2021
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Monteith AJ, Miller JM, Williams JM, Voss K, Rathmell JC, Crofford LJ, Skaar EP. Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating . Journal of immunology (Baltimore, Md. : 1950). 2021 Dec 20.
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Rathmell JC, Rathmell WK. Pushing the boundaries with collision collaboration: the marriage of ideas. The Journal of clinical investigation. 2021 Dec 19;131(131).
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Ramsey HE, Greenwood D, Zhang S, Childress M, Arrate MP, Gorska AE, Fuller L, Zhao Y, Stengel K, Fischer MA, Stubbs MC, Liu PCC, Boyd K, Rathmell JC, Hiebert SW, Savona MR. BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Dec 15;27(27). 598-607.
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Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. Journal of immunology (Baltimore, Md. : 1950). 2021 Dec 15;206(206). 1127-1139. NIHMSID: NIHMS1663959.
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Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. The Journal of clinical investigation. 2021 Dec 15;131(131).
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Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8 T cells during the primary immune response. Immunity. 2021 Dec 13;54(54). 829-844.e5. NIHMSID: NIHMS1678613.
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Yoo W, Zieba JK, Foegeding NJ, Torres TP, Shelton CD, Shealy NG, Byndloss AJ, Cevallos SA, Gertz E, Tiffany CR, Thomas JD, Litvak Y, Nguyen H, Olsan EE, Bennett BJ, Rathmell JC, Major AS, Bäumler AJ, Byndloss MX. High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine -oxide. Science (New York, N.Y.). 2021 Dec 13;373(373). 813-818.
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Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. 2021 Dec;593(593). 282-288. NIHMSID: NIHMS1686455.
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Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. Cancer research. 2021 Dec 1;81(81). 2345-2357. NIHMSID: NIHMS1677888.
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Baechle JJ, Hanna DN, Sekhar KR, Rathmell JC, Rathmell WK, Baregamian N. Integrative computational immunogenomic profiling of cortisol-secreting adrenocortical carcinoma. Journal of cellular and molecular medicine. 2021 Dec;25(25). 10061-10072.
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Dudzinski SO, Bader JE, Beckermann KE, Young KL, Hongo R, Madden MZ, Abraham A, Reinfeld BE, Ye X, MacIver NJ, Giorgio TD, Rathmell JC. Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages. Journal of immunology (Baltimore, Md. : 1950). 2021 Nov 12.
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Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2021 Nov 3.
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Voss K, Hong HS, Bader JE, Sugiura A, Lyssiotis CA, Rathmell JC. A guide to interrogating immunometabolism. Nature reviews. Immunology. 2021 Oct;21(21). 637-652. NIHMSID: NIHMS1699125.
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Hinshaw DC, Hanna A, Lama-Sherpa T, Metge B, Kammerud SC, Benavides GA, Kumar A, Alsheikh HA, Mota M, Chen D, Ballinger SW, Rathmell JC, Ponnazhagan S, Darley-Usmar V, Samant RS, Shevde LA. Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages. Cancer research. 2021 Jul 21.
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Baechle JJ, Hanna DN, Sekhar KR, Rathmell JC, Rathmell WK, Baregamian N. Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment. Surgery. 2021 Jul 11.
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Reinfeld BI, Rathmell WK, Kim TK, Rathmell JC. The therapeutic implications of immunosuppressive tumor aerobic glycolysis. Cellular & molecular immunology. 2021 Jul 8.
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Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker L, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM. Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine. BioRxiv : the preprint server for biology. 2021 Jul.
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Madden MZ, Rathmell JC. The Complex Integration of T-cell Metabolism and Immunotherapy. Cancer discovery. 2021 Jul;11(11). 1636-1643. NIHMSID: NIHMS1671246.
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Jia W, Poe JC, Su H, Anand S, Matsushima GK, Rathmell JC, Maillard I, Radojcic V, Imai K, Reyes NJ, Cardona DM, Li Z, Suthers AN, Curry-Chisolm IM, DiCioccio RA, Saban DR, Chen BJ, Chao NJ, Sarantopoulos S. BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation. Blood. 2021 May 6;137(137). 2544-2557.
