Feng Wang, Ph.D.

Assistant Professor
Radiology & Radiological Sciences
Delivery Address
Medical Center North
1161 21st Avenue South, CCC-1118

Feng Wang, PhD, earned a PhD in Physical Chemistry from Vanderbilt University. After completing a post-doctoral fellowship in Biophysics at Vanderbilt University, she joined the faculty in 2008. Dr. Wang was the recipient of the Best Teacher Award (UESTC) in 1998 and the Warren Award in 2002. Dr. Wang’s research is focused on the MRI protocols for functional study of non-human primates and MRI assays for investigating spinal cord injuries. In addition, she is applying an array of quantitative MRI methods for assessing kidney disease using murine models. She is a member of the American Chemical Society and ISMRM.

Section: Vanderbilt University Institute of Imaging Science


Mishra A, Majumdar S, Wang F, Wilson GH, Gore JC, Chen LM. Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeysHum Brain Mapp [print-electronic]. 2018 Sep 9/25/2018; PMID: 30251760, DOI: 10.1002/hbm.24375, ISSN: 1097-0193.

Wu TL, Wang F, Li M, Schilling KG, Gao Y, Anderson AW, Chen LM, Ding Z, Gore JC. Resting-state white matter-cortical connectivity in non-human primate brainNeuroimage [print-electronic]. 2018 Sep 9/8/2018; 184: 45-55. PMID: 30205207, PII: S1053-8119(18)30806-1, DOI: 10.1016/j.neuroimage.2018.09.021, ISSN: 1095-9572.

Wang F, Katagiri D, Li K, Takahashi K, Wang S, Nagasaka S, Li H, Quarles CC, Zhang MZ, Shimizu A, Gore JC, Harris RC, Takahashi T. Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRIMagn Reson Med [print-electronic]. 2018 May 5/30/2018; PMID: 29845659, DOI: 10.1002/mrm.27231, ISSN: 1522-2594.

Zhang XY, Wang F, Xu J, Gochberg DF, Gore JC, Zu Z. Increased CEST specificity for amide and fast-exchanging amine protons using exchange-dependent relaxation rateNMR Biomed [print-electronic]. 2017 Nov 11/29/2017; PMID: 29193448, DOI: 10.1002/nbm.3863, ISSN: 1099-1492.

Wu TL, Wang F, Mishra A, Wilson GH, Byun N, Chen LM, Gore JC. Resting-state functional connectivity in the rat cervical spinal cord at 9.4 TMagn Reson Med [print-electronic]. 2017 Sep 9/14/2017; PMID: 28905408, DOI: 10.1002/mrm.26905, ISSN: 1522-2594.

Schilling KG, Gao Y, Stepniewska I, Wu TL, Wang F, Landman BA, Gore JC, Chen LM, Anderson AW. The VALiDATe29 MRI Based Multi-Channel Atlas of the Squirrel Monkey BrainNeuroinformatics [print-electronic]. 2017 Jul 7/26/2017; PMID: 28748393, PII: 10.1007/s12021-017-9334-0, DOI: 10.1007/s12021-017-9334-0, ISSN: 1559-0089.

Wang F, Takahashi K, Li H, Zu Z, Li K, Xu J, Harris RC, Takahashi T, Gore JC. Assessment of unilateral ureter obstruction with multi-parametric MRIMagn Reson Med [print-electronic]. 2017 Jul 7/24/2017; PMID: 28736875, DOI: 10.1002/mrm.26849, ISSN: 1522-2594.

Zhang XY, Xie J, Wang F, Lin EC, Xu J, Gochberg DF, Gore JC, Zu Z. Assignment of the molecular origins of CEST signals at 2¿ppm in rat brainMagn Reson Med [print-electronic]. 2017 Jun 6/26/2017; PMID: 28653349, DOI: 10.1002/mrm.26802, ISSN: 1522-2594.

