity of research activities at the Aminu Kano Teaching Hospital (AKTH) in Kano, Nigeria necessitates urgent measures to improve research infrastructure in grants administration and management. The overall goal of this training program is to build infrastructure capacity in research administration and management and research ethics at AKTH in Nigeria to support the many HIV-related research projects and clinical trials, both planned and underway, at this site. To achieve the aims outlined in this application, we will perform a mixed methods needs assessment of the research administration and management environment in AKTH in year 1 and generate an Action Plan that will identify infrastructure needs, prioritize processes, and guide program implementation. We will capacitate the newly established AKTH Office of Research Administration and improve the knowledge and skills of AKTH research administrators and grant managers via short term in-person trainings at Vanderbilt, in Kano, Nigeria and by remote learning opportunities. We will enhance the administrative efficiency and performance of research ethics operations at AKTH through training and mentoring of AKTH IRB members and office staff and the development and implementation of systematic processes to streamline protocols, to include a REDCap protocol tracking database and standard operating procedures in research ethics and responsible conduct of research. The proposed infrastructure training award will enable the creation of a high-quality research administration environment at AKTH that is knowledgeable and compliant with the fiscal, management, and ethical standards of sponsored HIV-related research.</p> <p>Project Details: <a href="https://reporter.nih.gov/search/vGDO77v3QE29jE3snLD9eg/project-details/10240150">NIH Reporter</a></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=420" hreflang="und">Muktar Aliyu</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=669" hreflang="und">William Wester</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2111" hreflang="und">Holly Cassell</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2117" hreflang="und">Donna Ingles</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 12 May 2021 14:34:27 +0000 ridingkm 2701 at https://www.vumc.org/global-health Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/childhood-status-epilepticus-and-epilepsy-determinants <span class="field--node--title">Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/index.php/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 04/01/2021 - 13:29</span> <a href="/global-health/index.php/blog-post-rss/2696" class="feed-icon" title="Subscribe to Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Abstract Status epilepticus (SE) is the most common serious neurological emergency among children worldwide. In the low- and middle-income countries (LMICs) of sub-Saharan Africa, the burden of childhood SE-associated mortality and morbidity appears to be especially high. However, the phenotypes of childhood SE, clinical predictors of SE-associated mortality and of SE-associated neurodevelopmental morbidity, and genomic predictors of SE, SE-associated mortality and neurodevelopmental morbidity have not been well-characterized in this region. The clinical and genomic predictors of benzodiazepine-resistant SE, which is common and may contribute to SE-associated mortality, have also not been well-characterized, especially among African children. A large percentage of children (~80%) with SE in northern Nigeria experience SE as their first seizure, and the estimated incidence of childhood SE in Kano is relatively high. Little is known of the clinical and genomic risk factors for the development of epilepsy among African children who experience SE as their first seizure. The H3Africa consortium is yielding insights into the genomic factors of common human diseases across the African continent and and will provide controls for genome-wide association studies (GWAS) of SE. This project, Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED), will establish a large cohort of children with SE in Kano, northern Nigeria who present to pediatric emergency rooms in Kano. Innovative capacity building will include the incorporation of point-of-care EEG and EEG-video in large pediatric emergency rooms in Kano, performed by specially trained community health extension workers (CHEWs) who will be trained in both basic epilepsy care and EEG technology. A team of specialists working together at Aminu Kano Teaching Hospital (AKTH) and at Vanderbilt University Medical Center (VUMC) will utilize video exams, EEG-video, detailed histories, and brain MRI to perform deep phenotyping on this large cohort of children with SE. Clinical risk factors for in-hospital SE-associated mortality, short-term SE- associated mortality, long-term SE-associated mortality, and SE-associated neurodevelopmental morbidity will be determined. GWAS will be performed on the entire cohort, with gender matched controls from H3Africa, through collaborations between AKTH, Bayero University Kano, the Sydney Brenner Institute for Molecular Bioscience in South Africa, and VUMC. Genomic risk factors for childhood SE-associated mortality and morbidity will be determined, as well as clinical and genomic risk factors for development of epilepsy among children who experience SE as their first seizure and clinical and genomic risk factors for benzodiazepine- resistant SE. SEED will provide valuable insights into childhood SE in sub-Saharan Africa.</p> <p><strong><a href="https://reporter.nih.gov/search/m_2mDM0dI0yfqAecOVdqcA/project-details/10051221#details">Link to NIH Reporter site for more details. </a></strong></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2125" hreflang="und"> Childhood Status Epilepticus</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=716" hreflang="und">Epilepsy</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2126" hreflang="und">Genome-wide Association Studies: GWAS</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2127" hreflang="und">Aminu Kano Teaching Hospital AKTH and Bayero University Kano</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2128" hreflang="und">Sydney Brenner Institute for Molecular Bioscience and H3Africa</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2104" hreflang="und">University of the Witwatersrand</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2129" hreflang="und">Michele Ramsay</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=715" hreflang="und">Edwin Trevathan</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2110" hreflang="und">Umar Sabo</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2117" hreflang="und">Donna Ingles</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Thu, 01 Apr 2021 18:29:19 +0000 ridingkm 2696 at https://www.vumc.org/global-health Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/traditional-healer-initiated-hiv-counseling-and <span class="field--node--title">Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 01/01/2021 - 16:58</span> <a href="/global-health/blog-post-rss/2681" class="feed-icon" title="Subscribe to Traditional Healer-initiated HIV Counseling and Testing in Rural South Africa"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to the health facility. South Africa has made progress towards their 90-90-90 goals, yet a substantial proportion of the population do not test regularly; only 33.9% of adults in rural Mpumalanga (our study site) underwent HIV testing in the past year. In South Africa, people of low socioeconomic status (SES), men, immigrants, and those who distrust the health system have higher