Preliminary determination of drug safety involves evaluation of retinal toxicity. We longitudinally assess visual function after drug treatment using ERG, and we examine and measure changes in retinal structure and morphometry using OCT and conventional histological methods.
We harvest ocular (vitreous, retina, choroid, etc.) and other tissues (liver, spleen, etc.) for assessment of drug concentration, clearance and calculation of half-life. We harvest tissue for delivery to and assessment by the client, we utilize the client's analysis methods for PK assessment in-house, or our chemists develop assay methods to suit specific compounds for PK assessment in-house.