Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes.

Roumie CL, Greevy RA, Grijalva CG, Hung AM, Liu X, Murff HJ, Elasy TA, Griffin MR. Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes. JAMA. 2014 Jun 11;311(311). 2288-96. PMID: 24915260 [PubMed] PMCID: PMC4149288 NIHMSID: NIHMS615684.

Abstract

Preferred second-line medication for diabetes treatment after metformin failure remains uncertain.