• Talbot HK, Nian H, Zhu Y, Chen Q, Williams JV, Griffin MR. Clinical Effectiveness of Split-Virion Versus Subunit Trivalent Influenza Vaccines in Older Adults. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 Feb 18. PMID: 25697739 [PubMed].

Abstract 

 Inactivated influenza vaccines are manufactured using either split-virion or subunit methods. These 2 methods produce similar hemagglutinin antibody responses, but different cellular immune responses.