Wang F, Zu Z, Wu R, Wu TL, Gore JC, Chen LM. MRI evaluation of regional and longitudinal changes in Z-spectra of injured spinal cord of monkeysMagn Reson Med [print-electronic]. 2017 May 5/25/2017; PMID: 28547862, DOI: 10.1002/mrm.26756, ISSN: 1522-2594.

Shi Z, Wu R, Yang PF, Wang F, Wu TL, Mishra A, Chen LM, Gore JC. High spatial correspondence at a columnar level between activation and resting state fMRI signals and local field potentialsProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 May 5/1/2017; PMID: 28461461, PII: 1620520114, DOI: 10.1073/pnas.1620520114, ISSN: 1091-6490.

Wu R, Wang F, Yang PF, Min Chen L. High-resolution Functional MRI Identified Distinct Global Intrinsic Functional Networks of Nociceptive Posterior Insula and S2 regions in Squirrel Monkey BrainNeuroimage [print-electronic]. 2017 Apr 4/28/2017; PMID: 28461059, PII: S1053-8119(17)30386-5, DOI: 10.1016/j.neuroimage.2017.04.067, ISSN: 1095-9572.

Zhang XY, Wang F, Li H, Xu J, Gochberg DF, Gore JC, Zu Z. CEST imaging of fast exchanging amine pools with corrections for competing effects at 9.4 TNMR Biomed [print-electronic]. 2017 Mar 3/8/2017; PMID: 28272785, DOI: 10.1002/nbm.3715, ISSN: 1099-1492.

Zhang XY, Wang F, Li H, Xu J, Gochberg DF, Gore JC, Zu Z. Accuracy in the quantification of chemical exchange saturation transfer (CEST) and relayed nuclear Overhauser enhancement (rNOE) saturation transfer effectsNMR Biomed [print-electronic]. 2017 Mar 3/8/2017; PMID: 28272761, DOI: 10.1002/nbm.3716, ISSN: 1099-1492.

Chen LM, Yang PF, Wang F, Mishra A, Shi Z, Wu R, Wu TL, Wilson GH, Ding Z, Gore JC. Biophysical and neural basis of resting state functional connectivity: Evidence from non-human primatesMagn Reson Imaging [print-electronic]. 2017 Feb 2/2/2017; 39: 71-81. PMID: 28161319, PII: S0730-725X(17)30027-9, DOI: 10.1016/j.mri.2017.01.020, ISSN: 1873-5894.

Wu TL, Mishra A, Wang F, Yang PF, Gore JC, Chen LM. Effects of isoflurane anesthesia on resting-state fMRI signals and functional connectivity within primary somatosensory cortex of monkeysBrain Behav. 2016 Dec; 6(12): e00591. PMID: 28032008, PMCID: PMC5167001, PII: BRB3591, DOI: 10.1002/brb3.591, ISSN: 2162-3279.

Wu TL, Wang F, Anderson AW, Chen LM, Ding Z, Gore JC. Effects of anesthesia on resting state BOLD signals in white matter of non-human primatesMagn Reson Imaging [print-electronic]. 2016 Nov; 34(9): 1235-41. PMID: 27451405, PMCID: PMC5055423, PII: S0730-725X(16)30078-9, DOI: 10.1016/j.mri.2016.07.001, ISSN: 1873-5894.

Zhang XY, Wang F, Jin T, Xu J, Xie J, Gochberg DF, Gore JC, Zu Z. MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4¿TMagn Reson Med [print-electronic]. 2016 Sep 9/8/2016; PMID: 27604612, DOI: 10.1002/mrm.26396, ISSN: 1522-2594.

Qi HX, Wang F, Liao CC, Friedman RM, Tang C, Kaas JH, Avison MJ. Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeysNeuroimage [print-electronic]. 2016 Aug 8/12/2016; PMID: 27523450, PII: S1053-8119(16)30393-7, DOI: 10.1016/j.neuroimage.2016.08.015, ISSN: 1095-9572.