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Tiriveedhi V, Ivy MT, Myles EL, Zent R, Rathmell JC, Titze J. Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response. Cancers. 2021 Apr 2;13(13).
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Rathmell JC. Obesity, Immunity, and Cancer. The New England journal of medicine. 2021 Mar 25;384(384). 1160-1162. NIHMSID: NIHMS1692469.
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Shiuan E, Reddy A, Dudzinski SO, Lim AR, Sugiura A, Hongo R, Young K, Liu XD, Smith CC, O'Neal J, Dahlman KB, McAlister R, Chen B, Ruma K, Roscoe N, Bender J, Ward J, Kim JY, Vaupel C, Bordeaux J, Ganesan S, Mayer TM, Riedlinger GM, Vincent BG, Davis NB, Haake SM, Rathmell JC, Jonasch E, Rini BI, Rathmell WK, Beckermann KE. Clinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma. Cancers. 2021 Mar 23;13(13).
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Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR. Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Frontiers in immunology. 12(12). 757836 p.
2020
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Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. ELife. 2020 Dec 23;9(9).
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Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. JCI insight. 2020 Dec 20;5(5).
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Bader JE, Voss K, Rathmell JC. Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. Molecular cell. 2020 Dec 18;78(78). 1019-1033. NIHMSID: NIHMS1598189.
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Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, Sun J. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8 T Cell Fitness and Functionality. Immunity. 2020 Dec 14;52(52). 201-202. NIHMSID: NIHMS1068771.
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Lim AR, Rathmell WK, Rathmell JC. The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy. ELife. 2020 Dec 5;9(9).
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Jiang X, Dudzinski S, Beckermann KE, Young K, McKinley E, J McIntyre O, Rathmell JC, Xu J, Gore JC. MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy. Journal for immunotherapy of cancer. 2020 Dec;8(8).
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Makowski L, Chaib M, Rathmell JC. Immunometabolism: From basic mechanisms to translation. Immunological reviews. 2020 Dec;295(295). 5-14. NIHMSID: NIHMS1667234.
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Raddatz MA, Huffstater T, Bersi MR, Reinfeld BI, Madden MZ, Booton SE, Rathmell WK, Rathmell JC, Lindman BR, Madhur MS, Merryman WD. Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. Arteriosclerosis, thrombosis, and vascular biology. 2020 Dec;40(40). e153-e165. NIHMSID: NIHMS1581976.
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Wu H, Herr D, MacIver NJ, Rathmell JC, Gerriets VA. CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism. International immunopharmacology. 2020 Nov;88(88). 106922 p. NIHMSID: NIHMS1624734.
2019
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Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, Sun J. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8 T Cell Fitness and Functionality. Immunity. 2019 Sep 17;51(51). 491-507.e7.
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Dudzinski SO, Cameron BD, Wang J, Rathmell JC, Giorgio TD, Kirschner AN. Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. Journal for immunotherapy of cancer. 2019 Aug 14;7(7). 218 p.
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Savona MR, Rathmell JC. Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade. Cancer discovery. 2019 Jul;9(9). 831-833.
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Van der Windt GJW. Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T cell efficacy. Blood. 2019 May 10.
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Cantrell DA. Antigen receptor control of methionine metabolism in T cells. ELife. 2019 Mar 27;8(8).
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M M. Myeloid -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. Journal of immunology (Baltimore, Md. : 1950). 2019 Feb;202(202). 1265-1286.
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B B. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8 T cells. Science immunology. 2019 Jan;4(4).
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Fuseini H, Cephus JY, Wu P, Davis JB, Contreras DC, Gandhi VD, Rathmell JC, Newcomb DC. ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. Frontiers in immunology. 10(10). 2740 p.
2018
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Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM. Computational immune monitoring reveals abnormal double negative T cells present across human tumor types. Cancer immunology research. 2018 Nov 9.
