Professor of Anesthesiology and Molecular and Biophysics (MPB)Light Hall 1265Lab Phone615-343-7409Lab AddressLight hall2215B Garland AveNashvilleTennessee37232
Director, Anesthesiology Basic Science Division
B.H. Robbins Director in Anesthesiology Research
Rainelli is currently investigating regulatory mechanisms of SPAK/OSR1 kinases.
Rainelli attended Meharry Medical college where he obtained his Ph.D in biomedical sciences. He also attended the University of Montreal in Quebec where he majored in biochemistry (B.S.), and Laval University where he obtained a Masters in Sciences in Molecular Biology.
Training in Fundamental Neuroscience 2015-2017
Vanderbilt Program in Molecular Medicine 2015-2018
Bianca is involved with studies of KCC3; understanding how genetically-modified mutant mice can be used to understand the molecular mechanisms leading to peripheral nerve disease in humans.
Bianca attended the University of Rochester where she obtained her B.S. in neuroscience.
Associate Professor of AnesthesiologyEmory University
(2009 - 2014) Studied the relationship between KCC2 and pain perception
Studied the binding of peptides and inhibitors to the SPAK kinase binding pocket
Assistant ProfessorDepartment of Medicine, University of Louisville
(2003 - 2011) Studied the regulation of NKCC1 by WNK4 and SPAK/OSR1 kinases
Published 16 manuscripts in the lab!
(2012 - 2014) Identified a protease that cleaves SPAK
J. Biol. Chem. 289: 29273-29284 (2014)
(2000 - 2003) Discovered and studied SPAK / cation-chloride cotransporters interaction
J. Biol. Chem. 277: 50812-50819, 2002.
J. Biol. Chem. 278: 52848‑52856, 2003.
(2010 - 2014) Studied the regulation of NKCC1 by Cab39, WNK4, and SPAK
Am. J. Physiol. Cell Physiol. 303(11), C1198-C1205, 2012.
J. Biol. Chem. 289: 17680-17688, 2014.
Former Graduate Students
Assistant Professor, Department of Pharmacology, Vanderbilt
Graduated in 2007
Graduated in 2014
NIH, Office of Director
Graduated in 2008
Regulation of the neuronal K+-Cl- cotransporter, KCC2, by protein associated with myc
AHA-Fellowship (2004-2006), AAAS Mass Media Science and Engineering Fellowship Summer 2004
To read a bit about Nicole's current position at NIH and some advice she offers to graduate students click here
PostDoctoral Fellow, Pediatrics - Human Gene Therapy, Stanford University
Research Scientist, Gladstone Institute
Graduated in 2007
KCC2 and NKCC1 in the control of neuronal Cl- and brain excitability
Interdisciplinary Graduate Program 2015-2016
Training in Fundamental Neuroscience 2016- 2019
M.S. (Neuroscience), Vanderbilt University 2019
Cara received her B.S. in Liberal Arts and Sciences from the University of Illinois Urbana-Champaign in 2015.
Former Undergraduate Students
Senior, University of Tennessee - Knoxville
Jordan worked on understanding cell physiology with OXR1 receptor and NKCC1.
Jordan is currently working towards his goals of becoming a physician-scientist with a focus in oncology.