Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. | Cooperative Human Tissue Network Western Division

Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut. 2009 Sep;58(58). 1267-74. PMID: 19625278 [PubMed] PMCID: PMC2719085

Abstract

Autoimmune pancreatitis (AIP) is a poorly understood human disease affecting the exocrine pancreas. The goal of the present study was to elucidate the pathogenic mechanisms underlying pancreatic autoimmunity in a murine disease model.