Mechanism of CNS demyelination
Dr. Sriram is Professor of Neurology and Immunology and Head of the Neuroimmunology Divsion. He has worked in the field of multiple sclerosis and allied demyelinating disorders for his entire professional career.
Dr. Sriram received his M.B.B.S. from University of Madras, India. He then completed an internship in Internal Medicine at Ford Medical Center in Detroit, Michigan and Neurology residency at Stanford University Medical Center.
He was Acting Assistant Professor of Neurology at Stanford University School of Medicine, Stanford, CA -where he completed a Senior Research Associate in the Department of Neurology. He then moved to the University of Vermont College of Medicine, where he was Assistant, and then Associate Professor of Neurology.
In 1993 Dr. Sriram moved to Nashville, TN and founded a Multiple Sclerosis Center at Vanderbilt University Medical Center. It was the first comprehensive Multiple Sclerosis Center of the southeast.
The main focus of Dr. Srirams laboratory is to examine the immunological factor(s) which are likely involved in recovery of lesions from MS. Dr. Srirams laboratory discovered that one particular cytokine, IL-33 is an important player in promoting recovery in animal models of multiple sclerosis. Patients who have stable disease show increased levels of IL-33 in their blood and in the cerebrospinal fluid.
Dr. Srirams lab has also found certain novel genes that play a role in the induction of IL-33. In addition certain agents which have been used for multiple sclerosis in the past and since discarded may is likely to be a good candidate for promoting recovery.
Along with Drs Pawate and Bagnato, Dr. Sriram is interested in developing novel MRI techniques for examining recovery.