2015 - 2019
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Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J. Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science (New York, N.Y.). 2019 Dec 25;366(366). 505-508.
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Marcinkiewcz CA, Bierlein-De La Rosa G, Dorrier CE, McKnight M, DiBerto JF, Pati D, Gianessi CA, Hon OJ, Tipton G, McElligott ZA, Delpire E, Kash TL. Sex-Dependent Modulation of Anxiety and Fear by 5-HT Receptors in the Bed Nucleus of the Stria Terminalis. ACS chemical neuroscience. 2019 Dec 17;10(10). 3154-3166.
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Perry JSA, Morioka S, Medina CB, Iker Etchegaray J, Barron B, Raymond MH, Lucas CD, Onengut-Gumuscu S, Delpire E, Ravichandran KS. Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway. Nature cell biology. 2019 Dec;21(21). 1532-1543.
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Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science signaling. 2019 Oct 15;12(12).
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Cai K, Wang J, Eissman J, Wang J, Nwosu G, Shen W, Liang HC, Li XJ, Zhu HX, Yi YH, Song J, Xu D, Delpire E, Liao WP, Shi YW, Kang JQ. A missense mutation in SLC6A1 associated with Lennox-Gastaut syndrome impairs GABA transporter 1 protein trafficking and function. Experimental neurology. 2019 Oct;320(320). 112973 p. NIHMSID: NIHMS1056923.
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Jin SC, Furey CG, Zeng X, Allocco A, Nelson-Williams C, Dong W, Karimy JK, Wang K, Ma S, Delpire E, Kahle KT. SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus. Molecular genetics & genomic medicine. 2019 Sep;7(7). e892.
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Koumangoye R, Omer S, Delpire E. Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells. American journal of physiology. Cell physiology. 2018 May 2;305(305). C258-C276.
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Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID. Mechanism of Hyperkalemia-Induced Metabolic Acidosis. Journal of the American Society of Nephrology : JASN. 2018 May;29(29). 1411-1425.
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Delpire E, Gagnon KB. Na -K -2Cl Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia. Comprehensive Physiology. 2018 Mar 25;8(8). 871-901.
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Flores B, Schornak CC, Delpire E. A role for KCC3 in maintaining cell volume of peripheral nerve fibers. Neurochemistry international. 2018 Jan 20.
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Delpire E, Hamilton KL, Hawke TJ, Isenberg JS, Lotersztajn S, Yuan JX, Adams JC. AJP-Cell Physiology begins landmark reviews in cell physiology: an editorial from the senior editors of AJP-Cell Physiology. American journal of physiology. Cell physiology. 2018 Jan 1;314(314). C1-C2.
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Markkanen M, Ludwig A, Khirug S, Pryazhnikov E, Soni S, Khiroug L, Delpire E, Rivera C, Airaksinen MS, Uvarov P. Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function. Brain research. 2017 Nov 15;1675(1675). 87-101.
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Koumangoye R, Delpire E. DNPEP is not the only peptidase that produces SPAK fragments in kidney. Physiological reports. 2017 Nov;5(5).
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Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature medicine. 2017 Aug;23(23). 997-1003.
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Zhang J, Karimy JK, Delpire E, Kahle KT. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert opinion on therapeutic targets. 2017 Aug;21(21). 795-804.
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Bowerman M, Salsac C, Bernard V, Soulard C, Dionne A, Coque E, Benlefki S, Hince P, Dion PA, Butler-Browne G, Camu W, Bouchard JP, Delpire E, Rouleau GA, Raoul C, Scamps F. KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects. Neurobiology of disease. 2017 Jun 21;106(106). 35-48.
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Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends in neurosciences. 2017 May;40(40). 276-294.
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Grimm PR, Coleman R, Delpire E, Welling PA. Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. Journal of the American Society of Nephrology : JASN. 2017 Apr 25;28(28). 2595-2606.
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Wills TA, Baucum AJ, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG. Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression. Addiction biology. 2017 Mar;22(22). 275-290. NIHMSID: NIHMS736401.
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Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell metabolism. 2017 Feb 7;25(25). 285-299.
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Radke AK, Jury NJ, Delpire E, Nakazawa K, Holmes A. Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit. Alcohol (Fayetteville, N.Y.). 2017 Feb;58(58). 47-51. NIHMSID: NIHMS842677.
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Delpire E. The mysterious role of the neuronal anion exchanger-3. The Journal of physiology. 2017 Feb 1;595(595). 601-602.
