I like the collaborative environment that I have experienced at VUIIS.
I help with the maintenance of imaging systems and design of supporting hardware.
Colvin DC, Does MD, Yue Z, Quarles C, Yankeelov TE, Gore JC. New Insights into Tumor Microstructure with Temporal Diffusion Spectroscopy. Cancer Res 2008; 68:5941-47.
Gore JC, Xu J, Colvin DC, Yankeelov TE, Parsons EC, Does MD. Characterization of tissue structure at varying length scales using temporal diffusion spectroscopy. NMR Biomed. 2010 Aug; 23(7):745-56. Review
Colvin DC, Loveless ME, Does MD, Yue Z, Yankeelov TE, Gore JC. Earlier detection of tumor treatment response using magnetic resonance diffusion imaging with oscillating gradients. Magn Reson Imaging. 2011 Apr; 29(3):315-23.
Atuegwu NC, Colvin DC, Loveless ME, Xu L, Gore JC, Yankeelov TE. Incorporation of diffusion-weighted magnetic resonance imaging data into a simple mathematical model of tumor growth. Phys Med Biol. 2011 Dec 7;57(1):225-240.
Attia AS, Schroeder KA, Wilson KJ, Seeley EH, Hammer ND, Colvin DC, Manier ML, Nicklay JJ, Rose KL, Gore JC, Caprioli RM, Skaar EP. Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI. Cell Host Microbe 2012 Jun 14;11(6): 664-73
My interests include the development of novel magnetic resonance imaging techniques for preclinical and translational research, with applications ranging from lung cancer to brain cancer to staph infection to stroke.
My work at the VUIIS involves collaborating with scientific investigators in developing magnetic resonance imaging protocols for use in preclinical and translational research, as well as assisting in the management of the magnetic resonance imaging resources within our facility. My daily activities range from programming, testing, and optimizing novel imaging pulse sequences, to acquisition and analysis of MRI data, to providing technical support for collaborators both within the VUIIS and the Vanderbilt medical research community.
Cheung, Y. Y.; Yu, H; Xu, K; Zou, B; Wu, M; McManus, O. B.; Li, M; Lindsley, C. W.; Hopkins, C. R. "Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor," J. Med. Chem., 2012, 55, 6975-6979.
Melancon, B. J.; Utley, T. J.; Sevel, C; Mattman, M. E.; Cheung, Y. Y.; Bridges, T. M.; Morrison, R. D.; Sheffler, D. J.; Niswender, C. M.; Daniels, J. S.; Conn, P. J.; Lindsley, C. W.; Wood, M. R. "Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012," Bioorg. Med. Chem. Lett. 2012, 22, 5053-5040.
Allard, M; Barnes, K; Chen, X; Cheung, Y. Y., Duff, B; Heap, C; Inthavongsay, J; Johnson, M; Krishnamoorthy, R; Manley, C; Steffke, S; Varughese, D; Wang, R; Wang , Y; Schwartz, C. E. "Total synthesis of Resolvin E1," Tetrahedron Lett. 2011, 52, 2023-2626
Cheung, Y. Y.; Zamorano, R; Blobaum, A. L.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R. "Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4," ACS Combi. Sci. 2011, 13, 159-165
Mader, M. M.; Shih, C.; Considine, E.; De Dos, A.; Grossman, C. S.; Hipskind, P. A.; Lin, H-S.; Lobb, K. L.; Lopez, B.; Lopez, J. E.; Cabrejas, L. M. M.; Richett, M. E.; White, W. T.; Cheung, Y. Y.; Huang, Z.; Reilly, J. E.; Dinn, S. R. "Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives," Bioorg. Med. Chem. Lett. 2005, 15, 617-620.
