Reynolds Research

Reynolds Research Home

Stuart Reynolds, MD

My research focuses on benign functional bladder and pelvic floor disorders, such as overactive bladder (OAB) and incontinence, to improve the lives of those affected by these conditions.  I use multiple different modalities to try to answer these questions.  Presently, I have three main research areas:

  • Causes of Overactive Bladder (OAB)

    • My research examines nervous system mechanisms that cause sensation hypersensitivity and (sometimes) pain and investigates how these contributes to bladder and urinary hypersensitivity in people with OAB.  We have several projects ongoing that involve nerve testing and nerve responses to sensory stimulation, measuring bladder sensations as the bladder fills, and MRI imaging of the spinal cord.  These studies are identifying many aspects about what contributes to OAB that we didn’t know before and will change how we manage OAB in the future. 
  • Urinary Psychology (Uropsychology) and bladder behaviors

    • Another area is focused on psychological and social aspects of OAB and behaviors or habits that people adopt to help cope with or manage their condition.  This research investigates how psychological and social stress impact the bladder and how everyday experiences impact on bladder symptoms.  My collaborators and I have projects where we are tracking and recording day-to-day experiences of stress and anxiety, bladder symptoms, and coping behaviors and habits as well as a project that measures the immediate effects of psychological stress on bladder sensations and a laboratory setting.  We believe these studies will uncover important aspects of the relationship between the mind, emotions and the bladder that can be targeted for treatment in future studies. 
  • Toilet and restroom use and accessibility

    • This is a newer area of focus that extends beyond OAB and specific urinary conditions and relates to public restroom use and toilet access or availability.  Accessing and using public restrooms can be difficult for everyone and many people will limit public restroom use or avoid public restrooms. This can impact how individuals function in society and even at their jobs – like taxi and bus drivers, school teachers, and nurses and medical personnel – job restrictions can have bad impacts on bladder health that lead to bladder conditions, like OAB or bladder infections.  We have projects that are looking at these impacts, including studies that are figuring out the best way to study these impacts and outcomes.  This work will be really important for public health and bladder health.

 

Projects and Interests

Central Sensitization in OAB

CENTRAL SENSITIZATION IN OAB

Psychosocial impacts on urinary conditions

Psychosocial impacts on urinary conditions

Toilet environments and restroom access

Toilet environments and restroom access

Bladder health and behaviors

Bladder health and behaviors

Urinary microbiology and microbiome

Urinary microbiology and microbiome

Funding/Grant Listings

Active Grants

Reynolds (PI):  Central Sensitization and Psychosocial Impacts on Overactive Bladder  R01DK128293, NIH/NIDDK, Project Period:    9/24/2021 – 7/30/2025

Reynolds (PI):  Stress and Anxiety Effects on Overactive Bladder: A Controlled Study  R01DK129624, NIH/NIDDK, Project Period:    9/15/2021 – 7/31/2026

Reynolds (Co-Inv):  Effects of Sacral Neuromodulation on Central Sensitization in OAB Patients, SUFU Research Foundation Neuromodulation Grant, Danford (PI), Project Period: 02/01/2014 – 01/19/2022 (No cost extension)

Reynolds (Co-Inv):  Effects of Bladder Onabotulinum Toxin Injection on Central Sensitization in OAB Patients, SUFU Research Foundation Chemodenervation Grant, Brown (PI), Project Period: 10/1/2014 – 01/19/2022 (No cost extension)

Past Grants

Reynolds (PI):  Utilization of Urodynamics Use in the United States,  Urologic Diseases of America (UDA), Project Period: 11/01/2011-03/01/2012

Reynolds (PI): Afferent hyperactivity mechanisms in overactive bladder syndrome, Vanderbilt Physician Scientist Development Program (VPSD), Project Period: 07/01/2014 – 09/24/2015

Reynolds (PI): Afferent hyperactivity mechanisms in overactive bladder syndrome, NIH Loan Repayment Program (NIDDK), Project Period: 07/01/2013 – 06/30/2018

Reynolds (PI):  Afferent hyperactivity mechanisms in overactive bladder syndrome, K23DK103910, NIH/NIDDK Career Development Award, Project Period: 9/25/2015 – 08/31/2021