rates of HIV stigma, are more likely to seek care from traditional healers, and are less likely to receive an HIV test. The demographic and sociological characteristics of healers closely mirror this population, making them an ideal group to bridge the health care utilization divide. Development of a Healer-Clinician HIV Prevention Collaborative will facilitate testing and preventive service linkage among those who have traditionally avoided/refused testing via three synergistic strategies: (1) Healer-Initiated Counseling and Testing (HICT) to reinforce the value of HIV testing and teach HIV stigma reduction and coping strategies; (2) Establishing a path for patients to navigate between traditional and allopathic systems to encourage repeat HIV testing (or treatment, if HIV-positive); and (3) Improving the environment at the health facility via a stigma reduction training and “open house” sessions where healers and providers work together to provide patients an opportunity to better understand health services (and increase the likelihood that patients return). We propose to pilot this novel intervention with patients seeking treatment from a select group of trained traditional healers. We hypothesize that patient's seeking traditional treatment will find the offer of testing acceptable, will uptake HIV testing despite high levels of stigma and mistrust of the health system, and will engage in treatment at the health facility after linkage by their traditional healer. The Specific Aims of this study are to: (1) Conduct qualitative interviews with “non-testers” from varied SES and demographic groups to understand the interface of HIV stigma, mistrust in the health system, and HIV testing to create the most acceptable model of healer-based testing; (2) Adapt a successful South African community-based HIV prevention project to create a Healer-Clinician HIV Testing and Prevention Collaborative; and (3) Pilot our Healer-Clinician Collaborative and assess uptake of HIV testing as well as linkage to treatment and prevention services among participants offered healer-initiated counseling and testing. Our team has a proven record of engaging traditional healers to improve patient outcomes, conducting research to evaluate and address mistrust in the health system, HIV stigma, and developing interventions to increase HIV testing uptake.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=783" hreflang="und">Traditional Healers</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=306" hreflang="und">HIV</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 01 Jan 2021 22:58:05 +0000 ridingkm 2681 at https://www.vumc.org/global-health HIV Mobility and Engagement in Care in TN https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/hiv-mobility-and-engagement-care-tn <span class="field--node--title">HIV Mobility and Engagement in Care in TN</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/index.php/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 10/15/2020 - 16:50</span> <a href="/global-health/index.php/blog-post-rss/2622" class="feed-icon" title="Subscribe to HIV Mobility and Engagement in Care in TN"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The project connects Vanderbilt researchers across disciplines in order to understand how often people living with HIV move within or outside of the state, and if this mobility is associated with HIV outcomes.</p> <p>Dr. Ahonkhai’s current work aims to design novel care delivery interventions to improve quality of HIV treatment in resource-limited settings, especially vulnerable populations. Much of her research has focused on populations in Nigeria and South Africa to assess quality of HIV care. Dr. Clouse also has an extensive background in designing and implementing HIV studies, with an emphasis on population mobility and engagement in HIV care in South Africa.</p> <p><em><a href="https://www.vumc.org/global-health/index.php/latest-news-vigh/impact-mobility-hiv-continuum-care-tennessee">VIGH News Article</a></em></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=786" hreflang="und">Aimalohi Ahonkhai</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=355" hreflang="und">Kate Clouse</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=306" hreflang="und">HIV</a>, <a href="/global-health/index.php/current-funding-portfolio-ordered-start-date?tag=2102" hreflang="und">Tennessee Center for AIDS research</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Thu, 15 Oct 2020 21:50:01 +0000 ridingkm 2622 at https://www.vumc.org/global-health UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/uem-vanderbilt-academic-partnership-enhancements <span class="field--node--title">UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 09/09/2020 - 14:07</span> <a href="/global-health/blog-post-rss/2667" class="feed-icon" title="Subscribe to UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p style="margin-top: 5px; margin-bottom: 8px;">The Republic of Mozambique, a Portuguese-speaking country of 28 million people on the southeast coast of Africa, has experienced significant economic growth and distinct progress in improving health indicators over the past two decades. Since the end of a devastating civil war in 1992, health has been a government priority, particularly in response to the crushing burden of HIV/AIDS (the 2015 national prevalence was estimated at 13.2% among adults aged 15-49 years). The UN’s 2018 Human Development Index ranks Mozambique 180th out of the world’s 189 countries.</p> <p>While national efforts to expand HIV health care service delivery have focused on strengthening community-based and regional clinics, there has simultaneously been significant targeted investment to build infrastructure and human capacity in HIV research, innovation, and health education. Medical research, including epidemiologic and health services research, has grown dramatically. This growth has stemmed from both international collaborative projects, such as our current D43 Partnership for Research in Implementation Science- Mozambique (PRISM) award between the Faculty of Medicine at University Eduardo Mondale (UEM) and the Vanderbilt Institute for Global Health (VIGH) at Vanderbilt University Medical Center (VUMC), and also from Mozambique’s increased emphasis on research as a key component of professional and graduate education in biomedical sciences and public health.</p> <p>We seek to substantially build upon the groundwork laid by the PRISM collaboration for HIV implementation science research capacity at UEM, Mozambique’s principal medical school.  Through a series of PRISM evaluations, we have identified two areas for which UEM needs further infrastructure development to better serve the growth in research initiatives.  We propose here the UEM-Vanderbilt Academic Partnership for Enhancements in Research (APER) program which will focus on further strengthening UEM´s local HIV research capacity through targeted capacity building in Grants Management and Biostatistics, two significant gaps identified in current capacity building activities.</p> <p>Our Specific Aims are to 1) Promote sustainability and increased faculty competitiveness in grants management through capacitation of the newly created UEM Office of Project Support in coordination with the Faculty of Medicine Administration/Finance Office; and to 2) Develop a Biostatistics “Core” within UEM´s Implementation Science Unit to provide biostatistics support to faculty and students in the conduct of their research.