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Delpire E, Kahle KT. The KCC3 cotransporter as a therapeutic target for peripheral neuropathy. Expert opinion on therapeutic targets. 2017 Feb;21(21). 113-116.
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Delpire E, Weaver CD. Challenges of Finding Novel Drugs Targeting the K-Cl Cotransporter. ACS chemical neuroscience. 2016 Dec 21;7(7). 1624-1627.
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Delpire E, Wolfe L, Flores B, Koumangoye R, Schornak CC, Omer S, Pusey B, Lau C, Markello T, Adams DR. A patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1. Cold Spring Harbor molecular case studies. 2016 Nov;2(2). a001289.
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Sun YT, Tzeng SF, Lin TS, Hsu KS, Delpire E, Shen MR. KCC3 deficiency-induced disruption of paranodal loops and impairment of axonal excitability in the peripheral nervous system. Neuroscience. 2016 Oct 29;335(335). 91-102.
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Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science signaling. 2016 Aug 2;9(9). ra77.
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Koumangoye R, Delpire E. The Ste20 kinases SPAK and OSR1 travel between cells through exosomes. American journal of physiology. Cell physiology. 2016 Jul 1;311(311). C43-53.
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Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2016 Apr 29.
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Delpire E. STIM and Orai Proteins in Calcium Signaling: an AJP-Cell Physiology series of Themed Reviews. American journal of physiology. Cell physiology. 2016 Mar 15;310(310). C401.
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Lee H, Bach E, Noh J, Delpire E, Kandler K. Hyperpolarization-independent maturation and refinement of GABA/glycinergic connections in the auditory brain stem. Journal of neurophysiology. 2016 Mar;115(115). 1170-82.
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Kahle KT, Delpire E. Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target. Journal of neurophysiology. 2016 Jan 1;115(115). 8-18.
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Delpire E. Research antibodies: do not use them to stain your reputation. American journal of physiology. Cell physiology. 2015 Dec 1;309(309). C707-8.
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Üner A, Gonçalves GH, Li W, Porceban M, Caron N, Schönke M, Delpire E, Sakimura K, Bjørbæk C. The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis. Molecular metabolism. 2015 Oct;4(4). 678-91.
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Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E. K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends in molecular medicine. 2015 Jul 1.
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Feng X, Zhang Y, Shao N, Wang Y, Zhuang Z, Wu P, Lee MJ, Liu Y, Wang X, Zhuang J, Delpire E, Gu D, Cai H. Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway. American journal of physiology. Renal physiology. 2015 May 15;308(308). F1119-27.
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Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA. Integrated compensatory network is activated in the absence of NCC phosphorylation. The Journal of clinical investigation. 2015 May;125(125). 2136-50.
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Wade JB, Liu J, Coleman R, Grimm PR, Delpire E, Welling PA. SPAK-mediated NCC regulation in response to low-K+ diet. American journal of physiology. Renal physiology. 2015 Apr 15;308(308). F923-31.
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Mathieu V, Chantôme A, Lefranc F, Cimmino A, Miklos W, Paulitschke V, Mohr T, Maddau L, Kornienko A, Berger W, Vandier C, Evidente A, Delpire E, Kiss R. Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase. Cellular and molecular life sciences : CMLS. 2015 Apr 14.
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Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice. Hypertension. 2015 Mar;65(65). 569-76. NIHMSID: NIHMS648917.
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Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Investigative ophthalmology & visual science. 2015 Jan;56(56). 310-21.
2010 - 2014
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Shisler D, Austin TM, Delpire E, Sawyer DB, Pandey AK. Syndrome of severe pain associated with a continuous bumetanide infusion. International journal of cardiology. 2014 Dec 15;177(177). e61-2. NIHMSID: NIHMS646295.
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Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. Journal of the American Society of Nephrology : JASN. 2014 Dec;25(25). 2752-63.
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Ding J, Delpire E. Deletion of KCC3 in parvalbumin neurons leads to locomotor deficit in a conditional mouse model of peripheral neuropathy associated with agenesis of the corpus callosum. Behavioural brain research. 2014 Nov 1;274(274). 128-36. NIHMSID: NIHMS625448.
