Srinivasa S, Suresh C, Mottla J, Hamarneh SR, Irazoqui JE, Frontera W, Torriani M, Stanley T, Makimura H. FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2016 Feb;26(26). 36-41. PMID: 26774404 [PubMed] PMCID: PMC4716612 NIHMSID: NIHMS748441.
To investigate the relationship of skeletal muscle FNDC5 mRNA expression and circulating irisin to the GH/IGF-I axis and to skeletal muscle mitochondrial function and mitochondria-related gene expression in obese men.