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=156" hreflang="und">Capacity Building Research</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=790" hreflang="und">Implementation Science</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=553" hreflang="und">University Eduardo Mondlane (UEM)</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 09 Sep 2020 19:07:07 +0000 ridingkm 2667 at https://www.vumc.org/global-health Liberia IRB Practicum and Workshop Series: Ethics Supplement https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/liberia-irb-practicum-and-workshop-series-ethics <span class="field--node--title">Liberia IRB Practicum and Workshop Series: Ethics Supplement</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 09/04/2020 - 14:10</span> <a href="/global-health/blog-post-rss/2668" class="feed-icon" title="Subscribe to Liberia IRB Practicum and Workshop Series: Ethics Supplement"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="MsoNormal">Building on the partnership with University of Liberia, College of Health Sciences (ULCHS), the Vanderbilt Institute for Global Health (VIGH) will develop a develop a one-year research ethics education program for members of four institutional review boards (IRBs) in Monrovia, Liberia. Research education and training activities will adapt to the Liberian context from the well-established Collaborative Research Ethics Education (Formação Colaborativa em Etica na Pesquisa, FoCEP) Program for Mozambique.<p></p></p> <ul> <li>Two-Part Research Ethics Practicum Targeting Liberian IRB Directors/Administrators</li> <li>Two Part IRB Committee Member Workshop Series on Research Ethics, Research Integrity, and RCR<span style="font-size:11.0pt;font-family:&quot;Arial&quot;,sans-serif;mso-fareast-font-family:&#10;Calibri;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA;mso-bidi-font-style:italic"> </span></li> </ul> <p>This project is a Supplement for VU-Mozambique Collaborative Research Ethics Education Program <p></p>Formação Colaborativa em Ética na Pesquisa (FoCEP) 5R25TW009722-08<p></p></p> <p>This program builds upon successes of its first five-year period and will continue to nurture a new generation of global health researchers from Mozambique in the ethical review of human participant research and the responsible conduct of research (RCR). This program will continue to strengthen the development and institutionalization of a system for ethical review of human research protocols in Mozambique's biomedical research institutions and newly developed Research Ethics Committees (REC). The present proposal has been developed in response to focused and carefully considered requests from the leadership of UEM and the Mozambican National Bioethics Committee for Health (Comité Nacional de Bioética para Saúde, CNBS) for VUMC's assistance in developing national capacity for ethical review of human studies protocols and teaching research ethics to biomedical and public health investigators.</p> <p><a href="https://projectreporter.nih.gov/project_info_details.cfm?aid=9927718&amp;icde=52694503">NIH Reporter Details</a></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2105" hreflang="und">Ethics Research Training</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2106" hreflang="und">Elizabeth Heitman</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=741" hreflang="und">Liberia</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=382" hreflang="und">Marie Martin</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 04 Sep 2020 19:10:55 +0000 ridingkm 2668 at https://www.vumc.org/global-health Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (V-BRCH) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/vanderbilt-nigeria-building-research-capacity-hivnon <span class="field--node--title"> Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (V-BRCH)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 06/01/2020 - 16:25</span> <a href="/global-health/blog-post-rss/2619" class="feed-icon" title="Subscribe to Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (V-BRCH)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://vumc.org/v-brch" target="_blank">https://vumc.org/v-brch</a></div> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The Vanderbilt-Nigeria Building Research Capacity in HIV/Non-communicable Diseases (V-BRCH) Program builds capacity of Nigerian investigators to successfully initiate and implement high-quality clinical trials in HIV-associated non-communicable diseases.</p> <p>The project builds upon longstanding and highly successful collaborations between two leading research institutions in Nigeria and the United States — Aminu Kano Teaching Hospital (AKTH) and Vanderbilt University Medical Center. V-BRCH will be led by Muktar Aliyu, MD, DrPH, professor of Health Policy and Medicine and associate director for research for VIGH, William Wester, MD, MPH, professor of Medicine at VUMC, and Mahmoud Sani, MBBS, PhD, professor of Medicine and Dean of Clinical Sciences at Bayero University Nigeria and Consultant Cardiologist at AKTH.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=420" hreflang="und">Muktar Aliyu</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=669" hreflang="und">William Wester</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=306" hreflang="und">HIV</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=754" hreflang="und">Non-Communicable Diseases (NCDs)</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2117" hreflang="und">Donna Ingles</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 01 Jun 2020 21:25:59 +0000 ridingkm 2619 at https://www.vumc.org/global-health UEM Partnership for Research in Implementation Science in Mozambique (PRISM) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/uem-partnership-research-implementation-science-0 <span class="field--node--title">UEM Partnership for Research in Implementation Science in Mozambique (PRISM)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 05/15/2020 - 16:34</span> <a href="/global-health/blog-post-rss/2620" class="feed-icon" title="Subscribe to UEM Partnership for Research in Implementation Science in Mozambique (PRISM)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The UEM Partnership for Research in Implementation Science in Mozambique (PRISM) program supports a partnership between VIGH and University Eduardo Mondlane (UEM) in Mozambique to build upon the successes of the first five year grant and continues to build research capacity and conduct HIV-focused implementation science research at UEM.</p> <p>The program is beginning to achieve a critical mass of investigators and will continue to train the next generation of Mozambican researchers, said Troy Moon, MD, MPH, associate professor of Pediatrics at VUMC, who leads PRISM and directs several other HIV-related grants in Mozambique. Mohsin Sidat, MD, MSc, PhD, former Dean of the Faculty of Medicine at University Eduardo Mondlane co-directs the program and serves as director of the newly created UEM Implementation Science Unit.