My research at the VUIIS focuses on the rational design and synthesis of small molecules as novel ligands for TSPO with the goal of developing them into [18F]-PET tracers to be used for cancer imaging. I am also involved in collaborative projects which require either the radiosynthesis development of novel [18F]-PET tracers or the production of known [18F]-PET tracers such as FLT, FES, F-Choline and SFB for pre-clinical imaging stud
Having worked in healthcare as a radiologic technologist for seven years, I have shifted my focus to science and research, specializing in advanced imaging techniques at the forefront of medical advancement. I hold an undergraduate degree in radiologic technology and a master’s degree in radiologic sciences, further expanding my expertise in the field.
At VUIIS, I have developed imaging programs for DXA, ultrasound, the X-ray velocimeter, and the HR-pQCT. I have genuinely enjoyed the opportunity to pioneer emerging imaging modalities within the fields of science, radiology, and medical technology, all of which I admire and love.
I love the collaborative environment and the many opportunities for learning and development.
I am very interested in the synthesis new materials for use in the imaging and cancer treatment realm.
I synthesize new materials for molecular imaging and cancer treatment therapies. In addition, I synthesize precursors for radio-labeling. We are currently working on multiple projects in this realm.
Lucas BC, Bogovic JA, Carass A, Bazin PL, Prince JL, Pham DL, Landman BA. The Java Image Science Toolkit (JIST) for Rapid Prototyping and Publishing of Neuroimaging Software. Neuroinformatics. 2010 Jan 14. PMID:20077162 NIHMS PMC:177090
B. A. Landman, H. Wan, J. Bogovic, P.-L. Bazin, and J. L. Prince. Resolution of Crossing Fibers with Constrained Compressed Sensing using Traditional Diffusion Tensor MRI', In Proceedings of the SPIE Medical Imaging Conference. San Diego, CA, February 2010 NIHMS/PMC:158459
B. A. Landman, H. Wan, J. Bogovic, and J. L. Prince. Simultaneous Truth and Performance Level Estimation with Incomplete, Over-complete, and Ancillary Data, In Proceedings of the SPIE Medical Imaging Conference. San Diego, CA, February 2010
B. A. Landman, P-L Bazin, S. A. Smith, and J. L. Prince, Robust Estimation of Spatially Variable Noise Fields, Magnetic Resonance in Medicine, Aug;62(2):500-9. 2009 PMID:19526510 PMC2806192
B. A. Landman, J. A. Farrell, C. K. Jones, S. A. Smith, J. L. Prince, P. C. van Zijl, and S. Mori. Effects of Diffusion Weighting Schemes on the Reproducibility of DTI-derived Fractional Anisotropy, Mean Diffusivity, and Principal Eigenvector Measurements at 1.5T, NeuroImage. 36(4): 1123-1138. July 2007. PMID:17532649
Our research concentrates on analyzing large-scale cross-sectional and longitudinal neuroimaging data. Specifically, we are interested in population characterization with magnetic resonance imaging (MRI), multi-parametric studies (DTI, sMRI, qMRI), and shape modeling.
We are working technologies to enable large-scale and high throughput medical image analysis. Current projects include investigation of statistical label fusion techniques and multi-modal MRI approaches. In support of the VUIIS Center for Computational Imaging, we are developing imaging informatics and automated analysis technologies.
Zhongliang Zu*, Xiaoyu Jiang, Junzhong Xu, John C. Gore, "Spin-lock imaging of 3-o-Methyl-D Glucose (3oMG) in brain tumors", Magnetic Resonance in Medicine, 2018, DOI: 10.1002/mrm.27128
Zhongliang Zu*, Hua Li, Xiaoyu Jiang, John C. Gore, "Spin-lock imaging of exogenous exchange-based contrast agents to assess tissue pH", Magnetic Resonance in Medicine, 2018, 79(1):298.
Xiao-yong Zhang, Feng Wang, Tao Jin, Junzhong Xu, Jingping Xie, Daniel F. Gochberg, John C. Gore, Zhongliang Zu*, "MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4 T", Magnetic Resonance in Medicine, 2017, 78(2), 588.