Zhang XY, Wang F, Afzal A, Xu J, Gore JC, Gochberg DF, Zu Z. A new NOE-mediated MT signal at around -1.6ppm for detecting ischemic stroke in rat brainMagn Reson Imaging [print-electronic]. 2016 May 5/20/2016; 34(8): 1100-6. PMID: 27211260, PII: S0730-725X(16)30048-0, DOI: 10.1016/j.mri.2016.05.002, ISSN: 1873-5894.

Wang F, Li K, Mishra A, Gochberg D, Min Chen L, Gore JC. Longitudinal assessment of spinal cord injuries in nonhuman primates with quantitative magnetization transferMagn Reson Med [print-electronic]. 2016 Apr; 75(4): 1685-96. PMID: 25960050, PMCID: PMC4637273, DOI: 10.1002/mrm.25725, ISSN: 1522-2594.

Gao Y, Parvathaneni P, Schilling KG, Wang F, Stepniewska I, Xu Z, Choe AS, Ding Z, Gore JC, Chen LM, Landman BA, Anderson AW. A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (Saimiri sciureus) based on diffusion tensor imagingProc SPIE Int Soc Opt Eng [print-electronic]. 2016 Feb 2/27/2016; 9784: PMID: 27064328, PMCID: PMC4825691, DOI: 10.1117/12.2217325, ISSN: 0277-786X.

Wang F, Kopylov D, Zu Z, Takahashi K, Wang S, Quarles CC, Gore JC, Harris RC, Takahashi T. Mapping murine diabetic kidney disease using chemical exchange saturation transfer MRIMagn Reson Med [print-electronic]. 2015 Nov 11/26/2015; PMID: 26608660, PMCID: PMC4882276, DOI: 10.1002/mrm.26045, ISSN: 1522-2594.

Li H, Jiang X, Wang F, Xu J, Gore JC. Structural information revealed by the dispersion of ADC with frequencyMagn Reson Imaging [print-electronic]. 2015 Nov; 33(9): 1083-90. PMID: 26117695, PMCID: PMC4593726, PII: S0730-725X(15)00154-X, DOI: 10.1016/j.mri.2015.06.009, ISSN: 1873-5894.

Wang F, Qi HX, Zu Z, Mishra A, Tang C, Gore JC, Chen LM. Multiparametric MRI reveals dynamic changes in molecular signatures of injured spinal cord in monkeysMagn Reson Med [print-electronic]. 2015 Oct; 74(4): 1125-37. PMID: 25334025, PMCID: PMC4405405, DOI: 10.1002/mrm.25488, ISSN: 1522-2594.

Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Mernaugh RL, Chen W, Roberts J, Osborn JW, Itani HA, Harrison DG. Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced HypertensionCirc. Res [print-electronic]. 2015 Aug 8/28/2015; 117(6): 547-57. PMID: 26156232, PMCID: PMC4629828, PII: CIRCRESAHA.115.306010, DOI: 10.1161/CIRCRESAHA.115.306010, ISSN: 1524-4571.

Yang PF, Wang F, Chen LM. Differential fMRI Activation Patterns to Noxious Heat and Tactile Stimuli in the Primate Spinal CordJ. Neurosci. 2015 Jul 7/22/2015; 35(29): 10493-502. PMID: 26203144, PMCID: PMC4510289, PII: 35/29/10493, DOI: 10.1523/JNEUROSCI.0583-15.2015, ISSN: 1529-2401.

Chen LM, Mishra A, Yang PF, Wang F, Gore JC. Injury alters intrinsic functional connectivity within the primate spinal cordProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 May 5/12/2015; 112(19): 5991-6. PMID: 25902510, PMCID: PMC4434735, PII: 1424106112, DOI: 10.1073/pnas.1424106112, ISSN: 1091-6490.