</p> <p><em><a href="https://news.vumc.org/2020/06/09/vigh-awarded-3-million-for-building-research-capacity-in-nigeria-and-mozambique/">VUMC Reporter Article</a></em></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=553" hreflang="und">University Eduardo Mondlane (UEM)</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2103" hreflang="und">Federal University of São Paulo</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=156" hreflang="und">Capacity Building Research</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 15 May 2020 21:34:39 +0000 ridingkm 2620 at https://www.vumc.org/global-health The Risk Of HIV Acquisition Among Traditional Healers In South Africa: Implementing Novel Strategies To Improve Protective Behavior https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/risk-hiv-acquisition-among-traditional-healers-south <span class="field--node--title">The Risk Of HIV Acquisition Among Traditional Healers In South Africa: Implementing Novel Strategies To Improve Protective Behavior</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 04/01/2020 - 16:41</span> <a href="/global-health/blog-post-rss/2621" class="feed-icon" title="Subscribe to The Risk Of HIV Acquisition Among Traditional Healers In South Africa: Implementing Novel Strategies To Improve Protective Behavior"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Project Narrative: Traditional healers, community-based partners with the national health system of South Africa, are exposed to patient blood an average of 1,500 times during their careers due to the practice of delivering herbal remedies via herbs rubbed into dozens of sub-cutaneous cuts. The purpose of this proposal is to compare two implementation strategies to increase consistent use of PPE: (1) a health care worker provided training program followed by 3 educational outreach and coaching visits at the healer's place of practice vs. (2) a training and educational outreach initiative led by a team of health care workers and healers who adopted and use PPE on their own (early adopters) to assess their effects on exposure to patient blood. With an HIV prevalence among healers well above that in the baseline population (30% vs. 19%) and HIV prevalence of 59% among those exposed to patient blood, this study will allow us to test a novel implementation strategy for delivering PPE training to prevent new HIV infections among a newly identified high-risk population in a region with the world's highest HIV prevalence.</p> <p><strong><a href="https://www.vumc.org/global-health/latest-news-vigh/preventing-occupational-exposure-bloodborne-pathogens-among-rural-south-african"><em>VIGH News Article</em></a></strong><br /> <br /> <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9922456&amp;icde=52027446">NIH Reporter Grant Number 1R21AI150302-01</a></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=783" hreflang="und">Traditional Healers</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=306" hreflang="und">HIV</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2104" hreflang="und">University of the Witwatersrand</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 01 Apr 2020 21:41:31 +0000 ridingkm 2621 at https://www.vumc.org/global-health CareConekta: study protocol for a randomized controlled trial of a mobile health intervention to improve engagement in postpartum HIV care in South Africa https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/careconekta-study-protocol-randomized-controlled-trial <span class="field--node--title">CareConekta: study protocol for a randomized controlled trial of a mobile health intervention to improve engagement in postpartum HIV care in South Africa</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Sun, 03/01/2020 - 16:56</span> <a href="/global-health/blog-post-rss/2623" class="feed-icon" title="Subscribe to CareConekta: study protocol for a randomized controlled trial of a mobile health intervention to improve engagement in postpartum HIV care in South Africa"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>South Africa has more HIV/AIDS patients than any other country and is home to the world’s largest antiretroviral program. According to the World Bank, as of 2018 the prevalence of HIV among South Africans ages 15 to 49 was 20.4%. Nearly one in three pregnant women attending antenatal care in South Africa is living with HIV.</p> <p>As South Africans with HIV move around the country, there is a risk they will disengage from the health care system or otherwise become lost to follow-up care.</p> <p>To study and address this risk, <a href="https://my.vanderbilt.edu/kateclouse/">Kate Clouse</a>, PhD, MPH, assistant professor of Nursing and Medicine and part of the core faculty at the Vanderbilt Institute for Global Health, is working with researchers in South Africa and California on a randomized controlled trial of a smartphone app called CareConekta. Clouse devised CareConekta in collaboration with University of Cape Town researchers Tamsin Phillips, PhD, and Landon Myer, PhD, MBChB.</p> <p>The app is designed to facilitate patient engagement with HIV care across the peripartum period, that is, shortly before, during and immediately after giving birth.</p> <p><em><a href="https://news.vumc.org/2020/05/07/team-to-test-app-for-improving-hiv-care-for-new-mothers-in-south-africa/">VUMC Reporter Article</a></em></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=355" hreflang="und">Kate Clouse</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=771" hreflang="und">MHealth</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=148" hreflang="und">Biomedical research informatics</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Sun, 01 Mar 2020 22:56:14 +0000 ridingkm 2623 at https://www.vumc.org/global-health PeerNaija: A Mobile Health Platform https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/peernaija-mobile-health-platform <span class="field--node--title">PeerNaija: A Mobile Health Platform</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 09/26/2019 - 18:48</span> <a href="/global-health/blog-post-rss/2688" class="feed-icon" title="Subscribe to PeerNaija: A Mobile Health Platform"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The scale-up of global antiretroviral therapy (ART) represents an unparalleled global health success story, leading to impressive overall reductions in HIV-related morbidity and mortality. However, adolescents and young adults (AYA), especially those in Sub-Saharan Africa, have largely been left out of this story. While AIDS-related deaths declined by 30% for adults from 2005-2012, they increased by 50% among AYA over the same period, making AIDS the leading cause of death among African youth. AYA living with HIV perform poorly across the entire care continuum. ART adherence is central to effective HIV treatment, but AYA have high rates of virologic failure, virologic rebound after initial suppression, and attrition from HIV care. Unique developmental features of adolescence and young adulthood such as impulsivity, risk-taking, and poor concrete thinking make daily medication adherence even more challenging in this population. In addition, the attitudes and behaviors of young people are often strongly influenced by their peers. This influence can be seen as a powerful incentive for desired behaviors. Much of the literature has focused on financial incentives, which have shown success in promoting health behaviors. There are few data exploring mobile health (mHealth) technologies to exploit social and financial incentives, yet mHealth platforms allow for the delivery of novel behavioral interventions. With the proliferation of mobile phone ownership in Sub-Saharan Africa in general and in Nigeria in particular, such interventions can be delivered where there is greatest need. More than 75% of HIV-infected AYA live in Sub-Saharan Africa, and fully 10% reside in Nigeria. In this proposal, we will adapt an mHealth application, PEERNaija, to leverage both social and financial incentives to improve medication adherence among AYA living with HIV in Nigeria. We will also work with our partners at APIN Public Health in Nigeria to improve capacity to conduct independent mHealth research. The PEERNaija application will feature routine medication reminders, along with individual adherence monitoring with adherence scores, anonymized peer adherence scores (from peers attending the same clinic; social incentive), and a monthly lottery-based prize for youth with the highest adherence scores (financial incentive). To accomplish these aims, we will build on previous collaborations between Vanderbilt and APIN, a multi-site PEPFAR-supported program serving more than 250,000 persons living with HIV in Nigeria. We will engage key stakeholders in the community through focus groups and key informant interviews to guide iterative adaptation of the app. We will recruit a cohort of 50 HIV-infected AYA to pilot the app and assess feasibility, acceptability, adoption, and preliminary efficacy of important clinical measures (including adherence and virologic suppression). The proposed study will provide important preliminary data for the role of mHealth platforms to harness and deliver social and financial incentives to promote adherence efforts, especially for vulnerable youth, and for a larger intervention trial evaluating this app among HIV-infected AYA in Nigeria.