Dario Englot, MS, PhD, MD

Dario
Englot
MS, PhD, MD
Associate Professor of Neurological Surgery
Neurology, Radiology & Radiological Sciences, Computer Science, Electrical & Computer Engineering, and Biomedical Engineering
(415) 732-9102

One major focus of my lab is to understand the complex network perturbations in patients with epilepsy, by relating network changes to neurocognitive problems, disease parameters, and changes in vigilance. We also study the effects of brain surgery and neurostimulation on brain networks in epilepsy patients, surgical outcomes in functional neurosurgery, and normal human brain network physiology in relation to consciousness, cognition, and arousal.

Our current projects utilize multimodal data from human intracranial EEG (iEEG), functional MRI (fMRI), diffusion tensor imaging (DTI), and other tools to evaluate resting-state, seizure-related, and task-based paradigms in epilepsy.

Publications

Makhoul GS, Doss DJ, Johnson GW, Withers CP, Cavender AC, Hidalgo Monroy Lerma B, Reda A, Bibro CE, Liao E, Kang H, Dawant BM, Reddy SB, Crudele AN, Constantinidis C, Roberson SW, Bick SK, Morgan VL, Englot DJ (2025) Collapse of interictal suppressive networks permits seizure spread. Brain, in press.

Doss DJ, Shless JS, Bick SK, Makhoul GS, Negi AS, Bibro CE, Rashingkar R, Gummadavelli A, Chang C, Gallagher MJ, Naftel RP, Reddy SB, Williams-Roberson S, Morgan VL, Johnson GW, Englot DJ (2024) The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy. Brain 147(9):3009-3017. 

Johnson GW, Doss DJ, Morgan VL, Paulo DL, Cai LY, Shless JS, Negi AS, Gummadavelli A, Kang H, Reddy SB, Naftel RP, Bick SK, Roberson SW, Dawant BM, Wallace MT, Englot DJ (2023) The interictal suppression hypothesis in focal epilepsy: network-level supporting evidence. Brain 146(7):2828-2845.

Paulo DL, Wills KE, Johnson GW, Gonzalez HFJ, Rolston JD, Naftel RP, Reddy SB, Morgan VL, Kang H, Roberson SW, Narasimhan S, Englot DJ (2022)  SEEG functional connectivity measures to identify epileptogenic zones: Stability, medication influence, and recording condition. Neurology 98(20):e2060-e2072.

González HFJ, Narasimhan S, Johnson GW, Wills KE, Haas KF, Konrad PE, Chang C, Morgan VL, Rubinov M, Englot DJ (2021) Role of the nucleus basalis as a key network node in temporal lobe epilepsy. Neurology 96(9):e1334-e1346.

dario.englot@vumc.org

I am a neurosurgeon who treats patients with epilepsy, movement disorders and pain disorders. I conduct research aimed at increasing responder rates in neuromodulation and identifying new strategies for brain stimulation and ablation therapies. My research interests include electrophysiology, neuroimaging and brain network analysis. I lead the Brain Imaging and Electrophysiology Network (BIEN) Lab at Vanderbilt.

Zipei Tan

Zipei
Tan
Graduate Student
(615) 828-3139
zipei.tan@vanderbilt.edu

I am primarily interested in developing new diffusion MRI methods to better characterize properties of cancer cells. I am currently working on a better estimation for newly developed MRI models and signals. I am also developing a new diffusion MRI method to explore the desired cell properties for clinical application.

Ghassan Makhoul

Ghassan
Makhoul
ghassan.makhoul@vanderbilt.edu

I am a graduate student in the BIEN lab researching epilepsy via network neuroscience. I am also concurrently a medical student at the University of Arkansas for Medical Sciences (UAMS). I am interested in understanding how epilepsy remodels brain networks and how this may inform our overall understanding of the brain. I investigate these questions with diffusion weighted imaging and intracranial electroencephalography.

Research: My current research focusses on how seizure foci may remodel normal tissue, such as brainstem nuclei. Repeated seizure propagation may disrupt these nuclei's ability to convey arousal information or conduct sleep stages. Presently, I am using diffusion weight imaging to assess changes in brainstem connectivity.

Publications: 1. Collapse of interictal suppressive networks permits seizure spread https://pubmed.ncbi.nlm.nih.gov/40473247/

Elizabeth Keeling, Ph.D.

Elizabeth
Keeling
Research Fellow Trainee
elizabeth.keeling@vumc.org

I am focused on development and application of advanced MRI methods in the central nervous system outside the brain, with focuses on the spinal cord and optic nerve. Our work investigates different features of these anatomical features, such as function and white matter integrity, in the context of health and relevant diseases, such as multiple sclerosis

I am currently working on characterizing resting state functional connectivity in the lumbar spinal cord in multiple sclerosis patients compared to healthy controls using both region of interest and data-driven analyses. I am also developing an advanced MRI protocol for optic nerve imaging, with a focus on probing white matter/structural integrity and distinguishing between cerebrospinal fluid and the nerve.

Bailey Busher

Bailey
Busher
Imaging Research Specialist I
(954) 806-4473
bailey.busher@vumc.org

Bailey Busher is a Research Imaging Specialist at VUIIS. She received her BA in Medicine, Health, and Society and a minor in Theatre from Vanderbilt University in 2025 where she was also a student athlete on the Vanderbilt Dance Team. Her research interests include exploring advanced MRI techniques to enhance understanding of multiple sclerosis and its impact on disability-related measures.

Terri Cody

Terri
Cody
Administrative Officer
Vanderbilt University Institute of Imaging Science
(615) 875-7408
terri.l.cody@vumc.org

As the Administrative Officer, I oversee the daily operations, budgeting and resource management to ensure efficiency within the Institute. 

I coordinate administrative processes, support staff, and implement policies to meet organizational goals.

Aimee Salakhov

Aimee
Salakhov
Imaging Research Specialist I
aimee.salakhov@vumc.org

I work as a research assistant recruiting healthy volunteers and individuals with multiple sclerosis for MRI imaging at the Neuroimaging Outside of the Brain Lab.

Lori Arlinghaus-Davis

Lori
Arlinghaus-Davis

Imaging Research Scientist, VUIIS 2009 thru 2011

Current: Senior Manager, Clinical Science, Hyperfine

Fatemeh Adelnia

Fatemeh
Adelnia

Research Fellow 2019 thru 2022

Current: Research Assistant Professor, Radiology & Radiological Sciences, VUMC

Sumeda B. Abeykoon

Sumeda
B
Abeykoon

Instructor and Assistant Editor (CAUSE), Middle Tennessee State University 2012 thru 2014

Current: Lecturer, Middle Tennessee State University, Murfreesboro, TN