Mahadevan-Jansen A. In vivo Raman spectroscopy for biochemical monitoring of the human cervix throughout pregnancy. American journal of obstetrics and gynecology. 2018 Dec;218(218). 528.e1-528.e18. PMID: 29410109 [PubMed] PMCID: PMC5916496 NIHMSID: NIHMS952540.
The cervix must undergo significant biochemical remodeling to allow for successful parturition. This process is not fully understood, especially in instances of spontaneous preterm birth. In vivo Raman spectroscopy is an optical technique that can be used to investigate the biochemical composition of tissue longitudinally and noninvasively in human beings, and has been utilized to measure physiology and disease states in a variety of medical applications.