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Tina Hartert, MD, MPH, James Gern, MD (consortium PI)
Funding Agency: NCI
Grant Number:: UH3 OD023282CREW will provide a large (nearly 9000 births and long-term follow-up of 6000-7000 children and young adults) and diverse national dataset that will be optimized for systems analysis of early life exposures and events that influence asthma endotypes. The study goals are to establish how environmental and host factors in early life promote the development of specific asthma endotypes.
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Tina Hartert
Funding Agency: NIH/NIAID
Grant Number: U19 AI 095227Twelve city SARS-CoV-2 surveillance study of household units to understand immune response, transmission, symptomatology and role of asthma and allergies in infection.
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Tina Hartert, MD, MPH, Thomas Braciale
Funding Agency: NIH/NIAID
Grant Number: R01 AI136526This study explores a novel hypothesis, extending evidence from animal studies and ecological data, that available and safe oral leukotriene modifying agents may decrease influenza-related morbidity and mortality and to corroborate the action in human lungs.
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Wei Zheng
Funding Agency: NIH
Grant Number: R01 CA82729, UM1 CA173640The Shanghai Men's Health Study (SMHS), funded by the NCI since 2001, is a population-based cohort study of 61,482 men aged between 35 and 75 years and recruited from 2002 to 2006. At baseline, detailed information on dietary intakes, personal habits, occupational history, medical history, and other lifestyle factors was collected, and anthropometrics were measured. Blood or buccal cells and urine samples were collected from 89% of participants. The cohort has been followed through multiple in-person surveys to update exposure information and through record linkages with the population-based Shanghai Cancer Registry and Shanghai Vital Statistics Registry to obtain information on cancer occurrence and survival status. Over the years, SMHS data and biological samples have been used to evaluate many important etiologic hypotheses addressing the contributions of environmental, dietary, lifestyle, and genetic exposures to the development of cancer and other chronic diseases. More information can be found in the SMHS website: https://swhs-smhs.app.vumc.org/. (Research activities are ongoing.)
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Xiao-Ou Shu
Funding Agency: NIH
Grant Number: UM1CA182910This population-based prospective cohort study was initiated in 1996, in which ~75,000 Chinese women living in Shanghai were recruited from 1996 to 2000. In addition to survey data, most study participants donated a blood or mouthwash sample and a urine sample at baseline. This cohort of women is being followed for incidence of site-specific cancers and cause-specific mortality. Five in-person follow-up surveys have been completed, each with a response rate greater than 90%. The resources from this study have supported more than 200 studies, including approximately 40 international research consortia, to address etiologic hypotheses for cancers and other chronic diseases. The SWHS, with its large sample size, wealth of resources, unique exposure patterns, and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts.
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Wei Zheng, Martha Shrubsole
Agency: NIH
Grant Number: U01CA202979The SCCS was initiated in 2001. Nearly 86,000 adults aged 40-79 at cohort entry were recruited during 2002-2009 across 12 southern states, mostly at Community Health Centers (institutions providing basic health and preventive services in underserved areas). By design, two-thirds of the cohort was selected to be African American and the remainder predominantly non-Hispanic white to help remedy the underrepresentation of African Americans in health studies and enable direct black/white comparisons. Most of the cohort members, both black and white, had low income and education levels. In addition to detailed survey data, biospecimens were collected from more than 76,000 cohort members at baseline, with blood obtained and stored for approximately 39,000, mouth rinses/saliva for 38,000, and urine for 24,000, so that genomic DNA could be extracted from nearly 90% of participants. In 2018, we initiated stool sample collection and have collected these samples from ~8,500 cohort members. This cohort is being followed for incidence of site-specific cancers and cause-specific mortality. Data and biospecimens collected in the SCCS have been used to support large numbers of epidemiologic and genetic studies of cancer and other chronic diseases.
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Wilbroad Mutale, MBChB, PhD, Douglas C Heimburger, MD, MS
Funding Agency: NIH
Grant Number: 5D43 TW009744UVP trains Zambian PhD- and postdoctoral HIV researchers, equipping them with research skills in non-communicable complications and comorbidities of HIV, while expanding the University of Zambia (UNZA) / University Teaching Hospital's (UTH) research training and investigative capacities.
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Douglas C Heimburger, MD, MS, Muktar Aliyu, MBBS, DrPH
Funding Agency: NIH/NIAID
Grant Number: 2D43 TW009337Vanderbilt-Emory-Cornell-Duke (VECD) is one of six consortia that comprise the Fogarty Global Health Program for Fellows and Scholars. The purpose of this program is to provide mentored global health research training opportunities in low- and middle-income countries (LMICs) for pre- and post-doctoral candidates from the U.S. and LMICs. The program is sponsored by the Fogarty International Center (FIC) and several collaborating Institutes and Centers at the National Institutes of Health (NIH). Multiple training sites are available through VECD.
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Tina Hartert, MD, MPH, Stokes Peebles, MD
Funding Agency: NIH/NIAID
Grant Number: U19 AI 095227We will use a combination of human natural quasi-randomization studies of infant RSV infection specifically designed to assess the impact of infant RSV infection on subsequent respiratory health and the airway epithelium, and in vitro models of RSV infection of nasal airway epithelial cells (NAECs). The overarching objectives of the 3 aims that will test these hypotheses are: 1) to determine whether the age of first infant RSV infection is associated with risk of subsequent incident recurrent wheeze and asthma; 2) to delineate the longitudinal effects of RSV on airway epithelial cell differentiation and metabolism throughout infancy and childhood; 3) to evaluate host gene infant RSV infection interactions and RSV-dependent NAEC DNAm longitudinally to identify changes and temporal stability of RSV-dependent DNAm marks and their association with recurrent wheeze and asthma.