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Delpire E. How carbonic anhydrases and pH buffers facilitate the movement of carbon dioxide through biological membranes. Focus on "Evidence from simultaneous intracellular- and surface-pH transients that carbonic anhydrase II enhances CO2 fluxes across Xenopus oocyte plasma membranes"; "Evidence from simultaneous intracellular- and surface-pH transients that carbonic anhydrase IV enhances CO2 fluxes across Xenopus oocyte plasma membranes"; and "Evidence from mathematical modeling that carbonic anhydrase II and IV enhance CO2 fluxes across Xenopus oocyte plasma membranes". American journal of physiology. Cell physiology. 2014 Nov 1;307(307). C788-90.
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Markadieu N, Rios K, Spiller BW, McDonald WH, Welling PA, Delpire E. Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage. The Journal of biological chemistry. 2014 Oct 17;289(289). 29273-84.
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Delpire E, Staley KJ. Novel determinants of the neuronal Cl(-) concentration. The Journal of physiology. 2014 Oct 1;592(592). 4099-114.
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Terker AS, Yang CL, McCormick JA, Meermeier NP, Rogers SL, Grossmann S, Trompf K, Delpire E, Loffing J, Ellison DH. Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. Hypertension. 2014 Jul;64(64). 178-84. NIHMSID: NIHMS585005.
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ArrayAustin TM, Nannemann DP, Deluca SL, Meiler J, Delpire E. In silico analysis and experimental verification of OSR1 kinase - Peptide interaction. Journal of structural biology. 2014 Jul;187(187). 58-65. NIHMSID: NIHMS597167.
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Mahadevan V, Pressey JC, Acton BA, Uvarov P, Huang MY, Chevrier J, Puchalski A, Li CM, Ivakine EA, Airaksinen MS, Delpire E, McInnes RR, Woodin MA. Kainate receptors coexist in a functional complex with KCC2 and regulate chloride homeostasis in hippocampal neurons. Cell reports. 2014 Jun 26;7(7). 1762-70.
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Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E. A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters. The Journal of biological chemistry. 2014 Jun 20;289(289). 17680-8.
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Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. American journal of physiology. Renal physiology. 2014 May 1;306(306). F1059-68.
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Markadieu N, Delpire E. Physiology and pathophysiology of SLC12A1/2 transporters. Pflügers Archiv : European journal of physiology. 2014 Jan;466(466). 91-105. NIHMSID: NIHMS529652.
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Miller OH, Yang L, Wang CC, Hargroder EA, Zhang Y, Delpire E, Hall BJ. GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. ELife. 3(3). e03581.
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Nguyen MT, Lee DH, Delpire E, McDonough AA. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition. American journal of physiology. Renal physiology. 2013 Aug 15;305(305). F510-9.
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Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA. The absence of intrarenal ACE protects against hypertension. The Journal of clinical investigation. 2013 May;123(123). 2011-23.
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Gagnon KB, Delpire E. Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts. American journal of physiology. Cell physiology. 2013 Apr 15;304(304). C693-714.
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Ivakine EA, Acton BA, Mahadevan V, Ormond J, Tang M, Pressey JC, Huang MY, Ng D, Delpire E, Salter MW, Woodin MA, McInnes RR. Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 2013 Feb 26;110(110). 3561-6.
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Saritas T, Borschewski A, McCormick JA, Paliege A, Dathe C, Uchida S, Terker A, Himmerkus N, Bleich M, Demaretz S, Laghmani K, Delpire E, Ellison DH, Bachmann S, Mutig K. SPAK differentially mediates vasopressin effects on sodium cotransporters. Journal of the American Society of Nephrology : JASN. 2013 Feb;24(24). 407-18.
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McCall NM, Sprow GM, Delpire E, Thiele TE, Kash TL, Pleil KE. Effects of sex and deletion of neuropeptide Y2 receptors from GABAergic neurons on affective and alcohol drinking behaviors in mice. Frontiers in integrative neuroscience. 7(7). 100 p.
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Ding J, Ponce-Coria J, Delpire E. A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function. PloS one. 8(8). e61112.
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Ares GR, Haque MZ, Delpire E, Ortiz PA. Hyperphosphorylation of Na-K-2Cl cotransporter in thick ascending limbs of Dahl salt-sensitive rats. Hypertension. 2012 Dec;60(60). 1464-70.
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Ponce-Coria J, Gagnon KB, Delpire E. Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers. American journal of physiology. Cell physiology. 2012 Dec 1;303(303). C1198-205.
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Grimm PR, Taneja TK, Liu J, Coleman R, Chen YY, Delpire E, Wade JB, Welling PA. SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner. The Journal of biological chemistry. 2012 Nov 2;287(287). 37673-90.