Xiao-yong Zhang, Jingping Xie, Feng Wang, Eugene C, Lin, Junzhong Xu, Daniel F. Gochberg, John C. Gore, Zhongliang Zu*, "Assignment of the molecular origins of CEST signals at 2 ppm in rat brain", Magnetic Resonance in Medicine, 2017, 78(3), 881.
Xiao-yong Zhang, Feng Wang, Aqeela Afzal, Junzhong Xu, John C. Gore, Daniel F. Gochberg, Zhongliang Zu*, "A new NOE-mediated MT signal at around -1.6 ppm for detecting ischemic stroke in rat brain", Magnetic Resonance Imaging, 2016, 34; 1100.
I am interested in molecular and functional molecular MR imaging using advanced MR sequences including chemical exchange saturation transfer (CEST), magnetization transfer (MT), spin-lock, and MRS spectroscopy, etc. and their applications in tumors, ischemic stroke, and neurological and muscular disorders.
I am working as a principle investigator and a co-investigator on multiple NIH-funded projects. Specifically, I developed novel MR techniques to detect abnormal glucose metabolism and extracellular pH in tumors, intracellular pH in stroke, and high-energy phosphate metabolism in muscular disorders by employing their chemical exchange effect. I also pioneered a study supported by NIH on a novel nuclear Overhauser enhancement (NOE) contrast that may reflect membrane choline phospholipids.
Yang PF, Chen YY, Chen DY, Hu JW, Chen JH, Yen CT, 'Comparison of fMRI BOLD Response Patterns by Electrical Stimulation of the Ventroposterior Complex and Medial Thalamus of the Rat' PLoS One. 2013, 8(6):e66821.
Pai-Feng Yang, Der-Yow Chen, James W Hu, Jyh-Horng Chen, Chen-Tung Yen, 'Functionaltracing of medial nociceptive pathways using activity-dependent manganese-enhanced MRI' Pain 2011, 152: 194-203.
Jun-Cheng Weng, Jyh-Horng Chen, Pai-Feng Yang, Wen-Yih I. Tseng, 'Functional Mapping ofRat Barrel Activation Following Whisker Stimulation Using Activity-Induced Manganese-Dependent Contrast' Neuroimage 2007, 36: 1179-1188.
My research interest is to better understand the neural mechanism underlying pain perception and following spinal cord injury.
My current research projects are fMRI of nociception in non-human primates.
My research pursuits revolve around advancing engineering solutions to address the technical challenges encountered in the field of MRI. My primary objectives encompass improving RF and B0 homogeneity in high-field MRI, accelerating acquisition speed, reducing RF heating near implants, and enhancing the Signal-to-Noise Ratio. Our current research projects include: 1. Solving dark bands in tcMRgFUS using passive reflective antennas; 2. Developing next-generation integrated RF Tx/Rx and B0 shimming coils for 7T brain and spinal cord MRI; 3. Developing flexible RF coils and baluns; 4. Developing RF-transparent B0 shimming coil array; 5. Implementing low-cost wireless coils for clinical scanners; 6. Developing novel materials and devices to reduce RF-related heating near MRI implants.
I received my Ph.D. in particle physics and nuclear physics from the Institute of High Energy Physics, Chinese Academy of Sciences in 2014. I also joined the Radiofrequency (RF) lab of the Institute of Biophysics in 2011, where I developed RF coils and RF/analog circuits for 7 T and 9.4 T scanners. At the end of 2014, I moved to Vanderbilt University Institute of Imaging Science as a Postdoctoral Research Fellow. In 2016, I joined the Vanderbilt faculty as a Research Instructor. I am currently a Research Associate Professor at the Department of Electrical Engineering and Computer Science at Vanderbilt University and the Department of Radiology at Vanderbilt University Medical Center. I am a recipient of the IEEE IMWS-BIO Best student paper award in 2013, and the Summa Cum Laude Award and Magna Cum Laude Award of ISMRM.