J. Oliver McIntyre, Ph.D.

Research Professor
Radiology & Radiological Sciences
Research Professor
Delivery Address
Medical Center North
1161 21st Avenue South, CCC-1118

J. Oliver McIntyre, PhD, is a graduate of Cambridge University (Cambridge, England), earning a BA and MA in Biochemistry. He earned a PhD in Molecular Biology and completed a post-doctoral fellowship in Biophysics at Vanderbilt University. Prior to joining the Vanderbilt Radiology faculty in 2012 as Research Professor of Radiology and Radiological Sciences, Dr. McIntyre served on the Vanderbilt faculty for the Departments of Molecular Biology, Biological Sciences and Cancer Biology for 32 years. His research is focused primarily on preclinical studies of cancer and the tumor microenvironment using novel approaches with translational potential to address clinical challenges including: the early detection of cancer, the delivery of targeted therapy, monitoring anti-tumor drug efficacy and treating metastatic disease.

Section: Vanderbilt University Institute of Imaging Science


Li H, Jiang X, Xie J, McIntyre JO, Gore JC, Xu J. Time-Dependent Influence of Cell Membrane Permeability on MR Diffusion MeasurementsMagn Reson Med [print-electronic]. 2016 May; 75(5): 1927-34. PMID: 26096552, PMCID: PMC4676747, DOI: 10.1002/mrm.25724, ISSN: 1522-2594.

Haskett DG, Maestas D, Howerton SJ, Smith T, Ardila DC, Doetschman T, Utzinger U, McGrath D, McIntyre JO, Vande Geest JP. 2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of AneurysmMicrosc. Microanal [print-electronic]. 2016 Apr; 22(2): 349-60. PMID: 26903264, PMCID: PMC4823162, PII: S1431927616000088, DOI: 10.1017/S1431927616000088, ISSN: 1435-8115.

Sorace AG, Quarles CC, Whisenant JG, Hanker AB, McIntyre JO, Sanchez VM, Yankeelov TE. Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary resultsBreast Cancer Res. Treat [print-electronic]. 2016 Jan; 155(2): 273-84. PMID: 26791520, PMCID: PMC4833210, PII: 10.1007/s10549-016-3680-8, DOI: 10.1007/s10549-016-3680-8, ISSN: 1573-7217.

Samuelson LE, Scherer RL, VanSaun MN, Fan KH, Dozier EA, Carter KJ, Koyama T, Shyr Y, Aschner M, Stanwood GD, Bornhop DJ, Matrisian LM, McIntyre JONew tools for the quantitative assessment of prodrug delivery and neurotoxicityNeurotoxicology [print-electronic]. 2015 Mar; 47: 88-98. PMID: 25732874, PMCID: PMC4501381, PII: S0161-813X(15)00023-6, DOI: 10.1016/j.neuro.2015.02.005, ISSN: 1872-9711.

Felix DD, Gore JC, Yankeelov TE, Peterson TE, Barnes S, Whisenant J, Weis J, Shoukouhi S, Virostko J, Nickels M, McIntyre JO, Sanders M, Abramson V, Tantawy MN. Detection of breast cancer microcalcification using (99m)Tc-MDP SPECT or Osteosense 750EX FMT imagingNucl. Med. Biol [print-electronic]. 2015 Mar; 42(3): 269-73. PMID: 25533764, PMCID: PMC4889014, PII: S0969-8051(14)00549-6, DOI: 10.1016/j.nucmedbio.2014.11.010, ISSN: 1872-9614.

Whisenant JG, McIntyre JO, Peterson TE, Kang H, Sánchez V, Manning HC, Arteaga CL, Yankeelov TE. Utility of [18¿F]FLT-PET to assess treatment response in trastuzumab-resistant and trastuzumab-sensitive HER2-overexpressing human breast cancer xenograftsMol Imaging Biol. 2015 Feb; 17(1): 119-28. PMID: 25034624, PMCID: PMC4311727, DOI: 10.1007/s11307-014-0770-z, ISSN: 1860-2002.

Whisenant JG, Sorace AG, McIntyre JO, Kang H, Sánchez V, Loveless ME, Yankeelov TE. Evaluating treatment response using DW-MRI and DCE-MRI in trastuzumab responsive and resistant HER2-overexpressing human breast cancer xenograftsTransl Oncol. 2014 Dec; 7(6): 768-79. PMID: 25500087, PMCID: PMC4311041, PII: S1936-5233(14)00104-1, DOI: 10.1016/j.tranon.2014.09.011, ISSN: 1936-5233.

