Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PloS one. 9(9). e98705. PMID: 24879016 [PubMed] PMCID: PMC4039535
Hypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma. The relationship of these factors to discretely alter cell metabolic activities has largely been described in cancer cells, or in hypoxic conditions, where other confounding factors undoubtedly compete. These transcription factors and their specific roles in promoting cancer metabolic phenotypes from the earliest stages are poorly understood in pre-malignant cells.