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=786" hreflang="und">Aimalohi Ahonkhai</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=771" hreflang="und">MHealth</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=441" hreflang="und">Nigeria</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Thu, 26 Sep 2019 23:48:27 +0000 ridingkm 2688 at https://www.vumc.org/global-health Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/bridging-childhood-epilepsy-treatment-gap-africa <span class="field--node--title">Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 08/28/2019 - 12:30</span> <a href="/global-health/blog-post-rss/2412" class="feed-icon" title="Subscribe to Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>Principal Investigator: <a href="https://www.vumc.org/global-health/person/edwin-trevathan-md-mph">Edwin Trevathan, MD, MPH</a></strong></p> <p>About half of the world's children with epilepsy do not receive treatment – known as the epilepsy treatment gap – with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs). We will conduct the first cluster-randomized clinical trial (cRCT) to determine the efficacy, implementation, and cost-effectiveness of a novel intervention shifting childhood epilepsy care to epilepsy-trained community health extension workers in an effort to close the epilepsy treatment gap. This research will provide information to help extend epilepsy treatment to children in LMICs and worldwide who suffer from untreated seizures.</p> <p><strong>Abstract: </strong>About half of the world's children with epilepsy are not receiving treatment – known as the epilepsy treatment gap, and largely due to the 67%-90% of children in low- and middle-income countries (LMICs) with epilepsy who do not receive treatment.</p> <p>Task-shifting epilepsy care to community health extension workers (CHEWs) working in primary healthcare centers (PHCs) has been recommended by the World Health Organization, but evidence of efficacy for task-shifted epilepsy care is lacking, and large-scale task-shifted epilepsy care has not been implemented. In preparation for a first cluster-randomized clinical trial (cRCT) of task- shifted childhood epilepsy care, we developed and piloted in northern Nigeria (R21TW010899).</p> <ul> <li>(a) a scalable epilepsy training program for CHEWs,</li> <li>(b) an epilepsy community education program in the local language (Hausa), and</li> <li>(c) an epilepsy data collection and management system. We also</li> <li>(d) validated an epilepsy screening tool in this population and</li> <li>(e) documented the feasibility of enrolling children into a study of task- shifted epilepsy care. We now propose this project, “Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)”, as the first cRCT of task-shifted childhood epilepsy care in Africa.</li> </ul> <p>Sixty PHCs in three northern Nigeria cities (Kano, Zaria, and Kaduna) with an estimated epilepsy treatment gap of 70% will be randomly selected; 30 PHCs will provide task-shifted (to CHEWs) childhood epilepsy care, and 30 PHCs will provide enhanced usual care (EUC) (referral to a physician for epilepsy management plus primary care by an epilepsy- trained CHEW).</p> <p>CHEWs with additional training in epilepsy will screen ~270,000 children ages 1-17, of which we estimate (based on preliminary data) 1700-2552 will have untreated epilepsy, 1530-2297 will enroll in the cRCT, and 1377-2067 will complete the 24-month cRCT. Assuming an equal proportion of children who are seizure-free for at least six months at 24 months follow-up in the two cRCT arms, we will achieve ≥ 80% power to determine an efficacy difference of 10% or greater between the arms.</p> <p>Secondary outcomes of the cRCT will include the percent seizure reduction from enrollment baseline, time to next seizure after a 3-month period of seizure freedom, and accuracy of epilepsy diagnosis and seizure type classification, as determined by blinded physician epilepsy specialists.</p> <p>Socio-behavioral and implementation outcomes will also be determined for the two arms of the cRCT, including acceptability, appropriateness, and feasibility among the healthcare providers and quality of life, epilepsy-associated stigma, and trust in healthcare providers among parents/guardians and enrolled patients (if age 15-17 years).</p> <p>The cost-effectiveness of the task-shifted epilepsy care intervention will be determined in US dollars and Nigerian Naira per additional quality adjusted life year (QALY). This cRCT will inform the implementation of task-shifted care systems to address the childhood epilepsy treatment gap and establish a network of community-based clinical epilepsy research centers in northern Nigeria.</p> <p>More from the NIH Reporter (1R01NS113171-01)</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=715" hreflang="und">Edwin Trevathan</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=716" hreflang="und">Epilepsy</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=111" hreflang="und">Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=784" hreflang="und">Community Health Workers</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=441" hreflang="und">Nigeria</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 28 Aug 2019 17:30:33 +0000 ridingkm 2412 at https://www.vumc.org/global-health The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/partnership-research-emerging-viral-infections-sierra <span class="field--node--title">The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 08/28/2019 - 12:20</span> <a href="/global-health/blog-post-rss/2410" class="feed-icon" title="Subscribe to The Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Project Summary/ Abstract: The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have just completed a Planning Grant for Emerging Epidemic Virus Research Training for West African Countries with Widespread Transmission of Ebola- Guinea, Liberia, and Sierra Leone (D71TW010411), that has allowed us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Combining this with our extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades managing institutional research, training, and capacity-building grants; we propose here our comprehensive research training plan in response to PAR-18-840-Global Infectious Disease Research Training. We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone (USL), College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aims are to 1) Enhance research capacity at KGH and COMAHS for the conduct of scientifically valid and ethically acceptable clinical trials, with a focus on Ebola, Lassa, and other VHF; 2) Strengthen and expand the KGH and COMAHS research pool with a focus on Implementation Science research for the clinical management of patients with VHF; and 3) Nurture innovative mentored research by PREVSL trainees/alumni to address the clinical management of VHF. Our comprehensive training program will consist of a combination of (1) long-term Masters training in clinical investigation with a focus on vaccine clinical trial capacity; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research through in-country short courses and Masters training in Public Health; and (4) sustainable capacity building at KGH and COMAHS for the management and administration of future research grant opportunities.