Warren Taylor, M.D., MHSc, Associate Professor of Psychiatry, served as lead author on a paper titled "APOE ε4 associated with preserved executive function
performance and maintenance of temporal and cingulate brain volumes in younger adults" in the journal Brain Imaging & Behavior. According to the abstract, the APOE ε4 allele is associated with cognitive deficits and brain atrophy in older adults, but studies in younger adults are mixed. The ε4 allele benefits younger adults
by allowing them to maintain executive function performance and volumes of cingulate and temporal cortex regions with aging, at least through age fifty years.