Myelomeningocele Trial (MOMS)
Primary investigator of the NIH-funded Myelomeningocele Trial (MOMS) 1 and 2
Our doctors are pioneers in fetal intervention for myelomeningocele. Drs. Tulipan and Bruner completed the first human interventions in 1998. Dr. John Brock, III helped create the protocol that became the MOMS Trial, the only randomized trial comparing pre- and post-natal myelomeningocele closure in the world. This trial included three institutions, including Vanderbilt. Outcomes of this trial are summarized in the papers below, all of which include authors from our division.
- Effect of Prenatal Repair of Myelomeningocele on Urological Outcomes at School Age. Brock JW 3rd, Thomas JC, Baskin LS, Zderic SA, Thom EA, Burrows PK, Lee H, Houtrow AJ, MacPherson C, Adzick NS; Eunice Kennedy Shriver NICHD MOMS Trial Group. J Urol. 2019 May
- Bladder Function After Fetal Surgery for Myelomeningocele. Brock JW 3rd, Carr MC, Adzick NS, Burrows PK, Thomas JC, Thom EA, Howell LJ, Farrell JA, Dabrowiak ME, Farmer DL, Cheng EY, Kropp BP, Caldamone AA, Bulas DI, Tolivaisa S, Baskin LS; MOMS Investigators. Pediatrics. 2015 Oct;136(4)
- A randomized trial of prenatal versus postnatal repair of myelomeningocele. Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL; MOMS Investigators. N Engl J Med. 2011 Mar 17;364(11):993-1004.