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=742" hreflang="und">Sierra Leone</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=156" hreflang="und">Capacity Building Research</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=791" hreflang="und">clinical trial capacity</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=792" hreflang="und">Viral Hemorrhagic Fevers</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=221" hreflang="und">Ebola</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Wed, 28 Aug 2019 17:20:55 +0000 ridingkm 2410 at https://www.vumc.org/global-health Collaborative Research Ethics Education-Mozambique (Formaçao Colaborativa em Etica na Pesquisa, FoCEP) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/collaborative-research-ethics-education-mozambique <span class="field--node--title">Collaborative Research Ethics Education-Mozambique (Formaçao Colaborativa em Etica na Pesquisa, FoCEP)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 08/23/2019 - 12:23</span> <a href="/global-health/blog-post-rss/2411" class="feed-icon" title="Subscribe to Collaborative Research Ethics Education-Mozambique (Formaçao Colaborativa em Etica na Pesquisa, FoCEP)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The goal of the program is to build capacity for research ethics training and education in Mozambican academic institutions and other Portuguese speaking African countries, namely Angola and Cape Verde.  Support will be given for foreign graduate students to pursue PhD training in Applied Ethics as well as an executive Research Ethics Certificate course on the principles of ethics applicable to resource-limited countries.</p> <p>Abstract: The growth in research activity projected for the next decade by the Mozambican government and multiple international agencies highlights the continued need for capacity building in research ethics well into the future. With the groundwork laid for systems of basic, translational, clinical and public health research, parallel capacity development in research ethics will be essential to address critical locally relevant research questions in an ethically-consistent way. The four most evident areas in which attention is needed are: 1) ethics education, review and oversight of graduate and professional student researchers and their thesis research projects; 2) the burgeoning growth of research using biological specimens and clinical and epidemiologic data, including the development of biobanks and a national data warehouse; 3) research on the prevention and treatment of infectious and non-communicable diseases; and 4) international collaborative research that requires dual review and agreement on the authority of the potentially different regulatory requirements of partner countries. A team of experienced research ethics educators from UEM, UTSW, and VIGH, in collaboration with the National Bioethics Committee for Health (CNBS) seeks to renew the Formação Colaborativa em Etíca na Pesquisa, FoCEP (Collaborative Research Ethics Education-Mozambique). We propose a series of interrelated educational aims and activities intended to build capacity for ethical design, review, and conduct of biomedical research in Mozambique. The specific aims of this study are to 1) expand the cadre of Mozambican leaders in biomedical research with in-depth knowledge and practical skills in both research design and the ethical conduct of clinical and epidemiologic research through a tailored MPH program and masters-level curriculum enhancements at UEM; 2) enhance the knowledge and practical skills of Mozambican REC members and research educators in research ethics, RCR, and research integrity; and 3) further create, evaluate, and distribute curricular materials on research ethics and the responsible conduct of research tailored to Portuguese speaking Africa. After 5 years of collaborative engagement in phase one of FoCEP activities, the program implementation team is uniquely familiar with the country's challenges and are well positioned to further develop Mozambique's capacity in research ethics, ethical review of research protocols, and the provision of research ethics and integrity education to the country's next generation of health researchers. The team has comprehensive knowledge of research ethics and the responsible conduct of research; skill in health sciences education; and fluency in Portuguese that, together with its established relationships within the National and Institutional Bioethics Committees, Ministry of Health, and research-oriented universities, make it well suited to carry out this renewal program proposed here.</p> <p>Project Details: <a href="https://reporter.nih.gov/search/bTh3_8kxpE21BWjkxwq3Mw/project-details/10075335#details">NIH Reporter</a></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=231" hreflang="und">Ethics</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=553" hreflang="und">University Eduardo Mondlane (UEM)</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 23 Aug 2019 17:23:47 +0000 ridingkm 2411 at https://www.vumc.org/global-health Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/immunogenetic-predictors-active-and-incipient-tb-hiv <span class="field--node--title">Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts</span> <div class="field field--name-field-barista-posts-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?cat=803" hreflang="und">Funding (Active Grants)</a></div> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/ridingkm-0" typeof="schema:Person" property="schema:name" datatype="">ridingkm</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 07/11/2019 - 16:47</span> <a href="/global-health/blog-post-rss/2404" class="feed-icon" title="Subscribe to Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>Principal Investigators: </strong></p> <p><a href="https://www.vumc.org/global-health/person/timothy-r-sterling-md">Timothy Sterling, MD</a><br /> Bruno Andrade<br /> Thomas Hawn</p> <p>Critical to preventing tuberculosis (TB) is a better understanding of the protective and predisposing factors for progression from M. tuberculosis infection to TB disease. Our group has reported a peripheral blood correlate of risk (COR) transcriptional signature that identified persons with incipient (asymptomatic) TB who progressed to active (symptomatic)TB within 12 months, and also human genetic polymorphisms in a DNA sensor gene region (PYHIN1-IFI16-AIM2) associated with TB risk. We seek to evaluate the immunogenetic and epidemiologic risk factors for active and incipient TB in a Brazilian cohort of HIV-negative and HIV-positive close TB contacts, to identify host pathways associated with protection against TB (for future vaccines), and to identify persons who would benefit from TB preventive therapy.