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Gagnon KB, Delpire E. Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport. Physiological reviews. 2012 Oct;92(92). 1577-617. NIHMSID: NIHMS709609.
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Mao S, Garzon-Muvdi T, Di Fulvio M, Chen Y, Delpire E, Alvarez FJ, Alvarez-Leefmans FJ. Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation. Journal of neurophysiology. 2012 Aug 1;108(108). 834-52.
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Delpire E, Baranczak A, Waterson AG, Kim K, Kett N, Morrison RD, Daniels JS, Weaver CD, Lindsley CW. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorganic & medicinal chemistry letters. 2012 Jul 15;22(22). 4532-5. NIHMSID: NIHMS383474.
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Sun YT, Shieh CC, Delpire E, Shen MR. K⁺-Cl⁻ cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activation. The Journal of physiology. 2012 Jul 15;590(590). 3231-43.
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Lucas O, Hilaire C, Delpire E, Scamps F. KCC3-dependent chloride extrusion in adult sensory neurons. Molecular and cellular neurosciences. 2012 Jul;50(50). 211-20.
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Nguyen MT, Yang LE, Fletcher NK, Lee DH, Kocinsky H, Bachmann S, Delpire E, McDonough AA. Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron. American journal of physiology. Renal physiology. 2012 Jul 1;303(303). F92-104.
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Zhou B, Wang D, Feng X, Zhang Y, Wang Y, Zhuang J, Zhang X, Chen G, Delpire E, Gu D, Cai H. WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway. American journal of physiology. Renal physiology. 2012 Mar 1;302(302). F533-9.
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Wills TA, Klug JR, Silberman Y, Baucum AJ, Weitlauf C, Colbran RJ, Delpire E, Winder DG. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proceedings of the National Academy of Sciences of the United States of America. 2012 Jan 31;109(109). E278-87.
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Wang CC, Held RG, Chang SC, Yang L, Delpire E, Ghosh A, Hall BJ. A critical role for GluN2B-containing NMDA receptors in cortical development and function. Neuron. 2011 Dec 8;72(72). 789-805.
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Austin TM, Delpire E. Inhibition of KCC2 in mouse spinal cord neurons leads to hypersensitivity to thermal stimulation. Anesthesia and analgesia. 2011 Dec;113(113). 1509-15. NIHMSID: NIHMS318883.
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Delpire E, Gagnon KB. Kinetics of hyperosmotically stimulated Na-K-2Cl cotransporter in Xenopus laevis oocytes. American journal of physiology. Cell physiology. 2011 Nov;301(301). C1074-85.
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Kiselycznyk C, Svenningsson P, Delpire E, Holmes A. Genetic, pharmacological and lesion analyses reveal a selective role for corticohippocampal GLUN2B in a novel repeated swim stress paradigm. Neuroscience. 2011 Oct 13;193(193). 259-68.
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Badanich KA, Doremus-Fitzwater TL, Mulholland PJ, Randall PK, Delpire E, Becker HC. NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol. Genes, brain, and behavior. 2011 Oct;10(10). 805-16. NIHMSID: NIHMS625937.
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McCormick JA, Mutig K, Nelson JH, Saritas T, Hoorn EJ, Yang CL, Rogers S, Curry J, Delpire E, Bachmann S, Ellison DH. A SPAK isoform switch modulates renal salt transport and blood pressure. Cell metabolism. 2011 Sep 7;14(14). 352-64. NIHMSID: NIHMS318683.
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Stil A, Jean-Xavier C, Liabeuf S, Brocard C, Delpire E, Vinay L, Viemari JC. Contribution of the potassium-chloride co-transporter KCC2 to the modulation of lumbar spinal networks in mice. The European journal of neuroscience. 2011 Apr;33(33). 1212-22.
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Gagnon KB, Rios K, Delpire E. Functional insights into the activation mechanism of Ste20-related kinases. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 28(28). 1219-30.
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Delpire E, Gagnon KB, Ledford JJ, Wallace JM. Housing and husbandry of Xenopus laevis affect the quality of oocytes for heterologous expression studies. Journal of the American Association for Laboratory Animal Science : JAALAS. 2011 Jan;50(50). 46-53.
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Sun YT, Lin TS, Tzeng SF, Delpire E, Shen MR. Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves. Glia. 2010 Oct;58(58). 1544-52.
