Building a cohort, the easy way

Teams mounting separate clinical trials at Vanderbilt University Medical Center sought to form research cohorts on two rare, life-threatening adverse drug reactions: drug-induced torsade de pointes (an arrythmia) and Stevens-Johnson syndrome/toxic epidermal necrolysis.

In a paper in the Journal of the American Medical Informatics Association, Sarah DeLozier, Joshua Denny, MD, MS, FACMI, and colleagues* report an automated solution for identifying candidates for these trials. 

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*Additional authors include Peter SpeltzLeigh Anne TangJaney Wang, MS, MEngJoshua Smith, PhDDario Giuse, PhDDan Roden, MD; Jason Brito; Elizabeth Phillips, MD; Kristina Williams, MSN; Teresa Strickland, RN; and Giovanni Davogustto, MD. The study was supported in part by the National Institutes of Health (GM115305).