Dr. Karnes' primary area of research interest is cardiovascular and immune pharmacogenomics, specifically investigating the utility of genetic polymorphisms to predict adverse drug reactions. He employs a translational approach to investigate pharmacogenomic associations using observational studies, functional genomics techniques, and eventually prospective clinical trials. his ultimate career goal is to facilitate personalized cardiovascular medicine and genotype-guided prescribing to avoid serious drug toxicities.
Dr. Karnes also serves as the Director of Scientific Programs for the University of Arizona-Banner All of Us Research Program. He is an author on over 60 peer-reviewed manuscripts and over 30 abstracts presented at national and international meetings. He's active in multiple professional societies including the American Society for Clinical Pharmacology and Therapeutics, the American Heart Association, and the American College of Clinical Pharmacy.
He has received support for his research from the American Heart Association, the Flinn Foundation, the American College of Clinical Pharmacy, and the NIH, including R01 and K01 grants from the National Heart, Lung, and Blood Institute.
Visit Dr. Karnes' faculty website here and laboratory website here for more information.
Follow Dr. Karnes on Twitter @jasonhkarnes
A full list of publications can be found here: https://www.ncbi.nlm.nih.gov/myncbi/jason.karnes.1/bibliography/public/
Dr. Digna Velez Edwards is a genetic epidemiologist, Associate Professor of Obstetrics and Gynecology and Biomedical Informatics, Director of the Division of Quantitative Sciences in the Department of Obstetrics and Gynecology, Director of Women's Health Research center, Investigator of the Vanderbilt Genetics Institute, and a member of the Vanderbilt Epidemiology Center. She has doctoral training in human genetics and has a master's degree in statistics. She started as faculty in the department of Obstetrics and Gynecology in 2010 pursuing research focused on understanding the genetic factors influencing differences in health care outcomes across groups. She also studied the role of gene and environment interactions in the risk for complex diseases, with a specific interest in fibroproliferative disorders that include uterine fibroids and keloids and diseases that disproportionately impact women's reproductive health.
Since the start of her faculty appointment, Dr. Velez Edwards has developed and coordinated a repository of biospecimens from participants in the Right from the Start pregnancy cohort to be used for genetic epidemiology studies examining reproductive health complications and risk for adverse pregnancy outcomes. She has several ongoing research projects utilizing this resource, as well as large clinical databases that link clinical information to DNA. These studies focus on understanding the differences in health care outcomes across groups in genetic risk for several complex diseases, including preterm birth, miscarriage, uterine fibroids and pelvic organ prolapse.
Her research is focused on understanding and identifying genetic risk factors for complex diseases with a specific focus on diseases that disproportionately impact certain sub-groups and genetic factors related to women's health and reproductive outcomes. She utilizes large clinical databases that link electronic health record (EHR) information to DNA and the Right from the Start cohort, a community-based prospective pregnancy cohort.
Current research projects include genetic studies of preterm birth, miscarriage, uterine fibroids, pelvic organ prolapse and keloids. These studies include genome-wide association analyses, next-generation sequencing, evaluation of biomarkers and phenome-wide association studies.
Christopher Lindsell is a collaborative biostatistician who is a leader in the application of rigorous of biostatistical methods in the acute care environment, and to the intersection between emergency care and public health. He is currently the Director of the Duke Clinical Research Institute and Adjunct Professor in the Department of Biomedical Informatics at VUMC.
He has led data coordinating centers for numerous multi-center clinical trials, including FDA-regulated trials, and for epidemiological studies. He holds patents on risk stratification in septic shock, and he has contributed significantly to a number of NIH-funded networks, including the CTSA. His current focus is on learning health systems, leveraging clinical processes and data systems to enhance learning from pragmatic trials and observational studies, and for designing and implementing dissemination and implementation research.
PhD, Epidemiology, University of Southampton
Association for Clinical and Translational Science (ACTS) president, 2020 - 2021
Associate Director, Center for Clinical Quality and Improvement Research, 2017 - 2021