Klingensmith ME, Neville LJ, Delpire E, Wolfe MM, Soybel DI. Gastrin-mediated effects of omeprazole on rat colon mucosa. Surgery. 1999 Aug;126(126). 272-8. PMID: 10455894 [PubMed]
Omeprazole increases circulating gastrin levels, which in turn may affect the growth and differentiation of colon mucosa. Chloride transport mechanisms in normal colon were analyzed as markers for possible trophic actions of endogenous hypergastrinemia.