</p> <p>Drs. Timothy Sterling, Bruno Andrade (Instituto Brasileiro para Investigação da Tuberculose (IBIT), Salvador, Brazil), and Thomas Hawn (University of Washington) received a 5 year R01 grant from the National Institutes of Health entitled, “Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts” (R01AI147765). This was in response to PAR-16-254, "Mechanisms of Mycobacterial-Induced Immunity in HIV-Infected and Uninfected Individuals to Inform Innovative Tuberculosis Vaccine Design (R01)." Total funding awarded for the 5-year project is $3.6 million, with subcontracts to the Fundação para o Desenvolvimento Científico e Tecnológico em Saúde (FIOTEC; Brazil), the University of Washington, and the University of Cape Town (South Africa). Collaborators include Spyros Kalams, Simon Mallal, Mark Pilkinton, and Peter Rebeiro at Vanderbilt; Valeria Rolla, Afranio Kritski, Marcelo Cordeiro Santos, Solange Cavalcante, Cristina Lourenco, and Ricardo Khouri in Brazil; Javeed Shah at the University of Washington; and Mark Hatherill, Thomas Scriba, and Stanley Kimbung at the University of Cape Town.</p> <p>This grant project seeks to understand the protective and predisposing factors for progression from M. tuberculosis infection to TB disease. The group has previously reported a peripheral blood correlate of risk (COR) transcriptional signature that identifies persons with incipient (asymptomatic) TB who subsequently progress to active (symptomatic) TB within 12 months, and also human genetic polymorphisms in a DNA sensor gene region (PYHIN1-IFI16-AIM2) associated with TB risk. In this project, the group will evaluate innate immune responses in macrophages and their correlates with human genetic polymorphisms, acquired immunity to M. tuberculosis, and epidemiologic factors associated with the risk of incipient and active TB. These studies will be performed in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort, which includes culture-confirmed TB cases and their close contacts in racially and ethnically diverse Brazil. This work may identify host pathways associated with protection against TB (for future host-directed therapies and vaccines), and to identify persons infected with M. tuberculosis who would benefit most from TB preventive therapy.</p> <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9848749&amp;icde=45469321">MORE from the NIH Reporter website</a></p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=537" hreflang="und">Timothy Sterling</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=782" hreflang="und">Tuberculosis</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=306" hreflang="und">HIV</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Thu, 11 Jul 2019 21:47:05 +0000 ridingkm 2404 at https://www.vumc.org/global-health Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/community-i-star-mozambique-community-implementation <span class="field--node--title">Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/leadee1-0" typeof="schema:Person" property="schema:name" datatype="">leadee1</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 05/06/2019 - 13:46</span> <a href="/global-health/blog-post-rss/2363" class="feed-icon" title="Subscribe to Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>PI: <a href="https://www.vumc.org/global-health/person/carolyn-audet-phd">Carolyn Audet, Ph.D.</a></p> <p><strong>Community I-STAR Mozambique: Community Implementation of SBIRT using Technology for Alcohol use Reduction in Mozambique</strong><br /> Hazardous drinking is a major public health burden worldwide with significant morbidity and mortality. Community I-STAR Mozambique will examine the implementation and effectiveness of two different strategies to train and supervise community health workers in Mozambique to sustainably provide community-based services to reduce hazardous drinking. The first strategy is Screening, Brief Intervention, Referral to Treatment (SBIRT), which utilizes mobile health technology. The second strategy will involve traditional training and supervision. Working with the Research Foundation for Mental Hygeine, Dr. Audet is responsible for providing assistance in study design, implementation, and training for fellows. This study will leverage existing platforms and participation of policy makers ready to apply and sustain evidence-informed policies over time, and it will inform policy decision-making and clinical practice not only in Mozambique but also in many other low- and middle-income countries.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=131" hreflang="und">Carolyn Audet</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=414" hreflang="und">Mozambique</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 06 May 2019 18:46:20 +0000 leadee1 2363 at https://www.vumc.org/global-health Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya) https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/higher-education-partnership-innovation-and <span class="field--node--title">Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya)</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/global-health/users/leadee1-0" typeof="schema:Person" property="schema:name" datatype="">leadee1</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 04/19/2019 - 12:00</span> <a href="/global-health/blog-post-rss/2351" class="feed-icon" title="Subscribe to Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya)"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>PI: <a href="https://www.vumc.org/global-health/person/martin-c-were-md-ms">Martin C. Were, M.D., M.S. </a></p> <p>VIGH core faculty member <a href="https://www.vumc.org/global-health/person/martin-c-were-md-ms" rel="noreferrer" target="_blank">Martin Were</a>, M.D., M.S., associate professor of Biomedical Informatics and Medicine, was recently awarded a cooperative agreement from the United States Agency for International Development (USAID) to establish the Higher Education Partnership for Innovation and Sustainable Biomedical Informatics Capacity in Kenya (PISBIC Kenya).  </p> <p>PISBIC Kenya focuses on building workforce capacity; building evidence about the impact, costs, and benefits of health informatics systems; and producing locally responsive digital health solutions.</p> <p>The program is a partnership between Moi University's Institute of Biomedical Informatics and Aga Khan University in Kenya and Vanderbilt University Medical Center and Purdue University in the United States. Dr. Were and his team will pursue the project goals to further the use of digital health technologies in order to improve health care quality, patient and population health outcomes, and data-driven decision-making to improve healthcare delivery systems.</p> <p>This program is one of four projects under the <a href="https://www.vumc.org/global-health/sites/vumc.org.global-health/files/documents/ALP%20one%20pager%202.25.19.pdf">Accelerating Local Potential Program</a> umbrella to help propel "higher education institutions in low- and middle-income countries to become global leaders in scientific education and research, and to increase their presence as a source of knowledge and innovation for local government officials, policy makers, and other development actors."</p> <p>PISBIC Kenya is supported by the U.S. Agency for International Development (USAID), the world's premier international development agency and a catalytic actor driving development results. USAID's work advances U.S. national security and economic prosperity, demonstrates American generosity, and promotes a path to recipient self-reliance and resilience. For more info, visit <a href="https://www.usaid.gov/">www.usaid.gov</a>.