Rock JB, Washington MK, Adsay NV, Greenson JK, Montgomery EA, Robert ME, Yantiss RK, Lehman AM, Frankel WL. Debating deposits: an interobserver variability study of lymph nodes and pericolonic tumor deposits in colonic adenocarcinoma. Archives of pathology & laboratory medicine. 2014 May;138(138). 636-42. PMID: 23902577 [PubMed] PMCID: PMC3935980 NIHMSID: NIHMS549980.
The American Joint Committee on Cancer's Cancer Staging Manual 7th edition defines pericolonic tumor deposits (TDs) as discrete tumor foci in pericolic fat showing no evidence of residual lymph node (LN). This definition relies on subjective features rather than size (5th edition) or shape (6th edition) and introduced the category N1c. Although typically straightforward, metastases are encountered for which the distinction between LNs and TDs is unclear. For data to be meaningful, agreement on distinguishing features between positive LNs and TDs is needed.