Wilson GH, Gore JC, Yankeelov TE, Barnes S, Peterson TE, True JM, Shokouhi S, McIntyre JO, Sanders M, Abramson V, Ngyuen TQ, Mahadevan-Jansen A, Tantawy MN. An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications Using (18)F-NaFJ. Nucl. Med [print-electronic]. 2014 Jul; 55(7): 1138-43. PMID: 24833491, PMCID: PMC4320039, PII: jnumed.114.139170, DOI: 10.2967/jnumed.114.139170, ISSN: 1535-5667.

Samuelson LE, Scherer RL, Matrisian LM, McIntyre JO, Bornhop DJ. Synthesis and in vitro efficacy of MMP9-activated NanoDendronsMol. Pharm [print-electronic]. 2013 Aug 8/5/2013; 10(8): 3164-74. PMID: 23750801, PMCID: PMC4824186, DOI: 10.1021/mp4002206, ISSN: 1543-8392.

Guo N, Xie J, Manning HC, Deane NG, Ansari MS, Coffey RJ, Gore J, Price RR, Baldwin RM, McIntyre JOA novel in vitro assay to assess phosphorylation of 3'-[(18)F]fluoro-3'-deoxythymidineMol Imaging Biol. 2011 Apr; 13(2): 257-64. PMID: 20532643, PMCID: PMC4180216, DOI: 10.1007/s11307-010-0351-8, ISSN: 1860-2002.

Gorden DL, Ivanova PT, Myers DS, McIntyre JO, VanSaun MN, Wright JK, Matrisian LM, Brown HA. Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine modelPLoS ONE [print-electronic]. 2011; 6(8): e22775. PMID: 21857953, PMCID: PMC3153459, PII: PONE-D-11-04361, DOI: 10.1371/journal.pone.0022775, ISSN: 1932-6203.

Uddin MJ, Crews BC, Blobaum AL, Kingsley PJ, Gorden DL, McIntyre JO, Matrisian LM, Subbaramaiah K, Dannenberg AJ, Piston DW, Marnett LJ. Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agentsCancer Res. 2010 May 5/1/2010; 70(9): 3618-27. PMID: 20430759, PMCID: PMC2864539, PII: 70/9/3618, DOI: 10.1158/0008-5472.CAN-09-2664, ISSN: 1538-7445.

McIntyre JO, Scherer RL, Matrisian LM. Near-infrared optical proteolytic beacons for in vivo imaging of matrix metalloproteinase activityMethods Mol. Biol. 2010; 622: 279-304. PMID: 20135290, PMCID: PMC4495730, DOI: 10.1007/978-1-60327-299-5_18, ISSN: 1940-6029.

McIntyre JO, Matrisian LM. Optical proteolytic beacons for in vivo detection of matrix metalloproteinase activityMethods Mol. Biol. 2009; 539: 155-74. PMID: 19377965, DOI: 10.1007/978-1-60327-003-8_9, ISSN: 1064-3745.

Scherer RL, McIntyre JO, Matrisian LM. Imaging matrix metalloproteinases in cancerCancer Metastasis Rev. 2008 Dec; 27(4): 679-90. PMID: 18465089, DOI: 10.1007/s10555-008-9152-9, ISSN: 0167-7659.

Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JOFunctional colonography of Min mice using dark lumen dynamic contrast-enhanced MRIMagn Reson Med. 2008 Sep; 60(3): 718-26. PMID: 18727087, PMCID: PMC2646120, DOI: 10.1002/mrm.21724, ISSN: 1522-2594.

Scherer RL, VanSaun MN, McIntyre JO, Matrisian LM. Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeaconMol Imaging. 2008 May; 7(3): 118-31. PMID: 19123982, PMCID: PMC2777890, ISSN: 1535-3508.

Martin MD, Fingleton B, Lynch CC, Wells S, McIntyre JO, Piston DW, Matrisian LM. Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowthClin. Exp. Metastasis [print-electronic]. 2008; 25(8): 877-85. PMID: 18787962, PMCID: PMC2588650, DOI: 10.1007/s10585-008-9206-y, ISSN: 1573-7276.

Lepage M, Dow WC, Melchior M, You Y, Fingleton B, Quarles CC, Pépin C, Gore JC, Matrisian LM, McIntyre JONoninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switchMol Imaging. 2007 Nov; 6(6): 393-403. PMID: 18053410, ISSN: 1535-3508.

