Kristin O'Grady, Ph.D.

Assistant Professor
Radiology & Radiological Sciences, Biomedical Engineering
Phone
(615)322-7209

I am interested in translating quantitative MR techniques to the clinic to better understand the pathological changes in the brain and spinal cord associated with neurological diseases such as multiple sclerosis.

My research is focused on developing quantitative MR methodologies for the brain and spinal cord with a current emphasis on improving thoracic and lumbar spinal cord MRI. This work is also part of an effort to improve our understanding of the effects of biological sex on pathological changes associated with neurological diseases such as multiple sclerosis.

Research Information

K.G. Schilling, S. Fadnavis, J. Batson, M. Visagie, A.J.E. Combes, S. By, C.D. McKnight, F. Bagnato, E. Garyfallidis, B.A. Landman, S.A. Smith, & K.P. O'Grady. "Denoising of diffusion MRI in the cervical spinal cord - effects of denoising strategy and acquisition on intra-cord contrast, signal modeling, and feature conspicuity." NeuroImage: 266: 119826 (2023). Epub: December 18, 2022. PMID: 36543265. PMCID: PMC9843739.

A.J.E. Combes, M.A. Clarke, K.P. O'Grady, K.G. Schilling, & S.A. Smith. "Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions" NeuroImage: Clinical 36: 103244 (2022). PMID: 36306717. PMCID: PMC9668663.

A.J.E. Combes, K.P. O'Grady, B.P. Rogers, K.G. Schilling, R.D. Lawless, M. Visagie, D.C. Houston, L.E. Prock, S.D. Malone, S. Satish, A.A. Witt, C.D. McKnight, F. Bagnato, J.C. Gore, & S.A. Smith. "Functional connectivity in the dorsal network of the cervical spinal cord is correlated with diffusion tensor imaging indices in relapsing-remitting multiple sclerosis." NeuroImage: Clinical 35: 103127 (2022). PMID: 35917721. PMCID: PMC9421501.

K.P. O'Grady, S. Satish, Q.R. Owen, B.A. Box, F. Bagnato, A.J.E. Combes, S.R. Cook, H. Westervelt, H.R. Feiler, R.D. Lawless, A. Sarma, S.D. Malone, J.M. Ndolo, K. Yoon, R.D. Dortch, B.P. Rogers, & S.A. Smith. "Relaxation-compensated chemical exchange saturation transfer MRI in the brain at 7T: application in relapsing-remitting multiple sclerosis." Frontiers in Neurology - Applied Neuroimaging 13: 764690 (2022). Epub: February 25, 2022. PMID: 35299614. PMCID: PMC8923037.

K.P. O'Grady, A.N. Dula, B.D. Lyttle, L.M. Thompson, B.N. Conrad, B.A. Box, L.J. McKeithan, S. Pawate, F. Bagnato, B.A. Landman, P. Newhouse, & S.A. Smith. "Glutamate-sensitive imaging and evaluation of cognitive impairment in multiple sclerosis." Multiple Sclerosis Journal 25(12): 1580-1592 (2019). Epub: September 19, 2018. PMID: 30230400. PMCID: PMC6424643.