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Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. 2018 Nov;563(563). 714-718.
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Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, De Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell. 2018 Oct 30.
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Rathmell WK, Rathmell JC, Linehan WM. Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Oct 29. JCO2018792309.
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Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, A Luevano L, Wolf MM, Baliga UK, Krieg C, Beeson C, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S. Targeting PIM Kinase with PD1 inhibition Improves Immunotherapeutic Anti-Tumor T Cell Response. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Oct 16.
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Priyadharshini B, Loschi M, Newton RH, Zhang JW, Finn KK, Gerriets VA, Huynh A, Rathmell JC, Blazar BR, Turka LA. Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. Journal of immunology (Baltimore, Md. : 1950). 2018 Oct 15;201(201). 2215-2219. NIHMSID: NIHMS1504878.
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Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene. 2018 May 23.
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Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nature medicine. 2018 May;24(24). 617-627. NIHMSID: NIHMS945763.
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Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nature medicine. 2018 Feb;24(24). 194-202. NIHMSID: NIHMS923829.
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Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL. Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell reports. 2018 Jan 23;22(22). 860-868. NIHMSID: NIHMS937936.
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Sugiura A, Rathmell JC. Metabolic Barriers to T Cell Function in Tumors. Journal of immunology (Baltimore, Md. : 1950). 2018 Jan 15;200(200). 400-407. NIHMSID: NIHMS905230.
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Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ. Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cellular and molecular gastroenterology and hepatology. 5(5). 627-629.e6.
2017
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Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell metabolism. 2017 Oct 3;26(26). 648-659.e8. NIHMSID: NIHMS905247.
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Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. Cell metabolism. 2017 Oct 3;26(26). 633-647.e7. NIHMSID: NIHMS910106.
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Andrejeva G, Rathmell JC. Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. Cell metabolism. 2017 Jul 5;26(26). 49-70.
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MacIver NJ, Rathmell JC. Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate. Current opinion in immunology. 2017 Jul 3.
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Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. JCI insight. 2017 Jun 15;2(2).
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Beckermann KE, Dudzinski SO, Rathmell JC. Dysfunctional T cell metabolism in the tumor microenvironment. Cytokine & growth factor reviews. 2017 Jun;35(35). 7-14.
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Olenchock BA, Rathmell JC, Vander Heiden MG. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. Immunity. 2017 May 16;46(46). 703-713.
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Rhoads JP, Major AS, Rathmell JC. Fine tuning of immunometabolism for the treatment of rheumatic diseases. Nature reviews. Rheumatology. 2017 May;13(13). 313-320. NIHMSID: NIHMS876311.
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Schmidt EA, Fee BE, Henry SC, Nichols AG, Shinohara ML, Rathmell JC, MacIver NJ, Coers J, Ilkayeva OR, Koves TR, Taylor GA. Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. The Journal of biological chemistry. 2017 Mar 17;292(292). 4651-4662.
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Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB. Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. Oncoimmunology. 6(6). e1305535.
2016
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Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL. Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. Cell reports. 2016 Dec 20;17(17). 3142-3152. NIHMSID: NIHMS832473.
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Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, De Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nature immunology. 2016 Dec;17(17). 1459-1466.
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Siska PJ, Rathmell JC. Metabolic Signaling Drives IFN-γ. Cell metabolism. 2016 Nov 8;24(24). 651-652.
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Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. Journal of immunological methods. 2016 Nov;438(438). 51-58. NIHMSID: NIHMS819816.
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Johnson MO, Siska PJ, Contreras DC, Rathmell JC. Nutrients and the microenvironment to feed a T cell army. Seminars in immunology. 2016 Oct 3.
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Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. 2016 Sep 20;45(45). 540-54. NIHMSID: NIHMS819812.
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Siska PJ, Van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC. Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. Journal of immunology (Baltimore, Md. : 1950). 2016 Sep 15;197(197). 2532-40. NIHMSID: NIHMS805191.
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O'Neill LA, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nature reviews. Immunology. 2016 Sep;16(16). 553-65. NIHMSID: NIHMS808179.