Harrell PC, McCawley LJ, Fingleton B, McIntyre JO, Matrisian LM. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cellsExp. Cell Res [print-electronic]. 2005 Feb 2/15/2005; 303(2): 308-20. PMID: 15652345, PII: S0014-4827(04)00574-9, DOI: 10.1016/j.yexcr.2004.09.020, ISSN: 0014-4827.

Fingleton B, Menon R, Carter KJ, Overstreet PD, Hachey DL, Matrisian LM, McIntyre JOProteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacyClin. Cancer Res. 2004 Dec 12/1/2004; 10(23): 7865-74. PMID: 15585619, PII: 10/23/7865, DOI: 10.1158/1078-0432.CCR-04-1252, ISSN: 1078-0432.

McIntyre JO, Fingleton B, Wells KS, Piston DW, Lynch CC, Gautam S, Matrisian LM. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activityBiochem. J. 2004 Feb 2/1/2004; 377(Pt 3): 617-28. PMID: 14556651, PMCID: PMC1223892, PII: BJ20030582, DOI: 10.1042/BJ20030582, ISSN: 1470-8728.

McIntyre JO, Matrisian LM. Molecular imaging of proteolytic activity in cancerJ. Cell. Biochem. 2003 Dec 12/15/2003; 90(6): 1087-97. PMID: 14635184, DOI: 10.1002/jcb.10713, ISSN: 0730-2312.

Jeyakumar LH, Ballester L, Cheng DS, McIntyre JO, Chang P, Olivey HE, Rollins-Smith L, Barnett JV, Murray K, Xin HB, Fleischer S. FKBP binding characteristics of cardiac microsomes from diverse vertebratesBiochem. Biophys. Res. Commun. 2001 Mar 3/9/2001; 281(4): 979-86. PMID: 11237759, PII: S0006-291X(01)94444-4, DOI: 10.1006/bbrc.2001.4444, ISSN: 0006-291X.

Loeb-Hennard C, McIntyre JO(R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domainBiochemistry. 2000 Oct 10/3/2000; 39(39): 11928-38. PMID: 11009606, PII: bi000425y, ISSN: 0006-2960.

Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sitesJ. Neurochem. 1999 Apr; 72(4): 1617-24. PMID: 10098869, ISSN: 0022-3042.

Green, D., Marks, A.R., Fleischer, S., and McIntyre, J.O. Wild Type and Mutant Human Heart (R)-3- Hydroxybutyrate Dehydrogenase Expressed in Insect Cells. Biochemistry. 1996; 35: 8158-65.

Klein, K., Rudy, B., McIntyre, J.O., Fleischer, S., and Trommer, W.E. Specific Interaction of (R)-3-Hydroxybutyrate Dehydrogenase with Membrane Phosphatidylcholine as Studied by ESR Specroscopy in Oriented Phospholipid Multibilayers: Coenzyme Binding Enhances the Interaction with Phosphatidylcholine. Biochemistry. 1996; 35: 3044-9.

Dalton LA, McIntyre JO, Fleischer S. Effect of selective thiol-group derivatization on enzyme kinetics of (R)-3-hydroxybutyrate dehydrogenaseBiochem. J. 1993 Dec 12/15/1993; 296 ( Pt 3): 563-9. PMID: 8280053, PMCID: PMC1137735, ISSN: 0264-6021.

Adami P, Duncan TM, McIntyre JO, Carter CE, Fu C, Melin M, Latruffe N, Fleischer S. Monoclonal antibodies for structure-function studies of (R)-3-hydroxybutyrate dehydrogenase, a lipid-dependent membrane-bound enzymeBiochem. J. 1993 Jun 6/15/1993; 292 ( Pt 3): 863-72. PMID: 7686368, PMCID: PMC1134194, ISSN: 0264-6021.

Fleischer B, McIntyre JO, Kempner ES. Target sizes of galactosyltransferase, sialyltransferase, and uridine diphosphatase in Golgi apparatus of rat liverBiochemistry. 1993 Mar 3/2/1993; 32(8): 2076-81. PMID: 8383532, ISSN: 0006-2960.

Cortese JD, McIntyre JO, Duncan TM, Fleischer S. Cooperativity in lipid activation of 3-hydroxybutyrate dehydrogenase: role of lecithin as an essential allosteric activatorBiochemistry. 1989 Apr 4/4/1989; 28(7): 3000-8. PMID: 2742824, ISSN: 0006-2960.

McIntyre JO, Latruffe N, Brenner SC, Fleischer S. Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondriaArch. Biochem. Biophys. 1988 Apr; 262(1): 85-98. PMID: 3355176, PII: 0003-9861(88)90171-3, ISSN: 0003-9861.