• Fill MA, Compton ML, McDonald EC, Moncayo AC, Dunn JR, Schaffner W, Bhatnagar J, Zaki SR, Jones TF, Shieh WJ. Novel Clinical and Pathologic Findings in a Heartland Virus-Associated Death. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016 Dec 7. PMID: 27927857 [PubMed].


We describe an investigation into a Heartland Virus (HRTV)-associated death in Tennessee with novel clinical and pathologic findings. HRTV can cause rapidly fatal, widely disseminated infection with multisystem organ failure in patients without substantial comorbidities. We identified viral antigen in multiple organ tissues where it was not detected previously.