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Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, De Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell metabolism. 2016 Apr 12;23(23). 649-62. NIHMSID: NIHMS773780.
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Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell reports. 2016 Apr 12;15(15). 323-35. NIHMSID: NIHMS768238.
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Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Developmental cell. 2016 Mar 7;36(36). 540-9. NIHMSID: NIHMS760116.
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McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA. Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proceedings of the National Academy of Sciences of the United States of America. 2016 Feb 9;113(113). E782-90.
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Johnson MO, Rathmell JC. AIF Is "Always In Fashion" for T Cells. Immunity. 2016 Jan 19;44(44). 11-3.
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Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. Journal of immunology (Baltimore, Md. : 1950). 2016 Jan 1;196(196). 196-206. NIHMSID: NIHMS734986.
2015
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Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell metabolism. 2015 Dec 1;22(22). 1009-19. NIHMSID: NIHMS722570.
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Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Aug 26.
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Siska PJ, Rathmell JC. PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1. Molecular cell. 2015 Jun 4;58(58). 711-2.
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Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiation research. 2015 Jun;183(183). 594-609.
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Siska PJ, Rathmell JC. T cell metabolic fitness in antitumor immunity. Trends in immunology. 2015 Apr;36(36). 257-64. NIHMSID: NIHMS672092.
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Kountikov EI, Poe JC, Maclver NJ, Rathmell JC, Tedder TF. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. The American journal of pathology. 2015 Mar;185(185). 617-30.
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Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nature immunology. 2015 Feb;16(16). 188-96. NIHMSID: NIHMS646214.
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Kishton RJ, Rathmell JC. Novel therapeutic targets of tumor metabolism. Cancer journal (Sudbury, Mass.). 21(21). 62-9. NIHMSID: NIHMS660026.
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Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of clinical investigation. 2015 Jan;125(125). 194-207.
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Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ. Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. Journal of cellular biochemistry. 2015 Jan;116(116). 67-80. NIHMSID: NIHMS630321.
2014
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Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Science signaling. 2014 Dec 23;7(7). ra121. NIHMSID: NIHMS666905.
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Wang B, Liu TY, Lai CH, Rao YH, Choi MC, Chi JT, Dai JW, Rathmell JC, Yao TP. Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. Molecular biology of the cell. 2014 Nov 1;25(25). 3300-7.
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Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell metabolism. 2014 Jul 1;20(20). 61-72. NIHMSID: NIHMS599060.
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Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. Journal of immunology (Baltimore, Md. : 1950). 2014 Apr 15;192(192). 3626-36. NIHMSID: NIHMS569837.
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Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, Macintyre AN, Goraksha-Hicks P, Rathmell JC, Makowski L. Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. The Journal of biological chemistry. 2014 Mar 14;289(289). 7884-96.
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Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC. Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. Cell death & disease. 5(5). e1470.
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Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PloS one. 9(9). e104104.
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Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PloS one. 9(9). e98705.
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Saucillo DC, Gerriets VA, Sheng J, Rathmell JC, Maciver NJ. Leptin metabolically licenses T cells for activation to link nutrition and immunity. Journal of immunology (Baltimore, Md. : 1950). 2014 Jan 1;192(192). 136-44. NIHMSID: NIHMS535099.
2013
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McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK. Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer biology & therapy. 2013 Apr;14(14). 315-8.
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Kurokawa M, Ito T, Yang CS, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. 2013 Feb 5;110(110). 2300-5.
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Macintyre AN, Rathmell JC. Activated lymphocytes as a metabolic model for carcinogenesis. Cancer & metabolism. 1(1). 5 p.
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MacIver NJ, Michalek RD, Rathmell JC. Metabolic regulation of T lymphocytes. Annual review of immunology. 31(31). 259-83. NIHMSID: NIHMS438917.
2012
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Caro-Maldonado A, Gerriets VA, Rathmell JC. Matched and mismatched metabolic fuels in lymphocyte function. Seminars in immunology. 2012 Dec;24(24). 405-13. NIHMSID: NIHMS430659.
