Dr. Donahue's focus is on acute, outpatient, and home care therapy primarily addressing orthopedic, oncologic, and geriatric conditions. She has a special research interest in the treatment of lymphedema in breast cancer survivors.
Certified Lymphedema Therapist, The Academy of Lymphatic Studies, Chattanooga, TN
MBA, (Masters of Business Administration), The Johns Hopkins University Carey Business
School, Baltimore, MD
Doctor of Physical Therapy, Northwestern University School of Medicine, Chicago, IL
BS, Biological Anthropology and Anatomy, Duke University, Durham, NC
Past Academic and Professional Appointments
Select Specialty Hospitals, Nashville, TN
Occupational Health Physiotherapist
Oxford Radcliffe Hospitals NHS Trust, Oxford, England
Dr. Donahue's research interests are in the areas of lymphedema, oncology, and manual techniques impacting tissue extensibility. She is collaborating with the Vanderbilt University Institute of Imaging Science (VUIIS) on breast cancer related lymphedema (BCRL) research, specifically development of non-invasive imaging techniques that are intended to better inform patient management and optimize lymphedema treatment interventions. While the reported incidence of lymphedema varies from 6-54% and the risk increases with time since treatment, currently it is not possible to determine a patient's specific risk for BCRL. If such a distinction could be made, early therapeutic intervention could be administered effectively to high-risk patients with the goal of preventing, or delaying, BCRL onset. Paula has helped demonstrate that new non-invasive MRI techniques that utilize "spin labeling" principles can measure lymphatic fluid flow dynamics and lymphatic node metabolic properties, which correlate with lymphatic obstruction. Importantly, as these methods utilize the magnetic properties of water as an endogenous tracer, they are completely non-invasive and therefore can readily be 1) implemented into standard clinical protocols, 2) applied in longitudinal studies, and 3) used to evaluate lymphatic property responses to therapeutic interventions.
- Crescenzi R, Donahue PM, Braxton VG, Scott AO, Mahany HB, Lants SK, Donahue MJ. 3.0 T relaxation time measurements of human lymph nodes in adults with and without lymphatic insufficiency: Implications for magnetic resonance lymphatic imaging. NMR in biomedicine. 2018 Oct 12. e4009. PMID: 30311705 [PubMed].
- Crescenzi R, Marton A, Donahue PMC, Mahany HB, Lants SK, Wang P, Beckman JA, Donahue MJ, Titze J. Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema. Obesity (Silver Spring, Md.). 2018 Feb;26(2). 310-317. PMID: 29280322 [PubMed]. PMCID: PMC5783748. NIHMSID: NIHMS920419.
- Donahue PM, Crescenzi R, Scott AO, Braxton V, Desai A, Smith SA, Jordi J, Meszoely IM, Grau AM, Kauffmann RM, Sweeting RS, Spotanski K, Ridner SH, Donahue MJ. Bilateral Changes in Deep Tissue Environment After Manual Lymphatic Drainage in Patients with Breast Cancer Treatment-Related Lymphedema. Lymphatic research and biology. 2017 Mar;15(1). 45-56. PMID: 28323572 [PubMed].
- Crescenzi R, Donahue PM, Hartley KG, Desai AA, Scott AO, Braxton V, Mahany H, Lants SK, Donahue MJ. Lymphedema evaluation using noninvasive 3T MR lymphangiography. Journal of magnetic resonance imaging : JMRI. 2017 Feb. PMID: 28245075 [PubMed].
- Donahue MJ, Donahue PC, Rane S, Thompson CR, Strother MK, Scott AO, Smith SA. Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI. Magnetic resonance in medicine. 2015 Mar 7. PMID: 25752499 [PubMed]. PMCID: PMC4561605. NIHMSID: NIHMS658865.
- Rane S, Donahue PM, Towse T, Ridner S, Chappell M, Jordi J, Gore J, Donahue MJ. Clinical feasibility of noninvasive visualization of lymphatic flow with principles of spin labeling MR imaging: implications for lymphedema assessment. RADIOLOGY. 2013 Dec;269(3). 893-902. PMID: 23864103 [PubMed].