Maribeth Ruth Nicholson, M.D., M.P.H.
Gastroenterology, Pediatric
Gastroenterology, Pediatric
The Wan laboratory seeks to understand the life cycles of these viruses using structural biology under near-native conditions. Our main tool for this is cryo-electron tomography (cryo-ET), which allows us to obtain molecular resolution information directly within complex environments including intact viruses and cellular sections. Cryo-ET is still an emerging method, and we seek to leverage state-of-the-art equipment and develop image-processing methods in order to pursue our biological goals.
1. Overcoming immune evasion in leukemia
2. Dissect graft-versus-host disease and graft-versus-leukemia in allogeneic stem cell transplantation (allo-SCT) by manipulating co-inhibitory molecules
3. Human correlative studies in line with clinical trials
Hematology and oncology