Takahashi T, Wang F, Quarles CC. Current MRI techniques for the assessment of renal diseaseCurr. Opin. Nephrol. Hypertens. 2015 May; 24(3): 217-23. PMID: 26066472, PMCID: PMC4467464, PII: 00041552-201505000-00004, DOI: 10.1097/MNH.0000000000000122, ISSN: 1473-6543.

Wang F, Jiang R, Takahashi K, Gore J, Harris RC, Takahashi T, Quarles CC. Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imagingMagn Reson Imaging [print-electronic]. 2014 Nov; 32(9): 1125-32. PMID: 25093632, PMCID: PMC4171209, PII: S0730-725X(14)00215-X, DOI: 10.1016/j.mri.2014.07.012, ISSN: 1873-5894.

Wang F, Jiang RT, Tantawy MN, Borza DB, Takahashi K, Gore JC, Harris RC, Takahashi T, Quarles CC. Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney diseaseJ Magn Reson Imaging [print-electronic]. 2014 Apr; 39(4): 866-71. PMID: 24006202, PMCID: PMC3858530, DOI: 10.1002/jmri.24242, ISSN: 1522-2586.

Chen G, Wang F, Gore JC, Roe AW. Layer-specific BOLD activation in awake monkey V1 revealed by ultra-high spatial resolution functional magnetic resonance imagingNeuroimage [print-electronic]. 2013 Jan 1/1/2013; 64: 147-55. PMID: 22960152, PMCID: PMC3508288, PII: S1053-8119(12)00868-3, DOI: 10.1016/j.neuroimage.2012.08.060, ISSN: 1095-9572.

Chen G, Wang F, Gore JC, Roe AW. Identification of cortical lamination in awake monkeys by high resolution magnetic resonance imagingNeuroimage [print-electronic]. 2012 Feb 2/15/2012; 59(4): 3441-9. PMID: 22080152, PMCID: PMC3288753, PII: S1053-8119(11)01243-2, DOI: 10.1016/j.neuroimage.2011.10.079, ISSN: 1095-9572.

Tantawy MN, Jiang R, Wang F, Takahashi K, Peterson TE, Zemel D, Hao CM, Fujita H, Harris RC, Quarles CC, Takahashi T. Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphyBMC Nephrol. 2012; 13: 168. PMID: 23228112, PMCID: PMC3542003, PII: 1471-2369-13-168, DOI: 10.1186/1471-2369-13-168, ISSN: 1471-2369.

Chen LM, Dillenburger BC, Wang F, Tang CH. Differential fMRI activation to noxious heat and tactile stimuli in parasylvian areas of new world monkeysPain [print-electronic]. 2012 Jan; 153(1): 158-69. PMID: 22115923, PMCID: PMC3245780, PII: S0304-3959(11)00592-6, DOI: 10.1016/j.pain.2011.10.006, ISSN: 1872-6623.

Chen G, Wang F, Dillenburger BC, Friedman RM, Chen LM, Gore JC, Avison MJ, Roe AW. Functional magnetic resonance imaging of awake monkeys: some approaches for improving imaging qualityMagn Reson Imaging [print-electronic]. 2012 Jan; 30(1): 36-47. PMID: 22055855, PMCID: PMC3236665, PII: S0730-725X(11)00341-9, DOI: 10.1016/j.mri.2011.09.010, ISSN: 1873-5894.

Lecoeur J, Wang F, Chen LM, Li R, Avison MJ, Dawant BM. Automated longitudinal registration of high resolution structural MRI brain sub-volumes in non-human primatesJ. Neurosci. Methods [print-electronic]. 2011 Oct 10/30/2011; 202(1): 99-108. PMID: 21920386, PMCID: PMC3374491, PII: S0165-0270(11)00521-8, DOI: 10.1016/j.jneumeth.2011.08.046, ISSN: 1872-678X.