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Gagnon KB, Delpire E. Molecular determinants of hyperosmotically activated NKCC1-mediated K+/K+ exchange. The Journal of physiology. 2010 Sep 15;588(588). 3385-96.
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Delpire E, Austin TM. Kinase regulation of Na+-K+-2Cl- cotransport in primary afferent neurons. The Journal of physiology. 2010 Sep 15;588(588). 3365-73.
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Gagnon KB, Delpire E. On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity. American journal of physiology. Cell physiology. 2010 Sep;299(299). C614-20.
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Welling PA, Chang YP, Delpire E, Wade JB. Multigene kinase network, kidney transport, and salt in essential hypertension. Kidney international. 2010 Jun;77(77). 1063-9. NIHMSID: NIHMS464217.
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Gagnon KB, Delpire E. Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1. The Journal of biological chemistry. 2010 May 7;285(285). 14115-21.
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Geng Y, Byun N, Delpire E. Behavioral analysis of Ste20 kinase SPAK knockout mice. Behavioural brain research. 2010 Apr 2;208(208). 377-82. NIHMSID: NIHMS164545.
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Brigman JL, Wright T, Talani G, Prasad-Mulcare S, Jinde S, Seabold GK, Mathur P, Davis MI, Bock R, Gustin RM, Colbran RJ, Alvarez VA, Nakazawa K, Delpire E, Lovinger DM, Holmes A. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Mar 31;30(30). 4590-600. NIHMSID: NIHMS192785.
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Boulenguez P, Liabeuf S, Bos R, Bras H, Jean-Xavier C, Brocard C, Stil A, Darbon P, Cattaert D, Delpire E, Marsala M, Vinay L. Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nature medicine. 2010 Mar;16(16). 302-7.
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Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JB. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. American journal of physiology. Cell physiology. 2010 Jan;298(298). C85-97.
2005 - 2009
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Delpire E. The mammalian family of sterile 20p-like protein kinases. Pflügers Archiv : European journal of physiology. 2009 Sep;458(458). 953-67.
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Geng Y, Hoke A, Delpire E. The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. The Journal of biological chemistry. 2009 May 22;284(284). 14020-8.
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Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proceedings of the National Academy of Sciences of the United States of America. 2009 Mar 31;106(106). 5383-8.
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Zhu L, Polley N, Mathews GC, Delpire E. NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus. Epilepsy research. 2008 May;79(79). 201-12. NIHMSID: NIHMS48266.
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Delpire E, Gagnon KB. SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. The Biochemical journal. 2008 Jan 15;409(409). 321-31.
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Garbarini N, Delpire E. The RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 22(22). 31-44. NIHMSID: NIHMS48160.
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Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS. A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. The Journal of biological chemistry. 2007 Oct 19;282(282). 30570-6.
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Byun N, Delpire E. Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice. Neurobiology of disease. 2007 Oct;28(28). 39-51. NIHMSID: NIHMS31877.
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Zhang LL, Delpire E, Vardi N. NKCC1 does not accumulate chloride in developing retinal neurons. Journal of neurophysiology. 2007 Jul;98(98). 266-77.
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Pieraut S, Laurent-Matha V, Sar C, Hubert T, Méchaly I, Hilaire C, Mersel M, Delpire E, Valmier J, Scamps F. NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Jun 20;27(27). 6751-9.
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Gagnon KB, England R, Diehl L, Delpire E. Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation. American journal of physiology. Cell physiology. 2007 May;292(292). C1809-15.
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Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G. WNK4 kinase is a negative regulator of K+-Cl- cotransporters. American journal of physiology. Renal physiology. 2007 Apr;292(292). F1197-207.
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Delpire E, Gagnon KB. Genome-wide analysis of SPAK/OSR1 binding motifs. Physiological genomics. 2007 Jan 17;28(28). 223-31.
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Gagnon KB, England R, Delpire E. A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 20(20). 131-42.
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Blaesse P, Guillemin I, Schindler J, Schweizer M, Delpire E, Khiroug L, Friauf E, Nothwang HG. Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Oct 11;26(26). 10407-19.
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Wouters M, De Laet A, Donck LV, Delpire E, Van Bogaert PP, Timmermans JP, De Kerchove d'Exaerde A, Smans K, Vanderwinden JM. Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker. American journal of physiology. Gastrointestinal and liver physiology. 2006 Jun;290(290). G1219-27.
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Gagnon KB, England R, Delpire E. Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Molecular and cellular biology. 2006 Jan;26(26). 689-98.
