Mount DB, Delpire E, Gamba G, Hall AE, Poch E, Hoover RS, Hebert SC. The electroneutral cation-chloride cotransporters. The Journal of experimental biology. 1998 Jul;201(201). 2091-102. PMID: 9639584 [PubMed]
Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter proteins share a common predicted membrane topology, with twelve putative transmembrane segments flanked by long hydrophilic N- and C-terminal cytoplasmic domains. The molecular identification of these transporters has had a significant impact on the study of their function, regulation and pathophysiology.