Perez DL, Vago DR, Pan H, Root J, Tuescher O, Fuchs BH, Leung L, Epstein J, Cain NM, Clarkin JF, Lenzenweger MF, Kernberg OF, Levy KN, Silbersweig DA, Stern E. Frontolimbic neural circuit changes in emotional processing and inhibitory control associated with clinical improvement following transference-focused psychotherapy in borderline personality disorder. Psychiatry and clinical neurosciences. 2016 Jan;70(70). 51-61. PMID: 26289141 [PubMed] PMCID: PMC4718821 NIHMSID: NIHMS735715.
Borderline personality disorder (BPD) is characterized by self-regulation deficits, including impulsivity and affective lability. Transference-focused psychotherapy (TFP) is an evidence-based treatment proven to reduce symptoms across multiple cognitive-emotional domains in BPD. This pilot study aimed to investigate neural activation associated with, and predictive of, clinical improvement in emotional and behavioral regulation in BPD following TFP.