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=713" hreflang="und">Martin Were</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=360" hreflang="und">Kenya</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2117" hreflang="und">Donna Ingles</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 19 Apr 2019 17:00:12 +0000 leadee1 2351 at https://www.vumc.org/global-health Population-based survey for Lwala Community Alliance https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/population-based-survey-lwala-community-alliance <span class="field--node--title">Population-based survey for Lwala Community Alliance </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Fri, 12/07/2018 - 16:12</span> <a href="/global-health/blog-post-rss/2325" class="feed-icon" title="Subscribe to Population-based survey for Lwala Community Alliance "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>PI: <strong><a href="https://www.vumc.org/global-health/person/troy-moon-md-mph">Troy Moon, M.D., M.P.H.</a></strong></p>&#13; &#13; <p>In collaboration with Lwala Community Alliance, VIGH is developing and implementing a population-based survey for the North, East, South &amp; Central Kamagambo wards of Rongo sub-county, Kenya. The implementation plan includes data and statistical analysis, and technical support. In addition, to providing a sampling frame, other support includes oversight of  Vanderbilt MPH student thesis and manuscript generation.</p>&#13; </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=544" hreflang="und">Troy Moon</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=374" hreflang="und">Lwala Community Alliance</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=809" hreflang="und">Monitoring and Evaluation</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Fri, 07 Dec 2018 22:12:45 +0000 Visitor 2325 at https://www.vumc.org/global-health Population mobility and retention in HIV care among postpartum women in South Africa https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/population-mobility-and-retention-hiv-care-among <span class="field--node--title">Population mobility and retention in HIV care among postpartum women in South Africa</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 10/01/2018 - 00:00</span> <a href="/global-health/blog-post-rss/2323" class="feed-icon" title="Subscribe to Population mobility and retention in HIV care among postpartum women in South Africa"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Principal Investigator(s): <br /> <a href="https://www.vumc.org/global-health/person/kate-clouse-phd-mph">Kate Clouse, Ph.D., M.P.H.</a></p> <p><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=8919531&amp;icde=39447271&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=4&amp;csb=default&amp;cs=ASC&amp;pball="><strong>Population mobility and retention in HIV care among postpartum women in South Africa (K01MH107256)</strong></a><br /> HIV-positive women in South Africa are at high risk of dropping out of HIV care soon after delivery, endangering the life of the mother and infant. The impact of population mobility around the time of delivery on retention in HIV care is unknown. This mentored K01 award will support training and research to explore the impact of population mobility on retention in postpartum HIV care and gather critical information for the development of future interventions to improve retention in HIV care.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=355" hreflang="und">Kate Clouse</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=516" hreflang="und">South Africa</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=315" hreflang="und">HIV/AIDS</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=387" hreflang="und">Maternal and Child Health</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Mon, 01 Oct 2018 05:00:00 +0000 Visitor 2323 at https://www.vumc.org/global-health Clayton-Dedonder Global Health Mentorship Fellows Program: UNZA Mentoring Programme https://www.vumc.org/global-health/current-funding-portfolio-ordered-start-date/clayton-dedonder-global-health-mentorship-fellows <span class="field--node--title">Clayton-Dedonder Global Health Mentorship Fellows Program: UNZA Mentoring Programme </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" typeof="schema:Person" property="schema:name" datatype="">Visitor</span></span> <span class="field field--name-created field--type-created field--label-hidden">Sun, 07/01/2018 - 00:00</span> <a href="/global-health/blog-post-rss/2324" class="feed-icon" title="Subscribe to Clayton-Dedonder Global Health Mentorship Fellows Program: UNZA Mentoring Programme "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>PI: <a href="https://www.vumc.org/global-health/person/douglas-c-heimburger-md-ms">Douglas Heimburger, M.D.</a> and <a href="https://www.vumc.org/global-health/person/marie-h-martin-phd-med">Marie Martin, Ph.D., M.Ed.</a></strong></p> <p>The Clayton-Dedonder Global Health Mentorship Fellows Program (CD) is a mentorship and training program awarded to the University of Zambia (UNZA) and its institutional partners. This fellowship will utilize and build upon the existing UNZA-Vanderbilt Partnership for HIV Nutrition-Metabolic Research Training (UVP) program by designing and implementing a Ph.D. mentoring program. The CD Fellowship will support intensive mentorship training to strengthen the UNZA Ph.D. Program under the UNZA College of Medicine to enhance its capacity to train future researchers. </p> <p>The intensive mentorship and leadership training program will both train junior faculty members and engage senior faculty members to hone their mentorship skills. Both senior and junior groups will comprise all Ph.D.-training disciplines at UNZA. Two core principles will guide this capacity building approach. First, senior UNZA faculty will lead the curriculum development process to facilitate context-appropriateness, ensure sustainability, enhance their knowledge, and hone their mentorship skills. Second, the IHI Collaborative Model will serve as a framework for curriculum development, implementation, and evaluation.</p> <p>Overall, this program will support UNZA to establish and grow its Ph.D. mentor training program for the College of Medicine's four schools (Medicine, Public Health, Health Sciences, and Nursing), train 10 Clayton-Dedonder fellows in mentorship of UNZA Ph.D. students and use an iterative evaluation model to optimize the training program and integrate it as a required component of the UNZA Ph.D. Program.</p> <p>The<a href="https://www.fic.nih.gov/News/Pages/2018-hiv-aids-mentoring-supplements-fellows-scholars.aspx"> Clayton-Dedonder Global Health Mentorship Fellows Program is funded by Fogarty</a> as part of its effort to strengthen HIV/AIDS research training in low- and middle-income countries. UNZA is one of six organizations to receive this funding.</p> </div> <div class="field field--name-field-barista-posts-tags field--type-entity-reference field--label-inline"> <div class="field__items"> <div class="field__item"><a href="/global-health/current-funding-portfolio-ordered-start-date?tag=795" hreflang="und">International Training Grant/Program</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=789" hreflang="und">University of Zambia (UNZA)</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=212" hreflang="und">Doug Heimburger</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=382" hreflang="und">Marie Martin</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=711" hreflang="und">Elizabeth Rose</a>, <a href="/global-health/current-funding-portfolio-ordered-start-date?tag=2111" hreflang="und">Holly Cassell</a></div> </div> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__item">1</div> </div> Sun, 01 Jul 2018 05:00:00 +0000 Visitor 2324 at https://www.vumc.org/global-health