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Gagnon KB, England R, Delpire E. Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. American journal of physiology. Cell physiology. 2006 Jan;290(290). C134-42.
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Mercado A, Vázquez N, Song L, Cortés R, Enck AH, Welch R, Delpire E, Gamba G, Mount DB. NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. American journal of physiology. Renal physiology. 2005 Dec;289(289). F1246-61.
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Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nature medicine. 2005 Nov;11(11). 1205-13.
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Zhu L, Lovinger D, Delpire E. Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride. Journal of neurophysiology. 2005 Mar;93(93). 1557-68.
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Adragna NC, Chen Y, Delpire E, Lauf PK, Morris M. Hypertension in K-Cl cotransporter-3 knockout mice. Advances in experimental medicine and biology. 559(559). 379-85.
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Delpire E, Piechotta K. STE20 kinases and cation-chloride cotransporters. Advances in experimental medicine and biology. 559(559). 43-53.
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Delpire E, Gagnon KB. SPAK and OSR1, key kinases involved in the regulation of chloride transport. Acta physiologica (Oxford, England). 187(187). 103-13.
2000 - 2004
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Laird JM, García-Nicas E, Delpire EJ, Cervero F. Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia. Neuroscience letters. 2004 May 6;361(361). 200-3.
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Karadsheh MF, Byun N, Mount DB, Delpire E. Localization of the KCC4 potassium-chloride cotransporter in the nervous system. Neuroscience. 123(123). 381-91.
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Piechotta K, Garbarini N, England R, Delpire E. Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. The Journal of biological chemistry. 2003 Dec 26;278(278). 52848-56.
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Thomson RB, Mentone S, Kim R, Earle K, Delpire E, Somlo S, Aronson PS. Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. American journal of physiology. Renal physiology. 2003 Nov;285(285). F870-80.
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Piechotta K, Lu J, Delpire E. Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). The Journal of biological chemistry. 2002 Dec 27;277(277). 50812-9.
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Howard HC, Mount DB, Rochefort D, Byun N, Dupré N, Lu J, Fan X, Song L, Rivière JB, Prévost C, Horst J, Simonati A, Lemcke B, Welch R, England R, Zhan FQ, Mercado A, Siesser WB, George AL, McDonald MP, Bouchard JP, Mathieu J, Delpire E, Rouleau GA. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nature genetics. 2002 Nov;32(32). 384-92.
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Woo NS, Lu J, England R, McClellan R, Dufour S, Mount DB, Deutch AY, Lovinger DM, Delpire E. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus. 12(12). 258-68.
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Delpire E, Mount DB. Human and murine phenotypes associated with defects in cation-chloride cotransport. Annual review of physiology. 64(64). 803-43.
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Lauf PK, Zhang J, Delpire E, Fyffe RE, Mount DB, Adragna NC. K-Cl co-transport: immunocytochemical and functional evidence for more than one KCC isoform in high K and low K sheep erythrocytes. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2001 Oct;130(130). 499-509.
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Karadsheh MF, Delpire E. Neuronal restrictive silencing element is found in the KCC2 gene: molecular basis for KCC2-specific expression in neurons. Journal of neurophysiology. 2001 Feb;85(85). 995-7.
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Lauf PK, Zhang J, Gagnon KB, Delpire E, Fyffe RE, Adragna NC. K-Cl cotransport: immunohistochemical and ion flux studies in human embryonic kidney (HEK293) cells transfected with full-length and C-terminal-domain-truncated KCC1 cDNAs. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 11(11). 143-60.
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Pearson MM, Lu J, Mount DB, Delpire E. Localization of the K(+)-Cl(-) cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts. Neuroscience. 103(103). 481-91.
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Delpire E. Cation-Chloride Cotransporters in Neuronal Communication. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. 2000 Dec;15(15). 309-312.
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Sung KW, Kirby M, McDonald MP, Lovinger DM, Delpire E. Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Oct 15;20(20). 7531-8.
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Strange K, Singer TD, Morrison R, Delpire E. Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue. American journal of physiology. Cell physiology. 2000 Sep;279(279). C860-7.
1995 - 1999
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Hallonquist H, Cima RR, Klingensmith ME, Purdy MJ, Delpire E, Zinner MJ, Soybel DI. Selective increase in gastric mucosal mRNA encoding basolateral Na-K-2C1 cotransporter following ileostomy in the rat. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2(2). 238-43.
