• Friedman C, Rubin J, Brown J, Buntin M, Corn M, Etheredge L, Gunter C, Musen M, Platt R, Stead W, Sullivan K, Van Houweling D. Toward a science of learning systems: a research agenda for the high-functioning Learning Health System. Journal of the American Medical Informatics Association : JAMIA. 2015 Jan;22(1). 43-50. PMID: 25342177 [PubMed].

Abstract 

The capability to share data, and harness its potential to generate knowledge rapidly and inform decisions, can have transformative effects that improve health. The infrastructure to achieve this goal at scale-marrying technology, process, and policy-is commonly referred to as the Learning Health System (LHS). Achieving an LHS raises numerous scientific challenges.