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Altman BJ, Rathmell JC. Metabolic stress in autophagy and cell death pathways. Cold Spring Harbor perspectives in biology. 2012 Sep;4(4). a008763. NIHMSID: NIHMS438926.
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Rathmell JC. Metabolism and autophagy in the immune system: immunometabolism comes of age. Immunological reviews. 2012 Sep;249(249). 5-13. NIHMSID: NIHMS438925.
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Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 17;109(109). 11818-23.
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Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, De Groot JF, De Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(8). 445-544.
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Gerriets VA, Rathmell JC. Metabolic pathways in T cell fate and function. Trends in immunology. 2012 Apr;33(33). 168-73. NIHMSID: NIHMS352110.
2011
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Rathmell JC. T cell Myc-tabolism. Immunity. 2011 Dec 23;35(35). 845-6. NIHMSID: NIHMS350985.
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Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011 Dec;152(152). 4691-705.
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Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 2011 Nov 8;108(108). 18348-53.
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MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. Journal of immunology (Baltimore, Md. : 1950). 2011 Oct 15;187(187). 4187-98. NIHMSID: NIHMS319681.
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Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer research. 2011 Aug 1;71(71). 5204-13. NIHMSID: NIHMS303625.
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Macintyre AN, Rathmell JC. PKM2 and the tricky balance of growth and energy in cancer. Molecular cell. 2011 Jun 24;42(42). 713-4. NIHMSID: NIHMS350982.
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Altman BJ, Jacobs SR, Mason EF, Michalek RD, MacIntyre AN, Coloff JL, Ilkayeva O, Jia W, He YW, Rathmell JC. Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene. 2011 Apr 21;30(30). 1855-67. NIHMSID: NIHMS250870.
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Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Molecular biology of the cell. 2011 Apr 15;22(22). 1207-16.
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Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE, Rathmell JC, Li C. ER stress modulates cellular metabolism. The Biochemical journal. 2011 Apr 1;435(435). 285-96. NIHMSID: NIHMS283361.
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Mason EF, Rathmell JC. Cell metabolism: an essential link between cell growth and apoptosis. Biochimica et biophysica acta. 2011 Apr;1813(1813). 645-54. NIHMSID: NIHMS233823.
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Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. Journal of immunology (Baltimore, Md. : 1950). 2011 Mar 15;186(186). 3299-303. NIHMSID: NIHMS331089.
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Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of biological chemistry. 2011 Feb 18;286(286). 5921-33.
2010
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Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer research. 2010 Oct 15;70(70). 8066-76. NIHMSID: NIHMS228701.
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Michalek RD, Rathmell JC. The metabolic life and times of a T-cell. Immunological reviews. 2010 Jul;236(236). 190-202. NIHMSID: NIHMS250599.
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Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer research. 2010 Apr 15;70(70). 3080-8. NIHMSID: NIHMS182094.
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Jacobs SR, Michalek RD, Rathmell JC. IL-7 is essential for homeostatic control of T cell metabolism in vivo. Journal of immunology (Baltimore, Md. : 1950). 2010 Apr 1;184(184). 3461-9. NIHMSID: NIHMS250598.
2009
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Goraksha-Hicks P, Rathmell JC. TGF-beta: a new role for an old AktTOR. Developmental cell. 2009 Jul;17(17). 6-8. NIHMSID: NIHMS159507.
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Rathmell JC, Newgard CB. Biochemistry. A glucose-to-gene link. Science (New York, N.Y.). 2009 May 22;324(324). 1021-2. NIHMSID: NIHMS159506.
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Altman BJ, Rathmell JC. Autophagy: not good OR bad, but good AND bad. Autophagy. 2009 May;5(5). 569-70. NIHMSID: NIHMS159501.
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Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S, Rathmell JC. An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. The Biochemical journal. 2009 Mar 1;418(418). 345-67. NIHMSID: NIHMS81578.
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Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Molecular endocrinology (Baltimore, Md.). 2009 Mar;23(23). 388-401.