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Klingensmith ME, Neville LJ, Delpire E, Wolfe MM, Soybel DI. Gastrin-mediated effects of omeprazole on rat colon mucosa. Surgery. 1999 Aug;126(126). 272-8.
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Lu J, Karadsheh M, Delpire E. Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains. Journal of neurobiology. 1999 Jun 15;39(39). 558-68.
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Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G. Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. The Journal of biological chemistry. 1999 Jun 4;274(274). 16355-62.
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Delpire E, Lu J, England R, Dull C, Thorne T. Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter. Nature genetics. 1999 Jun;22(22). 192-5.
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Wu Q, Delpire E, Hebert SC, Strange K. Functional demonstration of Na+-K+-2Cl- cotransporter activity in isolated, polarized choroid plexus cells. The American journal of physiology. 1998 Dec;275(275). C1565-72.
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Mount DB, Delpire E, Gamba G, Hall AE, Poch E, Hoover RS, Hebert SC. The electroneutral cation-chloride cotransporters. The Journal of experimental biology. 1998 Jul;201(201). 2091-102.
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Plotkin MD, Snyder EY, Hebert SC, Delpire E. Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain. Journal of neurobiology. 1997 Nov 20;33(33). 781-95.
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Randall J, Thorne T, Delpire E. Partial cloning and characterization of Slc12a2: the gene encoding the secretory Na+-K+-2Cl- cotransporter. The American journal of physiology. 1997 Oct;273(273). C1267-77.
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Plotkin MD, Kaplan MR, Peterson LN, Gullans SR, Hebert SC, Delpire E. Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system. The American journal of physiology. 1997 Jan;272(272). C173-83.
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Delpire E, Kaplan MR, Plotkin MD, Hebert SC. The Na-(K)-Cl cotransporter family in the mammalian kidney: molecular identification and function(s). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1996 Oct;11(11). 1967-73.
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Klingensmith ME, Hallonquist H, McCoy BP, Cima RR, Delpire E, Soybel DI. Pentagastrin selectively modulates levels of mRNAs encoding apical H/K adenosine triphosphatase and basolateral Na-K-Cl cotransporter in rat gastric fundic mucosa. Surgery. 1996 Aug;120(120). 242-6; discussion 246-7.
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Kaplan MR, Plotkin MD, Brown D, Hebert SC, Delpire E. Expression of the mouse Na-K-2Cl cotransporter, mBSC2, in the terminal inner medullary collecting duct, the glomerular and extraglomerular mesangium, and the glomerular afferent arteriole. The Journal of clinical investigation. 1996 Aug 1;98(98). 723-30.
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Kaplan MR, Mount DB, Delpire E. Molecular mechanisms of NaCl cotransport. Annual review of physiology. 58(58). 649-68.
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Raat NJ, Delpire E, Van Os CH, Bindels RJ. Culturing induced expression of basolateral Na+-K+-2Cl- cotransporter BSC2 in proximal tubule, aortic endothelium, and vascular smooth muscle. Pflügers Archiv : European journal of physiology. 1996 Jan;431(431). 458-60.
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Soybel DI, Gullans SR, Maxwell F, Delpire E. Role of basolateral Na(+)-K(+)-Cl- cotransport in HCl secretion by amphibian gastric mucosa. The American journal of physiology. 1995 Jul;269(269). C242-9.
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Delpire E, Rauchman MI, Beier DR, Hebert SC, Gullans SR. Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. The Journal of biological chemistry. 1994 Oct 14;269(269). 25677-83.
1985 - 1994
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Wasserman JC, Delpire E, Tonidandel W, Kojima R, Gullans SR. Molecular characterization of ROSIT, a renal osmotic stress-induced Na(+)-Cl(-)-organic solute cotransporter. The American journal of physiology. 1994 Oct;267(267). F688-94.
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Delpire E, Gullans SR. Cell volume and K+ transport during differentiation of mouse erythroleukemia cells. The American journal of physiology. 1994 Feb;266(266). C515-23.
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Rauchman MI, Nigam SK, Delpire E, Gullans SR. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. The American journal of physiology. 1993 Sep;265(265). F416-24.
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Lauf PK, Bauer J, Adragna NC, Fujise H, Zade-Oppen AM, Ryu KH, Delpire E. Erythrocyte K-Cl cotransport: properties and regulation. The American journal of physiology. 1992 Nov;263(263). C917-32.