Chen LM, Dillenburger BC, Wang F, Friedman RM, Avison MJ. High-resolution functional magnetic resonance imaging mapping of noxious heat and tactile activations along the central sulcus in New World monkeysPain [print-electronic]. 2011 Mar; 152(3): 522-32. PMID: 21177033, PMCID: PMC3039029, PII: S0304-3959(10)00682-2, DOI: 10.1016/j.pain.2010.10.048, ISSN: 1872-6623.

Lecoeur J, Wang F, Chen LM, Li R, Avison MJ, Dawant BM. Co-registration of high resolution MRI scans with partial brain coverage in non-human primatesProc SPIE Int Soc Opt Eng. 2011 Feb 2/11/2011; 7962: PMID: 24236222, PMCID: PMC3824268, DOI: 10.1117/12.877024, ISSN: 0277-786X.

Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ. The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitroChem. Res. Toxicol. 2010 Jun 6/21/2010; 23(6): 1076-88. PMID: 20377178, PMCID: PMC2891123, DOI: 10.1021/tx100053n, ISSN: 1520-5010.

Zhang N, Wang F, Turner GH, Gore JC, Avison MJ, Chen LM. Intra- and inter-subject variability of high field fMRI digit maps in somatosensory area 3b of new world monkeysNeuroscience [print-electronic]. 2010 Jan 1/13/2010; 165(1): 252-64. PMID: 19799969, PMCID: PMC2787639, PII: S0306-4522(09)01624-8, DOI: 10.1016/j.neuroscience.2009.09.066, ISSN: 1873-7544.

Wang F, Li F, Ganguly M, Marky LA, Gold B, Egli M, Stone MP. A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustardsBiochemistry [print-electronic]. 2008 Jul 7/8/2008; 47(27): 7147-57. PMID: 18549246, PMCID: PMC2730145, DOI: 10.1021/bi800375m, ISSN: 1520-4995.

Wang F, Elmquist CE, Stover JS, Rizzo CJ, Stone MP. DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzymeBiochemistry [print-electronic]. 2007 Jul 7/24/2007; 46(29): 8498-516. PMID: 17602664, PMCID: PMC2782574, DOI: 10.1021/bi700361u, ISSN: 0006-2960.

Elmquist CE, Wang F, Stover JS, Stone MP, Rizzo CJ. Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) within the NarI recognition sequenceChem. Res. Toxicol [print-electronic]. 2007 Mar; 20(3): 445-54. PMID: 17311423, PMCID: PMC2743555, DOI: 10.1021/tx060229d, ISSN: 0893-228X.

Gangluly, M, Wang, F, Kaushik, M, Stone, MP, Marky, MA, Gold B. A study of 7-deaza-2 -deoxyguanosine-2-deoxycytidine base pairing in DNA. Nucleic Acids Research. 2007; 18((35)): 6181-95.

Wang F, DeMuro NE, Elmquist CE, Stover JS, Rizzo CJ, Stone MP. Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletionsJ. Am. Chem. Soc. 2006 Aug 8/9/2006; 128(31): 10085-95. PMID: 16881637, PMCID: PMC2692337, DOI: 10.1021/ja062004v, ISSN: 0002-7863.

He J, Wang F, Polavarapu PL. Absolute configurations of chiral herbicides determined from vibrational circular dichroismChirality. 2005; 17 Suppl: S1-8. PMID: 15612041, DOI: 10.1002/chir.20096, ISSN: 0899-0042.

Wang F, Zhao C, Polavarapu PL. A study of the conformations of valinomycin in solution phaseBiopolymers. 2004 Sep; 75(1): 85-93. PMID: 15307200, DOI: 10.1002/bip.20103, ISSN: 0006-3525.

Wang F, Polavarapu, PL, Drabowicz, J, etc. Solution and Crystal Structures of Chiral Molecules Can Be Significantly Different: tert-Butylphenylphosphinoselenoic Acid. J. Phys. Chem. 2004; 108: 2072-9.

