Changho Choi, Ph.D.
Changho Choi, PhD, completed B.S. and M.S. studies in physics in South Korea and earned his doctoral degree in physics from University of Waterloo, Canada in 1996, where he began to work in the nuclear magnetic resonance (NMR) field. Following several years of solid-state physics NMR research, Dr. Choi started to work in brain MR spectroscopy (MRS) at the University of Alberta, Canada in 2000. He continued brain MRS during his independent research period at UT Southwestern Medical Center, TX. Dr. Choi joined Vanderbilt Radiology as a research professor in 2022. Dr. Choi’s research is focused on development of MRS and identification of metabolic imaging biomarkers in patients with brain cancers (e.g., evaluation of IDH mutation status by 2HG MRS). Dr. Choi has a secondary faculty appointment at Psychiatry and conduct collaborative research with neuropsychiatrists. He is a member of the Society of Neuro-Oncology and the International Society of Magnetic Resonance for Medicine.
Ganji SK, An Z, Tiwari V, Chang Y, Patel TR, Maher EA, Choi C. Optimization of spectrally-selective 180 RF pulse timings in J-difference editing (MEGA) of lactate. Magnetic Resonance in Medicine 2022;87(3):1150-1164. PMID:34657302. PMCID:PMC8776585. DOI:10.1002/mrm.29051.
Tiwari V, Daoud EV, Hatanpaa KJ, Gao A, Zhang S, An Z, Ganji SK, Raisanen JM, Lewis CM, Askari P, Baxter J, Levy M, Dimitrov I, Thomas BP, Pinho MC, Madden CJ, Pan E, Patel TR, DeBerardinis RJ, Sherry AD, Mickey BE, Malloy CR, Maher EA, Choi C. Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. Neuro-oncology 2020;22(7):1018-1029. PMID:32055850. PMCID:PMC7339885. DOI:10.1093/neuonc/noaa034.
An Z, Tiwari V, Baxter J, Levy M, Hatanpaa KJ, Pan E, Maher EA, Patel TR, Mickey BE, Choi C. 3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo. Magnetic Resonance in Medicine 2019;81(2):795-802. PMID:30277274. PMCID:PMC30277274.
Tiwari V, An Z, Wang Y, Choi C. Distinction of the GABA 2.29 ppm resonance using triple refocusing at 3T in vivo. Magnetic Resonance in Medicine 2018;80:1307-1319. PMID:29446149. PMCID:PMC6092256.
Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TV, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EM. Prospective longitudinal analysis of 2-hydroxyglutarate MR spectroscopy identifies broad clinical utility for the management of IDH-mutant glioma patients. Journal of Clinical Oncology 2016;34(33):4030-4039. PMID:28248126. PMCID:PMC5477829.
Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CM, Bachoo R, Maher EA. 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated glioma patients. Nature Medicine 2012;18:624-629. PMID:22281806, PMCID:PMC3615719.
Choi C, Coupland NJ, Hanstock CC, Ogilvie CJ, Higgins ACM, Gheorghiu D, Allen PS. Brain gamma-aminobutyric acid measurements by proton double quantum filtering with selective J rewinding. Magnetic Resonance in Medicine 2005;54(2):272-279. PMID:16032672.
Choi C, Balcom BJ, Beyea SD, Bremner TW, Grattan-Bellew PE, Armstrong RL. Spatially-resolved pore-size distribution of drying concrete with magnetic resonance imaging. Journal of Applied Physics 2000;88(6):3578-3581. Choi C, Pintar MM. Observation of CH3 tunneling manifold by level-crossing NMR. Physical Review Letters 1996;76(3):527-530.