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Delpire E, Lauf PK. Kinetics of DIDS inhibition of swelling-activated K-Cl cotransport in low K sheep erythrocytes. The Journal of membrane biology. 1992 Feb;126(126). 89-96.
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Delpire E, Lauf PK. Trans effects of cellular K and Cl on ouabain-resistant Rb(K) influx in low K sheep red blood cells: further evidence for asymmetry of K-Cl cotransport [corrected]. Pflügers Archiv : European journal of physiology. 1991 Nov;419(419). 540-2.
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Delpire E, Lauf PK. Magnesium and ATP dependence of K-Cl co-transport in low K+ sheep red blood cells. The Journal of physiology. 1991 Sep;441(441). 219-31.
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Delpire E, Lauf PK. Kinetics of Cl-dependent K fluxes in hyposmotically swollen low K sheep erythrocytes. The Journal of general physiology. 1991 Feb;97(97). 173-93.
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Delpire E, Cornet M, Gilles R. Volume regulation in rat pheochromocytoma cultured cells submitted to hypoosmotic conditions. Archives internationales de physiologie, de biochimie et de biophysique. 1991 Feb;99(99). 71-6.
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Buche A, Ouassaidi A, Hacha R, Delpire E, Gilles R, Houssier C. Glycine and other amino compounds prevent chromatin precipitation at physiological ionic strength. FEBS letters. 1989 Apr 24;247(247). 367-70.
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Delpire E, Duchêne C, Cornet M, Gilles R. Amiloride: an inhibitor of regulatory volume decrease in rat pheochromocytoma cultured cells. Pflügers Archiv : European journal of physiology. 1988 Feb;411(411). 223-5.
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Cornet M, Delpire E, Gilles R. Relations between cell volume control, microfilaments and microtubules networks in T2 and PC12 cultured cells. Journal de physiologie. 83(83). 43-9.
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Cornet M, Delpire E, Gilles R. Study of microfilaments network during volume regulation process of cultured PC 12 cells. Pflügers Archiv : European journal of physiology. 1987 Sep;410(410). 223-5.
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Delpire E, Duchêne C, Goessens G, Gilles R. Effects of osmotic shocks on the ultrastructure of different tissues and cell types. Experimental cell research. 1985 Sep;160(160). 106-16.
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Marcus DJ, Bedse G, Gaulden AD, Ryan JD, Kondev V, Winters ND, Rosas-Vidal LE, Altemus M, Mackie K, Lee FS, Delpire E, Patel S. Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening. Neuron. 2020 Dec 18;105(105). 1062-1076.e6.
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Wang J, Poliquin S, Mermer F, Eissman J, Delpire E, Wang J, Shen W, Cai K, Li BM, Li ZY, Xu D, Nwosu G, Flamm C, Liao WP, Shi YW, Kang JQ. Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism. Molecular brain. 2020 Dec 12;13(13). 76 p.
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Omer S, Koumangoye R, Delpire E. A mutation in the Na-K-2Cl cotransporter-1 leads to changes in cellular metabolism. Journal of cellular physiology. 2020 Oct;235(235). 7239-7250. NIHMSID: NIHMS1554634.
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Kamalova A, Futai K, Delpire E, Nakagawa T. AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility. Cell reports. 2020 Jul 21;32(32). 107921 p. NIHMSID: NIHMS1613943.
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McNeill A, Iovino E, Mansard L, Vache C, Baux D, Bedoukian E, Cox H, Dean J, Goudie D, Kumar A, Newbury-Ecob R, Fallerini C, Renieri A, Lopergolo D, Mari F, Blanchet C, Willems M, Roux AF, Pippucci T, Delpire E. SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect. Brain : a journal of neurology. 2020 Jul 13.
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Flores B, Delpire E. Osmotic Response of Dorsal Root Ganglion Neurons Expressing Wild-Type and Mutant KCC3 Transporters. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2020 Jun 8;54(54). 577-590. NIHMSID: NIHMS1609691.
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Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M. Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons. EMBO reports. 2020 Apr 3;21(21). e48880.
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Bi Y, Li C, Zhang Y, Wang Y, Chen S, Yue Q, Hoover RS, Wang XH, Delpire E, Eaton DC, Zhuang J, Cai H. Stimulatory Role of SPAK Signaling in the Regulation of Large Conductance Ca-Activated Potassium (BK) Channel Protein Expression in Kidney. Frontiers in physiology. 11(11). 638 p.