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Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC. Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Molecular biology of the cell. 2009 Feb;20(20). 1180-91.
2008
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Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. The Journal of biological chemistry. 2008 Dec 26;283(283). 36344-53.
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Michalek RD, Rathmell JC. Methed-up FOXOs can't in-Akt-ivate. Molecular cell. 2008 Oct 24;32(32). 160-2. NIHMSID: NIHMS81577.
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Maciver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. Journal of leukocyte biology. 2008 Oct;84(84). 949-57.
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Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends in biochemical sciences. 2008 Aug;33(33). 359-62. NIHMSID: NIHMS79312.
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Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. Journal of immunology (Baltimore, Md. : 1950). 2008 Apr 1;180(180). 4476-86. NIHMSID: NIHMS79262.
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Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood. 2008 Feb 15;111(111). 2101-11.
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Zhao Y, Wieman HL, Jacobs SR, Rathmell JC. Mechanisms and methods in glucose metabolism and cell death. Methods in enzymology. 442(442). 439-57. NIHMSID: NIHMS81576.
2007
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Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 2007 Jul 17;104(104). 12105-10.
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Rathmell JC, Kornbluth S. Filling a GAP(DH) in caspase-independent cell death. Cell. 2007 Jun 1;129(129). 861-3. NIHMSID: NIHMS79310.
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Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Molecular and cellular biology. 2007 Jun;27(27). 4328-39.
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Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Molecular biology of the cell. 2007 Apr;18(18). 1437-46.
2006
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Coloff JL, Rathmell JC. Metabolic regulation of Akt: roles reversed. The Journal of cell biology. 2006 Dec 18;175(175). 845-7.
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Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell metabolism. 2006 Dec;4(4). 475-90.
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Deming PB, Rathmell JC. Mitochondria, cell death, and B cell tolerance. Current directions in autoimmunity. 9(9). 95-119.
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Jacobs SR, Rathmell JC. Lymphocyte selection by starvation: glucose metabolism and cell death. Trends in immunology. 2006 Jan;27(27). 4-7.
2005
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Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell. 2005 Oct 7;123(123). 89-103. NIHMSID: NIHMS160583.
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Cinalli RM, Herman CE, Lew BO, Wieman HL, Thompson CB, Rathmell JC. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. European journal of immunology. 2005 Mar;35(35). 786-95. NIHMSID: NIHMS85583.
2004
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Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Aug;18(18). 1303-5. NIHMSID: NIHMS463226.
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Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2004 May 1;172(172). 5287-96. NIHMSID: NIHMS183701.
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Rathmell JC. B-cell homeostasis: digital survival or analog growth? Immunological reviews. 2004 Feb;197(197). 116-28.
2003
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Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology. 2003 Oct;23(23). 7315-28.
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Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. European journal of immunology. 2003 Aug;33(33). 2223-32.
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Rathmell JC. Apoptosis and B cell tolerance. Current directions in autoimmunity. 6(6). 38-60.
2002
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Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature immunology. 2002 Oct;3(3). 932-9.
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Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB. The CD28 signaling pathway regulates glucose metabolism. Immunity. 2002 Jun;16(16). 769-77.
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Plas DR, Rathmell JC, Thompson CB. Homeostatic control of lymphocyte survival: potential origins and implications. Nature immunology. 2002 Jun;3(3). 515-21.
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Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell. 2002 Apr;109 Suppl(109 Suppl). S97-107.
2001
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Rathmell JC, Farkash EA, Gao W, Thompson CB. IL-7 enhances the survival and maintains the size of naive T cells. Journal of immunology (Baltimore, Md. : 1950). 2001 Dec 15;167(167). 6869-76.
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Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology. 2001 Sep;21(21). 5899-912.
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Plas DR, Talapatra S, Edinger AL, Rathmell JC, Thompson CB. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry. 2001 Apr 13;276(276). 12041-8.
2000
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Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Molecular cell. 2000 Dec;6(6). 1389-99. NIHMSID: NIHMS272648.
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Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Molecular cell. 2000 Sep;6(6). 683-92.