Wang F, Polavarapu PL. Conformational analysis of melittin in solution phase: vibrational circular dichroism studyBiopolymers. 2003 Dec; 70(4): 614-9. PMID: 14648771, DOI: 10.1002/bip.10504, ISSN: 0006-3525.

Polavarapu PL, Petrovic A, Wang FIntrinsic rotation and molecular structureChirality. 2003; 15 Suppl: S143-9. PMID: 12884385, DOI: 10.1002/chir.10255, ISSN: 0899-0042.

Wang F, Wang Y, Polavarapu PL, Li T, Drabowicz J, Pietrusiewicz KM, Zygo K. Absolute configuration of tert-butyl-1-(2-methylnaphthyl)phosphine oxideJ. Org. Chem. 2002 Sep 9/6/2002; 67(18): 6539-41. PMID: 12201778, PII: jo025908h, ISSN: 0022-3263.

Wang F, Polavarapu PL, Schurig V, Schmidt R. Absolute configuration and conformational analysis of a degradation product of inhalation anesthetic Sevoflurane: A vibrational circular dichroism studyChirality. 2002 Aug; 14(8): 618-24. PMID: 12125030, DOI: 10.1002/chir.10106, ISSN: 0899-0042.

Wang, F, Polavarapu, PL, Lebon, F, Longhi, G, Abbate, S, Catellani, M. Absolute configuration and conformational stability of (S)-(+)-3-(2-methyl butyl)thiophene and (+)-3,4-di[(S)-2-methylbutyl)]thiophene and their polymers. J. Phys. Chem. A. 2002; 106: 5918-23.

Wang, F, Polavarapu, PL, Lebon, F, Longhi, G, Abbate, S, and Catellani, M. Conformational Analysis of (S)-(+)-1-Bromo-2-methylbutane and the Influence of Bromine on Conformational Stability. J. Phys. Chem. A. 2002; 106: 12365.

Lebon, F, Longhi, G, Abbate, S, Catellani, M, Wang, F, Polavarapu, PL. Circular Dichroism Spectra of Regioregular Poly{3[(S)-2-methylbutyl]-thiophene} and of poly{3,4-do[(S)-2-methylbutyl]-thiophene. Enantiomer. 2002; 7: 207-12.

Wang F, Wang H, Polavarapu PL, Rizzo CJ. Absolute configuration and conformational stability of (+)-2,5-dimethylthiolane and (-)-2,5-dimethylsulfolaneJ. Org. Chem. 2001 May 5/18/2001; 66(10): 3507-12. PMID: 11348137, PII: jo0100401, ISSN: 0022-3263.

Wang, F, Polavarapu, PL. Temperature Influence on the Secondary Structure of Avidin and Avidin-Biotin Complex: A Vibrational Circular Dichroism Study. J. Phys. Chem. B. 2001; 105: 7857-64.

Wang, F, Polavarapu, PL. Predominant Conformations of (2R,3R)-(-)-2,3- Butanediol. J. Phys. Chem. A. 2001; 105: 6991-7.

Wang, F, Polavarapu, PL. Vibrational Circular Dichroism: Predominant Conformations and Intermolecular Interactions in (R)-(-)-2-Butanol. J. Phys. Chem. A. 2000; 104: 10683-7.

Wang, F, Polavarapu, PL. Vibrational Circular Dichroism, Predominant Conformations, and Hydrogen Bonding in (S)-(-)-3-Butyn-2-ol. J. Phys. Chem. A. 2000; 104: 1822-6.

Wang, F, Polavarapu, PL. Conformational Stability of (+)-Epichlorohydrin. J. Phys. Chem. A. 2000; 104: 6189-96.

Wang, F, Polavarapu, PL, Drabowicz, J, Mikolajczyk, M. Absolute Configurations, Predominant Conformations and Tautomeric Structures of Enantiomeric tert-Butylphenylphosphine Oxides. J. Org. Chem. 2000; 65: 7561-5.

Clinical Interests