Occupational Epidemiology

Cancer Mortality Among Military Participants at U.S. Nuclear Weapons Tests
PI:  Boice, John Dunning Jr.     Funding Agency: NCI       Grant No.: U01 CA137026 
Description: The lifetime risk of cancer is being quantified among 125,000 United States atomic veterans who participated at one or more of the 230 aboveground atmospheric nuclear weapons tests at the Nevada Test Site or the Pacific Proving Ground between 1946 and 1958. Reliable estimates of radiation dose for individual atomic veterans are being made which were not possible in previous investigations. Advances in dose reconstruction methods will permit dose-response evaluations and risk quantification. New knowledge will be sought on specific cancer risks following protracted low-dose exposure to external and internal radiation, including the inhalation and ingestion of plutonium, uranium and radioactive fission products. The hypothesis to be tested is that chronic low-dose radiation exposure some 50 to 60 years ago can be linked to increases in leukemia and other diseases, including coronary heart disease.

Rotator Cuff Tears: Optimizing Diagnosis and Treatment Strategies
PI:  Jain, Nitin M.D., M.S.P.H.     Funding Agency: NIAMS       Grant No.: K23 AR059199 
Description: Phase I of this study is complete and we have recruited approximately 400 patients with shoulder pain. Recruitment for Phase II of this study includes ongoing efforts to enroll patients with rotator cuff tears. We have extensive epidemiological and outcomes data on the participants in our study. Our goal is to understand prognostic factors for better outcomes after surgical and non-surgical treatments for rotator cuff tears and comparative-effectiveness of these two treatment approaches. We welcome investigators and students who wish to collaborate with us.

Shanghai Women's Health Study (SWHS) 
PI: Zheng, Wei         Funding Agency:  NCI           Grant No.:  UM1 CA182910 
Description: This population-based prospective cohort study was initiated in 1996. From 1996 to 2000, approximately 75,000 Chinese women living in Shanghai were recruited into the study. In addition to survey data, most study participants donated blood (75%) and urine (87%) samples at baseline. Approximately 50% of study participants who did not donate a blood sample provided a sample of exfoliated buccal cells. This cohort of women is being followed for incidence of site-specific cancers and cause-specific mortality through a combination of in-person surveys and record linkages with population-based registries. Four in-person follow-up surveys have been completed, each with a response rate greater than 90%. The resources from this study have supported multiple studies, including approximately 40 international research consortia, to address etiologic hypotheses for cancers and other chronic diseases. The SWHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts.