Dario Englot, MS, PhD, MD
One major focus of my lab is to understand the complex network perturbations in patients with epilepsy, by relating network changes to neurocognitive problems, disease parameters, and changes in vigilance. We also study the effects of brain surgery and neurostimulation on brain networks in epilepsy patients, surgical outcomes in functional neurosurgery, and normal human brain network physiology in relation to consciousness, cognition, and arousal.
Our current projects utilize multimodal data from human intracranial EEG (iEEG), functional MRI (fMRI), diffusion tensor imaging (DTI), and other tools to evaluate resting-state, seizure-related, and task-based paradigms in epilepsy.
Publications
Makhoul GS, Doss DJ, Johnson GW, Withers CP, Cavender AC, Hidalgo Monroy Lerma B, Reda A, Bibro CE, Liao E, Kang H, Dawant BM, Reddy SB, Crudele AN, Constantinidis C, Roberson SW, Bick SK, Morgan VL, Englot DJ (2025) Collapse of interictal suppressive networks permits seizure spread. Brain, in press.
Doss DJ, Shless JS, Bick SK, Makhoul GS, Negi AS, Bibro CE, Rashingkar R, Gummadavelli A, Chang C, Gallagher MJ, Naftel RP, Reddy SB, Williams-Roberson S, Morgan VL, Johnson GW, Englot DJ (2024) The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy. Brain 147(9):3009-3017.
Johnson GW, Doss DJ, Morgan VL, Paulo DL, Cai LY, Shless JS, Negi AS, Gummadavelli A, Kang H, Reddy SB, Naftel RP, Bick SK, Roberson SW, Dawant BM, Wallace MT, Englot DJ (2023) The interictal suppression hypothesis in focal epilepsy: network-level supporting evidence. Brain 146(7):2828-2845.
Paulo DL, Wills KE, Johnson GW, Gonzalez HFJ, Rolston JD, Naftel RP, Reddy SB, Morgan VL, Kang H, Roberson SW, Narasimhan S, Englot DJ (2022) SEEG functional connectivity measures to identify epileptogenic zones: Stability, medication influence, and recording condition. Neurology 98(20):e2060-e2072.
González HFJ, Narasimhan S, Johnson GW, Wills KE, Haas KF, Konrad PE, Chang C, Morgan VL, Rubinov M, Englot DJ (2021) Role of the nucleus basalis as a key network node in temporal lobe epilepsy. Neurology 96(9):e1334-e1346.
I am a neurosurgeon who treats patients with epilepsy, movement disorders and pain disorders. I conduct research aimed at increasing responder rates in neuromodulation and identifying new strategies for brain stimulation and ablation therapies. My research interests include electrophysiology, neuroimaging and brain network analysis. I lead the Brain Imaging and Electrophysiology Network (BIEN) Lab at Vanderbilt.